Asking questions can help: development and preliminary evaluation of a question prompt list for palliative care patients.

abstract：:This study was undertaken to determine the prevalence of anti-cardiolipin antibodies (ACLAs) in patients with malignancy and to investigate a possible association of ACLAs with thromboembolic events in such patients. The study included 216 patients with solid and non-solid malignancies and an age-matched control group...

journal_title：British journal of cancer

authors： Zuckerman E,Toubi E,Golan TD,Rosenvald-Zuckerman T,Sabo E,Shmuel Z,Yeshurun D

更新日期：1995-08-01 00:00:00

abstract：:Natural human interferon beta (beta-IFN) was tested during the early phase of in vitro infection with HTLV-I virus of human cord blood mononuclear cells (CBL), to evaluate whether its antiviral and immunomodulating effects might prevent spreading of infection in the host. beta-IFN was found to reduce HTLV-I transmissi...

journal_title：British journal of cancer

authors： D'Onofrio C,Perno CF,Mazzetti P,Graziani G,Calio' R,Bonmassar E

更新日期：1988-05-01 00:00:00

abstract：BACKGROUND:There remains uncertainty on the need for bone staging in men with intermediate-risk prostate cancer. Current guidelines do not use mpMRI-staging information and rely on historic pathology grading. METHODS:We investigated the ability of mpMRI and the new Grade Group system to better predict bone metastasis ...

journal_title：British journal of cancer

authors： Thurtle D,Hsu RC,Chetan M,Lophatananon A,Hubbard R,Gnanapragasam VJ,Barrett T

更新日期：2016-11-22 00:00:00

abstract：:Capecitabine is an oral prodrug of 5-fluorouracil (FU). Since FU concentrations achieved in malignant lesions are an important determinant of efficacy, we investigated the intratumoral transcapillary transfer of capecitabine and its metabolites in vivo. A total of 10 patients with skin metastases from breast cancer re...

journal_title：British journal of cancer

authors： Mader RM,Schrolnberger C,Rizovski B,Brunner M,Wenzel C,Locker G,Eichler HG,Mueller M,Steger GG

更新日期：2003-03-10 00:00:00

abstract：:The x(c)(-) cystine transporter enhances biosynthesis of glutathione, a tripeptide thiol important in drug resistance and cellular defense against oxidative stress, by enabling cellular uptake of cystine, a rate-limiting precursor. Because it is known to regulate glutathione levels and growth of various cancer cell ty...

journal_title：British journal of cancer

authors： Lo M,Ling V,Wang YZ,Gout PW

更新日期：2008-08-05 00:00:00

abstract：BACKGROUND:Regulator of cullins-1 (ROC1) is a key subunit in the cullin-RING ligase (CRL) protein complex. Our previous study indicated that ROC1 was essential for bladder cancer cell survival and that ROC1 knockdown inhibited CRL activity, triggering G2 phase arrest and senescence. However, the role of ROC1 in the mal...

journal_title：British journal of cancer

authors： Wang W,Chen H,Liu Z,Qu P,Lan J,Chen H,Zou L,Qiu J

更新日期：2016-02-02 00:00:00

abstract：:The triple drug combination consisting of irinotecan, oxaliplatin and 5-fluorouracil (FOLFOXIRI) has demonstrated higher activity and efficacy compared to the doublet FOLFIRI. 5-Fluorouracil could be substituted in FOLFOXIRI regimen by capecitabine, an oral fluoropyrimidine with similar efficacy. Recently, a dose-find...

journal_title：British journal of cancer

authors： Vasile E,Masi G,Fornaro L,Cupini S,Loupakis F,Bursi S,Petrini I,Di Donato S,Brunetti IM,Ricci S,Antonuzzo A,Chiara S,Amoroso D,Andreuccetti M,Falcone A

更新日期：2009-06-02 00:00:00

abstract：:The assessment of a tumour's angiogenic potential, by measuring the microvessel density in histological sections, assumes that a 4-microm section is representative of whole tumour vascularity. This study has examined this assumption by comparing the vessel density found radiologically, after injecting specimens with c...

journal_title：British journal of cancer

authors： Martin L,Holcombe C,Green B,Leinster SJ,Winstanley J

更新日期：1997-01-01 00:00:00

abstract：:Two techniques for growing colonies of human tumour cells in soft agar have been applied to cell suspensions derived from fresh tumour tissue from 48 patients. Colonies were obtained in 31 cases, with plating efficiencies between 0.01 and 15%. In 11 cases the plating efficiencies were 1% or above. There was evidence t...

journal_title：British journal of cancer

authors： Courtenay VD,Selby PJ,Smith IE,Mills J,Peckham MJ

更新日期：1978-07-01 00:00:00

abstract：:This study describes the effects of the glucolipid synthase inhibitor P4, (DL-threo-1-phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol ), on various functional and phenotypic parameters of 5T33 murine myeloma cells. Cell recovery was reduced by >85% following incubation of the cells for 3 days in the presence of 4 mic...

