Abstract：
:The production of graft-versus-host (GVH) reactions in (PVGc X Wistar) F1 hybrids by the transfer of PVGc spleen cells resulted in significant resistance of these recipients to a subsequent challenge with the PVGc leukaemia. Protection was markedly dependent on dose and timing of allogeneic cell transfer and was abrogated by irradiation of the cells prior to transfer. GVH activity was shown to be a prerequisite for induction of the protective effect but was equally effective when produced by the transfer of Wistar spleen cells in place of PVGc cells. These points, plus the fact that invitro investigations of possible immune mechanisms failed to demonstrate cytotoxic immunity in treated rats, suggested a nonspecific "bystander" effect as the mechanism of protection. The implications of such a mechanism are discussed.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Johnson PR,Hersey Pdoi
10.1038/bjc.1976.61subject
Has Abstractpub_date
1976-04-01 00:00:00pages
370-8issue
4eissn
0007-0920issn
1532-1827journal_volume
33pub_type
杂志文章abstract：:In the early period following radical hepatectomy for hepatoma, recurrences in the remaining liver are frequently found. In regenerating liver, implantation and growth of tumour cells released into the portal system during surgical treatment might be promoted. We examined the relationship between liver regeneration an...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1992.170
更新日期：1992-06-01 00:00:00
abstract：BACKGROUND:Lithium accumulates in the colon and inhibits the enzyme GSK-3β that possesses anti-carcinogenic effects. We therefore examined the association between lithium use and colorectal cancer risk in a nationwide study. METHODS:We used the Danish Cancer Registry to identify all patients diagnosed with incident co...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2016.10
更新日期：2016-03-01 00:00:00
abstract：BACKGROUND:On theoretical grounds, the age of the grandmother and the age of the mother at delivery of her daughter may affect the breast cancer risk of the granddaughter. METHODS:We used the data relating to the Diagnostic Research Mamma-carcinoma cohort (DOM (Diagnostisch Onderzoek Mammacarcinoom) 3), which comprise...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605639
更新日期：2010-04-27 00:00:00
abstract：:We examined bone marrow aspirates from 100 metastasis-free primary breast cancer patients. In 38/100 patients (38%), tumour cells were detected in the marrow using an immunocytochemical technique with a cocktail of two monoclonal antibodies: anti-EMA and anti-cytokeratin. Median follow-up was 34 months: 15/38 (39%) tu...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1994.103
更新日期：1994-03-01 00:00:00
abstract：:This study was undertaken to determine the prevalence of anti-cardiolipin antibodies (ACLAs) in patients with malignancy and to investigate a possible association of ACLAs with thromboembolic events in such patients. The study included 216 patients with solid and non-solid malignancies and an age-matched control group...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1995.353
更新日期：1995-08-01 00:00:00
abstract：BACKGROUND:The target substrates of DNA mismatch recognising factors MutSalpha (MSH2+MSH6) and MutSbeta (MSH2+MSH3) have already been widely researched. However, the extent of their functional redundancy and clinical substance remains unclear. Mismatch repair (MMR)-deficient tumours are strongly associated with microsa...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605531
更新日期：2010-03-16 00:00:00
abstract：:A correction to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：British journal of cancer
pub_type： 已发布勘误
doi：10.1038/s41416-019-0505-7
更新日期：2019-07-01 00:00:00
abstract：BACKGROUND:Vascular endothelial growth factor (VEGF)-mediated angiogenesis mediates tumour growth and metastasis. Meningiomas are primarily benign, slow-growing, highly vascularised tumours. Aside from VEGF, there is little data on the function of major angiogenic proteins in meningiomas. METHODS:The VEGFA, platelet-d...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2012.459
更新日期：2012-11-06 00:00:00
abstract：BACKGROUND:Prenatal supplementation has been inversely associated with childhood, but not with infant, leukaemia. METHODS:Mothers of 443 cases of infant leukaemia diagnosed during 1996-2006 and 324 frequency-matched controls completed interviews. Associations were evaluated by unconditional logistic regression. RESUL...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605957
