Non-steroidal anti-inflammatory drugs and risk of gastric and oesophageal adenocarcinomas: results from a cohort study and a meta-analysis.


:Use of aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs) may reduce the risk of gastric or oesophageal adenocarcinomas. We examined the association between self-reported use of aspirin or non-aspirin NSAIDs in the earlier 12 months and gastric non-cardia (N=182), gastric cardia (N=178), and oesophageal adenocarcinomas (N=228) in a prospective cohort (N=311 115) followed for 7 years. Hazard ratios (HRs) and 95% confidence intervals (CIs) come from Cox models adjusted for potential confounders. Use of any aspirin (HR, 95% CI: 0.64, 0.47-0.86) or other NSAIDs (0.68, 0.51-0.92) was associated with a significantly lower risk of gastric non-cardia adenocarcinoma. Neither aspirin (0.86, 0.61-1.20) nor other NSAIDs (0.91, 0.67-1.22) had a significant association with gastric cardia cancer. We found no significant association between using aspirin (1.00, 0.73-1.37) or other NSAIDs (0.90, 69-1.17) and oesophageal adenocarcinoma. We also performed a meta-analysis of the association between the use of NSAIDs and risk of gastric and oesophageal adenocarcinoma. In this analysis, aspirin use was inversely associated with both gastric and oesophageal adenocarcinomas, with summary odds ratios (95% CI) for non-cardia, cardia, and oesophageal adenocarcinomas of 0.64 (0.52-0.80), 0.82 (0.65-1.04), and 0.64 (0.52-0.79), respectively. The corresponding numbers for other NSAIDs were 0.68 (0.57-0.81), 0.80 (0.67-0.95), and 0.65 (0.50-0.85), respectively.


Br J Cancer


Abnet CC,Freedman ND,Kamangar F,Leitzmann MF,Hollenbeck AR,Schatzkin A




Has Abstract


2009-02-10 00:00:00














  • In order for the light to shine so brightly, the darkness must be present-why do cancers fluoresce with 5-aminolaevulinic acid?

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    pub_type: 杂志文章,评审


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    authors: Bouffet E,Doz F,Demaille MC,Tron P,Roche H,Plantaz D,Thyss A,Stephan JL,Lejars O,Sariban E,Buclon M,Zücker JM,Brunat-Mentigny M,Bernard JL,Gentet JC

    更新日期:1998-04-01 00:00:00

  • Breastfeeding and childhood cancer risks: OSCC data.

    abstract::Matched pair analysis relating to 3376 mothers of children who died of cancer 1972-1981 and of healthy control children from the Oxford Survey of Childhood Cancers showed no evidence of protection from breastfeeding for acute lymphocytic leukaemia (OR 1.04, 95% CI 0.86-1.26), for all cancers combined (OR 1.04, 95% CI ...

    journal_title:British journal of cancer

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    authors: Lancashire RJ,Sorahan T,OSCC.

    更新日期:2003-04-07 00:00:00

  • Increasing incidence of childhood tumours of the central nervous system in Denmark, 1980-1996.

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    journal_title:British journal of cancer

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    authors: Raaschou-Nielsen O,Sørensen M,Carstensen H,Jensen T,Bernhardtsen T,Gjerris F,Schmiegelow K

    更新日期:2006-08-07 00:00:00

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    journal_title:British journal of cancer

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    更新日期:2001-07-20 00:00:00

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    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Sherlaw-Johnson C,Philips Z

    更新日期:2004-07-05 00:00:00

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    abstract::Multicellular tumour spheroids are cellular aggregates that can be prepared from many types of tumour cells. These three-dimensional structures provide a model for analysing the effects of cell-cell contact and intercellular microenvironments on phenomena such as autocrine regulation of growth factor synthesis. Autore...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Laderoute KR,Murphy BJ,Short SM,Grant TD,Knapp AM,Sutherland RM

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    更新日期:2006-12-18 00:00:00

  • Imaging tumour hypoxia with positron emission tomography.

