Cancer-associated fibroblasts-heroes or villains?

abstract：BACKGROUND:Cutaneous melanoma is the most serious skin malignancy and new therapeutic strategies are needed for advanced melanoma. TP53 mutations are rare in cutaneous melanoma and hence activation of wild-type p53 is a potential therapeutic strategy in cutaneous melanoma. Here, we investigated the WIP1 inhibitor, GSK2...

journal_title：British journal of cancer

authors： Wu CE,Esfandiari A,Ho YH,Wang N,Mahdi AK,Aptullahoglu E,Lovat P,Lunec J

更新日期：2018-02-20 00:00:00

abstract：:HER2/neu-derived peptides inducing MHC class II-restricted CD4+ T helper lymphocyte (Th) responses, although critical for tumour rejection, are not thoroughly characterized. Here, we report the generation and characterization of CD4+ T cell clones specifically recognizing a HER-2/neu-derived peptide (776-788) [designa...

journal_title：British journal of cancer

authors： Sotiriadou R,Perez SA,Gritzapis AD,Sotiropoulou PA,Echner H,Heinzel S,Mamalaki A,Pawelec G,Voelter W,Baxevanis CN,Papamichail M

更新日期：2001-11-16 00:00:00

abstract：:Cytologic examination of peritoneal lavage fluid is a useful predictor of peritoneal recurrence in gastric cancer. However, this technique is not overly sensitive and requires special abilities in the cytologist. In this study, telomerase activity was used to detect free cancer cells in peritoneal lavage fluid from pa...

journal_title：British journal of cancer

authors： Mori N,Oka M,Hazama S,Iizuka N,Yamamoto K,Yoshino S,Tangoku A,Noma T,Hirose K

更新日期：2000-10-01 00:00:00

abstract：:Ninety-two consecutive adult patients admitted with acute life-threatening complications of haematological malignancy were studied to determine long term outcome. The quality of life was evaluated in seven long term survivors who are currently alive more than 1 year after hospital discharge using three validated metho...

journal_title：British journal of cancer

authors： Yau E,Rohatiner AZ,Lister TA,Hinds CJ

更新日期：1991-11-01 00:00:00

abstract：:In rapidly frozen livers from chickens affected with myeloblastosis and Marek's disease and from unaffected control birds there exists a strong correlation between catalase activity and catalase Electron Paramagnetic Resonance (EPR) signal intensities. The diseased chickens had activities and signals reduced to as lit...

journal_title：British journal of cancer

authors： Williams-Smith DL,Payne LN,Wyard SJ

更新日期：1984-09-01 00:00:00

abstract：BACKGROUND:Early detection of non-small-cell lung cancer (NSCLC) and accurate prognostic risk assessment could improve patient outcome. We examined the significance of urinary N(1), N(12)-diacetylspermine (DiAcSpm) in the detection and prognostic stratification of NSCLC patients. METHODS:A DiAcSpm/cutoff ratio (DASr) ...

journal_title：British journal of cancer

authors： Takahashi Y,Sakaguchi K,Horio H,Hiramatsu K,Moriya S,Takahashi K,Kawakita M

更新日期：2015-11-17 00:00:00

abstract：:In a previous study we found that aromatic amines, particularly 4-aminobiphenyl, formed haemoglobin adducts at higher concentrations in the blood of smokers compared to non-smokers. We re-analyse here data on haemoglobin adducts of 14 aromatic amines in order to ascertain if the inter-individual variability left unexp...

journal_title：British journal of cancer

authors： Ronco G,Vineis P,Bryant MS,Skipper PL,Tannenbaum SR

更新日期：1990-04-01 00:00:00

abstract：BACKGROUND:The eicosanoid signalling pathway promotes the progression of malignancies through the production of proliferative prostaglandins (PGs). Cytosolic phospholipase A(2)α (cPLA(2)α) activity provides the substrate for cyclooxygenase-dependent PG release, and we have previously found that cPLA(2)α expression corr...

