当前位置： SCI文献检索 > BRITISH JOURNAL OF CANCER期刊下所有文献 > Adaptive ERK signalling activation in response to therapy and in silico prognostic evaluation of EGFR-MAPK in HNSCC.

Adaptive ERK signalling activation in response to therapy and in silico prognostic evaluation of EGFR-MAPK in HNSCC.

Abstract：

BACKGROUND:Head and neck squamous cell carcinoma (HNSCC) patients frequently develop treatment resistance to cetuximab, a monoclonal antibody against EGFR, as well as radiotherapy. Here we addressed extracellular signal-regulated kinase 1/2 (ERK1/2) regulation by cetuximab or fractionated irradiation (IR) and conducted in silico prognostic evaluation of the EGFR-MAPK axis in HNSCC. METHODS:Expression of ERK1/2 phosphorylation (pERK1/2) was determined in HNSCC cell lines, which were treated with cetuximab or fractionated-IR. Furthermore, the effect of fractionated IR on pERK1/2 was confirmed in an ex vivo HNSCC tissue culture model. Expression and prognostic significance of EGFR-ERK axis was evaluated in a cohort of radiotherapy plus cetuximab-treated HNSCC. Correlations among EGFR-MAPK signalling components and association between transcript and protein expression profiles and patient survival in HNSCC were analysed using publicly available databases. RESULTS:ERK1/2 phosphorylation was rebounded by prolonged cetuximab administration and was induced by fractionated IR, which could be suppressed by a MEK inhibitor as a radiosensitiser. In silico assessments suggested that EGFR-MAPK cascade genes and proteins could predict HNSCC patients' survival as a prognostic signature. CONCLUSIONS:Activation of ERK1/2 signalling contributes to the cellular defence of HNSCC against cetuximab and fractionated IR treatment. EGFR-MAPK axis has a prognostic significance in HNSCC.

journal_name

Br J Cancer

journal_title

British journal of cancer

authors

Rong C,Muller MF,Xiang F,Jensen A,Weichert W,Major G,Plinkert PK,Hess J,Affolter A

doi

10.1038/s41416-020-0892-9

subject

Has Abstract

pub_date

2020-07-01 00:00:00

pages

288-297

issue

2

eissn

0007-0920

issn

1532-1827

pii

10.1038/s41416-020-0892-9

journal_volume

123

pub_type

杂志文章

相关文献

BRITISH JOURNAL OF CANCER文献大全
  • Prognostic impact of chromosome aberrations in ovarian cancer.

    abstract：:Clinico-cytogenetic correlations were assessed in 88 patients with malignant ovarian tumours. Cytogenetic analysis of the primary tumours yielded normal karyotype (N) in 33 patients and abnormal karyotypes (A) in 55 patients. Within the A group, seven tumours had simple abnormalities (AS), i.e., numerical changes only...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1992.56

    authors： Pejovic T,Himmelmann A,Heim S,Mandahl N,Flodérus UM,Furgyik S,Elmfors B,Helm G,Willén H,Mitelman F

    更新日期：1992-02-01 00:00:00

  • Fruit and vegetable consumption in relation to hepatocellular carcinoma in a multi-centre, European cohort study.

    abstract：BACKGROUND:Vegetable and/or fruit intakes in association with hepatocellular carcinoma (HCC) risk have been investigated in case-control studies conducted in specific European countries and cohort studies conducted in Asia, with inconclusive results. No multi-centre European cohort has investigated the indicated associ...

    journal_title：British journal of cancer

    pub_type： 杂志文章,多中心研究

    doi：10.1038/bjc.2014.654

    authors： Bamia C,Lagiou P,Jenab M,Aleksandrova K,Fedirko V,Trichopoulos D,Overvad K,Tjønneland A,Olsen A,Clavel-Chapelon F,Boutron-Ruault MC,Kvaskoff M,Katzke VA,Kühn T,Boeing H,Nöthlings U,Palli D,Sieri S,Panico S,Tumino R

    更新日期：2015-03-31 00:00:00

  • Nine-factor-based immunohistochemistry classifier predicts recurrence for early-stage hepatocellular carcinoma after curative resection.