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    journal_title:British journal of cancer

    pub_type: 杂志文章,评审


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    journal_title:British journal of cancer

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    authors: Chiang JM,Chou YH,Chen TC,Ng KF,Lin JL

    更新日期:2002-04-08 00:00:00

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    authors: Takahashi Y,Sawada G,Kurashige J,Uchi R,Matsumura T,Ueo H,Takano Y,Akiyoshi S,Eguchi H,Sudo T,Sugimachi K,Doki Y,Mori M,Mimori K

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    authors: Brincker H,Hansen HS,Andersen AP

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    journal_title:British journal of cancer

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  • Radiotherapy for stage I Hodgkin's disease: 20 years experience at St Bartholomew's Hospital.

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    authors: Ganesan TS,Wrigley PF,Murray PA,Stansfeld AG,d'Ardenne AJ,Arnott S,Jones A,Shand WS,Malpas JS,Lister TA

    更新日期:1990-08-01 00:00:00

  • Influence of anaesthetics on tumour-cell kill and repopulation in B16 melanoma treated with melphalan.

    abstract::The influence of anaesthetics on the in vivo response of B16 melanoma to melphalan was studied using an in vitro cell-survival assay. Three anaesthetics were used, Saffan (Althesin) Sagatal (Nembutal) and Hypnorm. When Saffan was administered to tumour-bearing animals before melphalan there was a significant increase ...

    journal_title:British journal of cancer

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    authors: Peacock JH,Stephens TC

    更新日期:1978-12-01 00:00:00

  • Prognostic significance of circumferential resection margin involvement following oesophagectomy for cancer.

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    journal_title:British journal of cancer

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    authors: Xie B,Tam NN,Tsao SW,Wong YC

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  • A population-based cohort study of HRT use and breast cancer in southern Sweden.

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    authors: Olsson H,Bladström A,Ingvar C,Möller TR

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  • Statin use and all-cancer survival: prospective results from the Women's Health Initiative.

    abstract:BACKGROUND:This study aims to investigate the association between statin use and all-cancer survival in a prospective cohort of postmenopausal women, using data from the Women's Health Initiative Observational Study (WHI-OS) and Clinical Trial (WHI-CT). METHODS:The WHI study enrolled women aged 50-79 years from 1993 t...

    journal_title:British journal of cancer

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  • HER2 gene copy number status may influence clinical efficacy to anti-EGFR monoclonal antibodies in metastatic colorectal cancer patients.

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    authors: Martin V,Landi L,Molinari F,Fountzilas G,Geva R,Riva A,Saletti P,De Dosso S,Spitale A,Tejpar S,Kalogeras KT,Mazzucchelli L,Frattini M,Cappuzzo F

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    journal_title:British journal of cancer

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    authors: Chandanos E,Lindblad M,Jia C,Rubio CA,Ye W,Lagergren J

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    journal_title:British journal of cancer

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    authors: Agalliu I,Karlins E,Kwon EM,Iwasaki LM,Diamond A,Ostrander EA,Stanford JL

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    pub_type: 杂志文章


    authors: Jones M,Siracky J,Kelland LR,Harrap KR

    更新日期:1993-01-01 00:00:00

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    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Smitskamp-Wilms E,Giaccone G,Pinedo HM,van der Laan BF,Peters GJ

    更新日期:1995-10-01 00:00:00

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    journal_title:British journal of cancer

    pub_type: 杂志文章,评审


    authors: Malik K,Brown KW

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    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Welsch CW,Dombroske SE,McManus MJ

    更新日期:1978-08-01 00:00:00

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    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Courtenay VD,Selby PJ,Smith IE,Mills J,Peckham MJ

    更新日期:1978-07-01 00:00:00

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    journal_title:British journal of cancer

    pub_type: 临床试验,杂志文章


    authors: Lane DM,Eagle KF,Begent RH,Hope-Stone LD,Green AJ,Casey JL,Keep PA,Kelly AM,Ledermann JA,Glaser MG

    更新日期:1994-09-01 00:00:00