当前位置： SCI文献检索 > BRITISH JOURNAL OF CANCER期刊下所有文献 > Auditing the diagnosis of cancer in primary care: the experience in Scotland.

Auditing the diagnosis of cancer in primary care: the experience in Scotland.

Abstract：

INTRODUCTION:This paper reports on an ongoing primary care audit of cancer referrals undertaken in Scotland in 2006-2007 and 2007-2008. METHODS:General practitioners (GPs) in Scotland were asked to review all new cancer diagnoses within their practice during the preceding year. RESULTS:4181 patients were identified in year 1 and 12 294 in year 2. The pathway taken for patients to present to, and be referred from, their GP has been analysed for 7430 of the 12 294 patients identified within year 2 across five separate health boards. The time from first symptoms to presentation to a GP varied between tumour types, being the longest (median 30 days) for head and neck cancers and the shortest (median 2 days) for bladder cancer. In all, 25% of patients within the following tumour groups waited longer than 2 months to present to their GP following first symptoms: prostate, colorectal, melanoma and head and neck cancers. Once patients had presented to their GP, those with prostate and lung cancer were referred later (median time 11 days) than those with breast cancer (median time 2 days). The priority with which GPs referred patients varied considerably between tumour groups (breast cancer 77.5% 'urgent' compared with prostate cancer 44.7% 'urgent'). In one health board the proportion of cancer patients being referred urgently increased from 46% to 58% between the first and second audit. CONCLUSION:Our data show that there are very different patterns of presentation and referral for patients with cancer, with some tumour groups being more likely to be associated with a delayed diagnosis than others.

journal_name

Br J Cancer

journal_title

British journal of cancer

authors

Baughan P,O'Neill B,Fletcher E

doi

10.1038/sj.bjc.6605397

subject

Has Abstract

pub_date

2009-12-03 00:00:00

pages

S87-91

eissn

0007-0920

issn

1532-1827

pii

6605397

journal_volume

101 Suppl 2

pub_type

杂志文章

相关文献

BRITISH JOURNAL OF CANCER文献大全
  • Models for skin tumour risks in workers exposed to mineral oils.

    abstract：:The relationship between skin tumours in man and exposure to polyaromatic hydrocarbons has been studied in lathe operators exposed to cutting oils. Seven cases of scrotal cancer and 13 cases of senile keratosis and keratoacanthoma were observed. The risk varied as the 1.6th power of duration of exposure for cancer on ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1990.435

    authors： Järvholm B,Easton D

    更新日期：1990-12-01 00:00:00

  • Epidermal growth factor receptors in human prostate cancer: correlation with histological differentiation of the tumour.

    abstract：:The presence of specific and high affinity epidermal growth factor receptors (EGF-R) has been demonstrated in human prostate cancer (CaP). Scatchard analysis of the binding data revealed a linear plot consistent with a single class of binding sites with a mean dissociation constant (Kd) +/- s.d. = 1.6 +/- 0.4 nmol 1-1...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1989.216

    authors： Maddy SQ,Chisholm GD,Busuttil A,Habib FK

    更新日期：1989-07-01 00:00:00

  • A phase I/II study of combined weekly systemic cisplatin and locoregional hyperthermia in patients with previously irradiated recurrent carcinoma of the uterine cervix.

    abstract：:We investigated the feasibility and the anti-tumour activity of weekly cisplatin and the simultaneous application of local hyperthermia in patients with a pelvic recurrence of cervical cancer in previously irradiated area. Dose levels of cisplatin 60 mg m(-2), 70 mg m(-2) and 80 mg m(-2) were studied. Treatment object...

    journal_title：British journal of cancer

    pub_type： 临床试验,杂志文章

    doi：10.1038/sj.bjc.6690533

    authors： de Wit R,van der Zee J,van der Burg ME,Kruit WH,Logmans A,van Rhoon GC,Verweij J

    更新日期：1999-07-01 00:00:00

  • Daunorubicin and doxorubicin but not BCNU have deleterious effects on organotypic multicellular spheroids of gliomas.