    abstract：BACKGROUND:Immunoscore have shown a promising prognostic value in many cancers. We aimed to establish and validate an immune classifier to predict survival after curative resection of hepatocellular carcinoma (HCC) patients who have undergone curative resection. METHODS:The immunohistochemistry (IHC) classifier assay ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/s41416-020-0864-0

    authors： Liu WR,Tian MX,Tang Z,Fang Y,Zhou YF,Song SS,Jiang XF,Wang H,Tao CY,Zhou PY,Qu WF,Ding ZB,Peng YF,Zhou J,Fan J,Shi YH

    更新日期：2020-07-01 00:00:00

  • Impact on survival of modelling increased surgical resection rates in patients with non-small-cell lung cancer and cardiovascular comorbidities: a VICORI study.

    abstract：BACKGROUND:The impact of cardiovascular disease (CVD) comorbidity on resection rates and survival for patients with early-stage non-small-cell lung cancer (NSCLC) is unclear. We explored if CVD comorbidity explained surgical resection rate variation and the impact on survival if resection rates increased. METHODS:Canc...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/s41416-020-0869-8

    authors： Welch CA,Sweeting MJ,Lambert PC,Rutherford MJ,Jack RH,West D,Adlam D,Peake M

    更新日期：2020-08-01 00:00:00

  • Immunotherapy for acute myelogenous leukaemia.

    abstract：:One hundred and seven untreated patients with acute myelogenous leukaemia (AML) were admitted to St Bartholomew's Hospital between 10 October 1970 and 31 January 1973. Before receiving drugs to induce remission they were allocated alternatively into 2 groups to decide their remission treatment-a group to receive chemo...

    journal_title：British journal of cancer

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1038/bjc.1973.162

    authors： Powles RL,Crowther D,Bateman CJ,Beard ME,McElwain TJ,Russell J,Lister TA,Whitehouse JM,Wrigley PF,Pike M,Alexander P,Fairley GH

    更新日期：1973-11-01 00:00:00

  • The effect of family size on estimates of the frequency of hereditary non-polyposis colorectal cancer.

    abstract：:Diagnosis of hereditary non-polyposis colorectal cancer (HNPCC) is currently based on phenotypical analysis of an expanded pedigree. Diagnostic guidelines ('Amsterdam criteria') proposed by the International Collaborative Group on HNPCC are often too stringent for use with small families. There is also the possibility...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1995.508

    authors： Percesepe A,Anti M,Roncucci L,Armelao F,Marra G,Pahor M,Coco C,Gasbarrini G,Ponz de Leon M

    更新日期：1995-11-01 00:00:00

  • Increased expression of HGF and c-met in rat small intestine during recovery from methotrexate-induced mucositis.

    abstract：:Chemotherapy or radiotherapy often cause mucosal damage in the gut (gut mucositis) in cancer patients. As a step to investigate mechanisms underlying subsequent intestinal repair, we have examined the expression profiles of hepatocyte growth factor (HGF) and its receptor c-met, two molecules previously implicated in t...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1054/bjoc.1999.1023

    authors： Xian CJ,Couper R,Howarth GS,Read LC,Kallincos NC

    更新日期：2000-02-01 00:00:00

  • Population-based cancer incidence in Sikkim, India: report on ethnic variation.

    abstract：BACKGROUND:A Population-Based Cancer Registry (PBCR) was set up in Sikkim (a state in the North Eastern India) in 2003. We examined incidence rates by ethnic groups from 2003-2008. METHODS:Age-adjusted incidence rates (AARs) per 100,000 person-years were calculated by direct method using the world standard population,...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2011.598

    authors： Verma Y,Pradhan PK,Gurung N,Sapkota SD,Giri P,Sundas P,Bhattarai BN,Nadayil D,Ramnath T,Nandakumar A

    更新日期：2012-02-28 00:00:00

  • Morphometric grading of breast cancer: thresholds for tubular differentiation.

    abstract：:We evaluated the degree of tubular differentiation in 172 samples of invasive ductal breast cancer in order to determine numerical thresholds for histological breast cancer grading. The tubular differentiation in each sample was defined as the fraction of fields showing tubular differentiation (FTD). The analysis was ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1054/bjoc.2000.1222

    authors： Kronqvist P,Kuopio T,Collan Y

    更新日期：2000-05-01 00:00:00

  • Association of apolipoprotein E polymorphisms and dietary factors in colorectal cancer.

