Safety and outcome of definitive chemoradiotherapy in elderly patients with oesophageal cancer.


:Little is known about chemoradiotherapy (CRT) in elderly patients with a locally advanced oesophageal cancer (OC). The aim of our study was to evaluate the tolerance and the outcome of elderly patients older than 70 years treated with CRT for a non-metastatic OC. Chemoradiotherapy was based on radiotherapy combined with a cisplatin-based chemotherapy. Clinical complete response (CCR) to CRT was evaluated on upper digestive endoscopy and computed tomography scan 6-8 weeks after CRT completion. One hundred and nine consecutive patients were included. A CCR was observed in 63 patients (57.8%) and 2-year survival was 35.5%. Adverse events > or =grade 3 were observed in 26 (23.8%) patients. Chemotherapy dose reduction, chemotherapy delays more than 1 week, and treatment discontinuation were observed in 33 (30.3%), 45 (41.3%), and 17 patients (15.6%), respectively. Comorbidity index according to Charlson score was significantly associated with treatment tolerance. In multivariate analysis, a CCR to CRT (P<0.01), a dose of radiotherapy > or =80% (P=0.02), and a Charlson score < or =2 (P=0.046) were identified as independent prognostic factors of overall survival. These results suggest that CRT could be considered as an effective treatment without major toxicity in elderly patients with OC.


Br J Cancer


Tougeron D,Di Fiore F,Thureau S,Berbera N,Iwanicki-Caron I,Hamidou H,Paillot B,Michel P




Has Abstract


2008-11-18 00:00:00














  • Socioeconomic position, stage of lung cancer and time between referral and diagnosis in Denmark, 2001-2008.

    abstract:INTRODUCTION:We investigated the association between socioeconomic position, stage at diagnosis, and length of period between referral and diagnosis in a nationwide cohort of lung cancer patients. METHODS:Through the Danish Lung Cancer Register, we identified 18,103 persons diagnosed with lung cancer (small cell and n...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Dalton SO,Frederiksen BL,Jacobsen E,Steding-Jessen M,Østerlind K,Schüz J,Osler M,Johansen C

    更新日期:2011-09-27 00:00:00

  • The antileukaemic activity of 5-Aza-2 deoxycytidine (Aza-dC) in patients with relapsed and resistant leukaemia.

    abstract::In the present study we demonstrate that Aza-dC in combination with Amsacrine has major antileukaemic properties in patients who have not already received extensive Ara-C therapy. Eight out of 11 patients in their first relapse of acute leukaemia achieved complete remission. Cross resistance between Ara-C and Aza-dC w...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Richel DJ,Colly LP,Kluin-Nelemans JC,Willemze R

    更新日期:1991-07-01 00:00:00

  • Bosutinib plus capecitabine for selected advanced solid tumours: results of a phase 1 dose-escalation study.

    abstract:BACKGROUND:This phase 1 study evaluated the maximum tolerated dose (MTD), safety, and efficacy of bosutinib (competitive Src/Abl tyrosine kinase inhibitor) plus capecitabine. METHODS:Patients with locally advanced/metastatic breast, pancreatic, or colorectal cancers; cholangiocarcinoma; or glioblastoma received bosuti...

    journal_title:British journal of cancer

    pub_type: 杂志文章,多中心研究


    authors: Isakoff SJ,Wang D,Campone M,Calles A,Leip E,Turnbull K,Bardy-Bouxin N,Duvillié L,Calvo E

    更新日期:2014-11-25 00:00:00

  • Cost-effectivenes of paclitaxel plus cisplatin in advanced non-small-cell lung cancer.

    abstract::The aim of this study was to assess the cost-effectiveness of combination chemotherapy with paclitaxel/cisplatin, compared with standard etoposide/cisplatin in patients with advanced non-small cell lung cancer (NSCLC). We obtained the primary survival and resource utilization data from a large three-arm randomized tri...

    journal_title:British journal of cancer

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Earle CC,Evans WK

    更新日期:1999-05-01 00:00:00

  • Mutation analysis of the MSMB gene in familial prostate cancer.

    abstract:BACKGROUND:MSMB, a gene coding for beta-microseminoprotein, has been identified as a candidate susceptibility gene for prostate cancer (PrCa) in two genome-wide association studies (GWAS). SNP rs10993994 is 2 bp upstream of the transcription initiation site of MSMB and was identified as an associated PrCa risk variant....

