Season of diagnosis is a prognostic factor in Hodgkin's lymphoma: a possible role of sun-induced vitamin D.

abstract：:In several phase II-trials encouraging tumour responses rates in advanced metastatic melanoma (stage IV; AJCC-classification) have been reported for the application of biochemotherapy containing interleukin 2. This study was designed to compare the efficacy of therapy with dacarbazine (DTIC) and interferon alpha (IFN-...

journal_title：British journal of cancer

authors： Hauschild A,Garbe C,Stolz W,Ellwanger U,Seiter S,Dummer R,Ugurel S,Sebastian G,Nashan D,Linse R,Achtelik W,Mohr P,Kaufmann R,Fey M,Ulrich J,Tilgen W

更新日期：2001-04-20 00:00:00

abstract：:The aim of this phase I study was to determine the maximum tolerated dose of a 3-h infusion of paclitaxel, combined with carboplatin at a fixed AUC of 7 mg ml-1 min every 4 weeks for up to six cycles and to evaluate any possible pharmacokinetic interaction. Twelve chemonaive patients with ovarian cancer were treated w...

journal_title：British journal of cancer

authors： Siddiqui N,Boddy AV,Thomas HD,Bailey NP,Robson L,Lind MJ,Calvert AH

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Most oestrogen receptor (ER)-positive early breast cancer diagnosed today is highly curable with multimodality treatment. Systemic adjuvant treatments including endocrine therapy and chemotherapy have made a significant contribution to the increasing cure rates over the past three decades. However not all wo...

journal_title：British journal of cancer

authors： Yeo B,Zabaglo L,Hills M,Dodson A,Smith I,Dowsett M

更新日期：2015-07-28 00:00:00

abstract：:Hypomethylation has been reported to be responsible for the activation of several oncogenes. The possibility that hypomethylation is involved in the regulation of MET transcription was investigated through the analysis of the methylation status of one CpG island containing 43 CpGs in six cases of papillary carcinoma, ...

journal_title：British journal of cancer

authors： Scarpino S,Di Napoli A,Rapazzotti-Onelli M,Pilozzi E,Ruco L

更新日期：2004-08-16 00:00:00

abstract：BACKGROUND:The development of practical patient-reported outcome measures (PROM) to assess the user view of health programmes is increasingly important. Valid, shorter instruments are more likely to be used and completed than extensive questionnaires. METHODS:Consecutive adult outpatient attendees who were long-term s...

journal_title：British journal of cancer

authors： Phillips R,Absolom K,Stark D,Glaser A

更新日期：2010-11-09 00:00:00

abstract：:DT-diaphorase (DTD) is an important enzyme for the bioreductive activation of the new alkylating indoloquinone EO9. In preclinical studies, EO9 has shown selective anti-tumour activity against solid tumours and under hypoxic conditions. The levels of three reductive enzymes have been determined in three types of human...

journal_title：British journal of cancer

authors： Smitskamp-Wilms E,Giaccone G,Pinedo HM,van der Laan BF,Peters GJ

更新日期：1995-10-01 00:00:00

abstract：:It has been reported that the rho genes, which consist of a ras-related small GTPase protein family, regulate cytoskeletal structures and have the potential to transform cultured cells. To investigate the biological relevance of the rho genes in pancreatic carcinogenesis, we examined expressions of the rhoA, B and C g...

journal_title：British journal of cancer

authors： Suwa H,Ohshio G,Imamura T,Watanabe G,Arii S,Imamura M,Narumiya S,Hiai H,Fukumoto M

更新日期：1998-01-01 00:00:00

abstract：:This phase II study was designed to evaluate the activity and safety of a combination of irinotecan, docetaxel and oxaliplatin in metastatic gastric or gastroesophageal junction (GEJ) adenocarcinoma. Forty patients with measurable distant metastasis received irinotecan 150 mg m(-2) and docetaxel 60 mg m(-2) on day 1, ...

