Abstract:
BACKGROUND:Neuroblastoma is the most common malignancy of infancy but little is known about the aetiological factors associated with the development of this tumour. A number of epidemiological studies have previously examined the risk associated with paternal occupational exposures but most have involved small numbers of cases. Here we present results from a large, population-based, case-control study of subjects diagnosed over a period of more than 30 years and recorded in the national registry of childhood tumours in Great Britain. METHODS:A case-control study of paternal occupational data for 2920 cases of neuroblastoma, born and diagnosed in Great Britain between 1962 and 1999 and recorded in the National Registry of Childhood Tumours, and 2920 controls from the general population matched on sex, date of birth and birth registration district. Paternal occupations at birth, of the case or control child, were grouped by inferred exposure using an occupational exposure classification scheme. Conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95% CI), for each of the 32 paternal occupational exposure groups. RESULTS:Only paternal occupational exposure to leather was statistically significantly associated with neuroblastoma, OR=5.00 (95% CI 1.07-46.93). However, this association became non-significant on correction for multiple testing. CONCLUSION:Our findings do not support the hypothesis that paternal occupational exposure is an important aetiological factor for neuroblastoma.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
MacCarthy A,Bunch KJ,Fear NT,King JC,Vincent TJ,Murphy MFdoi
10.1038/sj.bjc.6605504subject
Has Abstractpub_date
2010-02-02 00:00:00pages
615-9issue
3eissn
0007-0920issn
1532-1827pii
6605504journal_volume
102pub_type
杂志文章abstract::Experimental studies show that vitamin D derivatives are potent anticarcinogenic factors. Epidemiological observations support this, and vitamin D sufficiency has been hypothesised to be an important risk-reducing factor in several forms of cancer. Vitamin D level exhibits seasonal variations. In the present work, we ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6602722
更新日期:2005-09-05 00:00:00
abstract::To understand the role of p53 tumour suppressor gene in the carcinogenesis of arsenic-related skin cancers from the blackfoot disease endemic area of Taiwan, we collected tumour samples from 23 patients with Bowen's disease, seven patients with basal cell carcinomas (BCC) and nine patients with squamous cell carcinoma...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6690467
更新日期:1999-06-01 00:00:00
abstract:BACKGROUND:Epigenetic silencing by promoter methylation and chromatin remodelling affects hundreds of genes and is a causal event for lung cancer. Treatment of patients with low doses of the demethylating agent 5-azacytidine in combination with the histone deacetylase inhibitor entinostat has yielded clinical responses...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2013.575
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND:To enhance the success rate of nanocarrier-mediated chemotherapy combined with an anti-angiogenic agent, it is crucial to identify parameters for tumour vasculature that can predict a response to the treatment of the anti-angiogenic agent. METHODS:To apply transforming growth factor (TGF)-beta type I recept...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6605367
更新日期:2009-12-01 00:00:00
abstract::Urokinase plasminogen activator (uPA) is a serine protease involved in cancer invasion and metastasis. uPA acts in vivo by binding to a membrane receptor known as uPAR. In this study, uPA and uPAR levels were semiquantitated by immunocytochemistry in 36 primary breast carcinomas. Using monoclonal antibody HD-UK 1, uPA...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1998.268
更新日期:1998-05-01 00:00:00
abstract::Classification of lymphoid malignancy has changed markedly in recent years and advances have been made in therapy. This study investigated the variations in treatment and survival of 1622 patients in a population-based registry. A total of 1009 cases of malignant lymphoma (ML) were classified according to the Kiel cla...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1995.406
更新日期:1995-09-01 00:00:00
abstract::Chemoradiotherapy (CRT) is now widely accepted as the primary treatment modality for squamous cell cancer of the anus. While randomised trials have clearly shown CRT to be more effective than radiotherapy alone, there remains uncertainty over the optimal integration of chemotherapy and radiation. We describe a series ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6600913
更新日期:2003-05-06 00:00:00
abstract::Serial transplantation of an HCG-producing human testicular teratoma in immune-deprived mice is described. The xenografted tumour was compared to the tumour of origin in histology, immunohistochemistry (using an immune peroxidase technique to localize HCG) autoradiography, marker production and growth rate. It is conc...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1979.104
更新日期:1979-05-01 00:00:00
abstract::The cytotoxicity of three platinum complexes, cis-diamminedichloroplatinum(II) (cis-platin), cis-dichloro-trans-dihydroxy-cis-bis (isopropylamine) platinum(IV), (CHIP) and diammine (1, 1-cyclobutane-dicarboxylato) platinum(II) (carboplatin) on Chinese Hamster ovary (CHO) and mouse sarcoma RIF-1 cells cultured in vitro...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1988.126
更新日期:1988-06-01 00:00:00
abstract::Eighteen patients with inoperable hepatocellular carcinoma (HCC) were treated with intrahepatic arterial yttrium-90 microspheres. All these patients showed a lung shunting below 15% and a tumour-to-normal ratio higher than 2 as determined by diagnostic technetium-99m macroaggregated albumin (Tc-MAA) gamma scintigraphy...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章
doi:10.1038/bjc.1994.436
更新日期:1994-11-01 00:00:00
abstract::This corrects the article DOI: 10.1038/bjc.2017.327. ...