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Kote-Jarai Z,Leongamornlert D,Tymrakiewicz M,Field H,Guy M,Al Olama AA,Morrison J,O'Brien L,Wilkinson R,Hall A,Sawyer E,Muir K,Hamdy F,Donovan J,Neal D,Easton D,Eeles R

    更新日期:2010-01-19 00:00:00

  • Activation of cyclin D1-related kinase in human lung adenocarcinoma.

    abstract::Cyclin D1 gene amplification is an important event in many cancers, but it is rarely found in non-small-cell lung cancer (NSCLC). This study was conducted in an attempt to clarify any other mechanisms related to cyclin D1 involvement in the malignant transformation of NSCLC, and we clearly showed for the first time th...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Igarashi K,Masaki T,Shiratori Y,Rengifo W,Nagata T,Hara K,Oka T,Nakajima J,Hisada T,Hata E,Omata M

    更新日期:1999-10-01 00:00:00

  • Prognostic implication of the CpG island methylator phenotype in colorectal cancers depends on tumour location.

    abstract:BACKGROUND:Colorectal cancer (CRC) is usually categorised as proximal or distal CRC. Recently, many researchers have tried to determine the molecular heterogeneity of CRCs along bowel subsites. However, the differential effects of the CpG island methylator phenotype (CIMP) and microsatellite instability (MSI) on the cl...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Bae JM,Kim JH,Cho NY,Kim TY,Kang GH

    更新日期:2013-08-20 00:00:00

  • Comparative analysis of lifestyle factors, screening test use, and clinicopathologic features in association with survival among Asian Americans with colorectal cancer.

    abstract:BACKGROUND:Colorectal cancer (CRC) diagnoses and disease-specific survival (DSS) vary between ethnic groups in the United States. However, few studies have assessed differences among Asian subgroups. METHODS:The Surveillance, Epidemiology, and End Results (SEER) database was used to identify patients with invasive CRC...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Yi M,Xu J,Liu P,Chang GJ,Du XL,Hu CY,Song Y,He J,Ren Y,Wei Y,Yang J,Hunt KK,Li X

    更新日期:2013-04-16 00:00:00

  • The incidence of B cell leukaemia and lymphopenia in B cell neoplasia in adults: a study using the Kiel classification of non-Hodgkin's lymphoma.

    abstract::The incidence of B cell leukaemia in 186 consecutive untreated patients with histologically defined B cell neoplasms is described. The lymphomas were classified by the Kiel convention. B cell leukaemia in the context of this paper refers to the situation where a neoplastic clone of B cells in the blood greatly outnumb...

    journal_title:British journal of cancer

    pub_type: 杂志文章


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    更新日期:1983-08-01 00:00:00

  • Sensitivity of markers of DNA stability and DNA repair activity to folate supplementation in healthy volunteers.

    abstract::We have previously reported that supplementation with folic acid (1.2 mg day(-1) for 12 week) elicited a significant improvement in the folate status of 61 healthy volunteers. We have examined effects of this supplement on markers of genomic stability. Little is known about the effect of folate supplementation on DNA ...

    journal_title:British journal of cancer

    pub_type: 杂志文章,随机对照试验


    authors: Basten GP,Duthie SJ,Pirie L,Vaughan N,Hill MH,Powers HJ

    更新日期:2006-06-19 00:00:00

  • Non-linearity of colony formation by human tumour cells from biopsy samples.

