Models for skin tumour risks in workers exposed to mineral oils.

abstract：:Use of aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs) may reduce the risk of gastric or oesophageal adenocarcinomas. We examined the association between self-reported use of aspirin or non-aspirin NSAIDs in the earlier 12 months and gastric non-cardia (N=182), gastric cardia (N=178), and oesophageal a...

journal_title：British journal of cancer

authors： Abnet CC,Freedman ND,Kamangar F,Leitzmann MF,Hollenbeck AR,Schatzkin A

更新日期：2009-02-10 00:00:00

abstract：:A sequential, quantitative loss of Peanut agglutinin (PNA) binding with progression of mouse mammary cells from normal to preneoplastic to neoplastic phenotypes was observed. Normal mammary epithelium, preneoplastic mammary lesions designated D2HAN (D2-type hyperplastic alveolar nodules) and a series of nine spontaneo...

journal_title：British journal of cancer

authors： Rak JW,McEachern D,Miller FR

更新日期：1992-05-01 00:00:00

abstract：BACKGROUND:Tumour stromal cells differ from its normal counterpart. We have shown that tumour endothelial cells (TECs) isolated from tumour tissues are also abnormal. Furthermore, we found that mRNAs of vascular endothelial growth factor-A (VEGF-A) and cyclooxygenase-2 (COX-2) were upregulated in TECs. Vascular endothe...

journal_title：British journal of cancer

authors： Kurosu T,Ohga N,Hida Y,Maishi N,Akiyama K,Kakuguchi W,Kuroshima T,Kondo M,Akino T,Totsuka Y,Shindoh M,Higashino F,Hida K

更新日期：2011-03-01 00:00:00

abstract：:The aims of this study were to identify prognostic variables for toxicity and survival in patients with cancer participating in phase I clinical trials and compare characteristics of those treated with cytotoxic chemotherapy (CT) and non-cytotoxic drugs (non-CT). Data were collected from 420 (114 CT, 306 non-CT) patie...

journal_title：British journal of cancer

authors： Han C,Braybrooke JP,Deplanque G,Taylor M,Mackintosh D,Kaur K,Samouri K,Ganesan TS,Harris AL,Talbot DC

更新日期：2003-10-06 00:00:00

abstract：:The aim of this study was to evaluate serum midkine (S-MK) concentrations as a prognostic tumour marker in oral squamous cell carcinoma (OSCC). We measured S-MK concentrations in patients with OSCC and healthy volunteers. In addition, we performed real-time quantitative reverse transcription-PCR analysis and immunohis...

journal_title：British journal of cancer

authors： Ota K,Fujimori H,Ueda M,Shiniriki S,Kudo M,Jono H,Fukuyoshi Y,Yamamoto Y,Sugiuchi H,Iwase H,Shinohara M,Ando Y

更新日期：2008-08-19 00:00:00

abstract：BACKGROUND:We and others have identified the aldo-keto reductase AKR1C3 as a potential drug target in prostate cancer, breast cancer and leukaemia. As a consequence, significant effort is being invested in the development of AKR1C3-selective inhibitors. METHODS:We report the screening of an in-house drug library to id...

journal_title：British journal of cancer

authors： Khanim F,Davies N,Veliça P,Hayden R,Ride J,Pararasa C,Chong MG,Gunther U,Veerapen N,Winn P,Farmer R,Trivier E,Rigoreau L,Drayson M,Bunce C

更新日期：2014-03-18 00:00:00

abstract：:The relationship between the systemic inflammatory response, tumour proliferative activity, T-lymphocytic infiltration, and COX-2 expression and survival was examined in patients with transitional cell carcinoma of the urinary bladder (n=103). Sixty-one patients had superficial disease and 42 patients had invasive dis...

