Paternal occupation and neuroblastoma: a case-control study based on cancer registry data for Great Britain 1962-1999.

Abstract:

BACKGROUND:Neuroblastoma is the most common malignancy of infancy but little is known about the aetiological factors associated with the development of this tumour. A number of epidemiological studies have previously examined the risk associated with paternal occupational exposures but most have involved small numbers of cases. Here we present results from a large, population-based, case-control study of subjects diagnosed over a period of more than 30 years and recorded in the national registry of childhood tumours in Great Britain. METHODS:A case-control study of paternal occupational data for 2920 cases of neuroblastoma, born and diagnosed in Great Britain between 1962 and 1999 and recorded in the National Registry of Childhood Tumours, and 2920 controls from the general population matched on sex, date of birth and birth registration district. Paternal occupations at birth, of the case or control child, were grouped by inferred exposure using an occupational exposure classification scheme. Conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95% CI), for each of the 32 paternal occupational exposure groups. RESULTS:Only paternal occupational exposure to leather was statistically significantly associated with neuroblastoma, OR=5.00 (95% CI 1.07-46.93). However, this association became non-significant on correction for multiple testing. CONCLUSION:Our findings do not support the hypothesis that paternal occupational exposure is an important aetiological factor for neuroblastoma.

journal_name

Br J Cancer

authors

MacCarthy A,Bunch KJ,Fear NT,King JC,Vincent TJ,Murphy MF

doi

10.1038/sj.bjc.6605504

subject

Has Abstract

pub_date

2010-02-02 00:00:00

pages

615-9

issue

3

eissn

0007-0920

issn

1532-1827

pii

6605504

journal_volume

102

pub_type

杂志文章
  • Season of diagnosis is a prognostic factor in Hodgkin's lymphoma: a possible role of sun-induced vitamin D.

    abstract::Experimental studies show that vitamin D derivatives are potent anticarcinogenic factors. Epidemiological observations support this, and vitamin D sufficiency has been hypothesised to be an important risk-reducing factor in several forms of cancer. Vitamin D level exhibits seasonal variations. In the present work, we ...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/sj.bjc.6602722

    authors: Porojnicu AC,Robsahm TE,Ree AH,Moan J

    更新日期:2005-09-05 00:00:00

  • Mutational spectrum of p53 gene in arsenic-related skin cancers from the blackfoot disease endemic area of Taiwan.

    abstract::To understand the role of p53 tumour suppressor gene in the carcinogenesis of arsenic-related skin cancers from the blackfoot disease endemic area of Taiwan, we collected tumour samples from 23 patients with Bowen's disease, seven patients with basal cell carcinomas (BCC) and nine patients with squamous cell carcinoma...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/sj.bjc.6690467

    authors: Hsu CH,Yang SA,Wang JY,Yu HS,Lin SR

    更新日期:1999-06-01 00:00:00

  • Aerosolised 5-azacytidine suppresses tumour growth and reprogrammes the epigenome in an orthotopic lung cancer model.

    abstract:BACKGROUND:Epigenetic silencing by promoter methylation and chromatin remodelling affects hundreds of genes and is a causal event for lung cancer. Treatment of patients with low doses of the demethylating agent 5-azacytidine in combination with the histone deacetylase inhibitor entinostat has yielded clinical responses...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.2013.575

    authors: Reed MD,Tellez CS,Grimes MJ,Picchi MA,Tessema M,Cheng YS,March TH,Kuehl PJ,Belinsky SA

    更新日期:2013-10-01 00:00:00

  • Increase in tumour permeability following TGF-beta type I receptor-inhibitor treatment observed by dynamic contrast-enhanced MRI.

    abstract:BACKGROUND:To enhance the success rate of nanocarrier-mediated chemotherapy combined with an anti-angiogenic agent, it is crucial to identify parameters for tumour vasculature that can predict a response to the treatment of the anti-angiogenic agent. METHODS:To apply transforming growth factor (TGF)-beta type I recept...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/sj.bjc.6605367

    authors: Minowa T,Kawano K,Kuribayashi H,Shiraishi K,Sugino T,Hattori Y,Yokoyama M,Maitani Y

