FADD protein release mirrors the development and aggressiveness of human non-small cell lung cancer.

abstract：:Many theories mention hypersensitive, promiscuous, outlaw or bypass signalling pathways to explain the acquisition of hormone independence in prostate cancer. Hormonal escape of prostate tumours is marked by many biological changes, including mucinous and neuroendocrine differentiation. Since expression of several muc...

journal_title：British journal of cancer

authors： Legrier ME,de Pinieux G,Boyé K,Arvelo F,Judde JG,Fontaine JJ,Bara J,Poupon MF

更新日期：2004-02-09 00:00:00

abstract：:The present study was designed to examine whether different p53 haplotypes of exon 4-intron 3-intron 6 affect the frequency of mutations and loss of heterozygosity (LOH) of the p53 gene in male oral squamous cell carcinomas (OSCCs) in Taiwan. We found that individuals without two Pro-W-G alleles had significantly high...

journal_title：British journal of cancer

authors： Hsieh LL,Huang TH,Chen IH,Liao CT,Wang HM,Lai CH,Liou SH,Chang JT,Cheng AJ

更新日期：2005-01-17 00:00:00

abstract：:No numerical aberration of chromosomes that might be specific for prostate cancer has so far been established. We used fluorescence in situ hybridisation (FISH) with centromere-specific probes for chromosomes 7, 8, 17, X and Y to establish the distribution of centromere copy numbers in frozen-stored or freshly prepare...

journal_title：British journal of cancer

authors： Matsuura H,Shiraishi T,Yatani R,Kawamura J

更新日期：1996-12-01 00:00:00

abstract：:In clinically organ-confined prostate cancer patients, bloodstream tumour cell dissemination generally occurs, and may be enhanced by surgical prostate manipulation. To evaluate cancer-cell seeding impact upon patient recurrence-free survival, 155 patients were prospectively enrolled then followed. Here, 57 patients p...

journal_title：British journal of cancer

authors： Eschwège P,Moutereau S,Droupy S,Douard R,Gala JL,Benoit G,Conti M,Manivet P,Loric S

更新日期：2009-02-24 00:00:00

abstract：:DBA/2J mice bearing a clonal isolate of the transplantable murine lymphocytic leukaemia line P388 were used to examine the effects of L-histidinol on the antitumour activity of three alkalyating agents (bis-chloroethylnitrosourea (BCNU), cis-diamminedichloroplatinum (II) (cisDDP) and cyclophosphamide) and the antitumo...

journal_title：British journal of cancer

authors： Warrington RC,Fang WD

更新日期：1989-11-01 00:00:00

abstract：:The prognostic value of flow cytometric parameters and tumour growth rate of melanoma metastases under the mouse renal capsule was investigated for tumours from 117 consecutive patients referred to the Helsinki University Central Hospital Melanoma Team. DNA flow cytometry (FCM) was interpretable for the tumours of 114...

journal_title：British journal of cancer

authors： Muhonen T,Pyrhönen S,Laasonen A,Wasenius VM,Asko-Seljavaara S,Franssila K,Kangas L

更新日期：1992-09-01 00:00:00

abstract：BACKGROUND:This study aims to investigate the association between statin use and all-cancer survival in a prospective cohort of postmenopausal women, using data from the Women's Health Initiative Observational Study (WHI-OS) and Clinical Trial (WHI-CT). METHODS:The WHI study enrolled women aged 50-79 years from 1993 t...

journal_title：British journal of cancer

authors： Wang A,Aragaki AK,Tang JY,Kurian AW,Manson JE,Chlebowski RT,Simon M,Desai P,Wassertheil-Smoller S,Liu S,Kritchevsky S,Wakelee HA,Stefanick ML

更新日期：2016-06-28 00:00:00

abstract：:Based on the assumption that an accelerated proliferation process prevails in tumour cell residues after surgery, the possibility that treatment acceleration would offer a therapeutic advantage in postoperative radiotherapy of locally advanced head and neck cancer was investigated. The value of T(pot) in predicting th...

