A human testicular teratoma serially transplanted in immune-deprived mice.

abstract：:This phase I study investigated the maximum tolerated dose and pharmacokinetics of a 3-weekly administration of BMS-188797, a paclitaxel derivate, at three dose levels (DLs) (80, 110 and 150 mg m(-2) DL), combined with cisplatin (standard dose 75 mg m(-2)). In 16 patients with advanced malignancies treated, one patien...

journal_title：British journal of cancer

authors： du Bois A,Jung B,Loehr A,Schaller-Kranz T,Cohen M,Frickhofen N

更新日期：2006-01-16 00:00:00

abstract：BACKGROUND:Although mortality rates are elevated in psychiatric patients relative to their healthy counterparts, little is known about the impact of mental health on survival in people with cancer. METHODS AND RESULTS:Among 16 498 Swedish men with cancer, survival was worse in those with a history of psychiatric hospi...

journal_title：British journal of cancer

authors： Batty GD,Whitley E,Gale CR,Osborn D,Tynelius P,Rasmussen F

更新日期：2012-05-22 00:00:00

abstract：:Matched pair analysis relating to 3376 mothers of children who died of cancer 1972-1981 and of healthy control children from the Oxford Survey of Childhood Cancers showed no evidence of protection from breastfeeding for acute lymphocytic leukaemia (OR 1.04, 95% CI 0.86-1.26), for all cancers combined (OR 1.04, 95% CI ...

journal_title：British journal of cancer

authors： Lancashire RJ,Sorahan T,OSCC.

更新日期：2003-04-07 00:00:00

abstract：:Forty-two patients with clinical stage IIIA or IIIB breast cancer were treated with neoadjuvant chemotherapy followed by mastectomy and radiotherapy. The median follow-up was 32 months (range 10-72 months) and the median time to progression was 17 months (range 10-30 months). A multivariate analysis showed that a long...

journal_title：British journal of cancer

authors： Honkoop AH,van Diest PJ,de Jong JS,Linn SC,Giaccone G,Hoekman K,Wagstaff J,Pinedo HM

更新日期：1998-02-01 00:00:00

abstract：:The neuropsychological performance of 85 women with early stage breast cancer scheduled for chemotherapy, 43 women scheduled for endocrine therapy and/or radiotherapy and 49 healthy control subjects was assessed at baseline (T1), postchemotherapy (or 6 months) (T2) and at 18 months (T3). Repeated measures analysis fou...

journal_title：British journal of cancer

authors： Jenkins V,Shilling V,Deutsch G,Bloomfield D,Morris R,Allan S,Bishop H,Hodson N,Mitra S,Sadler G,Shah E,Stein R,Whitehead S,Winstanley J

更新日期：2006-03-27 00:00:00

abstract：:Caveolin-1 and -2 (CAV1, CAV2) are closely linked genes localised to the fragile region of 7q31 (FRA7G), and loss of heterozygosity involving this region has been reported in breast cancer. Several studies have suggested that CAV1 is a negative regulator of HER2/neu signal transduction in vitro. However, the clinical ...

journal_title：British journal of cancer

authors： Sagara Y,Mimori K,Yoshinaga K,Tanaka F,Nishida K,Ohno S,Inoue H,Mori M

更新日期：2004-08-31 00:00:00

abstract：:Killing of autologous melanoma (auto-Me) was obtained with pooled allostimulated peripheral blood lymphocytes (PBL) in 34/42 cases and found not to be due to a cross-reactivity between melanoma and allogeneic normal antigens. To see whether generation of tumour cytotoxic PBL by allostimulation was due to release of IL...

journal_title：British journal of cancer

authors： Balsari A,Fossati G,Taramelli D,Tona G,Delia D,Giardini R,Parmiani G

更新日期：1985-07-01 00:00:00

abstract：BACKGROUND:There are limited data on surgical outcomes in gynaecological oncology. We report on predictors of complications in a multicentre prospective study. METHODS:Data on surgical procedures and resulting complications were contemporaneously recorded on consented patients in 10 participating UK gynaecological can...

journal_title：British journal of cancer

authors： Iyer R,Gentry-Maharaj A,Nordin A,Burnell M,Liston R,Manchanda R,Das N,Desai R,Gornall R,Beardmore-Gray A,Nevin J,Hillaby K,Leeson S,Linder A,Lopes A,Meechan D,Mould T,Varkey S,Olaitan A,Rufford B,Ryan A,Shanbhag

更新日期：2015-02-03 00:00:00

abstract：BACKGROUND:We evaluated the performance of primary high-risk human papillomavirus (hrHPV) testing by hybrid capture 2 (HC2) with different thresholds for positivity, in comparison with conventional cytology. METHODS:We used data of 25,871 women (aged 30-60 years) from the intervention group of the VUSA-Screen study (V...

journal_title：British journal of cancer

authors： Rijkaart DC,Coupe VM,van Kemenade FJ,Heideman DA,Hesselink AT,Verweij W,Rozendaal L,Verheijen RH,Snijders PJ,Berkhof J,Meijer CJ

