Avoidable deaths and random variation in patients' survival.

abstract：:A retrospective seroepidemiologic study was performed to examine the association between human papillomaviruses (HPV) 16 infection and carcinomas of the oropharynx, the oesophagus, penis and vagina. Sera were selected from the serum bank from the Antoni van Leeuwenhoek Hospital (Netherlands Cancer Institute) and the S...

journal_title：British journal of cancer

authors： Van Doornum GJ,Korse CM,Buning-Kager JC,Bonfrer JM,Horenblas S,Taal BG,Dillner J

更新日期：2003-04-07 00:00:00

abstract：:Allele imbalance on chromosome 11 loci in ovarian cancer is a frequent event, suggesting the presence of tumour-suppressor genes for ovarian carcinogenesis on this chromosome. Ten highly polymorphic (CA) repeat microsatellites were used to determine allele imbalance in 60 primary ovarian tumours, including 47 epitheli...

journal_title：British journal of cancer

authors： Gabra H,Taylor L,Cohen BB,Lessels A,Eccles DM,Leonard RC,Smyth JF,Steel CM

更新日期：1995-08-01 00:00:00

abstract：:Metallothioneins (MT) are ubiquitous, intracellular small proteins with high affinity for heavy metal ions. In the last decades, it was shown that MT overexpression in a variety of cancers is associated with resistance to anticancer drugs and is combined with a poor prognosis. In this prospective study, we examined th...

journal_title：British journal of cancer

authors： Weinlich G,Eisendle K,Hassler E,Baltaci M,Fritsch PO,Zelger B

更新日期：2006-03-27 00:00:00

abstract：BACKGROUND:To compare the imaging and clinical features of temporal lobe necrosis (TLN) in nasopharyngeal carcinoma (NPC) patients treated with two-dimensional radiotherapy (2D-RT) or those with intensity-modulated radiotherapy (IMRT). METHODS:We retrospectively analysed NPC patients who underwent 2D-RT (72 patients, ...

journal_title：British journal of cancer

authors： Mao YP,Zhou GQ,Liu LZ,Guo R,Sun Y,Li L,Lin AH,Zeng MS,Kang TB,Jia WH,Shao JY,Mai HQ,Ma J

更新日期：2014-05-27 00:00:00

abstract：:It is known that interferon-gamma (IFN-gamma) is produced by activated T and NK lymphoid cells, mononuclear cells, and macrophage and dendritic cells. Our previous studies have shown that IFN-gamma-like immunoreactivity also appears in human adrenal cortical tumour and phaeochromocytoma. To investigate whether human t...

journal_title：British journal of cancer

authors： Li Q,Zhang XQ,Nie L,Chen GS,Li H,Zhang F,Zhang LY,Hong L,Wang SF,Wang H

更新日期：2007-08-06 00:00:00

abstract：:Photodynamic therapy (PDT) is a form of cancer treatment based on the destruction of cells by the interaction of light, oxygen and a photosensitizer. Aminolaevulinic acid (ALA) is the prodrug of the photosensitizer protoporphyrin IX (PpIX). ALA-induced PDT depends on the rate of cellular synthesis of PpIX, which may v...

journal_title：British journal of cancer

authors： Wyld L,Smith O,Lawry J,Reed MW,Brown NJ

更新日期：1998-07-01 00:00:00

abstract：BACKGROUND:Treatment options for patients with metastatic gastroenteropancreatic neuroendocrine tumours (GEP NETs) are still limited. We investigated the antitumour activity and safety profile of pazopanib--a multitarget drug with anti-angiogenic activity in patients with metastatic GEP NETs. METHODS:This was a nonran...

journal_title：British journal of cancer

authors： Ahn HK,Choi JY,Kim KM,Kim H,Choi SH,Park SH,Park JO,Lim HY,Kang WK,Lee J,Park YS

