Abstract:
BACKGROUND:Systemic inflammatory response (SIR) is important in the relationship between the tumour, the host, and outcome in cancer patients. However, limited data exist regarding the prognostic significance of SIR in bladder cancer. We investigate the utility of pretreatment SIR in patients with urothelial carcinoma undergoing radical cystectomy. METHODS:The study cohort consisted of 419 patients with a median follow-up of 37.7 months. The SIRs used for each described prognostic nomogram are consistent with previously published data: C-reactive protein, albumin, white cell count, neutrophil count, lymphocyte count, and platelet count. Primary end point was disease-specific survival (DSS) and overall survival (OS) after surgery. Cox regression models were used to determine the time to disease-specific and overall mortality. Multivariate regression coefficients of the predictors were used to develop nomograms for predicting 5-year DSS and OS probability. RESULTS:Multivariate Cox regression analyses revealed that albumin, lymphocyte count, and platelet count were significantly associated with a significantly increased risk for death from bladder cancer. The nomograms including each index were developed to predict the probability of 5-year DSS and OS after radical cystectomy. The C statistics were 77.8% and 77.3%, respectively, and exceeded the 2002 AJCC (72.0% and 70.3%, respectively). In the decision curve analyses, the nomograms including SIR demonstrated higher net benefit gains compared with the models without SIR. CONCLUSIONS:Cellular components of SIR have better prognostic values compared with acute-phase protein in patients undergoing radical cystectomy for bladder cancer.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Ku JH,Kang M,Kim HS,Jeong CW,Kwak C,Kim HHdoi
10.1038/bjc.2014.631subject
Has Abstractpub_date
2015-02-03 00:00:00pages
461-7issue
3eissn
0007-0920issn
1532-1827pii
bjc2014631journal_volume
112pub_type
杂志文章abstract::In a population-based cohort study of all women aged over 50 years with breast cancer in the Swedish Cancer Register in 1961-2003, those diagnosed before 31 December 1987 were regarded as unexposed to tamoxifen, whereas those diagnosed after that date were considered potentially exposed. Crosslinkages within the Cance...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6603214
更新日期:2006-07-03 00:00:00
abstract::2-Amino-3,4-dihydro-6-methyl-4-oxo-5-(4-pyridylthio)-quinazoline dihydrochloride (nolatrexed dihydrochloride, Thymitaq, AG337), a specific inhibitor of thymidylate synthase, was developed using protein structure-based drug design. Intravenously administered nolatrexed is active clinically. As oral bioavailability is h...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1038/sj.bjc.6690146
更新日期:1999-02-01 00:00:00
abstract::Stathmin is an intracellular phosphoprotein that is overexpressed in a number of human malignancies. Our previous study using proteomic profiling showed that significant upregulation of stathmin occurs in oral squamous-cell carcinoma (OSCC)-derived cell lines. In the current study, to determine the potential involveme...
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更新日期:2006-03-13 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章,meta分析,评审
doi:10.1038/bjc.2017.130
更新日期:2017-06-06 00:00:00
abstract::In this study we sought factors that determine the survival of human colonic epithelial cells. Normal colonic epithelial cells are dependent on cell-cell contacts and survival factors for the inhibition of apoptosis whereas, during colorectal tumorigenesis, cells develop mechanisms to evade these controls. The ability...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1997.167
更新日期:1997-01-01 00:00:00
abstract::We report that all- trans retinoic acid (ATRA) enhanced the toxicity of docetaxel against DU145 and LNCaP prostate cancer cells, and that the nature of the interaction between ATRA and docetaxel was highly synergistic. Docetaxel-induced apoptotic cell death was associated with phosphorylation and hence inactivation of...
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pub_type: 杂志文章
doi:10.1054/bjoc.2001.1818
更新日期:2001-06-01 00:00:00
abstract::An increase in the number of identified therapeutic cancer targets achieved through recent biomedical research has resulted in the generation of a large number of molecules that need to be tested further. Current development of (anticancer) drugs is a rather inefficient process that for an average new molecule takes a...