journal_title：British journal of cancer

authors： Hilmy M,Campbell R,Bartlett JM,McNicol AM,Underwood MA,McMillan DC

更新日期：2006-11-06 00:00:00

abstract：:The mechanisms underlying sperm protein 17 (Sp17) gene expression in myeloma cells remained unclear. Using reverse transcription-polymerase chain reaction (RT-PCR), Sp17 transcripts were detected in ARK-B, ARP-1, RPMI-8226 and KMS-11 but not in H929, IM-9, MM1-R and U266 cells. Using a panel of primer pairs in methyla...

journal_title：British journal of cancer

authors： Wang Z,Zhang Y,Ramsahoye B,Bowen D,Lim SH

更新日期：2004-10-18 00:00:00

abstract：:Eleven patients with measurable subcutaneous or pulmonary metastases were selected for a study of the effectiveness of the radiosensitizer misonidazole (MIS). Evaluable data were obtained in 6 patients and radiosensitization demonstrated in 5. Patients were irradiated either before or after MIS, and each patient acted...

journal_title：British journal of cancer

authors： Ash DV,Peckham MJ,Steel GG

更新日期：1979-12-01 00:00:00

abstract：BACKGROUND:There are phase 3 clinical trials underway evaluating anti-PD-L1 antibodies as adjuvant (postoperative) monotherapies for resectable renal cell carcinoma (RCC) and triple-negative breast cancer (TNBC); in combination with antiangiogenic VEGF/VEGFR2 inhibitors (e.g., bevacizumab and sunitinib) for metastatic ...

journal_title：British journal of cancer

authors： Wu FTH,Xu P,Chow A,Man S,Krüger J,Khan KA,Paez-Ribes M,Pham E,Kerbel RS

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Efficacy and safety are the two considerations when characterising the effects of a new therapy. We sought to apply an innovative method of assessing the benefit-risk balance using data from a completed randomised controlled trial that compared erlotinib vs placebo added to gemcitabine in patients with advan...

journal_title：British journal of cancer

authors： Péron J,Roy P,Ding K,Parulekar WR,Roche L,Buyse M

更新日期：2015-03-17 00:00:00

abstract：:The cancer vaccine 105AD7 is an anti-idiotypic monoclonal antibody that mimics the tumour-associated antigen 791T/gp72 (CD55, Decay Accelerating Factor) on colorectal cancer cells. Phase I studies in patients with advanced disease confirmed that 105AD7 is non-toxic, and that T cell responses could be generated. A pros...

journal_title：British journal of cancer

authors： Maxwell-Armstrong CA,Durrant LG,Buckley TJ,Scholefield JH,Robins RA,Fielding K,Monson JR,Guillou P,Calvert H,Carmichael J,Hardcastle JD

更新日期：2001-06-01 00:00:00

abstract：BACKGROUND:Several microRNA (miRNA) molecules have emerged as important post-transcriptional regulators of tumour suppressor and oncogene expression. Ras association domain family member 1 (RASSF1) is a critical tumour suppressor that controls multiple aspects of cell proliferation such as cell cycle, cell division and...

journal_title：British journal of cancer

authors： Pruikkonen S,Kallio MJ

更新日期：2017-05-23 00:00:00

abstract：BACKGROUND:Patients with malignant pleural effusions (MPEs) generally have advanced disease with poor survival and few therapeutic options. Cells within MPEs may be used to stratify patients for targeted therapy. Targeted therapy with poly(ADP ribose) polymerase inhibitors (PARPi) depends on identifying homologous reco...

journal_title：British journal of cancer

authors： Patterson MJ,Sutton RE,Forrest I,Sharrock R,Lane M,Kaufmann A,O'Donnell R,Edmondson RJ,Wilson BT,Curtin NJ

更新日期：2014-07-08 00:00:00

abstract：:The aim of this study was to assess the cost-effectiveness of combination chemotherapy with paclitaxel/cisplatin, compared with standard etoposide/cisplatin in patients with advanced non-small cell lung cancer (NSCLC). We obtained the primary survival and resource utilization data from a large three-arm randomized tri...