更新日期：2010-09-28 00:00:00

abstract：:A correction to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：British journal of cancer

authors： Weisberg E,Manley P,Mestan J,Cowan-Jacob S,Ray A,Griffin JD

更新日期：2019-07-01 00:00:00

abstract：:Virus-directed enzyme prodrug therapy (VDEPT) utilising the bacterial enzyme nitroreductase delivered by a replication-defective adenovirus vector to activate the prodrug CB1954 is a promising strategy currently undergoing clinical trials in patients with a range of cancers. An understanding of the mechanism of tumour...

journal_title：British journal of cancer

authors： Palmer DH,Milner AE,Kerr DJ,Young LS

更新日期：2003-09-01 00:00:00

abstract：:A retrospective case-control study of 200 patients with head and neck cancer, and 200 controls matched for age and sex, confirmed the importance of tobacco and alcohol consumption in the aetiology of malignant tumours of the upper gastrointestinal and upper respiratory tracts. A male-female ratio of 3:1 was found, and...

journal_title：British journal of cancer

authors： Herity B,Moriarty M,Bourke GJ,Daly L

更新日期：1981-02-01 00:00:00

abstract：:This study describes the effects of the glucolipid synthase inhibitor P4, (DL-threo-1-phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol ), on various functional and phenotypic parameters of 5T33 murine myeloma cells. Cell recovery was reduced by >85% following incubation of the cells for 3 days in the presence of 4 mic...

journal_title：British journal of cancer

authors： Manning LS,Radin NS

更新日期：1999-11-01 00:00:00

abstract：BACKGROUND:Novel treatment strategies in Ewing sarcoma include targeted cellular therapies. Preclinical in vivo models are needed that reflect their activity against systemic (micro)metastatic disease. METHODS:Whole-body magnetic resonance imaging (WB-MRI) was used to monitor the engraftment and dissemination of human...

journal_title：British journal of cancer

authors： Liebsch L,Kailayangiri S,Beck L,Altvater B,Koch R,Dierkes C,Hotfilder M,Nagelmann N,Faber C,Kooijman H,Ring J,Vieth V,Rossig C

更新日期：2013-08-06 00:00:00

abstract：:Metastatic variant sublines of the murine large-cell lymphoma cell line RAW117 were tested for their growth and migration properties in vitro in medium conditioned by soluble factors released from syngeneic mouse liver-, lung-, and brain-derived microvessel endothelial cells. Medium conditioned with hepatic sinusoidal...

journal_title：British journal of cancer

authors： Hamada J,Cavanaugh PG,Lotan O,Nicolson GL

更新日期：1992-08-01 00:00:00

abstract：:The survival of 64 consecutive patients with disseminated midgut carcinoid tumours was compared in a retrospective study with that of 25 consecutive patients with sporadic malignant endocrine pancreatic tumours treated according to similar surgical principles. The presence of hepatic metastases implied a worse prognos...

journal_title：British journal of cancer

authors： Johanson V,Tisell LE,Olbe L,Wängberg B,Nilsson O,Ahlman H

更新日期：1999-06-01 00:00:00

abstract：BACKGROUND:Colorectal cancer (CRC) diagnoses and disease-specific survival (DSS) vary between ethnic groups in the United States. However, few studies have assessed differences among Asian subgroups. METHODS:The Surveillance, Epidemiology, and End Results (SEER) database was used to identify patients with invasive CRC...

journal_title：British journal of cancer

authors： Yi M,Xu J,Liu P,Chang GJ,Du XL,Hu CY,Song Y,He J,Ren Y,Wei Y,Yang J,Hunt KK,Li X

更新日期：2013-04-16 00:00:00

abstract：:In a prospective study we determined the frequency and causes of delay in the diagnosis of breast cancer after suspicious screening mammography. We included all women aged 50-75 years who underwent biennial screening mammography in the southern breast cancer screening region of the Netherlands between 1 January 1996 a...

journal_title：British journal of cancer

authors： Duijm LE,Groenewoud JH,Jansen FH,Fracheboud J,van Beek M,de Koning HJ

更新日期：2004-11-15 00:00:00

abstract：BACKGROUND:Random error in the numbers of avoidable deaths among cancer patients has not been considered in earlier studies. METHODS:Methods to obtain valid confidence intervals (CIs) for numbers of avoidable deaths were developed. The excess mortality rates were estimated for patients diagnosed with colon cancer in f...

journal_title：British journal of cancer

authors： Seppä K,Hakulinen T,Läärä E

更新日期：2012-05-22 00:00:00

abstract：:The effect of the combined administration of doxorubicin (DX) and verapamil (VRP) on the induction of DX resistance of B16 melanoma cells, was investigated both in vitro and in vivo. Cells grown in the presence of increasing concentrations of DX and of 1 microM VRP, tested at several passages, were more resistant than...

journal_title：British journal of cancer

authors： Formelli F,Supino R,Cleris L,Mariani M

更新日期：1988-04-01 00:00:00

abstract：:Do family history clinics offering counselling, surveillance and preventative programmes alleviate or exacerbate anxiety in women at a high risk of developing breast cancer? In this study risk perceptions and anxiety of 99 'at risk' women participating in the Tamoxifen Prevention Trial were compared with those of 87 '...