更新日期：2013-09-17 00:00:00

abstract：BACKGROUND:There are phase 3 clinical trials underway evaluating anti-PD-L1 antibodies as adjuvant (postoperative) monotherapies for resectable renal cell carcinoma (RCC) and triple-negative breast cancer (TNBC); in combination with antiangiogenic VEGF/VEGFR2 inhibitors (e.g., bevacizumab and sunitinib) for metastatic ...

journal_title：British journal of cancer

authors： Wu FTH,Xu P,Chow A,Man S,Krüger J,Khan KA,Paez-Ribes M,Pham E,Kerbel RS

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Immunoscore have shown a promising prognostic value in many cancers. We aimed to establish and validate an immune classifier to predict survival after curative resection of hepatocellular carcinoma (HCC) patients who have undergone curative resection. METHODS:The immunohistochemistry (IHC) classifier assay ...

journal_title：British journal of cancer

authors： Liu WR,Tian MX,Tang Z,Fang Y,Zhou YF,Song SS,Jiang XF,Wang H,Tao CY,Zhou PY,Qu WF,Ding ZB,Peng YF,Zhou J,Fan J,Shi YH

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Hypoxia can activate autophagy, a self-digest adaptive process that maintains cell turnover. Mammalian target of rapamycin (mTOR) inhibitors are used to treat cancer but also stimulate autophagy. METHODS:Human mammary cancer cells and derived xenografts were used to examine whether hypoxia could exacerbate ...

journal_title：British journal of cancer

authors： Seront E,Boidot R,Bouzin C,Karroum O,Jordan BF,Gallez B,Machiels JP,Feron O

更新日期：2013-11-12 00:00:00

abstract：:The aim of this study was to determine the correlation between changes in collagen metabolites (ICTP, mature cross-linked carboxy-terminal telopeptide of type I collagen; PINP, the amino-terminal propeptide of type I procollagen) and bone mineral density (BMD) in 206 pre- and post-menopausal breast cancer patients wit...

journal_title：British journal of cancer

authors： Saarto T,Blomqvist C,Risteli J,Risteli L,Sarna S,Elomaa I

更新日期：1998-07-01 00:00:00

abstract：:Cyclin D1 gene amplification is an important event in many cancers, but it is rarely found in non-small-cell lung cancer (NSCLC). This study was conducted in an attempt to clarify any other mechanisms related to cyclin D1 involvement in the malignant transformation of NSCLC, and we clearly showed for the first time th...

journal_title：British journal of cancer

authors： Igarashi K,Masaki T,Shiratori Y,Rengifo W,Nagata T,Hara K,Oka T,Nakajima J,Hisada T,Hata E,Omata M

更新日期：1999-10-01 00:00:00

abstract：BACKGROUND:Folate receptor 1 (FOLR1) is expressed in the majority of ovarian carcinomas (OvCa), making it an attractive target for therapy. However, clinical trials testing anti-FOLR1 therapies in OvCa show mixed results and require better understanding of the prognostic relevance of FOLR1 expression. We conducted a la...

journal_title：British journal of cancer

authors： Köbel M,Madore J,Ramus SJ,Clarke BA,Pharoah PD,Deen S,Bowtell DD,Odunsi K,Menon U,Morrison C,Lele S,Bshara W,Sucheston L,Beckmann MW,Hein A,Thiel FC,Hartmann A,Wachter DL,Anglesio MS,Høgdall E,Jensen A,Høgdall C

更新日期：2014-12-09 00:00:00

abstract：:The NCA (nonspecific cross-reacting antigen) was assayed in sera of patients with chronic myeloid leukaemia (CML). It was elevated to a mean value of 145·6 ng/ml (± 104·4 ng/ml) compared to 37·8 ng/ml (± 14·6 ng/ml) the sera of normal subjects. Patients with active disease generally had higher serum NCA levels than th...

journal_title：British journal of cancer

authors： Frénoy N,Ben-Bunant M,Berruel C,Child JA,Gendron MC,Missett JL,Razafimahaleo E,Burtin P

更新日期：1982-11-01 00:00:00

abstract：:Chromosome 9p21 gene copy number in Ewing's sarcoma family of tumour (ESFT) cell lines and primary ESFT has been evaluated using Multiplex Ligation-dependent probe amplification, and the clinical significance of CDKN2A loss and p16/p14(ARF) expression investigated. Homozygous deletion of CDKN2A was identified in 4/9 (...

