Abstract：
:Human primary thyroid follicular epithelial cells were transfected with a plasmid containing an origin-defective SV40 genome (SVori-) to produce several immortal cell lines. Two of the 10 cell lines analysed expressed specific features of thyroid epithelial function (iodide-trapping and thyroglobulin production). These two lines were characterised in detail and found to be growth factor-independent, capable of anchorage-independent growth at low frequency but non-tumorigenic in nude mice. These differentiated, These differentiated, partially transformed cell lines were shown to be suitable for gene transfer at high frequency using simple coprecipitation techniques.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Lemoine NR,Mayall ES,Jones T,Sheer D,McDermid S,Kendall-Taylor P,Wynford-Thomas Ddoi
10.1038/bjc.1989.387subject
Has Abstractpub_date
1989-12-01 00:00:00pages
897-903issue
6eissn
0007-0920issn
1532-1827journal_volume
60pub_type
杂志文章abstract：:Even though the majority of patients with bladder malignancies initially present with low stage disease, the clinical epidemiology of these so-called superficial bladder tumours is not well known. In this paper, disease characteristics at initial presentation and during follow-up are described in 1,745 primary cases d...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究
doi：10.1038/bjc.1993.147
更新日期：1993-04-01 00:00:00
abstract：:The aim of the study was to investigate whether 99Tc(m)-MIBI (Cardiolite), recently shown to be a substrate for P-glycoprotein, has the potential to be used as a marker for mdr1 gene expression and whether cyclosporin A (CyA) can modify its accumulation in vivo. Leukaemic cells from ten patients with acute myelocytic ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1998.290
更新日期：1998-06-01 00:00:00
abstract：BACKGROUND:Based on the microRNA (miRNA) signature of bladder cancer (BC) by deep sequencing, we recently found that several double-stranded mature miRNAs derived from the same pre-miRNAs were sufficiently expressed and acted as tumour suppressors by regulating common target genes in BC. Our deep-sequencing signature o...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2017.43
更新日期：2017-04-11 00:00:00
abstract：BACKGROUND:Pancreatic cancer is highly malignant and characterised by rapid and uncontrolled growth. While some of the important regulatory networks involved in pancreatic cancer have been determined, the cancer relevant genes have not been fully identified. METHODS:We screened genes that may control proliferation in ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2017.165
更新日期：2017-07-11 00:00:00
abstract：:As of June 1998, four randomized trials have been completed comparing the combination of paclitaxel and cisplatin with a cisplatin-based control arm. The results of three of these trials are available; one has been published as a full paper, the other two in abstract form only. Two of the reported trials (GOG-111 and ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1998.709
更新日期：1998-12-01 00:00:00
abstract：BACKGROUND:There is a need for sensitive and specific blood-borne markers for the detection of gastric cancer. Raised serum macrophage inhibitory factor (MIF) levels have been proposed as a marker for gastric cancer diagnosis but, to date, studies have only encompassed patients from high-incidence areas. METHODS:We ha...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2012.405
更新日期：2012-10-23 00:00:00
abstract：:Gallium-67 is a radionuclide that accumulates in haematological malignancies and is used for diagnostic purposes. Uptake of 67Ga into the cell occurs via the transferrin receptor, which is differentially expressed during the various cell cycle phases. With the aim of selectively increasing 67Ga uptake, we studied whet...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1996.411
更新日期：1996-08-01 00:00:00
abstract：:The large numbers of papillary thyroid carcinomas that have occurred in those exposed to high levels of short-lived isotopes in fallout after Chernobyl provide a unique opportunity to correlate latency and tumour biology. We show that short latency is associated with tumours with a phenotype that is significantly less...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601860
更新日期：2004-06-01 00:00:00
abstract：:Dipyridamole has been shown to enhance the in vitro activity of antimetabolite anticancer drugs through the inhibition of nucleoside transport. However, the clinical potential of dipyridamole has not been realized because of the avid binding of the drug to the plasma protein alpha1-acid glycoprotein (AGP). Dipyridamol...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6690591
更新日期：1999-08-01 00:00:00
abstract：PURPOSE:To determine the feasibility of induction chemotherapy and chemo-IMRT in head and neck squamous cell cancers at risk of bilateral nodal spread (midline tumours) and to evaluate whether bilateral superficial lobe parotid-sparing IMRT can reduce the incidence of ⩾G2 subjective xerostomia. METHODS:Patients with m...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2014.553
更新日期：2015-01-06 00:00:00
abstract：:Various procedures for immunoprotection in the A-SW mouse SEWA tumour system were compared. Four types of protector agents were used: polyoma virus, allogeneic S724 cells, A9/SEWA hybrid cells and xenogeneic ST(py) cells. Several injection schedules were also employed. On the whole, reasonable immunoprotection was obt...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1974.70
更新日期：1974-04-01 00:00:00
abstract：:A crude membrane fraction isolated from mouse tumour cells was treated with various chemicals. The effects on the immunogenicity of the membrane sample were tested in syngeneic mice for tumour protection, using a challenge dose of 10(5) viable tumour cells. Best protection was obtained after immunization of mice with ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1978.236
更新日期：1978-10-01 00:00:00
abstract：:The natural history of 45 cases of smouldering leukaemia has been studied. Males and females were equally represented, with a median age of 60.5. The median survival of the whole group was only 20 months, but rare cases lived 10 years or longer. 38% developed acute leukaemia; the remainder usually died of the results ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1982.179
更新日期：1982-08-01 00:00:00
abstract：:We analysed antibodies specific for human p53 in sera from primary breast cancer patients using three different immunoassays and we related these results to the p53 level in tumour tissue detected by immunohistochemistry. Only 44% (11/25) of apparently enzyme-linked immunosorbent assay (ELISA)-positive sera were from ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1995.242