journal_title：British journal of cancer

authors： Earle CC,Evans WK

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:We performed a cross-sectional study in Indonesia to evaluate the performance of a single-visit approach of cervical cancer screening, using visual inspection with acetic acid (VIA), histology and cryotherapy in low-resource settings. METHODS:Women having limited access to health-care facilities were screen...

journal_title：British journal of cancer

authors： Vet JN,Kooijman JL,Henderson FC,Aziz FM,Purwoto G,Susanto H,Surya IG,Budiningsih S,Cornain S,Fleuren GJ,Trimbos JB,Peters AA

更新日期：2012-08-21 00:00:00

abstract：:Flavone acetic acid (FAA) was administered at a dose of 4.8 g m-2 over 1 h to patients with advanced malignant disease in combination with Interleukin II. A new high performance liquid chromatography method is described to determine both the parent compound and eight drug-related products, and the conditions required ...

journal_title：British journal of cancer

authors： Stratford MR,Rustin GJ,Dennis MF,Watfa RR,Howells N,O'Reilly SM

更新日期：1993-06-01 00:00:00

abstract：:The Type 1 family of growth factor receptors includes epidermal growth factor receptor (EGFR), c-erbB-2, c-erbB-3 and c-erbB-4. Overexpression of the first two members is associated with poorer prognosis in patients with breast carcinoma. In this study we examined the expression of c-erbB-4 protein using the monoclona...

journal_title：British journal of cancer

authors： Kew TY,Bell JA,Pinder SE,Denley H,Srinivasan R,Gullick WJ,Nicholson RI,Blamey RW,Ellis IO

更新日期：2000-03-01 00:00:00

abstract：:Carcinomas of unknown primary (CUP) represent between 3 and 10% of malignancies. Treatment with nonspecific chemotherapy is commonly unhelpful and the median survival is between 3 and 6 months. Gene expression microarray (GEM) analysis has demonstrated that molecular signatures can aid in tumour classification and pro...

journal_title：British journal of cancer

authors： Bridgewater J,van Laar R,Floore A,Van'T Veer L

更新日期：2008-04-22 00:00:00

abstract：:Epidemiologic evidence has recently identified an association between an endemic outbreak of pleural and peritoneal mesothelioma in the Urgup region of Turkey and exposure to zeolite fibres. This malignancy is usually associated with exposure to asbestos dusts whose mineralogical characteristics differ from those of z...

journal_title：British journal of cancer

authors： Kelsey KT,Yano E,Liber HL,Little JB

更新日期：1986-07-01 00:00:00

abstract：BACKGROUND:The need to unfold the underlying mechanisms of lung cancer aggressiveness, the deadliest cancer in the world, is of prime importance. Because Fas-associated death domain protein (FADD) is the key adaptor molecule transmitting the apoptotic signal delivered by death receptors, we studied the presence and cor...

journal_title：British journal of cancer

authors： Cimino Y,Costes A,Damotte D,Validire P,Mistou S,Cagnard N,Alifano M,Régnard JF,Chiocchia G,Sautès-Fridman C,Tourneur L

更新日期：2012-06-05 00:00:00

abstract：BACKGROUND:The diagnosis of neuroendocrine neoplasms (NENs) is often delayed. This first UK population-based epidemiological study of NENs compares outcomes with non-NENs to identify any inequalities. METHODS:Age-standardised incidence rate (ASR), 1-year overall survival, hazard ratios and standardised mortality rates...

journal_title：British journal of cancer

authors： Genus TSE,Bouvier C,Wong KF,Srirajaskanthan R,Rous BA,Talbot DC,Valle JW,Khan M,Pearce N,Elshafie M,Reed NS,Morgan E,Deas A,White C,Huws D,Ramage J

更新日期：2019-11-01 00:00:00

abstract：:Cytologic examination of peritoneal lavage fluid is a useful predictor of peritoneal recurrence in gastric cancer. However, this technique is not overly sensitive and requires special abilities in the cytologist. In this study, telomerase activity was used to detect free cancer cells in peritoneal lavage fluid from pa...