journal_title：British journal of cancer

authors： Caiazza F,McCarthy NS,Young L,Hill AD,Harvey BJ,Thomas W

更新日期：2011-01-18 00:00:00

abstract：:Over a 10 year period, between 1974-1984, 257 adult cases of tissue sarcoma have been evaluated in the Department of Medical Oncology, Christie Hospital, Manchester. At registration locally advanced or metastatic diseases was present in 162 (63%). The male/female ratio was 1.5:1 and median age 54 years (range 14-85). ...

journal_title：British journal of cancer

authors： Bramwell VH,Crowther D,Deakin DP,Swindell R,Harris M

更新日期：1985-03-01 00:00:00

abstract：:Women with a family history of breast cancer generally self-refer because they have a feeling that their risk is high. However, they have, in general, only a hazy notion of the population risk of breast cancer and their own risk in relation to this. It is probable that they are helped by genetic counselling and, if at...

journal_title：British journal of cancer

authors： Evans DG,Blair V,Greenhalgh R,Hopwood P,Howell A

更新日期：1994-11-01 00:00:00

abstract：:Resistance of tumour cells to methylating and monochloroethylating agents in vitro and in vivo has been linked to levels of the DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT). In a clinical trial of temozolomide in advanced malignant melanoma, the relationship between pretreatment MGMT levels in biop...

journal_title：British journal of cancer

authors： Middleton MR,Lunn JM,Morris C,Rustin G,Wedge SR,Brampton MH,Lind MJ,Lee SM,Newell DR,Bleehen NM,Newlands ES,Calvert AH,Margison GP,Thatcher N

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND:HOX transcript antisense RNA (HOTAIR), which is expressed from the homebox C gene (HOXC) locus, is capable of reprogramming chromatin organisation and promoting cancer cell metastasis and can simultaneously bind the polycomb repressive complex 2, which enhances H3K27 trimethylation, and the LSD1-CoREST-REST ...

journal_title：British journal of cancer

authors： Li X,Wu Z,Mei Q,Li X,Guo M,Fu X,Han W

更新日期：2013-10-15 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is one of the most common types of malignant tumour and has poor prognosis. Currently, systematic chemotherapy is the only approach to prolong survival. Thus the development of new treatment regimens is urgently needed to improve the therapeutic efficacy. Our study intended to ...

journal_title：British journal of cancer

authors： Xu L,Zhu Y,Shao J,Chen M,Yan H,Li G,Zhu Y,Xu Z,Yang B,Luo P,He Q

更新日期：2017-04-11 00:00:00

abstract：BACKGROUND:Tumours are responsive to temozolomide (TMZ) if they are deficient in O(6)-methylguanine-DNA methyltransferase (MGMT), and mismatch repair (MMR) proficient. METHODS:The effect of TMZ on medulloblastoma (MB) cell killing was analysed with clonogenic survival assays. Expression of DNA repair genes and enzymes...

journal_title：British journal of cancer

authors： von Bueren AO,Bacolod MD,Hagel C,Heinimann K,Fedier A,Kordes U,Pietsch T,Koster J,Grotzer MA,Friedman HS,Marra G,Kool M,Rutkowski S

更新日期：2012-10-09 00:00:00

abstract：:In some clinical situations the endogenous production of glutamine may be insufficient to maintain optimal tissue structure and function such that glutamine becomes a conditionally essential amino acid. Studies in laboratory animals have demonstrated that glutamine supplementation can reduce the incidence and severity...

journal_title：British journal of cancer

authors： Jebb SA,Osborne RJ,Maughan TS,Mohideen N,Mack P,Mort D,Shelley MD,Elia M

更新日期：1994-10-01 00:00:00

abstract：:In a cohort of 29,584 residents of Linxian, China, followed from 1985 to 2001, we conducted a case-cohort study of the magnitude of the association of Helicobacter pylori seropositivity with cancer risk in a random sample of 300 oesophageal squamous cell carcinomas, 600 gastric cardia adenocarcinomas, all 363 diagnose...

