Avascular and vascular phases of tumour growth in the chick embryo.

abstract：:The NCA (nonspecific cross-reacting antigen) was assayed in sera of patients with chronic myeloid leukaemia (CML). It was elevated to a mean value of 145·6 ng/ml (± 104·4 ng/ml) compared to 37·8 ng/ml (± 14·6 ng/ml) the sera of normal subjects. Patients with active disease generally had higher serum NCA levels than th...

journal_title：British journal of cancer

authors： Frénoy N,Ben-Bunant M,Berruel C,Child JA,Gendron MC,Missett JL,Razafimahaleo E,Burtin P

更新日期：1982-11-01 00:00:00

abstract：:A novel sterically hindered platinum complex, AMD473 [cis-aminedichloro(2-methylpyridine) platinum (II)], has been selected for phase I clinical trials due to commence in 1997. AMD473 was rationally designed to react preferentially with nucleic acids over sulphur ligands such as glutathione. This report documents the ...

journal_title：British journal of cancer

authors： Holford J,Sharp SY,Murrer BA,Abrams M,Kelland LR

更新日期：1998-01-01 00:00:00

abstract：:Three hundred and nineteen patients with primary adenocarcinoma of the ovary were studied to define those factors, many of them histopathological, which influence survival. The paper considers the stage of spread at the time of operation, the histological type of the tumour, its grade and in particular its mitotic act...

journal_title：British journal of cancer

authors： Dyson JL,Beilby JO,Steele SJ

更新日期：1971-06-01 00:00:00

abstract：:Interactions between immune and malignant cells have been known to have clinical relevance for decades. The potential for immune control is now being therapeutically enhanced with checkpoint inhibitors and other novel agents to improve outcomes in cancer. The importance of the immune infiltrate as a prognostic marker ...

journal_title：British journal of cancer

authors： Barnes TA,Amir E

更新日期：2017-08-08 00:00:00

abstract：:Over the period 1966-1995, based on 11,662 patients, the incidence of squamous cell carcinoma of the skin increased three to four times in Norway mainly as a result of an increased number of localized tumours. In men, cancer of the auricle was the second most common site; in women the incidence was low. ...

journal_title：British journal of cancer

authors： Iversen T,Tretli S

更新日期：1999-10-01 00:00:00

abstract：:Cytogenetic investigation was performed on direct preparations of 15 endometrial cancers showing different histotypes. Clonal abnormalities were found in 11 out of 13 analysable cases. The modal chromosome number was near diploid in all cases. The abnormal karyotypes contained relatively simple numerical or structural...

journal_title：British journal of cancer

authors： Tibiletti MG,Bernasconi B,Taborelli M,Furlan D,Fabbri A,Franchi M,Taramelli R,Trubia M,Capella C

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Dulanermin (rhApo2L/TRAIL) induces apoptosis by binding to death receptors DR4 and DR5, leading to caspase activation and subsequent cell death. A Phase1a trial evaluated the safety and tolerability of dulanermin in patients with advanced tumours. One aim was to develop and validate pharmacodynamic biomarker...

journal_title：British journal of cancer

authors： Pan Y,Xu R,Peach M,Huang CP,Branstetter D,Novotny W,Herbst RS,Eckhardt SG,Holland PM

更新日期：2011-12-06 00:00:00

abstract：BACKGROUND:Tumour hypoxia is associated with impaired apoptosis, resistance to therapy and poor prognosis. We previously reported that high stromal expression of the endogenous marker of hypoxia, carbonic anhydrase IX (CAIX), is associated with significantly reduced survival in oral squamous cell carcinoma (OSCC). In a...

journal_title：British journal of cancer

authors： Klimowicz AC,Bose P,Petrillo SK,Magliocco AM,Dort JC,Brockton NT

更新日期：2013-10-01 00:00:00

abstract：:In a cohort of 29,584 residents of Linxian, China, followed from 1985 to 2001, we conducted a case-cohort study of the magnitude of the association of Helicobacter pylori seropositivity with cancer risk in a random sample of 300 oesophageal squamous cell carcinomas, 600 gastric cardia adenocarcinomas, all 363 diagnose...

