当前位置： SCI文献检索 > BRITISH JOURNAL OF CANCER期刊下所有文献 > Regulation of ITGA3 by the dual-stranded microRNA-199 family as a potential prognostic marker in bladder cancer.

Regulation of ITGA3 by the dual-stranded microRNA-199 family as a potential prognostic marker in bladder cancer.

Abstract：

BACKGROUND:Based on the microRNA (miRNA) signature of bladder cancer (BC) by deep sequencing, we recently found that several double-stranded mature miRNAs derived from the same pre-miRNAs were sufficiently expressed and acted as tumour suppressors by regulating common target genes in BC. Our deep-sequencing signature of BC showed that all miR-199 family members (miR-199a-3p/-5p and miR-199b-3p/-5p) were also downregulated. We hypothesised that these miRNAs may function as tumour suppressors by regulating common target genes. METHODS:Functional assays of BC cells were performed using transfection of mature miRNA. In silico analyses and luciferase reporter analyses were applied to identify target genes of these miRNAs. The overall survival of patients with BC in The Cancer Genome Atlas (TCGA) database was evaluated by the Kaplan-Meier method. RESULTS:Restoration of these miRNAs significantly inhibited cell migration and invasion in BC cells. Integrin α3 (ITGA3) was directly regulated by these miRNAs. The Cancer Genome Atlas database showed that patients with low pre-miR-199 family (miR-199a-1/-2 and miR-199b) expression exhibited significantly poorer overall survival compared with patients with high pre-miR-199 family expression. CONCLUSIONS:miR-199 family miRNAs functioned as tumour suppressors in BC cells by targeting ITGA3 and might be good prognostic markers for predicting survival in patients with BC.

journal_name

Br J Cancer

journal_title

British journal of cancer

authors

Sakaguchi T,Yoshino H,Yonemori M,Miyamoto K,Sugita S,Matsushita R,Itesako T,Tatarano S,Nakagawa M,Enokida H

doi

10.1038/bjc.2017.43

subject

Has Abstract

pub_date

2017-04-11 00:00:00

pages

1077-1087

issue

8

eissn

0007-0920

issn

1532-1827

pii

bjc201743

journal_volume

116

pub_type

杂志文章

相关文献

BRITISH JOURNAL OF CANCER文献大全
  • Non-linearity of colony formation by human tumour cells from biopsy samples.

    abstract：:The relationship between colony numbers and concentration of cells plated is an important parameter of clonogenic assay systems. The cloning efficiency for an ideal sample should be independent of cell concentration, thus giving a straight line through the origin when colony numbers are plotted against cell concentrat...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1985.195

    authors： Eliason JF,Aapro MS,Decrey D,Brink-Petersen M

    更新日期：1985-09-01 00:00:00

  • The clinical value of imaging with antibody to human chorionic gonadotrophin in the detection of residual choriocarcinoma.

    abstract：:Choriocarcinoma can be imaged by external scintigraphy after intravenous administration of radiolabelled antibody directed against human chorionic gonadotrophin (HCG). The purpose of this study was to investigate whether antibody imaging was sufficiently sensitive and specific to improve the selection of patients for ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1987.134

    authors： Begent RH,Bagshawe KD,Green AJ,Searle F

    更新日期：1987-06-01 00:00:00

  • A comparative analysis of management and prognosis in stage I and II fallopian tube carcinoma and epithelial ovarian cancer.

    abstract：:Staging and surgical as well as post-operative treatment of primary Fallopian tube carcinoma (FTC) followed the lines established for primary ovarian cancer (OC). In a nationwide retrospective analysis we were able to find a distinct difference between these two tumours. A total of 262 patients, 68 with FTC and 194 wi...

    journal_title：British journal of cancer

    pub_type： 杂志文章,多中心研究

    doi：10.1038/bjc.1994.105

    authors： Rosen AC,Sevelda P,Klein M,Graf AH,Lahousen M,Reiner A,Auerbach L,Vavra N,Rosen HR

    更新日期：1994-03-01 00:00:00

  • Red and processed meat consumption and risk of pancreatic cancer: meta-analysis of prospective studies.