journal_title：British journal of cancer

authors： Kamangar F,Qiao YL,Blaser MJ,Sun XD,Katki H,Fan JH,Perez-Perez GI,Abnet CC,Zhao P,Mark SD,Taylor PR,Dawsey SM

更新日期：2007-01-15 00:00:00

abstract：:The tumour suppressor gene CDKN2A, located on chromosome 9p21, encodes the cell cycle regulatory protein p16. Inactivation of the CDKN2A gene could lead to uncontrolled cell growth. In order to determine the role of CDKN2A in the development of sporadic ovarian cancer, loss of heterozygosity at 9p21-22, homozygous del...

journal_title：British journal of cancer

authors： Niederacher D,Yan HY,An HX,Bender HG,Beckmann MW

更新日期：1999-08-01 00:00:00

abstract：:The aim of this study was to examine the effects of oral and transdermal oestrogen replacement therapy on the risk of colorectal cancer. Data from a nested case-control study, designed to investigate the effect of hormone replacement therapy (HRT) on colorectal cancer were analysed. New cases of colorectal cancer, dia...

journal_title：British journal of cancer

authors： Csizmadi I,Collet JP,Benedetti A,Boivin JF,Hanley JA

更新日期：2004-01-12 00:00:00

abstract：:The prostate cancer cell lines PC3 and LNCaP have been shown to lack expression of the tumour suppressor gene MMAC1/PTEN, in contrast to the immortalized non-tumorigenic epithelial lines PNT1a and PNT2. We have measured the effects of reintroduction of wild type (wt) and mutant MMAC1 genes on to these genetic backgrou...

journal_title：British journal of cancer

authors： Sharrard RM,Maitland NJ

更新日期：2000-10-01 00:00:00

abstract：:The combination of heat and chemotherapy was studied in an intraperitoneal tumour model. Rats bearing peritoneal CC531 tumours (2-6 mm) were treated i.p. with cDDP or CBDCA [maximal tolerated dose (MTD)] in combination with regional hyperthermia (41.5 degrees C, 1 h) of the peritoneal cavity. The addition of hyperther...

journal_title：British journal of cancer

authors： Los G,van Vugt MJ,Pinedo HM

更新日期：1994-02-01 00:00:00

abstract：:To clarify the mechanism of acquired CDDP resistance in ovarian cancer, we compared the microsatellite instability (MSI) by the amplification of 10 microsatellite loci and immunohistochemical detection of hMSH2 and hMLH1 expression between the primary resected tumours and the secondary resected residual tumours after ...

journal_title：British journal of cancer

authors： Watanabe Y,Koi M,Hemmi H,Hoshai H,Noda K

更新日期：2001-09-28 00:00:00

abstract：BACKGROUND:We evaluated the performance of primary high-risk human papillomavirus (hrHPV) testing by hybrid capture 2 (HC2) with different thresholds for positivity, in comparison with conventional cytology. METHODS:We used data of 25,871 women (aged 30-60 years) from the intervention group of the VUSA-Screen study (V...

journal_title：British journal of cancer

authors： Rijkaart DC,Coupe VM,van Kemenade FJ,Heideman DA,Hesselink AT,Verweij W,Rozendaal L,Verheijen RH,Snijders PJ,Berkhof J,Meijer CJ

更新日期：2010-09-28 00:00:00

abstract：:The zinc finger protein glioma-associated oncogene homologue 1 (Gli-1) is a critical component of the Hedgehog (Hh) signalling pathway, which is essential for morphogenesis and stem-cell renewal, and is dysregulated in many cancer types. As data were not available on the role of Gli-1 expression in oesophageal cancer ...

journal_title：British journal of cancer

authors： Yoshikawa R,Nakano Y,Tao L,Koishi K,Matsumoto T,Sasako M,Tsujimura T,Hashimoto-Tamaoki T,Fujiwara Y