journal_title：British journal of cancer

authors： Awwad HK,Lotayef M,Shouman T,Begg AC,Wilson G,Bentzen SM,Abd El-Moneim H,Eissa S

更新日期：2002-02-12 00:00:00

abstract：:The study was originally set up to measure accurate cell kinetic parameters in two murine squamous cell carcinomas (scc) for comparison with radiobiological data on proliferation during radiotherapy. The tumours, AT84 and AT478, were both moderately well differentiated aneuploid scc. In the course of the study, severa...

journal_title：British journal of cancer

authors： Schultz-Hector S,Begg AC,Hofland I,Kummermehr J,Sund M

更新日期：1993-12-01 00:00:00

abstract：:It is known that interferon-gamma (IFN-gamma) is produced by activated T and NK lymphoid cells, mononuclear cells, and macrophage and dendritic cells. Our previous studies have shown that IFN-gamma-like immunoreactivity also appears in human adrenal cortical tumour and phaeochromocytoma. To investigate whether human t...

journal_title：British journal of cancer

authors： Li Q,Zhang XQ,Nie L,Chen GS,Li H,Zhang F,Zhang LY,Hong L,Wang SF,Wang H

更新日期：2007-08-06 00:00:00

abstract：:Hypoxic EMT-6 tumour cells displayed a high level of inducible nitric oxide synthase (iNOS) and an increased radiosensitivity after a 16 h exposure to lipopolysaccharide, a known activator of nuclear factor-kappaB (NF-kappaB). Both iNOS activation and radioresponse were impaired by the NF-kappaB inhibitors phenylarsin...

journal_title：British journal of cancer

authors： De Ridder M,Van den Berge DL,Verovski VN,Monsaert C,Wauters N,Storme GA

更新日期：2003-01-13 00:00:00

abstract：BACKGROUND:Immunohistological assessment of Ki 67 expression is less expensive than Oncotype Dx, which is currently used to identify patients with lymph node-negative breast cancer, who will benefit from adjuvant chemotherapy. METHODS:The relationship of immunohistologically measured Ki 67 to Oncotype DX recurrence sc...

journal_title：British journal of cancer

authors： Sahebjam S,Aloyz R,Pilavdzic D,Brisson ML,Ferrario C,Bouganim N,Cohen V,Miller WH Jr,Panasci LC

更新日期：2011-10-25 00:00:00

abstract：:The incidence of colorectal carcinoma is rising at an alarming pace in Asian urban societies such as Hong Kong. Detailed examination of the epidemiological pattern and genetic mutation of colorectal cancer in the Hong Kong Chinese population is overdue. We compared the reported age incidence of colorectal carcinoma in...

journal_title：British journal of cancer

authors： Yuen ST,Chung LP,Leung SY,Luk IS,Chan SY,Ho JC,Ho JW,Wyllie AH

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:This study aimed to evaluate the prognostic value of pre-treatment NLR in patients with oropharyngeal cancer. METHODS:Patients who completed definitive radiotherapy (RT) for oropharyngeal cancer and had blood counts taken pre-RT from 2002 to 2013 were included. NLR was calculated as total neutrophil/lymphoc...

journal_title：British journal of cancer

authors： Ng SP,Bahig H,Jethanandani A,Sturgis EM,Johnson FM,Elgohari B,Gunn GB,Ferrarotto R,Phan J,Rosenthal DI,Frank SJ,Fuller CD,Garden AS

更新日期：2020-10-14 00:00:00

abstract：:Breast cancer is the second most common cancer among women in Madras and southern India after cervix cancer. The Madras Metropolitan Tumour Registry (MMTR), a population-based cancer registry, collects data on the outcome of cancer diagnosis by both active and passive methods. A total of 2080 cases of invasive female ...

journal_title：British journal of cancer

authors： Gajalakshmi CK,Shanta V,Swaminathan R,Sankaranarayanan R,Black RJ

更新日期：1997-01-01 00:00:00

abstract：:To evaluate the impact of prior adjuvant chemotherapy on response rate (RR), progression-free (PFS) and overall survival (OS) of metastatic breast cancer patients treated with epirubicin/paclitaxel (ET) regimens. In all, 291 patients enrolled in five studies in metastatic breast cancer were analysed: 101 (35%) were ch...