更新日期：2010-11-23 00:00:00
abstract：:Eighteen patients with inoperable hepatocellular carcinoma (HCC) were treated with intrahepatic arterial yttrium-90 microspheres. All these patients showed a lung shunting below 15% and a tumour-to-normal ratio higher than 2 as determined by diagnostic technetium-99m macroaggregated albumin (Tc-MAA) gamma scintigraphy...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/bjc.1994.436
更新日期：1994-11-01 00:00:00
abstract：:The mechanisms underlying sperm protein 17 (Sp17) gene expression in myeloma cells remained unclear. Using reverse transcription-polymerase chain reaction (RT-PCR), Sp17 transcripts were detected in ARK-B, ARP-1, RPMI-8226 and KMS-11 but not in H929, IM-9, MM1-R and U266 cells. Using a panel of primer pairs in methyla...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602160
更新日期：2004-10-18 00:00:00
abstract：:Metallothioneins are ubiquitous low molecular weight proteins characterised by high cysteine content and affinity for binding heavy metals. Abnormal metallothionein function and expression have been implicated in various disease states, including neoplasia. The aim of this study was to investigate metallothionein expr...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1995.443
更新日期：1995-10-01 00:00:00
abstract：:Previously, we reported that Bcl-2 was frequently expressed in renal cell carcinoma (RCC) specimens, but p53 mutation was a rare event. However, it was unclear whether Bcl-2 positivity was associated with the clinicopathological characteristics and prognosis in RCC. Therefore, we investigated the expression of Bcl-2 p...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601454
更新日期：2004-01-12 00:00:00
abstract：BACKGROUND:Chromosomal instability (CIN) is a common trait of cancer characterised by the continuous gain and loss of chromosomes during mitosis. Excessive levels of CIN can suppress tumour growth, providing a possible therapeutic strategy. The Mps1/TTK kinase has been one of the prime targets to explore this concept, ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-018-0081-2
更新日期：2018-06-01 00:00:00
abstract：:The tumour suppressor gene CDKN2A, located on chromosome 9p21, encodes the cell cycle regulatory protein p16. Inactivation of the CDKN2A gene could lead to uncontrolled cell growth. In order to determine the role of CDKN2A in the development of sporadic ovarian cancer, loss of heterozygosity at 9p21-22, homozygous del...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6690621
更新日期：1999-08-01 00:00:00
abstract：:When purified fibre and hexon proteins of adenovirus 12 were given intramuscularly to 4-week-old BALB/c mice (250-300 mug/mouse) 2 h prior to inoculation with mouse sarcoma virus (0.05 ml of 10(4) FFU/ml) at the same site, significant suppression of tumour growth (P less than 0.001), and rapid regression in tumour siz...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1976.63
更新日期：1976-04-01 00:00:00
abstract：:Sera from 182 newly diagnosed breast cancer patients were assayed for antibodies to p53 using an enzyme-linked immunosorbent assay (ELISA) method, and antibodies were detected in 48 (26%) compared with 1 out of 76 (1.3%) normal control volunteers (P = 0.0001). In breast cancer patients, autoantibodies were found in al...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1994.219
更新日期：1994-06-01 00:00:00
abstract：:Oesophageal adenocarcinoma is believed to arise from metaplastic mucosa in the distal oesophagus, a condition also known as Barrett's oesophagus (BE). BE develops as a result of injury caused by refluxing gastric and duodenal contents and is associated with increased risk of malignant transformation. Matrix metallopro...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2001.1929
更新日期：2001-08-03 00:00:00
abstract：:We have studied the actions of C-1311, an imidazoacridinone analogue with potent in vivo antitumour activity, against a human tumour line (HeLa S3), in an examination of the events associated with the lethality of this agent. Continuous exposures (24 h) induced complete G2 arrest, although the concentration range of t...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1996.550
更新日期：1996-11-01 00:00:00