更新日期：2008-05-20 00:00:00

abstract：:Expression of the 37-kDa laminin binding protein (37LBP/p40), a precursor of the 67-kDa laminin receptor, is well-correlated with the biological aggressiveness of cancer cells. To elucidate the direct role played by 37LBP/p40 in cancer cells, a murine lung cancer cell line T11, the 37LBP/p40 expression of which was re...

journal_title：British journal of cancer

authors： Satoh K,Narumi K,Abe T,Sakai T,Kikuchi T,Tanaka M,Shimo-Oka T,Uchida M,Tezuka F,Isemura M,Nukiwa T

更新日期：1999-06-01 00:00:00

abstract：:This phase I study investigated the maximum tolerated dose and pharmacokinetics of a 3-weekly administration of BMS-188797, a paclitaxel derivate, at three dose levels (DLs) (80, 110 and 150 mg m(-2) DL), combined with cisplatin (standard dose 75 mg m(-2)). In 16 patients with advanced malignancies treated, one patien...

journal_title：British journal of cancer

authors： du Bois A,Jung B,Loehr A,Schaller-Kranz T,Cohen M,Frickhofen N

更新日期：2006-01-16 00:00:00

abstract：:The relationship between melanoma incidence and latitude was investigated in North American and Europe, using the data collected by 43 population-based cancer registries. In North America melanoma incidence increased with decreasing latitude, supporting the role of UV light in the induction of melanoma. Within England...

journal_title：British journal of cancer

authors： Crombie IK

更新日期：1979-11-01 00:00:00

abstract：:Short-term cultures from one synovial chondroma and three cases of synovial chondromatosis, a lesion for which no previous karyotypic information exists, were cytogenetically analysed. Whereas the chondroma displayed the relatively simple karyotype 46,XY,add(12)(q13),der(17)t(12;17)(q13;q21), more complex changes were...

journal_title：British journal of cancer

authors： Mertens F,Jonsson K,Willén H,Rydholm A,Kreicbergs A,Eriksson L,Olsson-Sandin G,Mitelman F,Mandahl N

更新日期：1996-07-01 00:00:00

abstract：:Methotrexate (MTX)-based chemotherapy extends survival in patients with primary brain lymphomas, but it is not clear whether multiagent chemotherapy is superior to MTX alone. Treatment options for patients with recurrent primary brain lymphoma are limited; there is no standard second-line chemotherapy. New chemotherap...

journal_title：British journal of cancer

authors： Reni M,Zaja F,Mason W,Perry J,Mazza E,Spina M,Bordonaro R,Ilariucci F,Faedi M,Corazzelli G,Manno P,Franceschi E,Pace A,Candela M,Abbadessa A,Stelitano C,Latte G,Ferreri AJ

更新日期：2007-03-26 00:00:00

abstract：:Capecitabine is an oral prodrug of 5-fluorouracil (FU). Since FU concentrations achieved in malignant lesions are an important determinant of efficacy, we investigated the intratumoral transcapillary transfer of capecitabine and its metabolites in vivo. A total of 10 patients with skin metastases from breast cancer re...

journal_title：British journal of cancer

authors： Mader RM,Schrolnberger C,Rizovski B,Brunner M,Wenzel C,Locker G,Eichler HG,Mueller M,Steger GG

更新日期：2003-03-10 00:00:00

abstract：:We screened 50 glioblastomas for P53 mutations. Five glioblastomas showed heterozygous mutations, while three were putatively heterozygous. Six of these eight glioblastomas showed elimination of wild-type P53 mRNA. These results strongly suggest that some sort of mechanism(s) favouring mutated over wild-type P53 mRNA ...

journal_title：British journal of cancer

authors： Szybka M,Zawlik I,Kulczycka D,Golanska E,Jesien E,Kupnicka D,Stawski R,Piaskowski S,Bieniek E,Zakrzewska M,Kordek R,Liberski PP,Rieske P

更新日期：2008-04-22 00:00:00