journal_title：British journal of cancer

authors： Gennari A,Bruzzi P,Orlandini C,Salvadori B,Donati S,Landucci E,Guarneri V,Rondini M,Ricci S,Conte P

更新日期：2004-03-08 00:00:00

abstract：:A new cancer-associated antigen CA130, recognised by two monoclonal antibodies (moABs) 130-22 and 145-9, was often found to be present at high levels in the sera of patients with ovarian cancer. There was a strong correlation between CA130 and CA125 values. The epitopes recognised by moABs 130-22 and 145-9 were proved...

journal_title：British journal of cancer

authors： Kobayashi H,Ohi H,Fujii T,Terao T

更新日期：1993-02-01 00:00:00

abstract：:To evaluate whether green tea consumption provides protection against stomach cancer, the relative risks (RRs) were calculated in the Japan Collaborative Study for Evaluation of Cancer Risk, sponsored by the Ministry of Health and Welfare (JACC Study). The study was based on 157 incident cases and 285 controls aged 40...

journal_title：British journal of cancer

authors： Hoshiyama Y,Kawaguchi T,Miura Y,Mizoue T,Tokui N,Yatsuya H,Sakata K,Kondo T,Kikuchi S,Toyoshima H,Hayakawa N,Tamakoshi A,Ohno Y,Yoshimura T,Japan Collaborative Cohort Study Group.

更新日期：2004-01-12 00:00:00

abstract：:5,6-Dimethylxanthenone-4-acetic acid, synthesised in this laboratory, reduces tumour blood flow, both in mice and in patients on Phase I trial. We used TUNEL (TdT-mediated dUTP nick end labelling) assays to investigate whether apoptosis induction was involved in its antivascular effect. 5,6-Dimethylxanthenone-4-acetic...

journal_title：British journal of cancer

authors： Ching LM,Cao Z,Kieda C,Zwain S,Jameson MB,Baguley BC

更新日期：2002-06-17 00:00:00

abstract：:Fifty-two previously untreated patients with advanced non-small-cell lung cancer (NSCLC) were treated on a 14 day cycle with cisplatin (60 mg m-2 i.v.) and vindesine (3 mg m-2 i.v.) on day 1, followed by a 3 day continuous infusion of 5-fluorouracil (800 mg m-2 day-1) starting on day 8. An overall response rate of 40....

journal_title：British journal of cancer

authors： Nakano T,Ikegami H,Nakamura S,Kawase T,Nishikawa H,Yokota S,Yoshida M,Tachibana T,Igarashi T,Komuta K,Higashino K

更新日期：1996-05-01 00:00:00

abstract：:MBD3: is a member of the methyl-CpG-binding domain family and is located on chromosome 19p13.3, a region of loss of heterozygosity in colon and lung cancers. We therefore screened samples for abnormalities in MBD3. Our results indicate that MBD3 is not a major target of genetic and epigenetic alteration in these cance...

journal_title：British journal of cancer

authors： Zhu Y,Harrison DJ,Bader SA

更新日期：2004-05-17 00:00:00

abstract：BACKGROUND:Inconsistencies between mitotic index (MI) and Ki67 measures have been identified in many breast tumour samples. The aim of this study was to describe the prognosis of hormone receptor-positive (HR+) HER2- tumours having discrepant MI and Ki67. METHODS:We included a cohort of breast cancer patients initiall...

journal_title：British journal of cancer

authors： Rossi L,Laas E,Mallon P,Vincent-Salomon A,Guinebretiere JM,Lerebours F,Rouzier R,Pierga JY,Reyal F

更新日期：2015-09-29 00:00:00

abstract：BACKGROUND:We previously reported that chaetocin has potent and selective anti-myeloma activity attributable to reactive oxygen species (ROS) induction imposed by inhibition of the redox enzyme thioredoxin reductase; we now detail its effects in solid tumours. METHODS:Cellular assays, transcriptional profiling and the...