journal_title：British journal of cancer

authors： Kamangar F,Qiao YL,Blaser MJ,Sun XD,Katki H,Fan JH,Perez-Perez GI,Abnet CC,Zhao P,Mark SD,Taylor PR,Dawsey SM

更新日期：2007-01-15 00:00:00

abstract：BACKGROUND:Some components of the Mediterranean diet have favourable effects on endometrial cancer, and the Mediterranean diet as a whole has been shown to have a beneficial role on various neoplasms. METHODS:We analysed this issue pooling data from three case-control studies carried out between 1983 and 2006 in vario...

journal_title：British journal of cancer

authors： Filomeno M,Bosetti C,Bidoli E,Levi F,Serraino D,Montella M,La Vecchia C,Tavani A

更新日期：2015-05-26 00:00:00

abstract：:Previous studies have reported inconsistent results regarding the modifying effect of hormone replacement therapy (HRT) on the association of body mass index (BMI) and the risk of colorectal cancer (CRC) among postmenopausal women. We assessed the use of HRT and BMI in 208 postmenopausal women with histologically conf...

journal_title：British journal of cancer

authors： Hoffmeister M,Raum E,Winter J,Chang-Claude J,Brenner H

更新日期：2007-12-03 00:00:00

abstract：:Protein kinase C (PKC) has a critical role in several signal transduction pathways, and is involved in renal cancer pathogenesis. Bryostatin-1 modulates PKC activity and has antitumour effects in preclinical studies. We conducted a multicentre phase II clinical trial in patients with advanced renal cancer to determine...

journal_title：British journal of cancer

authors： Madhusudan S,Protheroe A,Propper D,Han C,Corrie P,Earl H,Hancock B,Vasey P,Turner A,Balkwill F,Hoare S,Harris AL

更新日期：2003-10-20 00:00:00

abstract：:Flow cytometric (FCM) estimation of DNA content has been performed on tumour tissue from 197 patients with high and intermediate grade non-Hodgkin's lymphoma (NHL) to investigate the clinicopathological correlations and prognostic significance of DNA ploidy and proliferative activity. Fifty-one per cent of tumours wer...

journal_title：British journal of cancer

authors： Cowan RA,Harris M,Jones M,Crowther D

更新日期：1989-12-01 00:00:00

abstract：OBJECTIVE:Detection of lymph node involvement in women with IB2-IIB cervical cancer could have a positive effect on survival. We set out to evaluate the incidence of pelvic and/or para-aortic lymph node involvement using the sentinel node (SN) biopsy and its impact on survival. METHODS:From 2002 to 2010, 66 women with...

journal_title：British journal of cancer

authors： Chéreau E,Feron JG,Ballester M,Coutant C,Bezu C,Rouzier R,Touboul E,Daraï E

更新日期：2012-01-03 00:00:00

abstract：BACKGROUND:Heterogeneity and low incidence comprise the biggest challenge in sarcoma diagnosis and treatment. Chemotherapy, although efficient for some sarcoma subtypes, generally results in poor clinical responses and is mostly recommended for advanced disease. Specific genomic aberrations have been identified in some...

journal_title：British journal of cancer

authors： Brodin BA,Wennerberg K,Lidbrink E,Brosjö O,Potdar S,Wilson JN,Ma L,Moens LN,Hesla A,Porovic E,Bernhardsson E,Papakonstantinou A,Bauer H,Tsagkozis P,von Sivers K,Wejde J,Östling P,Kallioniemi O,Stragliotto CL

更新日期：2019-02-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) have been implicated as important factors in gliomas since they may both facilitate invasion into the surrounding brain and participate in neovascularization. We have tested the hypothesis that deregulated expression of gelatinase-A or B, or an activator of gelatinase-A, MT1-MMP, may c...