journal_title：British journal of cancer

authors： Di Lauro L,Nunziata C,Arena MG,Foggi P,Sperduti I,Lopez M

更新日期：2007-09-03 00:00:00

abstract：:A series of 176 archival cervical intraepithelial neoplasia (CIN) was analysed for the presence, viral load and integration status of 'high-risk' types of human papillomavirus (HR-HPV). The samples were assayed using newly developed methods based on real-time PCR. Two methods for the extraction of DNA from the paraffi...

journal_title：British journal of cancer

authors： Andersson S,Safari H,Mints M,Lewensohn-Fuchs I,Gyllensten U,Johansson B

更新日期：2005-06-20 00:00:00

abstract：:The importance of tumour angiogenesis in the process of tumour growth and progression in solid tumours has been widely accepted. Among many angiogenic factors, vascular endothelial growth factor (VEGF) has been shown to play a major role in the development and dissemination of the malignant tumours. Nitric oxide (NO) ...

journal_title：British journal of cancer

authors： Eroğlu A,Demirci S,Ayyildiz A,Kocaoğlu H,Akbulut H,Akgül H,Elhan HA

更新日期：1999-07-01 00:00:00

abstract：:In a clinical investigation of observed postoperative survival, 563 patients have been registered for primary surgical treatment of colorectal cancer since 1974. The potential prognostic factors examined within the first days of hospitalization for primary resection included age of the patients, operability, location ...

journal_title：British journal of cancer

authors： Staab HJ,Anderer FA,Brümmendorf T,Stumpf E,Fischer R

更新日期：1981-11-01 00:00:00

abstract：:The growth inhibitory effects of interferons, IFN-alpha and IFN-gamma on human lung cancer cell lines were studied using both a tetrazolium (MTT) colorimetric assay and direct cell counting. Significant discrepancies between the two assays were observed, the MTT assay consistently underestimating the growth inhibitory...

journal_title：British journal of cancer

authors： Jabbar SA,Twentyman PR,Watson JV

更新日期：1989-10-01 00:00:00

abstract：:The relationship between history of schistosomiasis and bladder cancer risk was investigated using data from a case-control study conducted between January 1994 and July 1996 in Alexandria, Egypt. Cases were 190 subjects with incident, histologically confirmed invasive cancer of the bladder, and controls were 187 subj...

journal_title：British journal of cancer

authors： Bedwani R,Renganathan E,El Kwhsky F,Braga C,Abu Seif HH,Abul Azm T,Zaki A,Franceschi S,Boffetta P,La Vecchia C

更新日期：1998-04-01 00:00:00

abstract：:The present study was designed in order to evaluate the response rate and the toxicity of continuous infusion of Interleukin 2 (IL2) in patients over 65 with metastatic renal cell carcinoma. Twenty-five patients, median age 69 (range 65-77), without any prior systemic anticancer therapy received a continuous infusion ...

journal_title：British journal of cancer

authors： Négrier S,Mercatello A,Bret M,Thiesse P,Blay JY,Coronel B,Merrouche Y,Oskam R,Franks CR,Clavel M

更新日期：1992-05-01 00:00:00

abstract：:The p53 tumour suppressor protein inhibits malignant progression by mediating cell cycle arrest, apoptosis or repair following cellular stress. One of the major regulators of p53 function is the MDM2 protein, and multiple forms of cellular stress activate p53 by inhibiting the MDM2-mediated degradation of p53. Mutatio...

journal_title：British journal of cancer

authors： Bálint E E,Vousden KH

更新日期：2001-12-14 00:00:00

abstract：:To test the hypothesis that high levels of endogenous oestrogens increase the risk for developing breast cancer, concentrations of oestrone, oestradiol and oestriol were measured in 24 h urine samples from 1000 women participants in a prospective study of breast cancer on the island of Guernsey. Sixty-nine subjects we...