    abstract：:ApoE single nucleotide polymorphisms (SNPs) Cys112Arg (Epsilon-4), and Arg158Cys (Epsilon-2) have been implicated in cardiovascular and Alzheimer's disease, but their role in colorectal cancer (CRC) has not been extensively studied. We investigated whether ApoE polymorphisms alone or in combination with dietary factor...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6605097

    authors： Mrkonjic M,Chappell E,Pethe VV,Manno M,Daftary D,Greenwood CM,Gallinger S,Zanke BW,Knight JA,Bapat B

    更新日期：2009-06-16 00:00:00

  • Systemic inflammation scores correlate with survival prognosis in patients with newly diagnosed brain metastases.

    abstract：BACKGROUND:Systemic inflammation measured by the neutrophil-to-lymphocyte ratio (NLR), leucocyte-to-lymphocyte ratio (LLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR) and CRP/albumin ratio (CRP/Alb) was shown to impact the survival prognosis in patients with extracranial solid cancer. METHO...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/s41416-020-01254-0

    authors： Starzer AM,Steindl A,Mair MJ,Deischinger C,Simonovska A,Widhalm G,Gatterbauer B,Dieckmann K,Heller G,Preusser M,Berghoff AS

    更新日期：2021-01-21 00:00:00

  • Correction: Direct therapeutic targeting of immune checkpoint PD-1 in pancreatic cancer.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：British journal of cancer

    pub_type： 已发布勘误

    doi：10.1038/s41416-020-0879-6

    authors： Gao M,Lin M,Moffitt RA,Salazar MA,Park J,Vacirca J,Huang C,Shroyer KR,Choi M,Georgakis GV,Sasson AR,Talamini MA,Kim J

    更新日期：2020-08-01 00:00:00

  • Alcohol, smoking, passive smoking and caffeine in relation to breast cancer risk in young women. UK National Case-Control Study Group.

    abstract：:The UK National Case-Control Study Group has examined the relationship between smoking (both own smoking and passive), alcohol consumption and caffeine consumption and the risk of breast cancer. A total of 755 women with breast cancer diagnosed before the age of 36, each with an age-matched general population control,...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1994.258

    authors： Smith SJ,Deacon JM,Chilvers CE

    更新日期：1994-07-01 00:00:00

  • The mechanisms of action of the carcinogenic nitroso and related compounds.

    abstract：:It is suggested that the proximate carcinogenic forms of dialkylnitrosamines are their oxidation products, which retain the alkylnitrosamino moiety, but have acquired a carbonyl function as a result of omega or beta oxidation of an alkyl group. Such metabolites resemble the locally acting carcinogenic "nitrosamides" a...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1973.169

    authors： Schoental R

    更新日期：1973-11-01 00:00:00

  • Allele loss from large regions of chromosome 17 is common only in certain histological subtypes of ovarian carcinomas.

    abstract：:Using a panel of ten polymorphic markers, we examined the frequency of loss of heterozygosity (LOH) on chromosome 17 in 55 sporadic ovarian tumours. LOH on 17p and 17q was observed to be 50% and 62% respectively. LOH at D17S5 was detected in 24/36 (67%) of malignant cases and in 19/43 (44%) at TP53; the marker D17S855...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1996.594

    authors： Papp J,Csokay B,Bosze P,Zalay Z,Toth J,Ponder B,Olah E

    更新日期：1996-11-01 00:00:00

  • Caveolin 1 and Caveolin 2 are associated with breast cancer basal-like and triple-negative immunophenotype.

    abstract：:Caveolin-1 (CAV1) and caveolin 2 (CAV2) are the principal structural proteins of caveolae, sphingolipid and cholesterol-rich invaginations of the plasma membrane involved in vesicular trafficking and signal transduction. Over the recent years there has been controversy about their role in breast cancer and their suita...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6604463

    authors： Elsheikh SE,Green AR,Rakha EA,Samaka RM,Ammar AA,Powe D,Reis-Filho JS,Ellis IO