    abstract：:In the present study organotypic multicellular spheroids (OMS) were used to study the effects of chemotherapeutic agents on malignant gliomas. Compared with the frequently used cell line models, OMS have several advantages with respect to the preservation of the cellular heterogeneity and the structure of the original...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1996.336

    authors： Kaaijk P,Troost D,de Boer OJ,Van Amstel P,Bakker PJ,Leenstra S,Bosch DA

    更新日期：1996-07-01 00:00:00

  • Investigations of tritiated menadiol sodium diphosphate (T-MNDP) as a radioactive drug.

    abstract：:An attempt has been made to develop tritiated derivatives of Synkavit (menadiol sodium diphosphate, MNDP) of high specific activity as a radioactive drug.This paper summarizes the preliminary biological and physical studies, with emphasis on approximate radiation dosimetry and the necessary preliminary testing, and th...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1974.85

    authors： Mitchell JS

    更新日期：1974-05-01 00:00:00

  • Tumour-derived TGF-beta1 modulates myofibroblast differentiation and promotes HGF/SF-dependent invasion of squamous carcinoma cells.

    abstract：:The development of an altered stromal microenvironment is a common feature of many tumours including squamous cell carcinoma (SCC), and there is increasing evidence that these changes in the stroma, which include increased expression of proteases and cytokines, may actually promote tumour progression. A common finding...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6601611

    authors： Lewis MP,Lygoe KA,Nystrom ML,Anderson WP,Speight PM,Marshall JF,Thomas GJ

    更新日期：2004-02-23 00:00:00

  • Gastric cancer in Gwynedd. Possible links with bracken.

    abstract：:One hundred and one histologically confirmed gastric cancer patients in Gwynedd, North Wales, were matched by sex, age and social class to two hospital inpatients without cancer. Seventy-seven of the gastric cancer cases were also matched, using the same criteria, to a patient with a confirmed cancer of a different si...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1990.165

    authors： Galpin OP,Whitaker CJ,Whitaker R,Kassab JY

    更新日期：1990-05-01 00:00:00

  • Cisplatin, 5-fluorouracil and interferon alpha 2b for recurrent or metastatic head and neck cancer.

    abstract：:On the basis of preclinical data suggesting the possibility of maximising the efficacy of 5-fluorouracil and cisplatin by interferon, a pilot clinical trial was initiated in recurrent and/or metastatic head and neck cancer. Thirty-four patients were treated with cisplatin at 100 mg m-2, followed by 5-fluorouracil at 1...

    journal_title：British journal of cancer

    pub_type： 临床试验,杂志文章

    doi：10.1038/bjc.1994.72

    authors： Cascinu S,Fedeli A,Luzi Fedeli S,Catalano G

    更新日期：1994-02-01 00:00:00

  • Oral capecitabine vs intravenous 5-fluorouracil and leucovorin: integrated efficacy data and novel analyses from two large, randomised, phase III trials.

    abstract：:This study evaluates the efficacy of capecitabine using data from a large, well-characterised population of patients with metastatic colorectal cancer (mCRC) treated in two identically designed phase III studies. A total of 1207 patients with previously untreated mCRC were randomised to either oral capecitabine (1250 ...

    journal_title：British journal of cancer

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1038/sj.bjc.6601676

    authors： Van Cutsem E,Hoff PM,Harper P,Bukowski RM,Cunningham D,Dufour P,Graeven U,Lokich J,Madajewicz S,Maroun JA,Marshall JL,Mitchell EP,Perez-Manga G,Rougier P,Schmiegel W,Schoelmerich J,Sobrero A,Schilsky RL

    更新日期：2004-03-22 00:00:00

  • In vitro and in vivo inhibitory effect of three Cox-2 inhibitors and epithelial-to-mesenchymal transition in human bladder cancer cell lines.

    abstract：BACKGROUND:Although the anti-tumour effect of cyclooxygenase-2 (Cox-2) inhibitors in invasive bladder cancer has been confirmed, its mechanisms of action are unclear. Recently, the concept of an epithelial-to-mesenchymal transition (EMT) promoting carcinoma progression has been suggested, and a key feature of the EMT i...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2011.262

    authors： Adhim Z,Matsuoka T,Bito T,Shigemura K,Lee KM,Kawabata M,Fujisawa M,Nibu K,Shirakawa T

    更新日期：2011-07-26 00:00:00

  • Mutations in residues of TP53 that directly contact DNA predict poor outcome in human primary breast cancer.