journal_title：British journal of cancer

authors： Brownhill SC,Taylor C,Burchill SA

更新日期：2007-06-18 00:00:00

abstract：:Complex biological pathways including angiogenesis, invasion, osteoclastic activation and bone matrix degradation are involved in the formation of bone metastasis (BM). The aim of our study was to investigate the cross-sectional and longitudinal associations of a panel of 12 serum biochemical markers reflecting biolog...

journal_title：British journal of cancer

authors： Voorzanger-Rousselot N,Juillet F,Mareau E,Zimmermann J,Kalebic T,Garnero P

更新日期：2006-08-21 00:00:00

abstract：:To evaluate the efficacy and safety of capecitabine and cisplatin in patients with recurrent gastric cancer after fluoropyrimidine-based adjuvant therapy. Patients with histologically confirmed and measurable advanced gastric cancer that had relapsed after fluoropyrimidine-based adjuvant chemotherapy received oral cap...

journal_title：British journal of cancer

authors： Kang HJ,Chang HM,Kim TW,Ryu MH,Sohn HJ,Yook JH,Oh ST,Kim BS,Lee JS,Kang YK

更新日期：2005-01-31 00:00:00

abstract：:To clarify the mechanism of acquired CDDP resistance in ovarian cancer, we compared the microsatellite instability (MSI) by the amplification of 10 microsatellite loci and immunohistochemical detection of hMSH2 and hMLH1 expression between the primary resected tumours and the secondary resected residual tumours after ...

journal_title：British journal of cancer

authors： Watanabe Y,Koi M,Hemmi H,Hoshai H,Noda K

更新日期：2001-09-28 00:00:00

abstract：BACKGROUND:Isolated groups, such as first generation non-Western immigrants, are at risk for suboptimal utilisation of the health care system resulting in a worse outcome. METHODS:From 1989 to 2007, all patients with stomach cancer were selected from the Comprehensive Cancer Centre North-East cancer registry. Associat...

journal_title：British journal of cancer

authors： Siemerink EJ,van der Aa MA,Siesling S,Hospers GA,Mulder NH

更新日期：2011-03-29 00:00:00

abstract：:Connective tissue growth factor (CTGF) is a major chemotactic and mitogenic factor for connective tissue cells. The amino acid sequence shares an overall 28-38% identity to IGFBPs and contains critical conserved sequences in the amino terminus. It has been demonstrated that human CTGF specifically binds IGFs with low ...

journal_title：British journal of cancer

authors： Vorwerk P,Wex H,Hohmann B,Oh Y,Rosenfeld RG,Mittler U

更新日期：2000-09-01 00:00:00

abstract：:We report that all- trans retinoic acid (ATRA) enhanced the toxicity of docetaxel against DU145 and LNCaP prostate cancer cells, and that the nature of the interaction between ATRA and docetaxel was highly synergistic. Docetaxel-induced apoptotic cell death was associated with phosphorylation and hence inactivation of...

journal_title：British journal of cancer

authors： Nehmé A,Varadarajan P,Sellakumar G,Gerhold M,Niedner H,Zhang Q,Lin X,Christen RD

更新日期：2001-06-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most malignant human tumours because of its high incidence of metastasis. The mechanisms underlying the metastasis of HCC, however, remain poorly understood. In this study, we performed cDNA microarray analysis to profile gene expression patterns in two subtypes of HCC, sol...

journal_title：British journal of cancer

authors： Wang W,Yang LY,Huang GW,Lu WQ,Yang ZL,Yang JQ,Liu HL

更新日期：2004-06-14 00:00:00

abstract：:A series of three dose escalating studies were conducted to investigate the ability of the 17alpha-hydroxylase/C(17,20)-lyase inhibitor abiraterone acetate, to cause maximum suppression of testosterone synthesis when delivered to castrate and noncastrate males with prostate cancer. Study A was a single dose study in c...