    abstract：BACKGROUND:Whether red and processed meat consumption is a risk factor for pancreatic cancer remains unclear. We conducted a meta-analysis to summarise the evidence from prospective studies of red and processed meat consumption and pancreatic cancer risk. METHODS:Relevant studies were identified by searching PubMed an...

    journal_title：British journal of cancer

    pub_type： 杂志文章,meta分析

    doi：10.1038/bjc.2011.585

    authors： Larsson SC,Wolk A

    更新日期：2012-01-31 00:00:00

  • Breast cancer cell-associated endopeptidase EC 24.11 modulates proliferative response to bombesin.

    abstract：:We have investigated the production, growth and inactivation of gastrin-releasing peptide (GRP)-like peptides in human breast cancer cell lines. Radioimmunoassay detected GRP-like immunoreactivity (GRP-LI) in T47D breast cancer cells but not in the conditioned medium, indicating rapid clearance. No GRP-LI was found in...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6690036

    authors： Burns DM,Walker B,Gray J,Nelson J

    更新日期：1999-01-01 00:00:00

  • Immunohistochemical discrimination of wild-type EGFR from EGFRvIII in fixed tumour specimens using anti-EGFR mAbs ICR9 and ICR10.

    abstract：BACKGROUND:The human epidermal growth factor receptor (EGFR) is an important therapeutic target in oncology, and three different types of EGFR inhibitors have been approved for the treatment of cancer patients. However, there has been no clear association between the expression levels of EGFR protein in the tumours det...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2012.27

    authors： Modjtahedi H,Khelwatty SA,Kirk RS,Seddon AM,Essapen S,Del Vecchio CA,Wong AJ,Eccles S

    更新日期：2012-02-28 00:00:00

  • Season of diagnosis is a prognostic factor in Hodgkin's lymphoma: a possible role of sun-induced vitamin D.

    abstract：:Experimental studies show that vitamin D derivatives are potent anticarcinogenic factors. Epidemiological observations support this, and vitamin D sufficiency has been hypothesised to be an important risk-reducing factor in several forms of cancer. Vitamin D level exhibits seasonal variations. In the present work, we ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6602722

    authors： Porojnicu AC,Robsahm TE,Ree AH,Moan J

    更新日期：2005-09-05 00:00:00

  • The impact of young age on cancer-specific and non-cancer-related survival after surgery for colorectal cancer: 10-year follow-up.

    abstract：BACKGROUND:It has been reported that although young patients present with more advanced disease, when adjusted for stage, cancer-specific survival is not different after surgery for colorectal cancer. However, few studies have examined non-cancer survival in young patients and 10-year survival has rarely been reported....

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6605222

    authors： McMillan DC,McArdle CS

    更新日期：2009-08-18 00:00:00

  • Asthma and risk of myelodysplastic syndromes: a population-based cohort study.

    abstract：BACKGROUND:Risk factors for the development of myelodysplastic syndromes (MDS) include age, exposure to ionising radiation, and cytotoxic drug treatment. Recently, asthma also has been suggested as a risk factor for MDS. METHODS:We undertook this nationwide population-based cohort study on patients with a first-time h...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2016.389

    authors： Frederiksen H,Farkas DK,Horváth-Puhó E,Nørgaard JM,Nørgaard M,Sørensen HT

    更新日期：2017-01-03 00:00:00

  • Indole-3-carbinol synergistically sensitises ovarian cancer cells to bortezomib treatment.

    abstract：BACKGROUND:Bortezomib is a proteasome inhibitor with minimal clinical activity as a monotherapy in solid tumours, but its combination with other targeted therapies is being actively investigated as a way to increase its anticarcinogenic properties. Here, we evaluate the therapeutic potential of co-treatment with bortez...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2011.546

    authors： Taylor-Harding B,Agadjanian H,Nassanian H,Kwon S,Guo X,Miller C,Karlan BY,Orsulic S,Walsh CS

    更新日期：2012-01-17 00:00:00

  • Enhanced antitumor effect of binimetinib in combination with capecitabine for biliary tract cancer patients with mutations in the RAS/RAF/MEK/ERK pathway: phase Ib study.