    abstract：:The tumour-suppressor gene TP53 is frequently mutated in breast tumours, and the majority of the mutations are clustered within the core domain, the region involved in DNA binding. We searched for alterations in this central domain of the TP53gene in 222 human breast cancer specimens using polymerase chain reaction-si...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1998.187

    authors： Berns EM,van Staveren IL,Look MP,Smid M,Klijn JG,Foekens JA

    更新日期：1998-04-01 00:00:00

  • Randomized double-blind phase II survival study comparing immunization with the anti-idiotypic monoclonal antibody 105AD7 against placebo in advanced colorectal cancer.

    abstract：:The cancer vaccine 105AD7 is an anti-idiotypic monoclonal antibody that mimics the tumour-associated antigen 791T/gp72 (CD55, Decay Accelerating Factor) on colorectal cancer cells. Phase I studies in patients with advanced disease confirmed that 105AD7 is non-toxic, and that T cell responses could be generated. A pros...

    journal_title：British journal of cancer

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1054/bjoc.2001.1725

    authors： Maxwell-Armstrong CA,Durrant LG,Buckley TJ,Scholefield JH,Robins RA,Fielding K,Monson JR,Guillou P,Calvert H,Carmichael J,Hardcastle JD

    更新日期：2001-06-01 00:00:00

  • A population-based cohort study of HRT use and breast cancer in southern Sweden.

    abstract：:The overall tumour incidence and breast cancer incidence related to hormone replacement therapy (HRT) were followed in a population-based cohort of 29 508 women, aged 25-65 when interviewed in 1990-92. By the end of the follow up in December 1999, there were 226 611 person-years of observation. A total of 1145 maligna...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1054/bjoc.2001.1899

    authors： Olsson H,Bladström A,Ingvar C,Möller TR

    更新日期：2001-09-01 00:00:00

  • A common polymorphism in the retinoic acid pathway modifies adrenocortical carcinoma age-dependent incidence.

    abstract：BACKGROUND:Genome-wide association studies (GWASs) have enriched the fields of genomics and drug development. Adrenocortical carcinoma (ACC) is a rare cancer with a bimodal age distribution and inadequate treatment options. Paediatric ACC is frequently associated with TP53 mutations, with particularly high incidence in...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/s41416-020-0764-3

    authors： Surakhy M,Wallace M,Bond E,Grochola LF,Perez H,Di Giovannantonio M,Zhang P,Malkin D,Carter H,Parise IZS,Zambetti G,Komechen H,Paraizo MM,Pagadala MS,Pinto EM,Lalli E,Figueiredo BC,Bond GL

    更新日期：2020-04-01 00:00:00

  • Beta-adrenergic signalling in neoplastic lung type 2 cells: glucocorticoid-dependent and -independent defects.

    abstract：:Tumorigenic mouse lung-derived type 2 cell lines have large reductions in both beta-adrenergic-stimulated cAMP production and ligand binding to beta-adrenergic receptors. These tumorigenic cells are also relatively insensitive to glucocorticoids. Because glucocorticoids regulate both beta-adrenergic receptor expressio...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1996.377

    authors： Droms KA

    更新日期：1996-08-01 00:00:00

  • Gene expression profiling may improve diagnosis in patients with carcinoma of unknown primary.

    abstract：:Carcinomas of unknown primary (CUP) represent between 3 and 10% of malignancies. Treatment with nonspecific chemotherapy is commonly unhelpful and the median survival is between 3 and 6 months. Gene expression microarray (GEM) analysis has demonstrated that molecular signatures can aid in tumour classification and pro...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6604315

    authors： Bridgewater J,van Laar R,Floore A,Van'T Veer L

    更新日期：2008-04-22 00:00:00

  • Are lower rates of surgery amongst older women with breast cancer in the UK explained by co-morbidity?

    abstract：BACKGROUND:Around 60% of women ≥ 80 years old, in the UK do not have surgery for their breast cancer (vs<10% of younger age groups). The extent to which this difference can be accounted for by co-morbidity has not been established. METHODS:A Cancer Registry/Hospital Episode Statistics-linked data set identified women ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2012.192

    authors： Lavelle K,Downing A,Thomas J,Lawrence G,Forman D,Oliver SE

    更新日期：2012-09-25 00:00:00

  • Role of immunologic disturbance in human oncogenesis: some facts and fancies.