    更新日期：2008-07-22 00:00:00

  • Cancer-associated fibroblasts-heroes or villains?

    abstract：:Cancer-associated fibroblasts (CAFs) were originally presumed to represent a homogeneous population uniformly driving tumorigenesis, united by their morphology and peritumoural location. Our understanding of CAFs has since been shaped by sophisticated in vitro and in vivo experiments, pathological association and, mor...

    journal_title：British journal of cancer

    pub_type： 杂志文章,评审

    doi：10.1038/s41416-019-0509-3

    authors： Gieniec KA,Butler LM,Worthley DL,Woods SL

    更新日期：2019-08-01 00:00:00

  • Should colorectal cancer screening start at the same age in European countries? Contributions from descriptive epidemiology.

    abstract：:We assessed incidence and mortality of colorectal cancer (CRC) at various ages among women and men in 38 European countries. The ages at which defined levels of incidence and mortality were reached varied between 9 and 17 years between countries. This variation requires consideration in the definition of screening gui...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6604488

    authors： Brenner H,Hoffmeister M,Haug U

    更新日期：2008-08-05 00:00:00

  • Protection of mice against cancer by immunization with membranes but not purified virions from virus infected cancer cells.

    abstract：:The life span of C57/Bl mice inoculated with Lewis lung carcinoma cells was prolonged if the mice were pre-immunized with membranes from these cells infected in vitro with influenza virus. Likewise, BALB/c mice were protected against the malignant tumour WEHI-11 by prior immunization with extracts of cultured WEHI-11 ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1975.106

    authors： Griffith IP,Crook NE,White DO

    更新日期：1975-06-01 00:00:00

  • Modulation of cisplatin cytotoxicity by sulphasalazine.

    abstract：:The efficacy of cisplatin [cis-diamminedichloroplatinum (II); DDP] is hampered by acquired or de novo resistance of malignant cells to its cytotoxic effects. We have previously reported that cisplatin resistance parallels glutathione S-transferase (GST) activity in several human small-cell lung cancer cell lines. In t...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1994.278

    authors： Awasthi S,Sharma R,Singhal SS,Herzog NK,Chaubey M,Awasthi YC

    更新日期：1994-08-01 00:00:00

  • Increased frequency of the k-ras G12C mutation in MYH polyposis colorectal adenomas.

    abstract：:Colorectal tumours from MYH polyposis patients display an excess of somatic G : C --> T : A transversions in the adenomatous polyposis coli gene. Here, we identify k-ras mutations in nine out of 54 (16.7%) MYH polyposis tumours. Their presence was associated with increased dysplasia and tubulovillous morphology (P=0.0...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6601747

    authors： Jones S,Lambert S,Williams GT,Best JM,Sampson JR,Cheadle JP

    更新日期：2004-04-19 00:00:00

  • Cyclin A is associated with an unfavourable outcome in patients with non-small-cell lung carcinomas.

    abstract：:Specimens of formalin-fixed, paraffin-embedded non-small-cell lung carcinomas (NSCLCs; n = 187) were analysed immunohistochemically for expression of cyclin A. The analysis was intended to determine whether cyclin A has additional prognostic value for predicting patients' survival and drug response. Of the 187 NSCLCs,...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1997.302

    authors： Volm M,Koomägi R,Mattern J,Stammler G

    更新日期：1997-01-01 00:00:00

  • The role of radiotherapy after chemotherapy in the management of persistent para-aortic nodal disease in non-seminomatous germ cell tumours.

    abstract：:In the years 1979-1982, 83 patients with malignant teratoma of the testis who had retroperitoneal adenopathy at presentation or after a period of surveillance were treated. Complete radiological resolution of disease was obtained in 34 patients and a residual mass remained in 26, the remainder having progression of th...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1986.105

    authors： Read G,Johnson RJ,Wilkinson PM

    更新日期：1986-05-01 00:00:00

  • Measurement of prostate-specific antigen in detection of benign or malignant breast disease in women.

