Abstract：
:The prognostic weight of histological and biological factors was compared with that of known clinical prognostic factors in a population of 108 consecutive previously untreated patients with head and neck squamous cell carcinoma. Parameters studied were: tumour vascularisation, mitotic index, histological differentiation, nuclear grade, keratinisation, desmoplasia, growth pattern, inflammation, tumour emboli in peripheral vessels, keratins 6, 13, 19 immunohistochemical expression, cytofluorometric ploidy and S-phase. In multivariate analysis (Cox), only age and nodal status had a significant impact on the overall survival, whereas T stage was the only significant factor associated with locoregional failure. The cumulative incidence of metastases was correlated not only with age, T and N stage, but also with histological differentiation. All the other histological and biological factors studied failed to provide further prognostic information. These findings may help to select patients with high metastatic risk.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Janot F,Klijanienko J,Russo A,Mamet JP,de Braud F,El-Naggar AK,Pignon JP,Luboinski B,Cvitkovic Edoi
10.1038/bjc.1996.92subject
Has Abstractpub_date
1996-02-01 00:00:00pages
531-8issue
4eissn
0007-0920issn
1532-1827journal_volume
73pub_type
杂志文章abstract：:Tumour recurrence and metastases of hepatocellular carcinoma (HCC) after hepatectomy are the major obstacles of long-term survival. The present study investigated the clinicopathological significance of a possible metastasis regulator Six1 in HCC patients who were undergone hepatectomy. Seventy-two pairs of RNA and 10...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603399
更新日期：2006-10-23 00:00:00
abstract：BACKGROUND:Use of antibiotics could alter human microbiota composition and decrease bacterial diversity. Such microbial dysbiosis may have implications in hepatocarcinogenesis; however, the association between antibiotic use and liver cancer risk has been minimally examined in humans. METHODS:We performed a nested cas...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2016.148
更新日期：2016-06-28 00:00:00
abstract：:Based on observations that for certain cancers, mortality varies according to sun exposure, vitamin D has been proposed to influence on disease progression. This study aims to investigate whether serum levels of 25(OH)D are associated with prognosis in patients with prostate cancer. In total, 160 patients with a serum...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604865
更新日期：2009-02-10 00:00:00
abstract：BACKGROUND:A phase Ib study of binimetinib and capecitabine for gemcitabine-pretreated biliary tract cancer (BTC) patients was conducted. METHODS:Binimetinib and capecitabine were dosed twice daily on days 1-14, in 3-week cycles. In the dose-escalation (DE) part, three dose levels (DL) were tested (DL1: binimetinib/ca...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-019-0523-5
更新日期：2019-08-01 00:00:00
abstract：BACKGROUND:The United Kingdom performs poorly in international comparisons of colorectal cancer survival with much of the deficit owing to high numbers of deaths close to the time of diagnosis. This retrospective cohort study investigates the patient, tumour and treatment characteristics of those who die in the first y...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2012.585
更新日期：2013-02-19 00:00:00
abstract：BACKGROUND:Surgery is considered to be the first line treatment for solid tumours. Recently, retrospective studies reported that general anaesthesia was associated with worse long-term cancer-free survival when compared with regional anaesthesia. This has important clinical implications; however, the mechanisms underly...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2014.426
更新日期：2014-09-23 00:00:00
abstract：BACKGROUND:Clear cell renal cancer frequently harbours von Hippel-Lindau (VHL) gene mutations, leading to stabilisation of the hypoxia-inducible factors (HIFs) and expression of their target genes. We investigated HIF-1 and HIF-2 in the regulation of microRNA-210 (miR-210), and its clinical relevance in renal tumours. ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2013.56
更新日期：2013-03-19 00:00:00
abstract：:Microsatellite instability is present in over 80% of the hereditary non-polyposis colorectal carcinoma and about 15-20% of the sporadic cancer. Microsatellite instability is caused by the inactivation of the mismatch repair genes, such as primarily hMLH1, hMSH2. To study the mechanisms of the inactivation of mismatch ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600148
更新日期：2002-02-12 00:00:00
abstract：BACKGROUND:Body mass index (BMI) has been associated with the risk of oesophageal cancer. But the influence of BMI on postoperative complication and prognosis has always been controversial. METHODS:In total, 2031 consecutive patients who underwent oesophagectomy between 1998 and 2008 were classified according to Asian...