journal_title:British journal of cancer
pub_type: 杂志文章,已发布勘误
doi:10.1038/bjc.2017.438
更新日期:2018-01-01 00:00:00
abstract::A correction to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:British journal of cancer
pub_type: 已发布勘误
doi:10.1038/s41416-019-0505-7
更新日期:2019-07-01 00:00:00
abstract::The prodrug N-[4-(daunorubicin-N-carbonyl-oxymethyl)phenyl] O-beta-glucuronyl carbamate (DNR-GA3) was synthesized for specific activation by human beta-glucuronidase, released in necrotic areas of tumour lesions. In vitro, DNR-GA3 was 18 times less toxic than daunorubicin (DNR) and the prodrug was completely activated...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1998.729
更新日期:1998-12-01 00:00:00
abstract::Monoclonal antibodies 19-9 and C-50 were used to assay the cancer associated tumour antigens CA 19-9 and CA-50 in plasma from patients with confirmed pancreatic cancer, and related to the blood group and Lewis blood cell status. The plasma expressions of CA 19-9 or CA-50 were similar, including cases where the patient...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1990.241
更新日期:1990-07-01 00:00:00
abstract::The discoidin domain receptors, (DDR)1 and DDR2, have been linked to numerous human cancers. We sought to determine expression levels of DDRs in human lung cancer, investigate prognostic determinates, and determine the prevalence of recently reported mutations in these receptor tyrosine kinases. Tumour samples from 14...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6603614
更新日期:2007-03-12 00:00:00
abstract::In order to elucidate the clinical significance of the erbB family, epidermal growth factor receptor (EGF-R), c-erbB-2, c-erbB-3 and c-erbB-4 in hepatocellular carcinoma (HCC), we investigated the expression of these proteins by means of immunohistochemistry for HCC as well as adjacent noncancerous lesions. EGF-R was ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.2000.1580
更新日期:2001-05-18 00:00:00
abstract::Nuclear polyploidization in the livers of CF-1 mice, exposed to dieldrin (0, 1, 5 and 10 ppm in the diet), was studied up to the median time of liver tumour development (ranging from 15 to 27 months) in the respective treatment groups. In untreated controls nuclear polyploidization is characterized by a linear increas...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1988.160
更新日期:1988-07-01 00:00:00
abstract::Fibroblast growth factor receptor 3 (FGFR3) is one of four high-affinity tyrosine kinase receptors for the FGF family of ligands, frequently associated with growth arrest and induction of differentiation. The extracellular immunoglobulin (IgG)-like domains II and III are responsible for ligand binding; alternative usa...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6601249
更新日期:2003-10-06 00:00:00
abstract::Prostate-specific antigen (PSA) is a serine protease secreted at low levels by normal luminal epithelial cells of the prostate and in significantly higher levels by prostate cancer cells. Therefore, PSA is a potential target for various immunotherapeutical approaches against prostate cancer. DNA vaccination has been i...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章
doi:10.1038/sj.bjc.6602019
更新日期:2004-08-16 00:00:00
abstract::Thirty-three patients with squamous cell carcinoma of the head and neck region were studied concerning p53 protein expression and mutations in exons 4-9 of the p53 gene using immunohistochemistry, polymerase chain reaction (PCR)-single strand conformation polymorphism analysis and DNA sequencing. Immunoreactivity was ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1995.159
更新日期:1995-04-01 00:00:00
abstract::The role of protein kinase C (PKC) in in vitro invasiveness of four different human renal cell carcinoma (RCC) cell lines of the clear cell type was investigated. Different PKC-inhibitors markedly inhibited invasiveness of the highly invasive cell lines, suggesting an invasion-promoting role of PKC in human RCC. Analy...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.1999.1043