journal_title：British journal of cancer

authors： Forsyth PA,Wong H,Laing TD,Rewcastle NB,Morris DG,Muzik H,Leco KJ,Johnston RN,Brasher PM,Sutherland G,Edwards DR

更新日期：1999-04-01 00:00:00

abstract：:Twenty-four patients with advanced cancer not reacting to conventional therapy were treated with 97 courses of i.v. MER (methanol extraction residue of BCG). MER was administered by i.v. infusion over a 4-h period, twice a week, in dosages varying from 0.05 mg to 1.25 mg. The skin reactivity to 5 recall antigens was e...

journal_title：British journal of cancer

authors： Robinson E,Bartal A,Honigman J,Cohen Y

更新日期：1977-09-01 00:00:00

abstract：BACKGROUND:Birt-Hogg-Dubé (BHD) syndrome is an autosomal dominant condition caused by germline FLCN mutations, and characterised by fibrofolliculomas, pneumothorax and renal cancer. The renal cancer risk, cancer phenotype and pneumothorax risk of BHD have not yet been fully clarified. The main focus of this study was t...

journal_title：British journal of cancer

authors： Houweling AC,Gijezen LM,Jonker MA,van Doorn MB,Oldenburg RA,van Spaendonck-Zwarts KY,Leter EM,van Os TA,van Grieken NC,Jaspars EH,de Jong MM,Bongers EM,Johannesma PC,Postmus PE,van Moorselaar RJ,van Waesberghe JH,Starink

更新日期：2011-12-06 00:00:00

abstract：:In contrast to cutaneous melanoma, there is no evidence that BRAF mutations are involved in the activation of the mitogen-activated protein kinase (MAPK) pathway in uveal melanoma, although there is increasing evidence that this pathway is activated frequently in the latter tumours. In this study, we performed mutatio...

journal_title：British journal of cancer

authors： Zuidervaart W,van Nieuwpoort F,Stark M,Dijkman R,Packer L,Borgstein AM,Pavey S,van der Velden P,Out C,Jager MJ,Hayward NK,Gruis NA

更新日期：2005-06-06 00:00:00

abstract：BACKGROUND:A frequent mechanism of acquired multidrug resistance in human cancers is overexpression of ATP-binding cassette transporters such as the Multi-Drug Resistance Protein 1 (MDR-1). Nutlin-3, an MDM2-p53 antagonist, has previously been reported to be a competitive MDR-1 inhibitor. METHODS:This study assessed w...

journal_title：British journal of cancer

authors： Chen L,Zhao Y,Halliday GC,Berry P,Rousseau RF,Middleton SA,Nichols GL,Del Bello F,Piergentili A,Newell DR,Lunec J,Tweddle DA

更新日期：2014-08-12 00:00:00

abstract：:The objective of this study was to prospectively measure peri-diagnostic and surgical time intervals for patients with suspected colorectal, lung, or prostate cancer. Prospective eligible patients were referred to a regional hospital in Ottawa, Canada between February 2004 and February 2005 for diagnostic assessment o...

journal_title：British journal of cancer

authors： Grunfeld E,Watters JM,Urquhart R,O'Rourke K,Jaffey J,Maziak DE,Morash C,Patel D,Evans WK

更新日期：2009-01-13 00:00:00

abstract：:We investigated trends in first-time hospital admissions and deaths attributable to hepatocellular carcinoma (HCC) in a large population-based cohort of 22 073 individuals diagnosed with hepatitis C viral (HCV) infection through laboratory testing in Scotland in 1991-2006. We identified new cases of HCC through record...

journal_title：British journal of cancer

authors： McDonald SA,Hutchinson SJ,Bird SM,Robertson C,Mills PR,Dillon JF,Goldberg DJ

更新日期：2008-09-02 00:00:00

abstract：:Endosialin is a transmembrane glycoprotein selectively expressed in blood vessels and stromal fibroblasts of various human tumours. It has been functionally implicated in angiogenesis, but the factors that control its expression have remained unclear. As insufficient delivery of oxygen is a driving force of angiogenes...