journal_title：British journal of cancer

authors： Isham CR,Tibodeau JD,Bossou AR,Merchan JR,Bible KC

更新日期：2012-01-17 00:00:00

abstract：BACKGROUND:Health-related quality of life (HRQoL) comprises different domains of physical, mental, and social well-being. In this analysis, we focus on sexual quality of life in Hodgkin Lymphoma (HL) patients. METHODS:Four-thousand one-hundred and sixty patients enroled in the HD10-HD12 trials underwent HRQoL assessme...

journal_title：British journal of cancer

authors： Behringer K,Müller H,Görgen H,Flechtner HH,Brillant C,Halbsguth TV,Thielen I,Eichenauer DA,Schober T,Nisters-Backes H,Fuchs M,Engert A,Borchmann P

更新日期：2013-01-15 00:00:00

abstract：:Intermittent use of chemotherapy for androgen-independent prostate cancer (AIPC) instead of treatment until disease progression may reduce toxicity. We prospectively tested this approach in eight AIPC patients responding to calcitriol plus docetaxel who reached a serum prostate-specific antigen (PSA) <4 ng ml(-1). Che...

journal_title：British journal of cancer

authors： Beer TM,Garzotto M,Henner WD,Eilers KM,Wersinger EM

更新日期：2003-09-15 00:00:00

abstract：:A set of monoclonal antibodies was constructed by immunising mice with peptide fragments of the c-myc oncogene product. One such antibody, Myc 1-6E10 was shown to bind to a 62,000 dalton protein identifiable with the c-myc product (p62c-myc). The antigen recognised was not destroyed by paraffin wax embedding. Myc 1-6E...

journal_title：British journal of cancer

authors： Sikora K,Evan G,Stewart J,Watson JV

更新日期：1985-08-01 00:00:00

abstract：BACKGROUND:Cediranib is a highly potent inhibitor of vascular endothelial growth factor (VEGF) signalling with activity against all three VEGF receptors. Bevacizumab is an anti-VEGF-A monoclonal antibody with clinical benefit in previously treated metastatic colorectal cancer (mCRC). METHODS:Patients with mCRC who had...

journal_title：British journal of cancer

authors： Cunningham D,Wong RP,D'Haens G,Douillard JY,Robertson J,Stone AM,Van Cutsem E,HORIZON I study group.

更新日期：2013-02-19 00:00:00

abstract：BACKGROUND:We evaluated the efficacy of aprepitant plus granisetron and an increased dose of dexamethasone in selected patients undergoing moderately emetogenic chemotherapy (MEC). METHODS:Nondrinking women <70 years undergoing MEC were randomly assigned to aprepitant (day 1, 125 mg; days 2 and 3, 80 mg) or placebo. D...

journal_title：British journal of cancer

authors： Tanioka M,Kitao A,Matsumoto K,Shibata N,Yamaguchi S,Fujiwara K,Minami H,Katakami N,Morita S,Negoro S

更新日期：2013-08-20 00:00:00

abstract：:Fibroblast growth factor receptor 3 (FGFR3) is one of four high-affinity tyrosine kinase receptors for the FGF family of ligands, frequently associated with growth arrest and induction of differentiation. The extracellular immunoglobulin (IgG)-like domains II and III are responsible for ligand binding; alternative usa...

journal_title：British journal of cancer

authors： Sturla LM,Merrick AE,Burchill SA

更新日期：2003-10-06 00:00:00

abstract：BACKGROUND:Lynch syndrome (LS) is associated with a significant lifetime risk of endometrial cancer (EC). There are limited data on factors modifying the EC risk in LS patients. METHODS:The study cohort included 136 LS mutation-positive women. Exposure data were collected by postal questionnaires. Cox regression model...

journal_title：British journal of cancer

authors： Staff S,Aaltonen M,Huhtala H,Pylvänäinen K,Mecklin JP,Mäenpää J

更新日期：2016-07-26 00:00:00