    abstract::The relationship between colony numbers and concentration of cells plated is an important parameter of clonogenic assay systems. The cloning efficiency for an ideal sample should be independent of cell concentration, thus giving a straight line through the origin when colony numbers are plotted against cell concentrat...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Eliason JF,Aapro MS,Decrey D,Brink-Petersen M

    更新日期:1985-09-01 00:00:00

  • The effect of interaction between hepatitis C virus and cigarette smoking on the risk of hepatocellular carcinoma.

    abstract::We evaluated the interaction between hepatitis C virus (HCV) and cigarette smoking on death from hepatocellular cancer in The Japan Collaborative Cohort Study. The odds ratio of death from HCC for smoking was 9.60 (1.50-61.35) and 1.71(0.58-5.08) among anti-HCV positive and negative individuals, respectively. ...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Fujita Y,Shibata A,Ogimoto I,Kurozawa Y,Nose T,Yoshimura T,Suzuki H,Iwai N,Sakata R,Ichikawa S,Tamakoshi A

    更新日期:2006-03-13 00:00:00

  • Ezrin promotes breast cancer progression by modulating AKT signals.

    abstract:BACKGROUND:Ezrin, which is known as a cytoskeleton linker protein, is closely linked with the metastatic progression of cancer and is frequently abnormally expressed in aggressive cancer types. However, the possible involvement of Ezrin in metastasis and angiogenesis in breast cancer remains unclear. METHODS:Immunohis...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Li N,Kong J,Lin Z,Yang Y,Jin T,Xu M,Sun J,Chen L

    更新日期:2019-04-01 00:00:00

  • Cellular pharmacology of novel C8-linked anthramycin-based sequence-selective DNA minor groove cross-linking agents.

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    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Smellie M,Kelland LR,Thurston DE,Souhami RL,Hartley JA

    更新日期:1994-07-01 00:00:00

  • Intermittent chemotherapy in metastatic androgen-independent prostate cancer.

    abstract::Intermittent use of chemotherapy for androgen-independent prostate cancer (AIPC) instead of treatment until disease progression may reduce toxicity. We prospectively tested this approach in eight AIPC patients responding to calcitriol plus docetaxel who reached a serum prostate-specific antigen (PSA) <4 ng ml(-1). Che...

    journal_title:British journal of cancer

    pub_type: 临床试验,杂志文章


    authors: Beer TM,Garzotto M,Henner WD,Eilers KM,Wersinger EM

    更新日期:2003-09-15 00:00:00

  • Targeting gene transcription: a new strategy to down-regulate c-erbB-2 expression in mammary carcinoma.

    abstract::Overexpression of the c-erbB-2 proto-oncogene in mammary carcinoma is frequently associated with amplification of the c-erbB-2 gene, but it also occurs from single-copy gene. Studies in mammary-derived cell lines have shown that, whether or not the gene is amplified, there is a 6- to 8-fold increase in the accumulatio...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Hollywood DP,Hurst HC

    更新日期:1995-04-01 00:00:00

  • Long-term results and recurrence patterns from SCALOP: a phase II randomised trial of gemcitabine- or capecitabine-based chemoradiation for locally advanced pancreatic cancer.

    abstract:BACKGROUND:SCALOP, a randomised, phase II trial, tested the activity and safety of gemcitabine (GEM)-based and capecitabine (CAP)-based chemoradiation (CRT) for locally advanced pancreatic cancer (LAPC). Here we present the long-term outcomes. METHODS:Eligibility: histologically proven LAPC ⩽7 cm. Following 12 weeks o...

    journal_title:British journal of cancer

    pub_type: 杂志文章,随机对照试验


    authors: Hurt CN,Falk S,Crosby T,McDonald A,Ray R,Joseph G,Staffurth J,Abrams RA,Griffiths G,Maughan T,Mukherjee S

    更新日期:2017-05-09 00:00:00

  • Prognostic implication of mucinous histology in colorectal cancer patients treated with adjuvant FOLFOX chemotherapy.