更新日期：1995-06-01 00:00:00
abstract：:The formation of cyclic AMP was studied in normal liver, subcutaneous hepatomas derived from MH1C1 cells, and premalignant liver and primary hepatomas induced by the carcinogens 2-acetylaminofluorene (AAF) and 4-dimethylamino-azobenzene (DAB). While only very slight effects of prostaglandins (PG) were seen in slices o...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1978.281
更新日期：1978-12-01 00:00:00
abstract：BACKGROUND:We assessed the sensitivity to adjuvant chemotherapy in cell cycle checkpoint kinase 2 (CHEK2) vs non-CHEK2 breast cancer patients by comparing the contralateral breast cancer incidence and distant disease-free and breast cancer-specific survival between both groups, stratified for adjuvant chemotherapy. ME...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2014.306
更新日期：2014-08-26 00:00:00
abstract：BACKGROUND:Estimating the future incidence of cancer is important to establish sufficient service provision, however, work in this area is limited for cancer in children, adolescents, and young adults (aged 0-24). METHODS:Age-period-cohort models were applied to cancer incidence rates for the period 1971-2013 in Engla...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2017.341
更新日期：2017-12-05 00:00:00
abstract：:Human topoisomerase II enzymes are targets for a number of widely used anticancer agents. We have analysed a lung adenocarcinoma cell line CALU3, which has co-amplified topoisomerase II alpha and ERBB2 sequences, for the structure of the amplicon and for expression of both topoisomerase II alpha and beta. The region o...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1993.430
更新日期：1993-10-01 00:00:00
abstract：:Comfrey is a rat liver toxin and carcinogen that has been used as a vegetable and herbal remedy by humans. In order to evaluate the mechanisms underlying its carcinogenicity, we examined the mutagenicity of comfrey in the transgenic Big Blue rat model. Our results indicate that comfrey is mutagenic in rat liver and th...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602420
更新日期：2005-03-14 00:00:00
abstract：:Ordinary lipomas are cytogenetically characterized by a variety of balanced rearrangements involving chromosome segment 12q13-15, whereas well differentiated liposarcomas (WDL) show supernumerary ring and giant marker chromosomes, known to contain amplified 12q sequences. The tight correlation between the presence of ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.1999.1090
更新日期：2000-04-01 00:00:00
abstract：BACKGROUND:Tumours are made up of a mixed population of different types of cells that include normal structures as well as ones associated with the malignancy, and there are multiple interactions between the malignant cells and the local microenvironment. These intercellular interactions, modulated by the microenvironm...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2011.517
更新日期：2012-01-03 00:00:00
abstract：:Darbepoetin alfa is a novel erythropoiesis stimulating protein (NESP), which stimulates erythropoiesis by the same mechanism as recombinant human erythropoietin (rHuEPO). NESP has been shown to be safe and efficacious in patients with chronic renal failure. NESP is biochemically distinct from rHuEPO, due to its increa...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1054/bjoc.2001.1748
更新日期：2001-04-01 00:00:00
abstract：:Response to endocrine therapy in 51 patients with advanced breast cancer was compared with the amount of elastosis in histological sections from their primary tumours. There appeared to be an association between elastosis and response: tumours with no elastosis showed a lower rate of response than those with gross ela...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1979.98
更新日期：1979-05-01 00:00:00
abstract：:Incidence and mortality data, stage of disease and treatment information for female breast cancer were obtained for the years 1975-1999 for the former Yorkshire Regional Health Authority area, from the Northern and Yorkshire Cancer Registry and Information Service. Deaths by age group and 3-year calendar period were s...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601614
更新日期：2004-02-09 00:00:00
abstract：BACKGROUND:Progression-free survival (PFS) is a surrogate endpoint widely used for overall survival (OS) in oncology. Validation of PFS as a surrogate must be done for each indication and each intervention. We aimed to identify all studies evaluating the validity of PFS as a surrogate for OS in oncology, and to describ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-020-0805-y
更新日期：2020-05-01 00:00:00
abstract：:In recent years, large discrepancies were described in the success rate of the tyrosinase reverse transcription polymerase chain reaction (RT-PCR) for detecting melanoma cells in the peripheral blood of melanoma patients. We present a quality control study in which we analysed the reproducibility of detection of tyros...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6690436
更新日期：1999-05-01 00:00:00
abstract：:Altered expression and activity of proteases is a key event in cancer, particularly in relation to invasion, modification of the extracellular matrix and metastasis. The transmembrane protease, serine 4 (TMPRSS4) is closely related to other cancer-associated proteases, such as hepsin, TMPRSS2 and matriptase. We review...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/bjc.2014.403
更新日期：2015-01-06 00:00:00
abstract：:Epidemiology has shown an association between exposure to extremely low frequency (ELF) electromagnetic fields (EMF) and childhood leukaemia. The causal nature and biological basis of this association are however questionable. Studies with aneuploid cell lines raised the hypothesis that ELF EMF may act as a coleukaemo...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601010
更新日期：2003-06-16 00:00:00
abstract：BACKGROUND:Biomarkers for metastatic castration-resistant prostatic cancer (mCRPC) are an unmet medical need. METHODS:The prognostic and predictive value for survival and response to salvage hormonal therapy (SHT) of baseline testosterone level (TL) was analysed in a cohort of 101 mCRPC patients participating in 9 non...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2014.189
更新日期：2014-04-29 00:00:00
abstract：:Portal vein embolisation (PVE) is used to increase the remnant liver volume before major liver resection for colorectal metastases. The resection rate after PVE is 60-70%, mainly limited by disease progression. The effect of PVE on tumour growth rate has not been investigated. The objective of this study was to compar...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604872
更新日期：2009-02-24 00:00:00