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pub_type: 杂志文章,评审
doi:10.1038/sj.bjc.6603925
更新日期:2007-09-03 00:00:00
abstract::Primary liver cancer (PLC) incidence trends from Africa are unknown. Using Kampala Cancer Registry data from 1960 to 1980 and 1991 to 2005, we identified 771 PLCs. Although rates were stable among men, PLC incidence among women increased >50%. Investigations of viral hepatitis, aflatoxin, obesity, and human immunodefi...
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pub_type: 杂志文章
doi:10.1038/sj.bjc.6604893
更新日期:2009-03-10 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1981.176
更新日期:1981-08-01 00:00:00
abstract::The possible use of liposomes (phospholipid vesicles) to direct cytotoxic drugs to tumours has led us to investigate the tissue localization of i.v. injected 99m-Tc-labelled liposomes in cancer patients. Twenty mg or 300 mg doses of liposomal lipid (7:2:1 molar ratio of phosphatidylcholine : cholesterol : phosphatidic...
journal_title:British journal of cancer
pub_type: 杂志文章
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abstract::Two-tumour-cell-aggregation factors derived from rat ascites hepatoma cells had different antigenicity; one, with a strong potency, was not absorbed by immunoadsorbent chromatography with anti-rat serum antibody and the other, with a weak potency, was. The unabsorbed factor possessed mitogenic activity on lymphocytes ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1978.192
更新日期:1978-08-01 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
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abstract::The p16 protein plays an important role in the transition of cells into the G1 phase of the cell cycle. We have studied the prevalence of p16 protein expression in breast carcinomas in a prospective series of 368 invasive and 52 non-invasive malignancies, as well as in 88 locally recurring tumours and three tumour cel...
journal_title:British journal of cancer
pub_type: 杂志文章
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更新日期:1998-12-01 00:00:00
abstract::Neuroendocrine tumours (NETs) comprise a heterogenous group of malignancies with an often unpredictable course, and with limited treatment options. Thus, new diagnostic, prognostic, and therapeutic markers are needed. To shed new lights into the biology of NETs, we have by cDNA transcript profiling, sought to identify...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604565
更新日期:2008-10-21 00:00:00
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pub_type: 杂志文章
doi:10.1038/sj.bjc.6690028
更新日期:1999-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1038/sj.bjc.6603385
更新日期:2006-10-23 00:00:00
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pub_type: 杂志文章
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abstract::Germline mutations in the LKB1 (STK11) gene (chromosome sub-band 19p13.3) cause characteristic hamartomas and pigmentation to develop in patients with Peutz-Jeghers syndrome. Peutz-Jeghers syndrome carries an overall risk of cancer that may be up to 20 times that of the general population and Peutz-Jeghers patients ar...
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pub_type: 杂志文章
doi:10.1038/sj.bjc.6690323
更新日期:1999-04-01 00:00:00
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abstract:BACKGROUND:Epidermal growth factor receptor (EGFR) is highly expressed in adenoid cystic carcinoma (ACC). The efficacy and toxicity of cetuximab with concomitant platinum-based chemoradio- or chemotherapy in patients with locally advanced or metastatic ACC, respectively, was evaluated. METHODS:Eligible patients (9 wit...
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2013-10-29 00:00:00
abstract::The discoidin domain receptors, (DDR)1 and DDR2, have been linked to numerous human cancers. We sought to determine expression levels of DDRs in human lung cancer, investigate prognostic determinates, and determine the prevalence of recently reported mutations in these receptor tyrosine kinases. Tumour samples from 14...
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journal_title:British journal of cancer
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更新日期:1978-07-01 00:00:00
abstract::The presence of specific and high affinity epidermal growth factor receptors (EGF-R) has been demonstrated in human prostate cancer (CaP). Scatchard analysis of the binding data revealed a linear plot consistent with a single class of binding sites with a mean dissociation constant (Kd) +/- s.d. = 1.6 +/- 0.4 nmol 1-1...
journal_title:British journal of cancer
pub_type: 杂志文章
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更新日期:1989-07-01 00:00:00
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更新日期:1989-11-01 00:00:00
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