Abstract：
:There is increasing evidence that the presence of a systemic inflammatory response plays an important role in survival following curative resection for colorectal cancer. The present study evaluated the relationship between C-reactive protein concentrations and survival in a cohort of patients receiving adjuvant 5-fluorouracil (5-FU) chemotherapy following potentially curative resection for colorectal cancer. In all, 222 patients undergoing potentially curative resection for colorectal cancer were studied. Of these, 50 patients received adjuvant 5-FU-based chemotherapy. Circulating concentrations of C-reactive protein were measured prior to surgery. The minimum follow-up was 15 months; the median follow-up of the survivors was 38 months. During this period 61 patients died, 32 patients of their cancer and 29 of intercurrent disease. In those patients who did not receive adjuvant chemotherapy, age (P < 0.001), Dukes stage (P < 0.05) and an elevated C-reactive protein (P < 0.01) were significantly associated with survival. In those patients who did receive adjuvant chemotherapy, an elevated C-reactive protein concentration (P < 0.01) was significantly associated with survival. The presence of a systemic inflammatory response is an independent predictor of poor outcome in patients receiving adjuvant 5-FU-based chemotherapy following potentially curative resection for colorectal cancer.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Crozier JE,McKee RF,McArdle CS,Angerson WJ,Anderson JH,Horgan PG,McMillan DCdoi
10.1038/sj.bjc.6603185subject
Has Abstractpub_date
2006-06-19 00:00:00pages
1833-6issue
12eissn
0007-0920issn
1532-1827pii
6603185journal_volume
94pub_type
杂志文章abstract：:Flow cytometric (FCM) estimation of DNA content has been performed on tumour tissue from 197 patients with high and intermediate grade non-Hodgkin's lymphoma (NHL) to investigate the clinicopathological correlations and prognostic significance of DNA ploidy and proliferative activity. Fifty-one per cent of tumours wer...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1989.388
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abstract：:A case-control study from Uganda found that the risk of Kaposi's sarcoma increased with increasing titre of antibodies against Kaposi's sarcoma-associated herpesvirus (KSHV) latent nuclear antigens, independently of HIV infection. Clinically, widespread Kaposi's sarcoma was more frequent among patients with HIV infect...
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journal_title：British journal of cancer
pub_type： 杂志文章
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更新日期：1976-08-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章,多中心研究
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1991.467
更新日期：1991-12-01 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1986.234
更新日期：1986-11-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1038/bjc.1979.200
更新日期：1979-09-01 00:00:00
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pub_type： 杂志文章
doi：10.1038/bjc.2016.353
更新日期：2016-11-22 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2014.631
更新日期：2015-02-03 00:00:00
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pub_type： 杂志文章
doi：10.1038/bjc.1982.97
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pub_type： 临床试验,杂志文章
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pub_type： 杂志文章,meta分析
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journal_title：British journal of cancer
pub_type： 杂志文章,随机对照试验
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journal_title：British journal of cancer
pub_type： 杂志文章
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更新日期：1981-02-01 00:00:00
abstract：:While statins have been highly effective for lowering serum cholesterol and reducing the incidence of coronary events, they have multiple other effects. Certain statins block the interaction of adhesion molecules that are important for cell-cell interactions including those between EBV-transformed B cells. These same ...
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pub_type： 杂志文章,评审
doi：10.1038/sj.bjc.6602561
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