    更新日期:2009-12-01 00:00:00

  • Semi-quantitation of urokinase plasminogen activator and its receptor in breast carcinomas by immunocytochemistry.

    abstract::Urokinase plasminogen activator (uPA) is a serine protease involved in cancer invasion and metastasis. uPA acts in vivo by binding to a membrane receptor known as uPAR. In this study, uPA and uPAR levels were semiquantitated by immunocytochemistry in 36 primary breast carcinomas. Using monoclonal antibody HD-UK 1, uPA...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1998.268

    authors: Kennedy S,Duffy MJ,Duggan C,Barnes C,Rafferty R,Kramer MD

    更新日期:1998-05-01 00:00:00

  • Treatment and survival of lymphoid malignancy in the north-west of England: a population-based study.

    abstract::Classification of lymphoid malignancy has changed markedly in recent years and advances have been made in therapy. This study investigated the variations in treatment and survival of 1622 patients in a population-based registry. A total of 1009 cases of malignant lymphoma (ML) were classified according to the Kiel cla...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1995.406

    authors: Youngson JH,Jones JM,Chang JG,Harris M,Banergee SS

    更新日期:1995-09-01 00:00:00

  • Concurrent chemoradiotherapy for squamous cell carcinoma of the anus using a shrinking field radiotherapy technique without a boost.

    abstract::Chemoradiotherapy (CRT) is now widely accepted as the primary treatment modality for squamous cell cancer of the anus. While randomised trials have clearly shown CRT to be more effective than radiotherapy alone, there remains uncertainty over the optimal integration of chemotherapy and radiation. We describe a series ...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/sj.bjc.6600913

    authors: Melcher AA,Sebag-Montefiore D

    更新日期:2003-05-06 00:00:00

  • A human testicular teratoma serially transplanted in immune-deprived mice.

    abstract::Serial transplantation of an HCG-producing human testicular teratoma in immune-deprived mice is described. The xenografted tumour was compared to the tumour of origin in histology, immunohistochemistry (using an immune peroxidase technique to localize HCG) autoradiography, marker production and growth rate. It is conc...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1979.104

    authors: Selby PJ,Heyderman E,Gibbs J,Peckham MJ

    更新日期:1979-05-01 00:00:00

  • An in vitro study comparing the cytotoxicity of three platinum complexes with regard to the effect of thiol depletion.

    abstract::The cytotoxicity of three platinum complexes, cis-diamminedichloroplatinum(II) (cis-platin), cis-dichloro-trans-dihydroxy-cis-bis (isopropylamine) platinum(IV), (CHIP) and diammine (1, 1-cyclobutane-dicarboxylato) platinum(II) (carboplatin) on Chinese Hamster ovary (CHO) and mouse sarcoma RIF-1 cells cultured in vitro...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1988.126

    authors: Smith E,Brock AP

    更新日期:1988-06-01 00:00:00

  • Treatment of inoperable hepatocellular carcinoma with intrahepatic arterial yttrium-90 microspheres: a phase I and II study.

    abstract::Eighteen patients with inoperable hepatocellular carcinoma (HCC) were treated with intrahepatic arterial yttrium-90 microspheres. All these patients showed a lung shunting below 15% and a tumour-to-normal ratio higher than 2 as determined by diagnostic technetium-99m macroaggregated albumin (Tc-MAA) gamma scintigraphy...

    journal_title:British journal of cancer

    pub_type: 临床试验,杂志文章

    doi:10.1038/bjc.1994.436

    authors: Lau WY,Leung WT,Ho S,Leung NW,Chan M,Lin J,Metreweli C,Johnson P,Li AK

    更新日期:1994-11-01 00:00:00

  • Phase 1 trials of PEGylated recombinant human hyaluronidase PH20 in patients with advanced solid tumours.

    abstract::This corrects the article DOI: 10.1038/bjc.2017.327. ...