journal_title：British journal of cancer
pub_type： 杂志文章,meta分析
doi：10.1038/bjc.2013.666
更新日期：2013-11-26 00:00:00
abstract：BACKGROUND:Epithelial ovarian cancer (EOC) cells are prone to metastasise throughout the peritoneal cavity. The epithelial-to-mesenchymal transition (EMT) is a necessary step towards metastatic tumour progression. CA125/MUC16 mucin is a high-molecular-weight glycoprotein overexpressed in the majority of serous carcinom...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2011.34
更新日期：2011-03-15 00:00:00
abstract：:Throughout the world there are problems recruiting ethnic minority patients into cancer clinical trials. A major barrier to trial entry may be distrust of research and the medical system. This may be compounded by the regulatory framework governing research with an emphasis on written consent, closed questions and con...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/bjc.2012.240
更新日期：2012-09-25 00:00:00
abstract：:Hormone concentrations in blood and total 12 h urine values were compared between 40 post-menopausal women with breast cancer and 40 control women in a study which carefully controlled for the possible confounding effects of age, weight and pregnancy history by individually matching cases and controls on these factors...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1990.56
更新日期：1990-02-01 00:00:00
abstract：:The production of graft-versus-host (GVH) reactions in (PVGc X Wistar) F1 hybrids by the transfer of PVGc spleen cells resulted in significant resistance of these recipients to a subsequent challenge with the PVGc leukaemia. Protection was markedly dependent on dose and timing of allogeneic cell transfer and was abrog...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1976.61
更新日期：1976-04-01 00:00:00
abstract：BACKGROUND:There remains uncertainty on the need for bone staging in men with intermediate-risk prostate cancer. Current guidelines do not use mpMRI-staging information and rely on historic pathology grading. METHODS:We investigated the ability of mpMRI and the new Grade Group system to better predict bone metastasis ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2016.353
更新日期：2016-11-22 00:00:00
abstract：BACKGROUND:Uterine serous papillary carcinoma (USPC) is a biologically aggressive variant of endometrial cancer. We investigated the expression of Serum Amyloid A (SAA) and evaluated its potential as a serum biomarker in USPC patients. METHODS:SAA gene and protein expression levels were evaluated in USPC and normal en...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605129
更新日期：2009-07-21 00:00:00
abstract：:BNP7787 (disodium 2,2'-dithio-bis-ethane sulphonate; Tavocept) is a novel agent developed to protect against cisplatin (cis-diammine-dichloroplatinum(II))-associated chronic toxicities. In this study, we determined the recommended dose of BNP7787 when preceding a fixed dose of cisplatin, the pharmacokinetics (PKs) and...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/sj.bjc.6602553
更新日期：2005-05-09 00:00:00
abstract：BACKGROUND:Neuroblastoma is the most common malignancy of infancy but little is known about the aetiological factors associated with the development of this tumour. A number of epidemiological studies have previously examined the risk associated with paternal occupational exposures but most have involved small numbers ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605504
更新日期：2010-02-02 00:00:00
abstract：:In some clinical situations the endogenous production of glutamine may be insufficient to maintain optimal tissue structure and function such that glutamine becomes a conditionally essential amino acid. Studies in laboratory animals have demonstrated that glutamine supplementation can reduce the incidence and severity...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/bjc.1994.385
更新日期：1994-10-01 00:00:00
abstract：:Alveolar macrophage (AM) phagocytic activity and glucose metabolism were evaluated during lung tumour growth in adult rats challenged i.v. with 10(5) viable Walker 256 tumour cells. Phagocytosis was estimated by the in vitro uptake of (14)C-labelled Pseudomonas aeruginosa and glucose oxidation was evaluated by (14)CO(...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1977.249
更新日期：1977-12-01 00:00:00