更新日期:2000-03-01 00:00:00
abstract::The modulating effect of 43 degrees C hyperthermia on the induction of oncogenic transformation by the antineoplastic agents, actinomycin D, mitomycin C, and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) was examined using the C3H 10T1/2 cell line. For any given level of cytotoxicity, cells exposed to the three chemothe...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1988.9
更新日期:1988-01-01 00:00:00
abstract:BACKGROUND:Prevalence of (pre)cancerous colorectal lesions are higher in men than in women, although transition rates from advanced lesions to cancer is similar in both sexes. Our aim was to investigate whether the sex-specific difference in incidence of premalignant colorectal lesions might be explained by the impact ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2016.324
更新日期:2016-11-22 00:00:00
abstract::The carcinoembryonic antigen (CEA) was produced and released by human colorectal carcinomata and also the normal attached mucosa when maintained in both monolayer and organ culture. Immunoperoxidase cytochemical methods were employed for the cellular localization of CEA which was demonstrable only on the neoplastic ce...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1975.97
更新日期:1975-05-01 00:00:00
abstract::The distribution of labelled cells through 5 different mouse tumours was measured after a single injection of [3H]-thymidine [( 3H]-TdR) or [3H]-deoxyuridine [( 3H]-UdR). All the tumours had areas where the percentage of labelled cells (the labelling index, LI) was high and areas where the LI was very low. The total a...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1985.3
更新日期:1985-01-01 00:00:00
abstract:BACKGROUND:Inconsistencies between mitotic index (MI) and Ki67 measures have been identified in many breast tumour samples. The aim of this study was to describe the prognosis of hormone receptor-positive (HR+) HER2- tumours having discrepant MI and Ki67. METHODS:We included a cohort of breast cancer patients initiall...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2015.239
更新日期:2015-09-29 00:00:00
abstract:BACKGROUND:Circulating tumour cells (CTCs) can provide information on patient prognosis and treatment efficacy. However, there is no universal method to detect CTC currently available. Here, we compared the performance of two CTC detection systems based on the expression of the EpCAM antigen (CellSearch assay) or on ce...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2011.294
更新日期:2011-09-06 00:00:00
abstract::Members of the public are increasingly consulted over health care and research priorities. Patient involvement in determining cancer research priorities, however, has remained underdeveloped. This paper presents the findings of the first consultation to be conducted with UK cancer patients concerning research prioriti...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6603662
更新日期:2007-03-26 00:00:00
abstract::5,6-Dimethylxanthenone-4-acetic acid, synthesised in this laboratory, reduces tumour blood flow, both in mice and in patients on Phase I trial. We used TUNEL (TdT-mediated dUTP nick end labelling) assays to investigate whether apoptosis induction was involved in its antivascular effect. 5,6-Dimethylxanthenone-4-acetic...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章
doi:10.1038/sj.bjc.6600368
更新日期:2002-06-17 00:00:00
abstract::The cytotoxic mechanism of a conjugate of doxorubicin (DXR) and glutathione (GSH) via glutaraldehyde (GSH-DXR) was investigated using DXR-sensitive (AH66P) and -resistant (AH66DR) rat hepatoma cells. GSH-DXR accumulated in AH66DR cells as well as in AH66P cells without efflux by P-gp and exhibited the potent cytocidal...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1997.557
更新日期:1997-01-01 00:00:00