journal_title：British journal of cancer

authors： Key TJ,Wang DY,Brown JB,Hermon C,Allen DS,Moore JW,Bulbrook RD,Fentiman IS,Pike MC

更新日期：1996-06-01 00:00:00

abstract：:A multicentric, prospective phase III study was carried out with the aim of testing the so-called 'worst drug rule' hypothesis, which suggests the use of an effective but 'less active' regimen that first eradicates tumoral cells resistant to a second effective and 'more active' regimen. With respect to this hypothesis...

journal_title：British journal of cancer

authors： Colucci G,Gebbia V,Galetta D,Riccardi F,Cariello S,Gebbia N

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Expression of epithelial cell adhesion molecule (EpCAM) is deregulated in epithelial malignancies. Beside its role in cell adhesion, EpCAM acts as signalling molecule with tumour-promoting functions. Thus, EpCAM is part of the molecular network of oncogenic receptors and considered an interesting therapeutic...

journal_title：British journal of cancer

authors： Massoner P,Thomm T,Mack B,Untergasser G,Martowicz A,Bobowski K,Klocker H,Gires O,Puhr M

更新日期：2014-08-26 00:00:00

abstract：:Four poly(ADP-ribose) polymerase (PADPRP) inhibitors [3-aminobenzamide, benzamide, 3,4-dihydro-5-methoxyisoquinolin-1(2H)-one (PD 128763) and 8-hydroxy-2-methylquinazolin-4(3H)-one (NU1025)] were compared with respect to their effects on a number of biological end points. The following parameters were assessed: their ...

journal_title：British journal of cancer

authors： Boulton S,Pemberton LC,Porteous JK,Curtin NJ,Griffin RJ,Golding BT,Durkacz BW

更新日期：1995-10-01 00:00:00

abstract：:Eighteen patients with inoperable hepatocellular carcinoma (HCC) were treated with intrahepatic arterial yttrium-90 microspheres. All these patients showed a lung shunting below 15% and a tumour-to-normal ratio higher than 2 as determined by diagnostic technetium-99m macroaggregated albumin (Tc-MAA) gamma scintigraphy...

journal_title：British journal of cancer

authors： Lau WY,Leung WT,Ho S,Leung NW,Chan M,Lin J,Metreweli C,Johnson P,Li AK

更新日期：1994-11-01 00:00:00

abstract：INTRODUCTION:This paper reports on an ongoing primary care audit of cancer referrals undertaken in Scotland in 2006-2007 and 2007-2008. METHODS:General practitioners (GPs) in Scotland were asked to review all new cancer diagnoses within their practice during the preceding year. RESULTS:4181 patients were identified i...

journal_title：British journal of cancer

authors： Baughan P,O'Neill B,Fletcher E

更新日期：2009-12-03 00:00:00

abstract：:A cohort study was conducted to investigate the mortality of individuals employed by biological research institutes in the UK. The inclusion criteria were met by 12,703 individuals, of whom 95% were traced (11,502 alive, 395 deaths, 246 embarkations). All-cause mortality was significantly reduced in men (standardised)...

journal_title：British journal of cancer

authors： Brown TP,Paulson J,Pannett B,Coupland C,Coggon D,Chilvers CE,Sasco AJ

更新日期：1996-05-01 00:00:00

abstract：:The purpose of the study was to determine the response rates (RR) and duration to second- and third-line chemotherapy programmes in patients with anthracycline-resistant breast cancer, utilizing various definitions of anthracycline resistance. This was a retrospective analysis performed on 1335 patients with metastati...

journal_title：British journal of cancer

authors： Pivot X,Asmar L,Buzdar AU,Valero V,Hortobagyi G

更新日期：2000-02-01 00:00:00

abstract：:Eleven patients suffering from intra-abdominal malignancy were treated with various doses of intraperitoneal mitomycin C adsorbed onto activated carbon particles. Seven of the patients underwent resection of their primary gastric tumour and all developed potentially life-threatening severe complications that proved to...