journal_title：British journal of cancer

authors： Thirlaway K,Fallowfield L,Nunnerley H,Powles T

更新日期：1996-06-01 00:00:00

abstract：:Minisatellite DNA probes which can detect a large number of autosomal loci dispersed throughout the human genome were used to examine the constitutional and tumour DNA of 35 patients with a variety of cancers of which eight were of gastrointestinal origin. Somatic changes were seen in the tumour DNA in ten of the 35 c...

journal_title：British journal of cancer

authors： Thein SL,Jeffreys AJ,Gooi HC,Cotter F,Flint J,O'Connor NT,Weatherall DJ,Wainscoat JS

更新日期：1987-04-01 00:00:00

abstract：:We screened 145 HIV-infected non-pregnant women at a tertiary care centre in Lusaka, Zambia. Liquid-based cytology and human papillomavirus (HPV) genotyping with PGMY09/11 biotinylated primers (Roche Linear Array HPV genotyping test) maximised sensitivity of cytology and HPV assessments. Among high-risk (HR) types, HP...

journal_title：British journal of cancer

authors： Sahasrabuddhe VV,Mwanahamuntu MH,Vermund SH,Huh WK,Lyon MD,Stringer JS,Parham GP

更新日期：2007-05-07 00:00:00

abstract：BACKGROUND:Cytosolic deacetylase histone deacetylase 6 (HDAC6) is involved in the autophagy degradation pathway of malformed proteins, an important survival mechanism in cancer cells. We evaluated modulation of autophagy-related proteins and cell death by the HDAC6-selective inhibitor C1A. METHODS:Autophagy substrates...

journal_title：British journal of cancer

authors： Kaliszczak M,van Hechanova E,Li Y,Alsadah H,Parzych K,Auner HW,Aboagye EO

更新日期：2018-11-01 00:00:00

abstract：:Forty-one human tumour cell lines were examined for the production of epidermal growth factor (EGF)/transforming growth factor (TGF)-alpha-like activity (EGF/TGF-alpha-LA), immunoreactive (IR-) EGF and IR-TGF-alpha. EGF/TGF-alpha-LA was determined by radioreceptor assay, in which the factors with capacity to bind to E...

journal_title：British journal of cancer

authors： Imanishi K,Yamaguchi K,Suzuki M,Honda S,Yanaihara N,Abe K

更新日期：1989-05-01 00:00:00

abstract：:Survival data on female invasive breast cancer with 9-year follow-up from five French cancer registries were analysed by logistic regression for prognostic factors of cancer stage. The Kaplan-Meier method and log-rank test were used to estimate and compare the overall survival probability at 5 and 7 years, and at the ...

journal_title：British journal of cancer

authors： Gentil-Brevet J,Colonna M,Danzon A,Grosclaude P,Chaplain G,Velten M,Bonnetain F,Arveux P

更新日期：2008-01-15 00:00:00

abstract：:The aetiologic fractions due to smoking and chewing tobacco have been quantified for the first time, for cancers of the oral cavity, oropharynx, hypopharynx, larynx and oesophagus. The overall aetiologic fractions due to smoking and/or chewing tobacco have been found to be 70% for cancer of the oral cavity, 84% for th...

journal_title：British journal of cancer

authors： Jayant K,Balakrishnan V,Sanghvi LD,Jussawalla DJ

更新日期：1977-02-01 00:00:00

abstract：:Specimens of formalin-fixed, paraffin-embedded non-small-cell lung carcinomas (NSCLCs; n = 187) were analysed immunohistochemically for expression of cyclin A. The analysis was intended to determine whether cyclin A has additional prognostic value for predicting patients' survival and drug response. Of the 187 NSCLCs,...

journal_title：British journal of cancer

authors： Volm M,Koomägi R,Mattern J,Stammler G

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:The role of tumour-infiltrating inflammation in the prognosis of patients with colorectal cancer (CRC) has not been fully evaluated. The primary objective of our meta-analysis was to determine the impact of tumour-infiltrating inflammation on survival outcomes. METHODS:Ovid MEDLINE and EMBASE were searched ...

journal_title：British journal of cancer

authors： Mei Z,Liu Y,Liu C,Cui A,Liang Z,Wang G,Peng H,Cui L,Li C

更新日期：2014-03-18 00:00:00

abstract：:Mutation of c-K-ras oncogene is an important step in progression of colon cancer. We used a hammerhead ribozyme (KrasRz) against mutated K-ras gene transcripts (codon 12, GTT) to inactivate mutant K-ras function in the colon cancer cell line SW480, harbouring a mutant K-ras gene. The beta-actin promoter-driven KrasRz ...

journal_title：British journal of cancer

authors： Tokunaga T,Tsuchida T,Kijima H,Okamoto K,Oshika Y,Sawa N,Ohnishi Y,Yamazaki H,Miura S,Ueyama Y,Nakamura M

更新日期：2000-09-01 00:00:00