    abstract：BACKGROUND:A phase Ib study of binimetinib and capecitabine for gemcitabine-pretreated biliary tract cancer (BTC) patients was conducted. METHODS:Binimetinib and capecitabine were dosed twice daily on days 1-14, in 3-week cycles. In the dose-escalation (DE) part, three dose levels (DL) were tested (DL1: binimetinib/ca...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/s41416-019-0523-5

    authors： Kim JW,Lee KH,Kim JW,Suh KJ,Nam AR,Bang JH,Bang YJ,Oh DY

    更新日期：2019-08-01 00:00:00

  • Sentinel node biopsy in early vulvar cancer.

    abstract：:Lymph node pathologic status is the most important prognostic factor in vulvar cancer; however, complete inguinofemoral node dissection is associated with significant morbidity. Lymphoscintigraphy associated with gamma-probe guided surgery reliably detects sentinel nodes in melanoma and breast cancer patients. This st...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1054/bjoc.1999.0918

    authors： De Cicco C,Sideri M,Bartolomei M,Grana C,Cremonesi M,Fiorenza M,Maggioni A,Bocciolone L,Mangioni C,Colombo N,Paganelli G

    更新日期：2000-01-01 00:00:00

  • S-phase specificity of cell killing by docetaxel (Taxotere) in synchronised HeLa cells.

    abstract：:Cell viability following short (1 h) contact with paclitaxel or docetaxel was assayed using synchronised HeLa cells. Docetaxel proved almost totally lethal against S-phase cells. Its toxicity was only partial against cells in mitosis, and declined to a minimum with progression to G1. For paclitaxel, cytotoxicity incre...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1995.232

    authors： Hennequin C,Giocanti N,Favaudon V

    更新日期：1995-06-01 00:00:00

  • Smoking, alcohol and gastric cancer risk in Korean men: the National Health Insurance Corporation Study.

    abstract：:We investigated the risk of gastric cancer by subsite in relation to cigarette smoking and alcohol in a large population-based cohort of 669 570 Korean men in an insurance plan followed for an average 6.5 years, yielding 3452 new cases of gastric cancer, of which 127 were cardia and upper-third gastric cancer, 2409 we...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6603893

    authors： Sung NY,Choi KS,Park EC,Park K,Lee SY,Lee AK,Choi IJ,Jung KW,Won YJ,Shin HR

    更新日期：2007-09-03 00:00:00

  • Conditional crude probabilities of death for English cancer patients.

    abstract：BACKGROUND:Cancer survival statistics are typically reported by using measures discounting the impact of other-cause mortality, such as net survival. This is a hypothetical measure and is interpreted as excluding the possibility of cancer patients dying from other causes. Crude probability of death partitions the all-c...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/s41416-019-0597-0

    authors： Wong KF,Lambert PC,Mozumder SI,Broggio J,Rutherford MJ

    更新日期：2019-11-01 00:00:00

  • Phase I dose-escalation and pharmacokinetic study of temozolomide (SCH 52365) for refractory or relapsing malignancies.

    abstract：:Temozolomide, an oral cytotoxic agent with approximately 100% bioavailability after one administration, has demonstrated schedule-dependent clinical activity against highly resistant cancers. Thirty patients with minimal prior chemotherapy were enrolled in this phase I trial to characterize the drug's safety, pharmaco...

    journal_title：British journal of cancer

    pub_type： 临床试验,杂志文章

    doi：10.1038/sj.bjc.6690802

    authors： Brada M,Judson I,Beale P,Moore S,Reidenberg P,Statkevich P,Dugan M,Batra V,Cutler D

    更新日期：1999-11-01 00:00:00

  • Presence of activin signal transduction in normal ovarian cells and epithelial ovarian carcinoma.

    abstract：:In this study, we have investigated the expression of inhibin subunits and activin receptors (ActRs) in normal and malignant ovarian cells. Each product of the inhibin subunits (alpha, betaa, betab) and activin receptors (ActRs) amplified by reverse transcription polymerase chain reaction were detected as a single ban...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1054/bjoc.1999.1127

    authors： Ito I,Minegishi T,Fukuda J,Shinozaki H,Auersperg N,Leung PC

    更新日期：2000-04-01 00:00:00

  • miR-23a promotes IKKα expression but suppresses ST7L expression to contribute to the malignancy of epithelial ovarian cancer cells.

