Prognostic value of preoperative serum CEA level compared to clinical staging. I. Colorectal carcinoma.

abstract：:E-cadherin function is thought to be impaired in epithelial cancer. To investigate the alterations in E-cadherin associated with cytoplasmic molecules including alpha-catenin, beta-catenin, gamma-catenin, p120CAS, and IQGAP1 in various endometrial cancers with different degree of differentiation, we examined the local...

journal_title：British journal of cancer

authors： Miyamoto S,Baba H,Kuroda S,Kaibuchi K,Fukuda T,Maehara Y,Saito T

更新日期：2000-11-01 00:00:00

abstract：:Regionally administered vasopressors might increase tumour chemotherapy uptake by differentially constricting normal and tumour blood vessels, leading to a selective increase in blood flow to the tumour. In this study, we compared the effects of the vasopressors angiotensin II, vasopressin and endothelin I and the vas...

journal_title：British journal of cancer

authors： Dworkin MJ,Carnochan P,Allen-Mersh TG

更新日期：1997-01-01 00:00:00

abstract：:A phase I study of the bispecific antibody MDX-H210 in combination with granulocyte colony-stimulating factor (G-CSF) was performed in stage IV breast carcinoma patients, overexpressing HER-2/neu. MDX-H210, constructed by crosslinking antigen binding fragments (F(ab') fragments) of monoclonal antibody (mAb) H22 to Fc ...

journal_title：British journal of cancer

authors： Repp R,van Ojik HH,Valerius T,Groenewegen G,Wieland G,Oetzel C,Stockmeyer B,Becker W,Eisenhut M,Steininger H,Deo YM,Blijham GH,Kalden JR,van de Winkel JG,Gramatzki M

更新日期：2003-12-15 00:00:00

abstract：:The orally administered tubulin-binding agent 1069C85 was developed with the hope of overcoming the multidrug resistance associated with existing anti-tubulin agents, such as the vinca alkaloids. A phase I study was performed using a single oral dose every 3 weeks, administered as a suspension reconstituted in 0.1% Tw...

journal_title：British journal of cancer

authors： Judson I,Briasoulis E,Raynaud F,Hanwell J,Berry C,Lacey H

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Regulator of cullins-1 (ROC1) is a key subunit in the cullin-RING ligase (CRL) protein complex. Our previous study indicated that ROC1 was essential for bladder cancer cell survival and that ROC1 knockdown inhibited CRL activity, triggering G2 phase arrest and senescence. However, the role of ROC1 in the mal...

journal_title：British journal of cancer

authors： Wang W,Chen H,Liu Z,Qu P,Lan J,Chen H,Zou L,Qiu J

更新日期：2016-02-02 00:00:00

abstract：:Serum concentrations of oestradiol-17β were measured by radio-immunoassay during 40 menstrual cycles from 38 normal premenopausal women. Repeated samples were studied from 25 normal postmenopausal women. The method was highly specific and extremely sensitive. In premenopausal women the pattern of serum oestradiol-17β ...

journal_title：British journal of cancer

authors： England PC,Skinner LG,Cottrell KM,Sellwood RA

更新日期：1974-06-01 00:00:00

abstract：:Covalent modifications of histones, such as acetylation, methylation, and phosphorylation, and other epigenetic modulations of the chromatin, such as methylation of DNA and ATP-dependent chromatin reorganisation, can play a major part in the multistep process of carcinogenesis, with far-reaching implications for human...

journal_title：British journal of cancer

authors： Hake SB,Xiao A,Allis CD

更新日期：2004-02-23 00:00:00

abstract：:The clinical formulation of the anti-tumour agent Taxol involves the use of a mixture of ethanol and Cremophor EL. Gel electrophoresis and density-gradient ultracentrifugation were used to detect effects of Taxol infusions on serum lipoproteins. Use of the Cremophor vehicle results in a decrease in the electrophoretic...

journal_title：British journal of cancer

authors： Sykes E,Woodburn K,Decker D,Kessel D

更新日期：1994-09-01 00:00:00

abstract：:Rats were given a single dose of dimethylnitrosamine (DMN, 20 mg/kg body weight) alone or 42 or 60 hours after a non-lethal hepatotoxic dose of carbon tetrachloride (CC1(4)) and killed 12 months later. DMN alone produced no tumours in the kidney and a few in the liver, but when given 42 hours after CC1(4), tumours for...

journal_title：British journal of cancer

authors： Pound AW,Lawson TA,Horn L

更新日期：1973-06-01 00:00:00

abstract：BACKGROUND:The addition of breast magnetic resonance imaging (MRI) to screening mammography for women with BRCA mutations significantly increases sensitivity, but there is little data on clinical outcomes. We report screening performance, cancer stage, distant recurrence rate, and breast cancer-specific mortality in ou...

journal_title：British journal of cancer

authors： Passaperuma K,Warner E,Causer PA,Hill KA,Messner S,Wong JW,Jong RA,Wright FC,Yaffe MJ,Ramsay EA,Balasingham S,Verity L,Eisen A,Curpen B,Shumak R,Plewes DB,Narod SA