journal_title：British journal of cancer

authors： O'Donnell A,Judson I,Dowsett M,Raynaud F,Dearnaley D,Mason M,Harland S,Robbins A,Halbert G,Nutley B,Jarman M

更新日期：2004-06-14 00:00:00

abstract：BACKGROUND:The role of tumour-infiltrating inflammation in the prognosis of patients with colorectal cancer (CRC) has not been fully evaluated. The primary objective of our meta-analysis was to determine the impact of tumour-infiltrating inflammation on survival outcomes. METHODS:Ovid MEDLINE and EMBASE were searched ...

journal_title：British journal of cancer

authors： Mei Z,Liu Y,Liu C,Cui A,Liang Z,Wang G,Peng H,Cui L,Li C

更新日期：2014-03-18 00:00:00

abstract：:We evaluated the degree of tubular differentiation in 172 samples of invasive ductal breast cancer in order to determine numerical thresholds for histological breast cancer grading. The tubular differentiation in each sample was defined as the fraction of fields showing tubular differentiation (FTD). The analysis was ...

journal_title：British journal of cancer

authors： Kronqvist P,Kuopio T,Collan Y

更新日期：2000-05-01 00:00:00

abstract：:Recently, apoptosis has been implicated as one of the end points of cells exposed to chemotherapeutic agents. The p53 and Bcl-2 family of proteins are involved in chemotherapy-induced apoptosis, but in a cell type-dependent manner. We sought to determine the roles played by the p53 and Bcl-2 family of proteins in 5-fl...

journal_title：British journal of cancer

authors： Nita ME,Nagawa H,Tominaga O,Tsuno N,Fujii S,Sasaki S,Fu CG,Takenoue T,Tsuruo T,Muto T

更新日期：1998-10-01 00:00:00

abstract：:NK911 is a novel supramolecular nanocarrier designed for the enhanced delivery of doxorubicin (DXR) and is one of the successful polymer micelle systems to exhibit an efficient accumulation in solid tumours in mice. The purpose of this study was to define the maximum-tolerated dose (MTD) and dose-limiting toxicities (...

journal_title：British journal of cancer

authors： Matsumura Y,Hamaguchi T,Ura T,Muro K,Yamada Y,Shimada Y,Shirao K,Okusaka T,Ueno H,Ikeda M,Watanabe N

更新日期：2004-11-15 00:00:00

abstract：:Human primary thyroid follicular epithelial cells were transfected with a plasmid containing an origin-defective SV40 genome (SVori-) to produce several immortal cell lines. Two of the 10 cell lines analysed expressed specific features of thyroid epithelial function (iodide-trapping and thyroglobulin production). Thes...

journal_title：British journal of cancer

authors： Lemoine NR,Mayall ES,Jones T,Sheer D,McDermid S,Kendall-Taylor P,Wynford-Thomas D

更新日期：1989-12-01 00:00:00

abstract：:In resection tissue samples of colorectal carcinomas, the concentration of urokinase-type plasminogen activator (u-Pa) was found to be significantly higher than in the normal parent mucosal tissue, while there was less tissue-type plasminogen activator (t-PA). u-PA and t-PA were also determined in endoscopic biopsies ...

journal_title：British journal of cancer

authors： de Bruin PA,Verspaget HW,Griffioen G,Verheijen JH,Dooijewaard G,Lamers CB

更新日期：1989-09-01 00:00:00

abstract：BACKGROUND:Prescribing anti-programmed death-1 (PD-1) immunotherapy for advanced melanoma is currently not restricted by any biomarker assessment. Determination of programmed death-ligand-1 (PD-L1)-expression status is technically challenging and is not mandatory, because negative tumours also achieve therapeutic respo...

journal_title：British journal of cancer

authors： Dupuis F,Lamant L,Gerard E,Torossian N,Chaltiel L,Filleron T,Beylot-Barry M,Dutriaux C,Prey S,Gros A,Jullie ML,Meyer N,Vergier B

更新日期：2018-07-01 00:00:00