journal_title：British journal of cancer

authors： Manning LS,Radin NS

更新日期：1999-11-01 00:00:00

abstract：:The prognostic weight of histological and biological factors was compared with that of known clinical prognostic factors in a population of 108 consecutive previously untreated patients with head and neck squamous cell carcinoma. Parameters studied were: tumour vascularisation, mitotic index, histological differentiat...

journal_title：British journal of cancer

authors： Janot F,Klijanienko J,Russo A,Mamet JP,de Braud F,El-Naggar AK,Pignon JP,Luboinski B,Cvitkovic E

更新日期：1996-02-01 00:00:00

abstract：:In the present study we have used flow cytometric DNA measurements on synchronised human NHIK 3025 cells to measure cell cycle progression under various conditions of reduced oxygenation. Our data indicate that addition of 0.1 mM deoxycytidine or uridine has no effect on the oxygen-dependent arrest in late G1 or on th...

journal_title：British journal of cancer

authors： Amellem O,Löffler M,Pettersen EO

更新日期：1994-11-01 00:00:00

abstract：:The vascular architecture of four different tumour cell lines (CaX, CaNT, SaS, HEC-1B) transplanted subcutaneously in mice was examined by means of microvascular corrosion casting in order to determine whether there is a characteristic vascular pattern for different tumour types and whether it differs significantly fr...

journal_title：British journal of cancer

authors： Konerding MA,Malkusch W,Klapthor B,van Ackern C,Fait E,Hill SA,Parkins C,Chaplin DJ,Presta M,Denekamp J

更新日期：1999-05-01 00:00:00

abstract：:We carried out a comparison of three commonly used mucin markers, CA549, CA15.3 and MCA. Serum samples from 184 healthy women and 237 patients with primary breast cancer were evaluated. The markers were measured using commercially available immunometric assays. Like CA15.3 and MCA, CA549 was significantly associated w...

journal_title：British journal of cancer

authors： Gion M,Plebani M,Mione R,Penzo C,Meo S,Burlina A

更新日期：1994-04-01 00:00:00

abstract：:The duration of the DNA synthesis period in normal and malignant human tissues from the larynx, trachea bronchus and esophagus of 13 patient has been estimated by a tritiated thymidine, carbon-14 thymidine double-labeling method in vitro. The DNA synthesis times range from approximately 10 to 25 hours, are shortest in...

journal_title：British journal of cancer

authors： Fabrikant JI

更新日期：1970-03-01 00:00:00

abstract：BACKGROUND:Isolated groups, such as first generation non-Western immigrants, are at risk for suboptimal utilisation of the health care system resulting in a worse outcome. METHODS:From 1989 to 2007, all patients with stomach cancer were selected from the Comprehensive Cancer Centre North-East cancer registry. Associat...

journal_title：British journal of cancer

authors： Siemerink EJ,van der Aa MA,Siesling S,Hospers GA,Mulder NH

更新日期：2011-03-29 00:00:00

abstract：BACKGROUND:Previous epidemiologic studies have shown inconsistent results for the association between alcohol intake and endometrial cancer risk. Most of the studies, however, assessed alcohol intake after cancer diagnosis, or measured alcohol intake at baseline only. METHODS:We prospectively examined the association ...

journal_title：British journal of cancer

authors： Je Y,De Vivo I,Giovannucci E

更新日期：2014-07-08 00:00:00

abstract：:Trends in long-term relative survival from breast cancer are examined for women diagnosed in England and Wales up to 2001, using both period and hybrid approaches. Large improvements in long-term survival are predicted. Women with breast cancer still experience persistent excess mortality up to at least 20 years after...

journal_title：British journal of cancer

authors： Woods LM,Rachet B,Cooper N,Coleman MP

更新日期：2007-04-10 00:00:00

abstract：:The factors affecting long-term survival following oesophagectomy for oesophageal cancer are poorly understood. We examined the significance of microscopic tumour involvement at the circumferential resection margin (CRM) on postoperative survival following oesophagectomy. The case notes of 329 patients who underwent a...

journal_title：British journal of cancer

authors： Khan OA,Fitzgerald JJ,Soomro I,Beggs FD,Morgan WE,Duffy JP

更新日期：2003-05-19 00:00:00

abstract：:Overexpression of the MDR1 product, P-glycoprotein (Pgp), has been shown to be one of the mechanisms underlying the development of multidrug resistance (MDR). Recently, one mutant p53 has been shown to stimulate the MDR1 gene promoter in vitro, whereas wild-type p53 repressed this activity. We measured Pgp and p53 exp...

journal_title：British journal of cancer

authors： De Angelis P,Stokke T,Smedshammer L,Lothe RA,Lehne G,Chen Y,Clausen OP

更新日期：1995-08-01 00:00:00

abstract：BACKGROUND:We evaluated the efficacy of aprepitant plus granisetron and an increased dose of dexamethasone in selected patients undergoing moderately emetogenic chemotherapy (MEC). METHODS:Nondrinking women <70 years undergoing MEC were randomly assigned to aprepitant (day 1, 125 mg; days 2 and 3, 80 mg) or placebo. D...