journal_title：British journal of cancer

authors： Ohradanova A,Gradin K,Barathova M,Zatovicova M,Holotnakova T,Kopacek J,Parkkila S,Poellinger L,Pastorekova S,Pastorek J

更新日期：2008-10-21 00:00:00

abstract：:Prolactin (PRL) has been reported to inhibit apoptosis in various cell types and to serve as a cofactor in the upregulation of CD25 on T cells during activation. We investigated a possible relation between prolactin receptor (PRL-R) or IL-2 receptor alpha (IL-2Ralpha, CD25) expression on circulating T lymphocytes and ...

journal_title：British journal of cancer

authors： Bauernhofer T,Kuss I,Friebe-Hoffmann U,Baum AS,Dworacki G,Vonderhaar BK,Whiteside TL

更新日期：2003-04-22 00:00:00

abstract：:Trends in long-term relative survival from breast cancer are examined for women diagnosed in England and Wales up to 2001, using both period and hybrid approaches. Large improvements in long-term survival are predicted. Women with breast cancer still experience persistent excess mortality up to at least 20 years after...

journal_title：British journal of cancer

authors： Woods LM,Rachet B,Cooper N,Coleman MP

更新日期：2007-04-10 00:00:00

abstract：BACKGROUND:The effectiveness of a therapeutic strategy that switches chemotherapy, based on Ki-67 tumour expression after initial therapy, relative to that of standard chemotherapy, has not been evaluated. METHODS:Patients were randomly assigned to the control arm or the Ki-67 response-guided arm (Ki-67 arm). Primary ...

journal_title：British journal of cancer

authors： Mukai H,Yamaguchi T,Takahashi M,Hozumi Y,Fujisawa T,Ohsumi S,Akabane H,Nishimura R,Takashima T,Park Y,Sagara Y,Toyama T,Imoto S,Mizuno T,Yamashita S,Fujii S,Uemura Y

更新日期：2020-06-01 00:00:00

abstract：:We previously demonstrated a characteristically high sensitivity of pancreatic cancer cells to interferon alpha (IFN-alpha) gene transfer, which induced a more prominent growth suppression and cell death in pancreatic cancer cells than in other types of cancers and normal cells. The IFN-alpha protein can exhibit both ...

journal_title：British journal of cancer

authors： Ohashi M,Yoshida K,Kushida M,Miura Y,Ohnami S,Ikarashi Y,Kitade Y,Yoshida T,Aoki K

更新日期：2005-08-22 00:00:00

abstract：:Mutation of c-K-ras oncogene is an important step in progression of colon cancer. We used a hammerhead ribozyme (KrasRz) against mutated K-ras gene transcripts (codon 12, GTT) to inactivate mutant K-ras function in the colon cancer cell line SW480, harbouring a mutant K-ras gene. The beta-actin promoter-driven KrasRz ...

journal_title：British journal of cancer

authors： Tokunaga T,Tsuchida T,Kijima H,Okamoto K,Oshika Y,Sawa N,Ohnishi Y,Yamazaki H,Miura S,Ueyama Y,Nakamura M

更新日期：2000-09-01 00:00:00

abstract：:Rhizoxin is a tubulin-binding anti-neoplastic agent which is active in a range of murine tumour models. The recommended schedule, of intravenous (i.v.) bolus administration at a dose of 2 mg m-2 every 3 weeks, has been assessed in three phase II trials of ovarian, renal and colorectal cancer. In general terms the drug...

journal_title：British journal of cancer

authors： Kerr DJ,Rustin GJ,Kaye SB,Selby P,Bleehen NM,Harper P,Brampton MH

更新日期：1995-11-01 00:00:00

abstract：:When assessing the value of a particular treatment, it is important to consider the impact it may have on the quality of life of those being treated. This is particularly so for cancer patients, whose life expectancy may be short. Patients with advanced colorectal cancer who participated in two international comparati...

journal_title：British journal of cancer

authors： Anderson H,Palmer MK

更新日期：1998-01-01 00:00:00