Abstract：
BACKGROUND:Several studies have reported discordant results regarding the impact of the CYP2D6 phenotype on both the effectiveness and the degree of endocrine symptoms associated with tamoxifen. Other studies have suggested that menopausal symptoms may be a predictive factor to tamoxifen response. METHODS:We investigated the relationship between the CYP2D6-predicted phenotype and tamoxifen response in a nested case-control study among women from the International Breast cancer Intervention Study (IBIS-I), which evaluated tamoxifen in the preventive setting. RESULTS:In this retrospective analysis of the tamoxifen-treated women in the IBIS-I study, 9 women (16.6%) who developed oestrogen receptor-positive invasive breast cancer had a 2D6 poor or intermediate metaboliser phenotype compared with 45 (20.6%) controls. Adjusted matched logistic regression revealed no significant difference between cases and controls for extensive vs intermediate metaboliser phenotype (OR=0.81 (0.30-2.23), P=0.7) or extensive vs poor metaboliser phenotype (OR=1.02 (0.31-3.32), P=0.9). Controls in the tamoxifen group with a poor metaboliser phenotype developed nonsignificantly fewer hot flushes compared with those with an extensive metaboliser phenotype (OR=0.40 (0.12-1.31)), but those with the intermediate phenotype developed nonsignificantly more hot flushes (OR=1.38 (0.58-3.29)) in an unadjusted analysis. CONCLUSION:Data from the preventive IBIS-I study did not support an association between the CYP2D6 phenotype and breast cancer outcome or the development of endocrine symptoms in tamoxifen-treated women.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Sestak I,Kealy R,Nikoloff M,Fontecha M,Forbes JF,Howell A,Cuzick Jdoi
10.1038/bjc.2012.278subject
Has Abstractpub_date
2012-07-10 00:00:00pages
230-3issue
2eissn
0007-0920issn
1532-1827pii
bjc2012278journal_volume
107pub_type
杂志文章,随机对照试验abstract：:Lung cancer is the primary cause of cancer mortality in developed countries. First diagnosis only when disease has already reached the metastatic phase is the main reason for failure in treatment. To this regard, although low-dose spiral computed tomography (CT) has proven to be effective in the early detection of lun...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/sj.bjc.6605660
更新日期：2010-06-08 00:00:00
abstract：:The role of high-risk human papillomavirus (hrHPV) testing in primary cervical screening has not been established. We generated a randomised evaluation design ultimately to clarify whether primary hrHPV testing implemented into routine screening can bring increase in the programme effectiveness. The aim of the present...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1038/sj.bjc.6602799
更新日期：2005-10-17 00:00:00
abstract：:The purpose of the study is to test the hypothesis that expression of cell cycle regulatory proteins p16(INK4a) and pRb is significantly associated with prognosis in ovarian carcinomas. We performed immunohistochemical analysis of p16(INK4a) and pRb expression and correlated with survival in a series of 300 patients w...
journal_title：British journal of cancer
pub_type： 杂志文章,随机对照试验
doi：10.1038/sj.bjc.6603531
更新日期：2007-01-29 00:00:00
abstract：BACKGROUND:We used bleomycin, etoposide, cisplatin (BEP), the most effective regimen in the treatment of germ cell tumours (GCTs) and increased dose-density by using pegfilgrastim to shorten cycle length. Our aim was to assess safety and tolerability. METHODS:Sixteen male patients with intermediate or poor prognosis m...
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abstract：:Cancer incidence in the Falkland Islands, 1989-2000, was compared with rates in England and Wales, from which most Islanders originate. Colon and rectum cancer incidence was significantly raised 1989-93 but greatly reduced after 1994, when colonoscopic screening in high-risk families and sigmoidoscopic screening in th...
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更新日期：2001-11-02 00:00:00
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pub_type： 杂志文章
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更新日期：2003-07-07 00:00:00
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pub_type： 杂志文章
doi：10.1038/sj.bjc.6602722
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journal_title：British journal of cancer
pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1038/sj.bjc.6601202
更新日期：2003-09-01 00:00:00
abstract：BACKGROUND:Gemcitabine-based chemotherapy is the standard treatment for pancreatic cancer. However, the issue of resistance remains unresolved. The aim of this study was to identify microRNAs (miRNAs) that govern the resistance to gemcitabine in pancreatic cancer. METHODS:miRNA microarray analysis using gemcitabine-re...
journal_title：British journal of cancer
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更新日期：2013-07-23 00:00:00
abstract：:During the period 1943-1980 a significant increase in the incidence of neuroblastoma was seen in Denmark. The incidence increased from a level corresponding to that in Finland to a level corresponding to that in the USA, and the increase appears to be continuing. The increase relates to children aged under 5 years, an...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1986.270
更新日期：1986-12-01 00:00:00
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pub_type： 杂志文章
doi：10.1038/bjc.1997.466
更新日期：1997-01-01 00:00:00
abstract：:Discrete masses are commonly detected during mammographic screening and most such lesions are benign. For lesions without pathognomonically benign imaging features that are still regarded likely to be non-malignant (Tabar grade 3) reliable biopsy results would be a clinically useful alternative to mammographic surveil...
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pub_type： 杂志文章
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更新日期：2008-04-08 00:00:00
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pub_type： 杂志文章
doi：10.1038/sj.bjc.6600759
更新日期：2003-03-24 00:00:00
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pub_type： 杂志文章
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更新日期：1998-11-01 00:00:00
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pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
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pub_type： 杂志文章,随机对照试验
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pub_type： 杂志文章
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更新日期：1995-07-01 00:00:00
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pub_type： 杂志文章
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更新日期：1997-01-01 00:00:00
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pub_type： 临床试验,杂志文章,多中心研究
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更新日期：2004-07-05 00:00:00
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
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更新日期：1989-07-01 00:00:00
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