    abstract：:A brief review is presented of the evidence linking the development of certain types of neoplasms, and of the malignant lymphomas in particular, to chronic immunosuppression in animals and man and to the naturally occurring human immunologic deficiency states. The discussion then focuses on Hodgkin's disease and consi...

    journal_title：British journal of cancer

    pub_type： 杂志文章,评审

    doi：10.1038/bjc.1971.78

    authors： Kaplan HS

    更新日期：1971-12-01 00:00:00

  • Association of 12 serum biochemical markers of angiogenesis, tumour invasion and bone turnover with bone metastases from breast cancer: a crossectional and longitudinal evaluation.

    abstract：:Complex biological pathways including angiogenesis, invasion, osteoclastic activation and bone matrix degradation are involved in the formation of bone metastasis (BM). The aim of our study was to investigate the cross-sectional and longitudinal associations of a panel of 12 serum biochemical markers reflecting biolog...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6603285

    authors： Voorzanger-Rousselot N,Juillet F,Mareau E,Zimmermann J,Kalebic T,Garnero P

    更新日期：2006-08-21 00:00:00

  • Absence of the DNA repair enzyme human 8-oxoguanine glycosylase is associated with an aggressive breast cancer phenotype.

    abstract：BACKGROUND:8-Oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) is the most abundant marker of DNA damage and it reflects oxidative stress. Human 8-oxoguanine glycosylase (hOGG1) is a DNA-repair enzyme that participates in 8-oxodG removal. METHODS:hOGG1 protein expression was immunohistochemically studied in 96 patients with...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2011.518

    authors： Karihtala P,Kauppila S,Puistola U,Jukkola-Vuorinen A

    更新日期：2012-01-17 00:00:00

  • A phase Ib/II translational study of sunitinib with neoadjuvant radiotherapy in soft-tissue sarcoma.

    abstract：BACKGROUND:Preoperative radiotherapy (RT) is commonly used to treat localised soft-tissue sarcomas (STS). Hypoxia is an important determinant of radioresistance. Whether antiangiogenic therapy can 'normalise' tumour vasculature, thereby improving oxygenation, remains unknown. METHODS:Two cohorts were prospectively enr...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2014.537

    authors： Lewin J,Khamly KK,Young RJ,Mitchell C,Hicks RJ,Toner GC,Ngan SY,Chander S,Powell GJ,Herschtal A,Te Marvelde L,Desai J,Choong PF,Stacker SA,Achen MG,Ferris N,Fox S,Slavin J,Thomas DM

    更新日期：2014-12-09 00:00:00

  • SCOTROC 2B: feasibility of carboplatin followed by docetaxel or docetaxel-irinotecan as first-line therapy for ovarian cancer.

    abstract：:The feasibility of combination irinotecan, carboplatin and docetaxel chemotherapy as first-line treatment for advanced epithelial ovarian carcinoma was assessed. One hundred patients were randomised to receive four 3-weekly cycles of carboplatin (area under the curve (AUC) 7) followed by four 3-weekly cycles of doceta...

    journal_title：British journal of cancer

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1038/sj.bjc.6602910

    authors： Clamp AR,Mäenpää J,Cruickshank D,Ledermann J,Wilkinson PM,Welch R,Chan S,Vasey P,Sorbe B,Hindley A,Jayson GC,Scottish Gynaecological Cancer Trials Group.

    更新日期：2006-01-16 00:00:00

  • Clinical and microarray analysis of breast cancers of all subtypes from two prospective preoperative chemotherapy studies.

    abstract：BACKGROUND:We aimed to analyse clinical and gene expression profiles to predict pathologic complete response and disease-free survival using two consecutive, prospective, preoperative chemotherapy trial cohorts. METHODS:Clinicopathological and gene expression data were evaluated in a cohort from two consecutive phase ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2016.184

    authors： Okuma HS,Koizumi F,Hirakawa A,Nakatochi M,Komori O,Hashimoto J,Kodaira M,Yunokawa M,Yamamoto H,Yonemori K,Shimizu C,Fujiwara Y,Tamura K

    更新日期：2016-08-09 00:00:00

  • Erythrocyte sedimentation rate and anaemia are independent predictors of survival in patients with clear cell renal cell carcinoma.

