Safety and outcome of definitive chemoradiotherapy in elderly patients with oesophageal cancer.

Abstract:

:Little is known about chemoradiotherapy (CRT) in elderly patients with a locally advanced oesophageal cancer (OC). The aim of our study was to evaluate the tolerance and the outcome of elderly patients older than 70 years treated with CRT for a non-metastatic OC. Chemoradiotherapy was based on radiotherapy combined with a cisplatin-based chemotherapy. Clinical complete response (CCR) to CRT was evaluated on upper digestive endoscopy and computed tomography scan 6-8 weeks after CRT completion. One hundred and nine consecutive patients were included. A CCR was observed in 63 patients (57.8%) and 2-year survival was 35.5%. Adverse events > or =grade 3 were observed in 26 (23.8%) patients. Chemotherapy dose reduction, chemotherapy delays more than 1 week, and treatment discontinuation were observed in 33 (30.3%), 45 (41.3%), and 17 patients (15.6%), respectively. Comorbidity index according to Charlson score was significantly associated with treatment tolerance. In multivariate analysis, a CCR to CRT (P<0.01), a dose of radiotherapy > or =80% (P=0.02), and a Charlson score < or =2 (P=0.046) were identified as independent prognostic factors of overall survival. These results suggest that CRT could be considered as an effective treatment without major toxicity in elderly patients with OC.

journal_name

Br J Cancer

authors

Tougeron D,Di Fiore F,Thureau S,Berbera N,Iwanicki-Caron I,Hamidou H,Paillot B,Michel P

doi

10.1038/sj.bjc.6604749

subject

Has Abstract

pub_date

2008-11-18 00:00:00

pages

1586-92

issue

10

eissn

0007-0920

issn

1532-1827

pii

6604749

journal_volume

99

pub_type

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