    abstract：BACKGROUND:Dysregulation of microRNAs (miRNAs) has been found in human epithelial ovarian cancer (EOC). However, the role and mechanism of action of miR-23a in EOC remain unclear. METHODS:The roles of miR-23a, IKKα, and ST7L in EOC were determined by MTT, colony formation, wounding healing, transwell, flow cytometry, ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2016.244

    authors： Yang Z,Wang XL,Bai R,Liu WY,Li X,Liu M,Tang H

    更新日期：2016-09-06 00:00:00

  • Serum laminin P1 in small cell lung cancer: a valuable indicator of distant metastasis?

    abstract：:Serum laminin P1 was studied in patients with small cell lung cancer (SCLC), non-small cell lung cancer (NSCLC), respiratory infections, pulmonary fibrosis, and in normal subjects. The level of serum laminin P1 was elevated (greater than 1.27 U ml-1) in 58.9% of SCLC and in 11.5% of NSCLC patients. Median value in SCL...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1992.123

    authors： Nakano T,Iwahashi N,Maeda J,Hada T,Higashino K

    更新日期：1992-04-01 00:00:00

  • Development of a gene panel for next-generation sequencing of clinically relevant mutations in cell-free DNA from cancer patients.

    abstract：BACKGROUND:When tumour tissue is unavailable, cell-free DNA (cfDNA)can serve as a surrogate for genetic analyses. Because mutated alleles in cfDNA are usually below 1%, next-generation sequencing (NGS)must be narrowed to target only clinically relevant genes. In this proof-of-concept study, we developed a panel to use ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2017.8

    authors： Malapelle U,Mayo de-Las-Casas C,Rocco D,Garzon M,Pisapia P,Jordana-Ariza N,Russo M,Sgariglia R,De Luca C,Pepe F,Martinez-Bueno A,Morales-Espinosa D,González-Cao M,Karachaliou N,Viteri Ramirez S,Bellevicine C,Molina-Vila M

    更新日期：2017-03-14 00:00:00

  • A phase I study of misonidazole and pelvic irradiation in patients with carcinoma of cervix.

    abstract：:A Phase I study of oral daily misonidazole (MISO) with conventional pelvic irradiation, has been conducted in patients with carcinoma of the cervix Stages IB, IIB, IIIB and IVA. MISO was administered in daily dosages to sequential groups of patients at doses of 0.15 g/m2, 0.30 g/m2 or 0.45 g/m2 for 22 days over 5 week...

    journal_title：British journal of cancer

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1038/bjc.1982.138

    authors： Thomas GM,Rauth AM,Black BE,Cummings BJ,Sorenti VL,Bush RS

    更新日期：1982-06-01 00:00:00

  • Resistance to alkylating agents and tumour differentiation in xenografts of small cell lung cancer.

    abstract：:Small cell bronchial carcinoma (SCC) xenografts with differing sensitivity to cyclophosphamide (CY) were investigated using a variety of techniques. Two xenografts (HX78 and HX88) were relatively sensitive to CY, one xenograft (HX72) was inherently resistant to CY and a fourth xenograft (HX78Cy) was a CY induced resis...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1985.98

    authors： Berman R,Gusterson B,Steel GG

    更新日期：1985-05-01 00:00:00

  • Detection of HPV-associated oropharyngeal tumours in a 16-year cohort: more than meets the eye.

    abstract：BACKGROUND:Accurate assessment of the prevalence of the human papilloma virus (HPV) in oropharyngeal tumours (OpSCC) is important because HPV-positive OpSCC are consistently associated with an improved overall survival. Recently, an algorithm has become available that reliably detects clinically relevant HPV in tumour ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2015.99

    authors： Melchers LJ,Mastik MF,Samaniego Cameron B,van Dijk BA,de Bock GH,van der Laan BF,van der Vegt B,Speel EJ,Roodenburg JL,Witjes MJ,Schuuring E

