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Macrophage migration inhibitory factor and DJ-1 in gastric cancer: differences between high-incidence and low-incidence areas.

Abstract：

BACKGROUND:There is a need for sensitive and specific blood-borne markers for the detection of gastric cancer. Raised serum macrophage inhibitory factor (MIF) levels have been proposed as a marker for gastric cancer diagnosis but, to date, studies have only encompassed patients from high-incidence areas. METHODS:We have compared the serum concentration of MIF in a large cohort of UK and Japanese gastric cancer patients, together with appropriate control subjects (age and gender matched). Carcinoembryonic antigen and H. pylori IgG were also measured, as was DJ-1, a novel candidate protein biomarker identified by analysis of gastric cancer cell line secretomes. RESULTS:Marked elevations of the serum concentration of MIF and DJ-1 were seen in Japanese patients with gastric cancer compared with Japanese controls, a trend not seen in the UK cohort. These results could not be accounted for by differences in age, disease stage or H. pylori status. CONCLUSION:In regions of high, but not low incidence of gastric cancer, both MIF and DJ-1 have elevated serum concentrations in gastric cancer patients, compared with controls. This suggests that differing mechanisms of disease pathogenesis may be at play in high- and low-incidence regions.

journal_name

Br J Cancer

journal_title

British journal of cancer

authors

Shimwell NJ,Ward DG,Mohri Y,Mohri T,Pallan L,Teng M,Miki YC,Kusunoki M,Tucker O,Wei W,Morse J,Johnson PJ

doi

10.1038/bjc.2012.405

subject

Has Abstract

pub_date

2012-10-23 00:00:00

pages

1595-601

issue

9

eissn

0007-0920

issn

1532-1827

pii

bjc2012405

journal_volume

107

pub_type

杂志文章

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