    journal_title:British journal of cancer

    pub_type: 杂志文章,已发布勘误

    doi:10.1038/bjc.2017.438

    authors: Infante JR,Korn RL,Rosen LS,LoRusso P,Dychter SS,Zhu J,Maneval DC,Jiang P,Shepard HM,Frost G,Von Hoff DD,Borad MJ,Ramanathan RK

    更新日期:2018-01-01 00:00:00

  • Correction: AMN107 (nilotinib): a novel and selective inhibitor of BCR-ABL.

    abstract::A correction to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:British journal of cancer

    pub_type: 已发布勘误

    doi:10.1038/s41416-019-0505-7

    authors: Weisberg E,Manley P,Mestan J,Cowan-Jacob S,Ray A,Griffin JD

    更新日期:2019-07-01 00:00:00

  • The efficacy of the anthracycline prodrug daunorubicin-GA3 in human ovarian cancer xenografts.

    abstract::The prodrug N-[4-(daunorubicin-N-carbonyl-oxymethyl)phenyl] O-beta-glucuronyl carbamate (DNR-GA3) was synthesized for specific activation by human beta-glucuronidase, released in necrotic areas of tumour lesions. In vitro, DNR-GA3 was 18 times less toxic than daunorubicin (DNR) and the prodrug was completely activated...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1998.729

    authors: Houba PH,Boven E,Erkelens CA,Leenders RG,Scheeren JW,Pinedo HM,Haisma HJ

    更新日期:1998-12-01 00:00:00

  • Cancer-associated tumour markers CA 19-9 and CA-50 in patients with pancreatic cancer with special reference to the Lewis blood cell status.

    abstract::Monoclonal antibodies 19-9 and C-50 were used to assay the cancer associated tumour antigens CA 19-9 and CA-50 in plasma from patients with confirmed pancreatic cancer, and related to the blood group and Lewis blood cell status. The plasma expressions of CA 19-9 or CA-50 were similar, including cases where the patient...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1990.241

    authors: Masson P,Pålsson B,Andrén-Sandberg A

    更新日期:1990-07-01 00:00:00

  • Expression and mutation analysis of the discoidin domain receptors 1 and 2 in non-small cell lung carcinoma.

    abstract::The discoidin domain receptors, (DDR)1 and DDR2, have been linked to numerous human cancers. We sought to determine expression levels of DDRs in human lung cancer, investigate prognostic determinates, and determine the prevalence of recently reported mutations in these receptor tyrosine kinases. Tumour samples from 14...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/sj.bjc.6603614

    authors: Ford CE,Lau SK,Zhu CQ,Andersson T,Tsao MS,Vogel WF

    更新日期:2007-03-12 00:00:00

  • Expression and clinical significance of erb-B receptor family in hepatocellular carcinoma.

    abstract::In order to elucidate the clinical significance of the erbB family, epidermal growth factor receptor (EGF-R), c-erbB-2, c-erbB-3 and c-erbB-4 in hepatocellular carcinoma (HCC), we investigated the expression of these proteins by means of immunohistochemistry for HCC as well as adjacent noncancerous lesions. EGF-R was ...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1054/bjoc.2000.1580

    authors: Ito Y,Takeda T,Sakon M,Tsujimoto M,Higashiyama S,Noda K,Miyoshi E,Monden M,Matsuura N

    更新日期:2001-05-18 00:00:00

  • Quantitative aspects of accelerated nuclear polyploidization and tumour formation in dieldrin treated CF-1 mouse liver.

    abstract::Nuclear polyploidization in the livers of CF-1 mice, exposed to dieldrin (0, 1, 5 and 10 ppm in the diet), was studied up to the median time of liver tumour development (ranging from 15 to 27 months) in the respective treatment groups. In untreated controls nuclear polyploidization is characterized by a linear increas...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1988.160

    authors: van Ravenzwaay B,Kunz W

    更新日期:1988-07-01 00:00:00

  • FGFR3IIIS: a novel soluble FGFR3 spliced variant that modulates growth is frequently expressed in tumour cells.