    abstract:BACKGROUND:There have been controversies in prognostic impact of mucinous histology on colorectal cancer, and its implication in patients treated with adjuvant 5-fluorouracil, leucovorin, and oxaliplatin (FOLFOX) is unclear. METHODS:Stage II and III colorectal cancer patients who underwent curative resection followed ...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Lee DW,Han SW,Lee HJ,Rhee YY,Bae JM,Cho NY,Lee KH,Kim TY,Oh DY,Im SA,Bang YJ,Jeong SY,Park KJ,Park JG,Kang GH,Kim TY

    更新日期:2013-05-28 00:00:00

  • Prostate cancer in BRCA2 germline mutation carriers is associated with poorer prognosis.

    abstract:BACKGROUND:The germline BRCA2 mutation is associated with increased prostate cancer (PrCa) risk. We have assessed survival in young PrCa cases with a germline mutation in BRCA2 and investigated loss of heterozygosity at BRCA2 in their tumours. METHODS:Two cohorts were compared: one was a group with young-onset PrCa, t...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Edwards SM,Evans DG,Hope Q,Norman AR,Barbachano Y,Bullock S,Kote-Jarai Z,Meitz J,Falconer A,Osin P,Fisher C,Guy M,Jhavar SG,Hall AL,O'Brien LT,Gehr-Swain BN,Wilkinson RA,Forrest MS,Dearnaley DP,Ardern-Jones AT,Pag

    更新日期:2010-09-07 00:00:00

  • Radiosensitization of hypoxic tumour cells by S-nitroso-N-acetylpenicillamine implicates a bioreductive mechanism of nitric oxide generation.

    abstract::The radiosensitizing activity of S-nitroso-N-acetylpenicillamine (SNAP), a nitric oxide (NO) donor, was assessed in a model of non-metabolic hypoxia achieved in an atmosphere of 95% nitrogen-5% carbon dioxide. A 10 min preincubation of hypoxic EMT-6 cells (10 x 10(6) ml(-1)) with 0.1 and 1 mM SNAP before radiation res...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Janssens MY,Verovski VN,Van den Berge DL,Monsaert C,Storme GA

    更新日期:1999-03-01 00:00:00

  • Survival of mice with NC carcinoma is unchanged by drugs that are thought to inhibit thromboxane synthesis or increase prostacyclin formation.

    abstract::Mice transplanted with NC carcinoma were treated with the thromboxane synthetase inhibitor dazmegrel (UK38485) or with nafazatrom (BAY G 6575), a compound that is reported to increase prostacyclin formation. Some experiments included the cytotoxic drugs methotrexate and melphalan. The tumours were excised under anaest...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Stamford IF,Melhuish PB,Carroll MA,Corrigan CJ,Patel S,Bennett A

    更新日期:1986-08-01 00:00:00

  • Diagnostic radiography and adult acute myeloid leukaemia: an interview and medical chart review study.

    abstract:BACKGROUND:Aetiology of acute myeloid leukaemia (AML) is not well understood, perhaps because of its distinct subtypes. High-dose ionising radiation is a known risk factor, but less is known about risk from low-dose exposure such as from diagnostic radiography. METHODS:Subjects were 412 matched case-control pairs. Ten...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Pogoda JM,Nichols PW,Ross RK,Stram DO,Thomas DC,Preston-Martin S

    更新日期:2011-04-26 00:00:00

  • Autologous cell vaccine as a post operative adjuvant treatment for high-risk melanoma patients (AJCC stages III and IV). The new American Joint Committee on Cancer.

    abstract::This study evaluates the overall survival and disease free survival of melanoma patients that were treated with an autologous melanoma cell vaccine, administered as a post-operative adjuvant. Included are 43 patients with totally resected metastatic melanoma (28-AJCC stage III, 15-AJCC stage IV), with a median follow ...

    journal_title:British journal of cancer

    pub_type: 临床试验,杂志文章


    authors: Lotem M,Peretz T,Drize O,Gimmon Z,Ad El D,Weitzen R,Goldberg H,Ben David I,Prus D,Hamburger T,Shiloni E