    abstract：:Using a highly sensitive chemiluminescent enzyme immunoassay, we have evaluated the measurement of serum prostate-specific antigen (PSA) as a potential diagnostic test for differentiation between women with breast cancer and those with benign breast disease. In a controlled study consisting of 284 women with well-docu...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6690252

    authors： Romppanen J,Keskikuru R,Kataja V,Eskelinen M,Kosma VM,Savolainen K,Uusitupa M,Mononen I

    更新日期：1999-03-01 00:00:00

  • Intermittent chemotherapy in metastatic androgen-independent prostate cancer.

    abstract：:Intermittent use of chemotherapy for androgen-independent prostate cancer (AIPC) instead of treatment until disease progression may reduce toxicity. We prospectively tested this approach in eight AIPC patients responding to calcitriol plus docetaxel who reached a serum prostate-specific antigen (PSA) <4 ng ml(-1). Che...

    journal_title：British journal of cancer

    pub_type： 临床试验,杂志文章

    doi：10.1038/sj.bjc.6601232

    authors： Beer TM,Garzotto M,Henner WD,Eilers KM,Wersinger EM

    更新日期：2003-09-15 00:00:00

  • The relationship between the systemic inflammatory response, tumour proliferative activity, T-lymphocytic infiltration and COX-2 expression and survival in patients with transitional cell carcinoma of the urinary bladder.

    abstract：:The relationship between the systemic inflammatory response, tumour proliferative activity, T-lymphocytic infiltration, and COX-2 expression and survival was examined in patients with transitional cell carcinoma of the urinary bladder (n=103). Sixty-one patients had superficial disease and 42 patients had invasive dis...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6603415

    authors： Hilmy M,Campbell R,Bartlett JM,McNicol AM,Underwood MA,McMillan DC

    更新日期：2006-11-06 00:00:00

  • Phase I/II study of gemcitabine plus mitoxantrone as salvage chemotherapy in metastatic breast cancer.

    abstract：:The purpose of this study was to determine the maximum-tolerated dose of gemcitabine plus mitoxantrone in women with metastatic breast cancer (MBC) and to evaluate activity and toxicity of this combination in a phase II trial. Sixty-three patients with MBC, previously treated with chemotherapy including anthracycline ...

    journal_title：British journal of cancer

    pub_type： 临床试验,杂志文章

    doi：10.1038/sj.bjc.6600780

    authors： Lorusso V,Crucitta E,Silvestris N,Catino A,Caporusso L,Mazzei A,Guida M,Latorre A,Sambiasi D,D'Amico C,Schittulli F,Calabrese P,De Lena M

    更新日期：2003-02-24 00:00:00

  • Declining mortality from breast cancer in Yorkshire, 1983-1998: extent and causes.

    abstract：:Incidence and mortality data, stage of disease and treatment information for female breast cancer were obtained for the years 1975-1999 for the former Yorkshire Regional Health Authority area, from the Northern and Yorkshire Cancer Registry and Information Service. Deaths by age group and 3-year calendar period were s...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6601614

    authors： Pisani P,Forman D

    更新日期：2004-02-09 00:00:00

  • The role of Mediterranean diet on the risk of pancreatic cancer.

    abstract：BACKGROUND:The Mediterranean diet has been shown to have a beneficial role on various neoplasms, but data are scanty on pancreatic cancer. METHODS:We analysed data from two case-control studies conducted in Italy between 1983 and 2008, including 362 and 326 pancreatic cancer cases and 1552 and 652 hospital-controls, r...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2013.345

    authors： Bosetti C,Turati F,Dal Pont A,Ferraroni M,Polesel J,Negri E,Serraino D,Talamini R,La Vecchia C,Zeegers MP

    更新日期：2013-09-03 00:00:00

  • Does smoking among friends explain apparent genetic effects on current smoking in adolescence and young adulthood?

    abstract：:We used data from a prospective cohort study of twins to investigate the influence of unmeasured genetic and measured and unmeasured environmental factors on the smoking behaviour of adolescents and young adults. Twins were surveyed in 1988 (aged 11-18 years), 1991, 1996 and 2004 with data from 1409, 1121, 732 and 758...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6604250

    authors： White VM,Byrnes GB,Webster B,Hopper JL

    更新日期：2008-04-22 00:00:00