journal_title：British journal of cancer

authors： Ubhi SS,McCulloch P,Veitch PS

更新日期：1997-01-01 00:00:00

abstract：:This is the first study to investigate the associations of IGF-1, IGF-2 and IGFBP-3 concentrations with the risk of colorectal cancer in prospectively collected blood samples from an Oriental population. Between 1986 and 1989 serum samples were collected at baseline from 18 244 men, aged 45-65 years, without a history...

journal_title：British journal of cancer

authors： Probst-Hensch NM,Yuan JM,Stanczyk FZ,Gao YT,Ross RK,Yu MC

更新日期：2001-11-30 00:00:00

abstract：:We analysed 26 metastases from 25 patients with sporadic cutaneous malignant melanoma for alterations in the CDKN2 gene by a combined polymerase chain reaction/single-strand conformation polymorphism (PCR/SSCP)/nucleotide sequencing approach. Eleven alterations (one in exon 1, five in exon 2 and five in the 3' non-cod...

journal_title：British journal of cancer

authors： Platz A,Ringborg U,Lagerlöf B,Lundqvist E,Sevigny P,Inganäs M

更新日期：1996-02-01 00:00:00

abstract：:In the present multicentre randomized phase II trial, the activity and toxicity of three platinum-based combination regimens for the treatment of advanced non-small-cell lung cancer (NSCLC) were evaluated. The three regimens were: MVP (mitomycin-C 6 mg m(-2) on day 1, vindesine 3 mg m(-2) on days 1 and 15, and cisplat...

journal_title：British journal of cancer

authors： Baldini E,Tibaldi C,Ardizzoni A,Salvati F,Antilli A,Portalone L,Barbera S,Romano F,De Marinis F,Migliorino MR,Noseda MA,Borghini U,Crippa M,Ferrara G,Raimondi M,Fioretti M,Bandera M,Pennucci MC,Galeasso G,Cacciani G

更新日期：1998-06-01 00:00:00

abstract：BACKGROUND:Cediranib is a highly potent inhibitor of vascular endothelial growth factor (VEGF) signalling with activity against all three VEGF receptors. Bevacizumab is an anti-VEGF-A monoclonal antibody with clinical benefit in previously treated metastatic colorectal cancer (mCRC). METHODS:Patients with mCRC who had...

journal_title：British journal of cancer

authors： Cunningham D,Wong RP,D'Haens G,Douillard JY,Robertson J,Stone AM,Van Cutsem E,HORIZON I study group.

更新日期：2013-02-19 00:00:00

abstract：BACKGROUND:When tumour tissue is unavailable, cell-free DNA (cfDNA)can serve as a surrogate for genetic analyses. Because mutated alleles in cfDNA are usually below 1%, next-generation sequencing (NGS)must be narrowed to target only clinically relevant genes. In this proof-of-concept study, we developed a panel to use ...

journal_title：British journal of cancer

authors： Malapelle U,Mayo de-Las-Casas C,Rocco D,Garzon M,Pisapia P,Jordana-Ariza N,Russo M,Sgariglia R,De Luca C,Pepe F,Martinez-Bueno A,Morales-Espinosa D,González-Cao M,Karachaliou N,Viteri Ramirez S,Bellevicine C,Molina-Vila M

更新日期：2017-03-14 00:00:00

abstract：BACKGROUND:Robot-assisted radical prostatectomy (RARP) has been rapidly adopted without robust evidence comparing its functional outcomes against laparoscopic radical prostatectomy (LRP) or open retropubic radical prostatectomy (ORP) approaches. This study compared patient-reported functional outcomes following RARP, L...

journal_title：British journal of cancer

authors： Nossiter J,Sujenthiran A,Charman SC,Cathcart PJ,Aggarwal A,Payne H,Clarke NW,van der Meulen J

更新日期：2018-02-20 00:00:00