journal_title：British journal of cancer

authors： Tanioka M,Kitao A,Matsumoto K,Shibata N,Yamaguchi S,Fujiwara K,Minami H,Katakami N,Morita S,Negoro S

更新日期：2013-08-20 00:00:00

abstract：:The role of high-risk human papillomavirus (hrHPV) testing in primary cervical screening has not been established. We generated a randomised evaluation design ultimately to clarify whether primary hrHPV testing implemented into routine screening can bring increase in the programme effectiveness. The aim of the present...

journal_title：British journal of cancer

authors： Kotaniemi-Talonen L,Nieminen P,Anttila A,Hakama M

更新日期：2005-10-17 00:00:00

abstract：:Monoclonal antibodies to epithelial-cell antigenic determinants, labelled with 123I and 125I, were administered parenterally to immunodeficient mice bearing human tumours derived from a human cancer cell line. Anterior, posterior and lateral radioscans of the body were taken with a gamma scintillation camera at variou...

journal_title：British journal of cancer

authors： Epenetos AA,Nimmon CC,Arklie J,Elliott AT,Hawkins LA,Knowles RW,Britton KE,Bodmer WF

更新日期：1982-07-01 00:00:00

abstract：:In vivo models of acquired resistance to the platinum-based agents cisplatin (CDDP), carboplatin (CBDCA), iproplatin (CHIP) and tetraplatin have been established using a panel of six parent human ovarian carcinoma lines, two (HX/110 and PXN/87) being derived from previously untreated patients. Resistance has been gene...

journal_title：British journal of cancer

authors： Jones M,Siracky J,Kelland LR,Harrap KR

更新日期：1993-01-01 00:00:00

abstract：:We evaluated the interaction between hepatitis C virus (HCV) and cigarette smoking on death from hepatocellular cancer in The Japan Collaborative Cohort Study. The odds ratio of death from HCC for smoking was 9.60 (1.50-61.35) and 1.71(0.58-5.08) among anti-HCV positive and negative individuals, respectively. ...

journal_title：British journal of cancer

authors： Fujita Y,Shibata A,Ogimoto I,Kurozawa Y,Nose T,Yoshimura T,Suzuki H,Iwai N,Sakata R,Ichikawa S,Tamakoshi A

更新日期：2006-03-13 00:00:00

abstract：:Between 1946 and 1976 over 9,000 women with breast cancer were seen within one year of diagnosis at the A. Maxwell Evans Clinic (AMEC) in Vancouver, British Columbia. By 1978, 275 had a subsequent diagnosis of a second primary in the contralateral breast: 100 were diagnosed within 1 year, and 175 after 1 year of the f...

journal_title：British journal of cancer

authors： Hislop TG,Elwood JM,Coldman AJ,Spinelli JJ,Worth AJ,Ellison LG

更新日期：1984-01-01 00:00:00

abstract：:Pancreatic cancer is a highly lethal malignancy with a dismal 5-year survival of less than 5%. The scarcity of early biomarkers has considerably hindered our ability to launch preventive measures for this malignancy in a timely manner. Neutrophil gelatinase-associated lipocalin (NGAL), a 24-kDa glycoprotein, was repor...

journal_title：British journal of cancer

authors： Moniaux N,Chakraborty S,Yalniz M,Gonzalez J,Shostrom VK,Standop J,Lele SM,Ouellette M,Pour PM,Sasson AR,Brand RE,Hollingsworth MA,Jain M,Batra SK

更新日期：2008-05-06 00:00:00

abstract：:Metabolic reprogramming towards aerobic glycolysis is a common feature of transformed cells and can be driven by a network of transcription factors. It is well established that c-Myc and hypoxia-inducible factor-1α (HIF-1α) contribute to metabolic reprogramming by driving the expression of glycolytic target genes. Mor...

journal_title：British journal of cancer

authors： Wilde BR,Ayer DE

更新日期：2015-12-01 00:00:00

abstract：:The purpose of the study is to test the hypothesis that expression of cell cycle regulatory proteins p16(INK4a) and pRb is significantly associated with prognosis in ovarian carcinomas. We performed immunohistochemical analysis of p16(INK4a) and pRb expression and correlated with survival in a series of 300 patients w...

journal_title：British journal of cancer

authors： Kommoss S,du Bois A,Ridder R,Trunk MJ,Schmidt D,Pfisterer J,Kommoss F,AGO-OVAR.

更新日期：2007-01-29 00:00:00

abstract：:Epidemiological evidence indicates that non-steroidal anti-inflammatory drugs (NSAIDs) protect against colorectal cancer (CRC) to a greater degree than other non-gastrointestinal cancers, but the molecular basis for this difference is unknown. We previously reported that aspirin induces signal-specific I kappa B alpha...

journal_title：British journal of cancer

authors： Din FV,Dunlop MG,Stark LA

更新日期：2004-07-19 00:00:00