    更新日期：2015-04-14 00:00:00

  • Cellular heterogeneity in normal and neoplastic human urothelium: a study using murine monoclonal antibodies.

    abstract：:To assist in the description of the cellular heterogeneity present in normal and neoplastic urothelium, a panel of monoclonal antibodies (MoAbs) was raised against human transitional cell carcinoma (TCC) of the urinary bladder. All immunizations were carried out using whole cells and membrane preparations from well di...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1987.220

    authors： Dotsikas G,Konowalchuk T,Major PP,Kovac PE,Ward GK,Stewart SS,Price GB,Elhilali MM,Mackillop WJ

    更新日期：1987-10-01 00:00:00

  • How to evaluate the risk/benefit of trimodality therapy in locally advanced non-small-cell lung cancer.

    abstract：:The trimodality approach represented by concurrent chemoradiotherapy followed by surgical resection is a highly effective, but potentially toxic therapy for locally advanced non-small-cell lung cancer (NSCLC). In this review, we discuss the current status of this therapy in patients with mediastinal node-positive (N2)...

    journal_title：British journal of cancer

    pub_type： 杂志文章,评审

    doi：10.1038/sj.bjc.6603751

    authors： Kunitoh H,Suzuki K

    更新日期：2007-05-21 00:00:00

  • Mutagenicity of comfrey (Symphytum Officinale) in rat liver.

    abstract：:Comfrey is a rat liver toxin and carcinogen that has been used as a vegetable and herbal remedy by humans. In order to evaluate the mechanisms underlying its carcinogenicity, we examined the mutagenicity of comfrey in the transgenic Big Blue rat model. Our results indicate that comfrey is mutagenic in rat liver and th...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6602420

    authors： Mei N,Guo L,Fu PP,Heflich RH,Chen T

    更新日期：2005-03-14 00:00:00

  • Collection of circulating progenitor cells after epirubicin, paclitaxel and filgrastim in patients with metastatic breast cancer.

    abstract：:The efficacy of high-dose chemotherapy (HDC) and circulating progenitor cell (CPC) transplantation in metastatic breast cancer (MBC) relies mainly on giving this treatment after a response to conventional induction chemotherapy has been achieved. For this reason an optimal mobilization regimen should be therapeuticall...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1997.231

    authors： Pedrazzoli P,Perotti C,Da Prada GA,Bertolini F,Gibelli N,Torretta L,Battaglia M,Pavesi L,Preti P,Salvaneschi L,Robustelli della Cuna G

    更新日期：1997-01-01 00:00:00

  • Targeting lymphangiogenesis to prevent tumour metastasis.

    abstract：:Recent studies involving animal models of cancer and clinicopathological analyses of human tumours suggest that the growth of lymphatic vessels (lymphangiogenesis) in or nearby tumours is associated with the metastatic spread of cancer. The best validated molecular signalling system for tumour lymphangiogenesis involv...

    journal_title：British journal of cancer

    pub_type： 杂志文章,评审

    doi：10.1038/sj.bjc.6603120

    authors： Achen MG,Mann GB,Stacker SA

    更新日期：2006-05-22 00:00:00

  • Multiple primary tumours in women following breast cancer, 1973-2000.

    abstract：:We investigated the predictors of the risk of developing a second primary cancer after breast cancer, this occurring in about 12% of affected women. The analysis included 335 191 females, registered in the National Cancer Institute's Surveillance Epidemiology and End Results (SEER) database, who had been diagnosed wit...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6603172

    authors： Raymond JS,Hogue CJ

    更新日期：2006-06-05 00:00:00

  • Cytotoxic drugs efficacy correlates with adipose tissue docosahexaenoic acid level in locally advanced breast carcinoma.

    abstract：:Experimental studies indicated that long-chain polyunsaturated fatty acids may increase sensitivity of mammary tumours to several cytotoxic drugs. To evaluate this hypothesis in breast cancer, we have prospectively studied the association between levels of fatty acids stored in breast adipose tissue and the response o...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6690281

    authors： Bougnoux P,Germain E,Chajès V,Hubert B,Lhuillery C,Le Floch O,Body G,Calais G

    更新日期：1999-04-01 00:00:00