    abstract::Fibroblast growth factor receptor 3 (FGFR3) is one of four high-affinity tyrosine kinase receptors for the FGF family of ligands, frequently associated with growth arrest and induction of differentiation. The extracellular immunoglobulin (IgG)-like domains II and III are responsible for ligand binding; alternative usa...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/sj.bjc.6601249

    authors: Sturla LM,Merrick AE,Burchill SA

    更新日期:2003-10-06 00:00:00

  • A phase I trial of DNA vaccination with a plasmid expressing prostate-specific antigen in patients with hormone-refractory prostate cancer.

    abstract::Prostate-specific antigen (PSA) is a serine protease secreted at low levels by normal luminal epithelial cells of the prostate and in significantly higher levels by prostate cancer cells. Therefore, PSA is a potential target for various immunotherapeutical approaches against prostate cancer. DNA vaccination has been i...

    journal_title:British journal of cancer

    pub_type: 临床试验,杂志文章

    doi:10.1038/sj.bjc.6602019

    authors: Pavlenko M,Roos AK,Lundqvist A,Palmborg A,Miller AM,Ozenci V,Bergman B,Egevad L,Hellström M,Kiessling R,Masucci G,Wersäll P,Nilsson S,Pisa P

    更新日期:2004-08-16 00:00:00

  • p53 mutations, protein expression and cell proliferation in squamous cell carcinomas of the head and neck.

    abstract::Thirty-three patients with squamous cell carcinoma of the head and neck region were studied concerning p53 protein expression and mutations in exons 4-9 of the p53 gene using immunohistochemistry, polymerase chain reaction (PCR)-single strand conformation polymorphism analysis and DNA sequencing. Immunoreactivity was ...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1995.159

    authors: Nylander K,Nilsson P,Mehle C,Roos G

    更新日期:1995-04-01 00:00:00

  • Protein kinase C in human renal cell carcinomas: role in invasion and differential isoenzyme expression.

    abstract::The role of protein kinase C (PKC) in in vitro invasiveness of four different human renal cell carcinoma (RCC) cell lines of the clear cell type was investigated. Different PKC-inhibitors markedly inhibited invasiveness of the highly invasive cell lines, suggesting an invasion-promoting role of PKC in human RCC. Analy...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1054/bjoc.1999.1043

    authors: Engers R,Mrzyk S,Springer E,Fabbro D,Weissgerber G,Gernharz CD,Gabbert HE

    更新日期:2000-03-01 00:00:00

  • The oncogenic potential of a combination of hyperthermia and chemotherapy agents.

    abstract::The modulating effect of 43 degrees C hyperthermia on the induction of oncogenic transformation by the antineoplastic agents, actinomycin D, mitomycin C, and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) was examined using the C3H 10T1/2 cell line. For any given level of cytotoxicity, cells exposed to the three chemothe...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1988.9

    authors: Komatsu K,Miller RC,Hall EJ

    更新日期:1988-01-01 00:00:00

  • Risk factors cannot explain the higher prevalence rates of precancerous colorectal lesions in men.

    abstract:BACKGROUND:Prevalence of (pre)cancerous colorectal lesions are higher in men than in women, although transition rates from advanced lesions to cancer is similar in both sexes. Our aim was to investigate whether the sex-specific difference in incidence of premalignant colorectal lesions might be explained by the impact ...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.2016.324

    authors: Waldmann E,Heinze G,Ferlitsch A,GessI I,Sallinger D,Jeschek P,Britto-Arias M,Salzl P,Fasching E,Jilma B,Kundi M,Trauner M,Ferlitsch M

    更新日期:2016-11-22 00:00:00

  • The monolayer and organ culture of human colorectal carcinomata and the associated "normal" colonic mucosa and their production of carcinoembryonic antigens.

    abstract::The carcinoembryonic antigen (CEA) was produced and released by human colorectal carcinomata and also the normal attached mucosa when maintained in both monolayer and organ culture. Immunoperoxidase cytochemical methods were employed for the cellular localization of CEA which was demonstrable only on the neoplastic ce...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1975.97

    authors: Breborowicz J,Easty GC,Birbeck M,Robertson D,Nery R,Neville AM

    更新日期:1975-05-01 00:00:00

  • The validity of the labelling index in tumour studies.