abstract：:We evaluated the myelotoxicity and the anti-tumor potential of tallimustine, three of its analogues and carzelesin, with melphalan as reference substance. Tallimustine was tested by clonogenic assays on both human bone marrow (BM) and cord blood (hCB) cells, the other compounds on hCB only. The degree of inhibition of...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1997.155
更新日期：1997-01-01 00:00:00
abstract：:We screened 145 HIV-infected non-pregnant women at a tertiary care centre in Lusaka, Zambia. Liquid-based cytology and human papillomavirus (HPV) genotyping with PGMY09/11 biotinylated primers (Roche Linear Array HPV genotyping test) maximised sensitivity of cytology and HPV assessments. Among high-risk (HR) types, HP...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603737
更新日期：2007-05-07 00:00:00
abstract：:We have evaluated the relation between cancer of the lower urinary tract ("bladder cancer") and the use of artificial sweeteners, by means of case-control studies in Manchester, U.K., and Nagoya, Japan, areas where extensive use occurred 30-40 years ago. In each area, a broadly based series of cases (555 in Manchester...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1982.59
更新日期：1982-03-01 00:00:00
abstract：:The conventional diffusion chamber (CDC) as described by Benestad (1970) had been modified to assay the colony forming capacity of RFM bone marrow and spleen cells in agar diffusion chambers (ADCs). The colonies are morphologically identical to those formed by the CFUc in agar culture in vitro and have an incidence of...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1974.216
更新日期：1974-11-01 00:00:00
abstract：:Serial transplantation of an HCG-producing human testicular teratoma in immune-deprived mice is described. The xenografted tumour was compared to the tumour of origin in histology, immunohistochemistry (using an immune peroxidase technique to localize HCG) autoradiography, marker production and growth rate. It is conc...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1979.104
更新日期：1979-05-01 00:00:00
abstract：BACKGROUND:Overexpression of ErbB2 receptor in breast cancer is associated with disease progression and poor prognosis. Trastuzumab, the only humanised anti-ErbB2 antibody currently used in breast cancer, has proven to be effective; however, a relevant problem for clinical practice is that a high fraction of breast can...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605499
更新日期：2010-02-02 00:00:00
abstract：:This corrects the article DOI: 10.1038/bjc.2017.327. ...
journal_title：British journal of cancer
pub_type： 杂志文章,已发布勘误
doi：10.1038/bjc.2017.438
更新日期：2018-01-01 00:00:00
abstract：:The S-phase fraction (SPF) in flow cytometric DNA histograms in soft tissue sarcoma (STS) can be calculated in various ways. The traditional planimetric method of Baisch has been shown to be prognostic, but is hampered by a failure rate of around 40%. We therefore tested other models to see if this rate could be decre...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6690193
更新日期：1999-03-01 00:00:00
abstract：:Photoradiation therapy of cancer in the presence of haematoporphyrin derivative is based on a retention of porphyrin in malignant tissue. After long term incubation of NHIK 3025 cells in the presence of 25 microgram ml-1 haematoporphyrin derivative, one fraction is easily removed from the cells by washing with a serum...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1983.154
更新日期：1983-07-01 00:00:00
abstract：BACKGROUND:Vegetable and/or fruit intakes in association with hepatocellular carcinoma (HCC) risk have been investigated in case-control studies conducted in specific European countries and cohort studies conducted in Asia, with inconclusive results. No multi-centre European cohort has investigated the indicated associ...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究
doi：10.1038/bjc.2014.654
更新日期：2015-03-31 00:00:00
abstract：:In the present study we have used flow cytometric DNA measurements on synchronised human NHIK 3025 cells to measure cell cycle progression under various conditions of reduced oxygenation. Our data indicate that addition of 0.1 mM deoxycytidine or uridine has no effect on the oxygen-dependent arrest in late G1 or on th...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1994.411
更新日期：1994-11-01 00:00:00