更新日期：2012-06-26 00:00:00

abstract：BACKGROUND:Multiple early gastric cancers (EGCs) may develop in 6-14% of patients even after achieving curative endoscopic submucosal dissection (ESD); however, a useful biomarker for predicting recurrence is not available. The present study investigated whether the expression of CD44 variant 9 (CD44v9), a functional c...

journal_title：British journal of cancer

authors： Hirata K,Suzuki H,Imaeda H,Matsuzaki J,Tsugawa H,Nagano O,Asakura K,Saya H,Hibi T

更新日期：2013-07-23 00:00:00

abstract：:Intrapleurally injected cells of an ascitic rat tumour produced intrapleural effusions and solid pleural deposits. BCG, or its methanol extraction residue (MER) injected into the pleural space, suppressed tumour development and prolonged survival. Treatment was effective if given a few days before or after tumour inje...

journal_title：British journal of cancer

authors： Pimm MV,Hopper DG,Baldwin RW

更新日期：1976-10-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：British journal of cancer

authors： Gkotzamanidou M,Sfikakis PP,Kyrtopoulos SA,Bamia C,Dimopoulos MA,Souliotis VL

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:We evaluated the associations of anthropometric indicators of general obesity (body mass index, BMI), an established risk factor of various cancer, and body fat distribution (waist circumference, WC; hip circumference, HC; and waist-to-hip ratio, WHR), which may better reflect metabolic complications of obes...

journal_title：British journal of cancer

authors： Freisling H,Arnold M,Soerjomataram I,O'Doherty MG,Ordóñez-Mena JM,Bamia C,Kampman E,Leitzmann M,Romieu I,Kee F,Tsilidis K,Tjønneland A,Trichopoulou A,Boffetta P,Benetou V,Bueno-de-Mesquita HBA,Huerta JM,Brenner H,Wils

更新日期：2017-05-23 00:00:00

abstract：:In a previous report we suggested that the estimation of prothymosin alpha (PTA) levels in primary breast tumours might be used to identify breast cancer patients at high risk for distant metastasis (Dominguez F et al (1993) Eur J Cancer 29A: 893-897). Here the role of tumour PTA levels as predictor was investigated w...

journal_title：British journal of cancer

authors： Magdalena C,Dominguez F,Loidi L,Puente JL

更新日期：2000-02-01 00:00:00

abstract：:Cancer Research UK has recently sponsored a meeting, organized by the UK Medical Research Council, on cancer drug resistance. Several of the molecular mechanisms responsible for this clinical outcome, such as DNA interstrand crosslink repair, apoptosis evasion, cytochrome P450 and P-glycoprotein, were discussed. There...

journal_title：British journal of cancer

authors： Yagüe E,Raguz S

更新日期：2005-10-31 00:00:00

abstract：:The purpose of this study was to evaluate the occurrence of lymphatic drainage to non-axillary sentinel nodes and to determine the implications of this phenomenon. A total of 549 breast cancer patients underwent lymphoscintigraphy after intratumoural injection of (99m)Tc-nanocolloid. The sentinel node was intraoperati...

journal_title：British journal of cancer

authors： Tanis PJ,Nieweg OE,Valdés Olmos RA,Peterse JL,Rutgers EJ,Hoefnagel CA,Kroon BB

更新日期：2002-09-23 00:00:00

abstract：BACKGROUND:We evaluated the association between smoking status and thyroid cancer risk and whether this association is mediated by body mass index (BMI) and thyroid-stimulating hormone (TSH). METHODS:We performed a cohort study of 96,855 Korean adults who were followed annually or biennially for a median of 5.9 years....

journal_title：British journal of cancer

authors： Cho A,Chang Y,Ahn J,Shin H,Ryu S

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:We and others have identified the aldo-keto reductase AKR1C3 as a potential drug target in prostate cancer, breast cancer and leukaemia. As a consequence, significant effort is being invested in the development of AKR1C3-selective inhibitors. METHODS:We report the screening of an in-house drug library to id...

journal_title：British journal of cancer

authors： Khanim F,Davies N,Veliça P,Hayden R,Ride J,Pararasa C,Chong MG,Gunther U,Veerapen N,Winn P,Farmer R,Trivier E,Rigoreau L,Drayson M,Bunce C

更新日期：2014-03-18 00:00:00

abstract：:The aim of this study is to evaluate different options for introducing liquid-based cytology (LBC) and human papillomavirus (HPV) testing into the UK cervical cancer screening programme. These include options that incorporate HPV testing either as a triage for mild and borderline smear abnormalities or as a primary sc...

journal_title：British journal of cancer

authors： Sherlaw-Johnson C,Philips Z

更新日期：2004-07-05 00:00:00

abstract：:This is a retrospective study of 520 patients with lung cancer, seen at the Tata Memorial Hospital between 1963 and 1970. Matched controls were obtained from those patients who came to the hospital within the same period and who were diagnosed as not having cancer. The patients and controls were matched for age, sex a...