    abstract::The distribution of labelled cells through 5 different mouse tumours was measured after a single injection of [3H]-thymidine [( 3H]-TdR) or [3H]-deoxyuridine [( 3H]-UdR). All the tumours had areas where the percentage of labelled cells (the labelling index, LI) was high and areas where the LI was very low. The total a...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1985.3

    authors: Hamilton E,Dobbin J

    更新日期:1985-01-01 00:00:00

  • Prognostic impact of discrepant Ki67 and mitotic index on hormone receptor-positive, HER2-negative breast carcinoma.

    abstract:BACKGROUND:Inconsistencies between mitotic index (MI) and Ki67 measures have been identified in many breast tumour samples. The aim of this study was to describe the prognosis of hormone receptor-positive (HR+) HER2- tumours having discrepant MI and Ki67. METHODS:We included a cohort of breast cancer patients initiall...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.2015.239

    authors: Rossi L,Laas E,Mallon P,Vincent-Salomon A,Guinebretiere JM,Lerebours F,Rouzier R,Pierga JY,Reyal F

    更新日期:2015-09-29 00:00:00

  • A direct comparison of CellSearch and ISET for circulating tumour-cell detection in patients with metastatic carcinomas.

    abstract:BACKGROUND:Circulating tumour cells (CTCs) can provide information on patient prognosis and treatment efficacy. However, there is no universal method to detect CTC currently available. Here, we compared the performance of two CTC detection systems based on the expression of the EpCAM antigen (CellSearch assay) or on ce...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.2011.294

    authors: Farace F,Massard C,Vimond N,Drusch F,Jacques N,Billiot F,Laplanche A,Chauchereau A,Lacroix L,Planchard D,Le Moulec S,André F,Fizazi K,Soria JC,Vielh P

    更新日期:2011-09-06 00:00:00

  • The research priorities of patients attending UK cancer treatment centres: findings from a modified nominal group study.

    abstract::Members of the public are increasingly consulted over health care and research priorities. Patient involvement in determining cancer research priorities, however, has remained underdeveloped. This paper presents the findings of the first consultation to be conducted with UK cancer patients concerning research prioriti...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/sj.bjc.6603662

    authors: Corner J,Wright D,Hopkinson J,Gunaratnam Y,McDonald JW,Foster C

    更新日期:2007-03-26 00:00:00

  • Induction of endothelial cell apoptosis by the antivascular agent 5,6-Dimethylxanthenone-4-acetic acid.

    abstract::5,6-Dimethylxanthenone-4-acetic acid, synthesised in this laboratory, reduces tumour blood flow, both in mice and in patients on Phase I trial. We used TUNEL (TdT-mediated dUTP nick end labelling) assays to investigate whether apoptosis induction was involved in its antivascular effect. 5,6-Dimethylxanthenone-4-acetic...

    journal_title:British journal of cancer

    pub_type: 临床试验,杂志文章

    doi:10.1038/sj.bjc.6600368

    authors: Ching LM,Cao Z,Kieda C,Zwain S,Jameson MB,Baguley BC

    更新日期:2002-06-17 00:00:00

  • Glutathione-doxorubicin conjugate expresses potent cytotoxicity by suppression of glutathione S-transferase activity: comparison between doxorubicin-sensitive and -resistant rat hepatoma cells.

    abstract::The cytotoxic mechanism of a conjugate of doxorubicin (DXR) and glutathione (GSH) via glutaraldehyde (GSH-DXR) was investigated using DXR-sensitive (AH66P) and -resistant (AH66DR) rat hepatoma cells. GSH-DXR accumulated in AH66DR cells as well as in AH66P cells without efflux by P-gp and exhibited the potent cytocidal...

    journal_title:British journal of cancer

    pub_type: 杂志文章

    doi:10.1038/bjc.1997.557

    authors: Asakura T,Ohkawa K,Takahashi N,Takada K,Inoue T,Yokoyama S

    更新日期:1997-01-01 00:00:00