    更新日期:2002-05-20 00:00:00

  • DKC1 enhances angiogenesis by promoting HIF-1α transcription and facilitates metastasis in colorectal cancer.

    abstract:BACKGROUND:Dyskeratosis congenita 1 (DKC1) is dysregulated in several cancers. However, the expression and function of DKC1 in colorectal cancer (CRC) is rarely reported. METHODS:Tissue microarrays (TAMs) including 411 cases of CRC tissues and corresponding paracancerous tissues were used to examine the DKC1 expressio...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Hou P,Shi P,Jiang T,Yin H,Chu S,Shi M,Bai J,Song J

    更新日期:2020-03-01 00:00:00

  • Inhibition of OATP1B1 by tyrosine kinase inhibitors: in vitro-in vivo correlations.

    abstract:BACKGROUND:Several tyrosine kinase inhibitors (TKIs) can decrease docetaxel clearance in patients by an unknown mechanism. We hypothesised that these interactions are mediated by the hepatic uptake transporter OATP1B1. METHODS:The influence of 16 approved TKIs on transport was studied in vitro using HEK293 cells expre...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Hu S,Mathijssen RH,de Bruijn P,Baker SD,Sparreboom A

    更新日期:2014-02-18 00:00:00

  • Epigenetic gene deregulation in cancer.

    abstract::A mini-review of the literature concerning epigenetic gene regulation in cancer. ...

    journal_title:British journal of cancer

    pub_type: 杂志文章,评审


    authors: Malik K,Brown KW

    更新日期:2000-12-01 00:00:00

  • Paediatric germ cell tumours and congenital abnormalities: a Children's Oncology Group study.

    abstract:METHODS:Maternally reported congenital abnormalities (CAs) were examined in a case-control study of 278 cases of paediatric germ cell tumours (GCTs) and 423 controls. RESULTS AND CONCLUSIONS:Germ cell tumours were significantly associated with cryptorchidism in males (OR=10.8, 95% CI: 2.1-55.1), but not with any other...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Johnson KJ,Ross JA,Poynter JN,Linabery AM,Robison LL,Shu XO

    更新日期:2009-08-04 00:00:00

  • Importance of extensive staging in patients with mucosa-associated lymphoid tissue (MALT)-type lymphoma.

    abstract::Lymphoma of the mucosa-associated lymphoid tissue (MALT) type usually arises in MALT acquired through chronic antigenic stimulation triggered by persistent infection and/or autoimmune processes. Due to specific ligand-receptor interactions between lymphoid cells and high-endothelial venules of MALT, both normal and ne...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Raderer M,Vorbeck F,Formanek M,Osterreicher C,Valencak J,Penz M,Kornek G,Hamilton G,Dragosics B,Chott A

    更新日期:2000-08-01 00:00:00

  • Phase II trial of raltitrexed ('Tomudex') in advanced small-cell lung cancer.

    abstract::Raltitrexed, a thymidylate synthase inhibitor, was given to 21 patients with advanced small-cell lung cancer, at a dose of 3 mg m(-2) as a 15-min intravenous infusion at 21-day intervals. All of the patients had extensive disease and 17 had received prior therapy. Patients with disease refractory to primary chemothera...

    journal_title:British journal of cancer

    pub_type: 临床试验,杂志文章


    authors: Woll PJ,Basser R,Le Chevalier T,Drings P,Perez Manga G,Adenis A,Seymour L,Smith F,Thatcher N

    更新日期:1997-01-01 00:00:00

  • Effect of Schistosoma haematobium and N-butyl-N-(4-hydroxybutyl)nitrosamine on the development of urothelial neoplasia in the baboon.

    abstract::Experiments were conducted to determine whether bladder cancer would develop in primates (Papio sp.) infected with S. haematobium and concurrently exposed to low initiating doses of the bladder carcinogen N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN). To control for the systemic effects of schistosomiasis, 5 baboons wer...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Hicks RM,James C,Webbe G

    更新日期:1980-11-01 00:00:00