journal_title：British journal of cancer

authors： Notani P,Sanghvi LD

更新日期：1974-06-01 00:00:00

abstract：BACKGROUND:Systemic inflammation measured by the neutrophil-to-lymphocyte ratio (NLR), leucocyte-to-lymphocyte ratio (LLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR) and CRP/albumin ratio (CRP/Alb) was shown to impact the survival prognosis in patients with extracranial solid cancer. METHO...

journal_title：British journal of cancer

authors： Starzer AM,Steindl A,Mair MJ,Deischinger C,Simonovska A,Widhalm G,Gatterbauer B,Dieckmann K,Heller G,Preusser M,Berghoff AS

更新日期：2021-01-21 00:00:00

abstract：:The effect of selected marine compounds with anti-tumoral activity on the cell microtubule network was tested by immunofluorescence analyses, or by other in vitro analyses involving competition with colchicine or with GTP for tubulin binding and tubulin polymerisation, studies that were carried out in parallel with ot...

journal_title：British journal of cancer

authors： García-Rocha M,García-Gravalos MD,Avila J

更新日期：1996-04-01 00:00:00

abstract：BACKGROUND:Anoctamin (ANO)/transmembrane member 16 (TMEM16) proteins mediate diverse physiological and pathophysiological functions including cancer cell proliferation. The present study aimed to identify the role of ANOs in pancreatic cancer. METHODS:In an initial screen of ANOs, ANO9/TMEM16J was overexpressed in pan...

journal_title：British journal of cancer

authors： Jun I,Park HS,Piao H,Han JW,An MJ,Yun BG,Zhang X,Cha YH,Shin YK,Yook JI,Jung J,Gee HY,Park JS,Yoon DS,Jeung HC,Lee MG

更新日期：2017-12-05 00:00:00

abstract：:One hundred and one histologically confirmed gastric cancer patients in Gwynedd, North Wales, were matched by sex, age and social class to two hospital inpatients without cancer. Seventy-seven of the gastric cancer cases were also matched, using the same criteria, to a patient with a confirmed cancer of a different si...

journal_title：British journal of cancer

authors： Galpin OP,Whitaker CJ,Whitaker R,Kassab JY

更新日期：1990-05-01 00:00:00

abstract：BACKGROUND:In this study, we evaluated the possibility that KRAS mutational status might be predictive of oxaliplatin (OXA) efficacy. We also explored the role of excision repair cross complementing group-1 (ERCC-1). METHODS:Ninety anti-epidermal growth factor receptor-naive advanced colorectal cancer patients were re...

journal_title：British journal of cancer

authors： Basso M,Strippoli A,Orlandi A,Martini M,Calegari MA,Schinzari G,Di Salvatore M,Cenci T,Cassano A,Larocca LM,Barone C

更新日期：2013-01-15 00:00:00

abstract：BACKGROUND:We modified and evaluated an advance care planning (ACP) intervention, which had been shown to improve compliance with patient's end of life (EoL) wishes, in a different patient population. METHODS:Patients with incurable cancer, and a Family Member (FM), were randomised one-to-one to usual care or usual ca...

journal_title：British journal of cancer

authors： Johnson SB,Butow PN,Bell ML,Detering K,Clayton JM,Silvester W,Kiely BE,Clarke S,Vaccaro L,Stockler MR,Beale P,Fitzgerald N,Tattersall MHN

更新日期：2018-11-01 00:00:00

abstract：:The p16 protein plays an important role in the transition of cells into the G1 phase of the cell cycle. We have studied the prevalence of p16 protein expression in breast carcinomas in a prospective series of 368 invasive and 52 non-invasive malignancies, as well as in 88 locally recurring tumours and three tumour cel...

journal_title：British journal of cancer

authors： Emig R,Magener A,Ehemann V,Meyer A,Stilgenbauer F,Volkmann M,Wallwiener D,Sinn HP

更新日期：1998-12-01 00:00:00

abstract：:Circulating serum factors have been said to abrogate the effects of immune response in cancer, i.e. "blocking" and "antigenic inhibition". The aim of this investigation was to isolate such specific factors in a purified and native state. F(ab)2 fragments isolated from hypernephroma were insolubilized on the surfaces o...

journal_title：British journal of cancer

authors： Langvad E,Hydén H,Wolf H,Kroeigaard N

更新日期：1975-12-01 00:00:00

abstract：:The ESPAC-1, ESPAC-1 plus, and early ESPAC-3(v1) results (458 randomized patients; 364 deaths) were used to estimate the effectiveness of adjuvant 5FU/FA vs resection alone for pancreatic cancer using meta-analysis. The pooled hazard ratio of 0.70 (95% CI=0.55-0.88) P=0.003, and the median survival of 23.2 (95% CI=20....

journal_title：British journal of cancer

authors： Neoptolemos JP,Stocken DD,Tudur Smith C,Bassi C,Ghaneh P,Owen E,Moore M,Padbury R,Doi R,Smith D,Büchler MW

更新日期：2009-01-27 00:00:00