    abstract：BACKGROUND:The 1997 international consensus conference on renal cell cancer (RCC) prognosis suggested erythrocyte sedimentation rate (ESR), alkaline phosphatase (ALP), and anaemia as prognostic biomarkers, but most studies reviewed were limited by small sample sizes. METHODS:The Cox proportional hazards model was used...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2012.565

    authors： Choi Y,Park B,Kim K,Jeong BC,Seo SI,Jeon SS,Choi HY,Lee JE,Lee HM

    更新日期：2013-02-05 00:00:00

  • Risk factors cannot explain the higher prevalence rates of precancerous colorectal lesions in men.

    abstract：BACKGROUND:Prevalence of (pre)cancerous colorectal lesions are higher in men than in women, although transition rates from advanced lesions to cancer is similar in both sexes. Our aim was to investigate whether the sex-specific difference in incidence of premalignant colorectal lesions might be explained by the impact ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2016.324

    authors： Waldmann E,Heinze G,Ferlitsch A,GessI I,Sallinger D,Jeschek P,Britto-Arias M,Salzl P,Fasching E,Jilma B,Kundi M,Trauner M,Ferlitsch M

    更新日期：2016-11-22 00:00:00

  • Lignans and breast cancer risk in pre- and post-menopausal women: meta-analyses of observational studies.

    abstract：:Phyto-oestrogens are plant compounds structurally similar to oestradiol, which have been proposed to have protective effects against breast cancer. The main class of phyto-oestrogens in the Western diet is lignans. Literature reports on the effect of lignans in breast cancer risk have been conflicting. We performed th...

    journal_title：British journal of cancer

    pub_type： 杂志文章,meta分析

    doi：10.1038/sj.bjc.6605003

    authors： Velentzis LS,Cantwell MM,Cardwell C,Keshtgar MR,Leathem AJ,Woodside JV

    更新日期：2009-05-05 00:00:00

  • Pepsinogen A, pepsinogen C, and gastrin as markers of atrophic chronic gastritis in European dyspeptics.

    abstract：:Serum levels of pepsinogen and gastrin are parameters that can be used as biomarkers for gastric mucosa. The aim of this study was to validate these serum biomarkers, that is pepsinogen A (PGA), pepsinogen C (PGC), PGA/PGC ratio, and gastrin, as screening tests for precancerous lesions: atrophic chronic gastritis (ACG...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6600877

    authors： Broutet N,Plebani M,Sakarovitch C,Sipponen P,Mégraud F,Eurohepygast Study Group.

    更新日期：2003-04-22 00:00:00

  • Detection of lymph node metastasis of oesophageal cancer by RT-nested PCR for SCC antigen gene mRNA.

    abstract：:With recent development in molecular biology, reverse transcriptase polymerase chain reaction (RT-PCR) has been applied to detect occult lymph node metastasis, but there have been few reports concerning oesophageal cancer. The objective of this study is to investigate the usefulness of the squamous cell carcinoma (SCC...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1054/bjoc.1999.0938

    authors： Kano M,Shimada Y,Kaganoi J,Sakurai T,Li Z,Sato F,Watanabe G,Imamura M

    更新日期：2000-01-01 00:00:00

  • Oestrogen-receptor status and sites of metastasis in breast cancer.

    abstract：:The oestrogen receptor (RE) status of the primary tumour has been assessed in 466 of a consecutive series of 550 patients with primary operable breast cancer. All patients were followed up (without treatment) until the development of recurrence or metastases. Distant metastases have so far occurred in 124 patients and...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1981.205

    authors： Campbell FC,Blamey RW,Elston CW,Nicholson RI,Griffiths K,Haybittle JL

    更新日期：1981-09-01 00:00:00

  • Possible intermediates in the action of adriamycin--a pulse radiolysis study.

    abstract：:Over a wide range of pH, the semiquinone free radicals formed by reduction of adriamycin exist as a form which is strongly stabilised by internal hydrogen bonding and resonance. They protonate with pKa = 2.9. Below this pH they exhibit absorption maxima at 430 nm (Emax = 13,200 dm3 mol-1 cm-1) and approximately 720 nm...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1985.74

    authors： Land EJ,Mukherjee T,Swallow AJ,Bruce JM

    更新日期：1985-04-01 00:00:00