abstract：:In this review, we discuss the recent identification in vivo of a population of CD11c+ cells exhibiting simultaneous expression of both endothelial and dendritic cell markers, termed vascular leukocytes (VLCs). VLCs are highly represented in human ovarian carcinomas and, depending on the milieu, can assemble into func...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/sj.bjc.6602476
更新日期：2005-04-11 00:00:00
abstract：:Nasopharyngeal carcinoma (NPC) is a distinct type of head and neck cancer. Approximately 70% of patients with newly diagnosed NPC present with locally advanced disease. Phase III clinical trials support the addition of chemotherapy to radiotherapy for the initial treatment of these patients. Once metastatic disease de...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/sj.bjc.6602449
更新日期：2005-03-14 00:00:00
abstract：:The appearance of a liver DNA synthesis promoter (HP) in rat plasma after dimethylnitrosamine (DMNA) or thioacetamide injection was investigated. After 48 h, DMNA (30 mg kg-1 body weight) produced liver (centrilobular) necrosis and intense hepatic regeneration, as assessed by microscopic observations of liver slices, ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1987.122
更新日期：1987-06-01 00:00:00
abstract：BACKGROUND:This study aimed to evaluate the safety and efficacy of dose-dense weekly chemotherapy, followed by resection and/or thoracic radiotherapy. METHODS:Patients with histologically documented thymoma with unresectable stage III disease received 9 weeks of chemotherapy: cisplatin 25 mg m(-2) on weeks 1-9; vincri...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605731
更新日期：2010-06-29 00:00:00
abstract：:Animal experiments remain essential to understand the fundamental mechanisms underpinning malignancy and to discover improved methods to prevent, diagnose and treat cancer. Excellent standards of animal care are fully consistent with the conduct of high quality cancer research. Here we provide updated guidelines on th...
journal_title：British journal of cancer
pub_type： 杂志文章,实务指引
doi：10.1038/sj.bjc.6605642
更新日期：2010-05-25 00:00:00
abstract：:The incidence of gastro-oesophageal junction (GEJ) adenocarcinoma is increasing in Western countries and prognosis is poor since metastasis is most often present at diagnosis. We examined samples from 87 resected type II GEJ adenocarcinomas, 30 of these with endoscopic diagnostic biopsy material, to evaluate transform...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.1999.1013
更新日期：2000-02-01 00:00:00
abstract：BACKGROUND:Lynch syndrome (LS) is associated with a significant lifetime risk of endometrial cancer (EC). There are limited data on factors modifying the EC risk in LS patients. METHODS:The study cohort included 136 LS mutation-positive women. Exposure data were collected by postal questionnaires. Cox regression model...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2016.193
更新日期：2016-07-26 00:00:00
abstract：:Previous studies have suggested that infant vaccinations may reduce the risk of subsequent childhood leukaemia. Vaccination histories were compared in 439 children (ages 0-14) diagnosed with acute lymphoblastic leukaemia (ALL) in nine Midwestern and Mid-Atlantic states (USA) between 1 January 1989 and 30 June 1993 and...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6690668
更新日期：1999-09-01 00:00:00
abstract：:In addition to cobalt, metallic nickel, cadmium and other metals (e.g. zinc and copper) dissolve when incubated with horse serum at 37°. The dissolving property of copper in serum resembles that of cobalt, its solubility being increased greatly in the presence of oxygen, whereas the solubilities of cadmium, zinc and m...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1972.38
更新日期：1972-08-01 00:00:00
abstract：:Follicular-phase (Day 11) plasma prolactin, and plasma and urinary oestrogen levels of 70 nulliparous nuns were compared with those of 80 of their sisters, of whom 62 were parous. The nuns and their nulliparous sisters did not differ significantly in their prolactin and oestrogen levels. No differences in plasma oestr...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1981.121
更新日期：1981-06-01 00:00:00
abstract：BACKGROUND:The risk and prognosis of ovarian cancer have not been well established in women with endometriosis. Thus, we investigated the impact of endometriosis on the risk and prognosis for ovarian cancer, and evaluated clinicopathologic characteristics of endometriosis-associated ovarian cancer (EAOC) in comparison ...
journal_title：British journal of cancer
pub_type： 杂志文章,meta分析
doi：10.1038/bjc.2014.29
更新日期：2014-04-02 00:00:00