journal_title：British journal of cancer

authors： Mori N,Oka M,Hazama S,Iizuka N,Yamamoto K,Yoshino S,Tangoku A,Noma T,Hirose K

更新日期：2000-10-01 00:00:00

abstract：BACKGROUND:Selecting patients with 'sufficient life expectancy' for Phase I oncology trials remains challenging. The Royal Marsden Hospital Score (RMS) previously identified high-risk patients as those with ≥ 2 of the following: albumin <35 g l(-1); LDH > upper limit of normal; >2 metastatic sites. This study developed...

journal_title：British journal of cancer

authors： Ploquin A,Olmos D,Lacombe D,A'Hern R,Duhamel A,Twelves C,Marsoni S,Morales-Barrera R,Soria JC,Verweij J,Voest EE,Schöffski P,Schellens JH,Kramar A,Kristeleit RS,Arkenau HT,Kaye SB,Penel N

更新日期：2012-09-25 00:00:00

abstract：:Studies of families who segregate BRCA2 mutations have found that men who carry disease-associated mutations have an increased risk of prostate cancer, particularly early-onset disease. A study of sporadic prostate cancer in the UK reported a prevalence of 2.3% for protein-truncating BRCA2 mutations among patients dia...

journal_title：British journal of cancer

authors： Agalliu I,Karlins E,Kwon EM,Iwasaki LM,Diamond A,Ostrander EA,Stanford JL

更新日期：2007-09-17 00:00:00

abstract：:Wnt-5a is one of the most highly investigated non-canonical Wnts and has been implicated in almost all aspects of non-canonical Wnt signalling. In terms of cancer development, Wnt-5a has, until recently, lived in the shadow of its better-characterised relatives. This was largely because of its apparent inability to tr...

journal_title：British journal of cancer

authors： McDonald SL,Silver A

更新日期：2009-07-21 00:00:00

abstract：BACKGROUND:A phase Ib study of binimetinib and capecitabine for gemcitabine-pretreated biliary tract cancer (BTC) patients was conducted. METHODS:Binimetinib and capecitabine were dosed twice daily on days 1-14, in 3-week cycles. In the dose-escalation (DE) part, three dose levels (DL) were tested (DL1: binimetinib/ca...

journal_title：British journal of cancer

authors： Kim JW,Lee KH,Kim JW,Suh KJ,Nam AR,Bang JH,Bang YJ,Oh DY

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Previous studies have demonstrated that senescent cancer-associated fibroblasts (CAFs) derived from genetically unstable oral squamous cell carcinomas (GU-OSCC), unlike non-senescent CAFs from genetically stable carcinomas (GS-OSCC), promoted keratinocyte invasion in vitro in a paracrine manner. The mechanis...

journal_title：British journal of cancer

authors： Hassona Y,Cirillo N,Heesom K,Parkinson EK,Prime SS

更新日期：2014-09-09 00:00:00

abstract：:Besides its cardiotoxic effect, doxorubicin also elicits inflammatory effects in vivo. 7-Monohydroxyethylrutoside (monoHER) has recently been used as a protector against doxorubicin-induced cardiotoxicity in vivo. It is not known yet whether monoHER can also protect against doxorubicin-induced inflammatory effects. Th...

journal_title：British journal of cancer

authors： Abou El Hassan MA,Verheul HM,Jorna AS,Schalkwijk C,van Bezu J,van der Vijgh WJ,Bast A

更新日期：2003-07-21 00:00:00

abstract：:Recent studies have suggested a correlation between the rate and incidence of apoptosis and the radiation response of particular cell lines. However, we found that increasing the rate of induction of apoptosis in the fibroblast line 208F, by transfecting it with human c-myc, did not lead to a change in its clonogenic ...

journal_title：British journal of cancer

authors： Aldridge DR,Arends MJ,Radford IR

更新日期：1995-03-01 00:00:00