Abstract:
:The UK National Case-Control Study Group has examined the relationship between smoking (both own smoking and passive), alcohol consumption and caffeine consumption and the risk of breast cancer. A total of 755 women with breast cancer diagnosed before the age of 36, each with an age-matched general population control, were interviewed, and detailed information on reproductive, contraceptive and medical history, personal attributes and habits were obtained. Additional data on passive smoking were obtained from a subgroup of women. There was no evidence of a statistically significant difference in breast cancer risk between subjects who had ever smoked as much as one cigarette per day and those who had not [relative risk (RR) = 1.01, 95% confidence interval (CI) 0.81-1.26]. Most relative risks for passive smoking exceeded unity, but there was little evidence of significant trends with increasing exposure. The lack of effect of own smoking, and the fact that such smokers are also themselves exposed to the effects of passive smoking, makes any relationship between exposure to others' smoking and breast cancer risk implausible. Alcohol consumption during the year prior to diagnosis and at ages 18 and 25 was examined. Consumers of 0.1-4.9 and 5.0-14.9 g per day generally had non-significantly increased risks compared with never drinkers, but consumers of more than 15 g per day had reduced risks.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Smith SJ,Deacon JM,Chilvers CEdoi
10.1038/bjc.1994.258subject
Has Abstractpub_date
1994-07-01 00:00:00pages
112-9issue
1eissn
0007-0920issn
1532-1827journal_volume
70pub_type
杂志文章abstract::There is increasing evidence that essential fatty acids (EFA) may have a role to play in the aetiology of some types of cancer although their precise mode of action is unknown. Differences in the metabolism of EFA between patients with benign or malignant prostatic disease may help to elucidate their role in the latte...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1991.481
更新日期:1991-12-01 00:00:00
abstract::We evaluated animal food intake and cooking methods in relation to endometrial cancer risk in a population-based case-control study in Shanghai, China. A validated food frequency questionnaire was used to collect the usual dietary habits of 1204 cases and 1212 controls aged 30-69 years between 1997 and 2003. Statistic...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6603458
更新日期:2006-12-04 00:00:00
abstract::There is evidence that patients living in outlying areas have poorer survival from cancer. This study set out to investigate whether they have more advanced disease at diagnosis. Case notes of 1323 patients in north and northeast Scotland who were diagnosed with lung or colorectal cancer in 1995 or 1996 were reviewed....
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.2000.1708
更新日期:2001-04-06 00:00:00
abstract:BACKGROUND:Several recent studies have demonstrated that microRNAs (miRNAs) are stably detectable in the plasma/serum. We hypothesised that miR-18a in the plasma is a potential biomarker in patients with pancreatic cancer. METHODS:miR-18a is located in the miR-17-92 cluster and reported to be highly expressed in pancr...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2011.453
更新日期:2011-11-22 00:00:00
abstract::The cytochrome P450 CYP1B1 is consistently overexpressed in tumour cells as compared to their normal counterparts, but its precise role in drug resistance is yet to be defined. It has been reported that transfection of CYP1B1 results in increased resistance to docetaxel in V79 cells (McFadyen et al, 2001). In this stu...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604195
更新日期:2008-02-12 00:00:00
abstract:BACKGROUND:Epithelial-to-mesenchymal transition (EMT) enhances motility, stemness, chemoresistance and metastasis. Little is known about how various pathways coordinate to elicit EMT's different functional aspects in non-small cell lung cancer (NSCLC). Thymidylate synthase (TS) has been previously correlated with EMT t...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-01095-x
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:8-Oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) is the most abundant marker of DNA damage and it reflects oxidative stress. Human 8-oxoguanine glycosylase (hOGG1) is a DNA-repair enzyme that participates in 8-oxodG removal. METHODS:hOGG1 protein expression was immunohistochemically studied in 96 patients with...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2011.518
更新日期:2012-01-17 00:00:00
abstract:BACKGROUND:The germline BRCA2 mutation is associated with increased prostate cancer (PrCa) risk. We have assessed survival in young PrCa cases with a germline mutation in BRCA2 and investigated loss of heterozygosity at BRCA2 in their tumours. METHODS:Two cohorts were compared: one was a group with young-onset PrCa, t...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6605822
更新日期:2010-09-07 00:00:00
abstract::Although osteosclerotic bone metastases are characteristic of prostate cancer, mixed metastases with a lytic component are not uncommon. Type I collagen is synthesised by osteoblasts and accounts for about 90% of the organic matrix of bone. We have used new specific immunoassays for PICP (carboxy-terminal propeptide o...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1995.204
更新日期:1995-05-01 00:00:00
abstract::Increases of individual beta tubulin isotypes in antimicrotubule drug resistant cell lines have been reported by several laboratories. We have previously described elevations in beta(III)and beta(IVa)isotypes in estramustine and paclitaxel resistant human prostate carcinoma cells. To investigate further the function o...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.2001.1956
更新日期:2001-09-01 00:00:00
abstract::To invade and metastasize, carcinomas must penetrate or lose their epithelial basement membrane (EBM), and then penetrate basement membranes (BMs) surrounding blood vessels, lymphatics, nerves and muscle cells. Knowledge of the composition of different BMs is necessary, so that appropriate antibodies and DNA probes ar...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1997.37
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:Our previous study demonstrated that extracellular adenosine 5'-triphosphate (ATP) stimulated prostate cancer cell invasion via P2Y receptors. However, the purinergic receptor subtype(s) involved in this process remains unclear. Here we aimed to determine whether P2Y2, one subtype of P2Y receptors, was invol...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2013.484
更新日期:2013-09-17 00:00:00
abstract::The prognostic value of tissue-type plasminogen activator (tPA) measured in samples derived from 865 patients with primary breast cancer using a recently developed enzyme-linked immunosorbent assay (ELISA) was evaluated. Since the assay could easily be adapted to the assessment of the complex of tPA with its type-1 in...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6690353
更新日期:1999-04-01 00:00:00
abstract::The cellular pharmacology of a series of C8-linked pyrrolobenzodiazepine dimers with polymethylene linkers of n = 3-6 (compounds 1-4) has been studied in a range of human tumour cell lines. The four compounds showed the same pattern of relative activity in five ovarian carcinoma cell lines and one cervical carcinoma c...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1994.248
更新日期:1994-07-01 00:00:00
abstract:BACKGROUND:The arachidonic acid metabolite 12(S)-HETE is suspected to enhance metastatic spread by inducing cancer cell- and lymph endothelial cell (LEC) motility. However, the molecular mechanisms leading to 12(S)-HETE-triggered cell migration are still elusive. METHODS:To delineate the signalling pathways involved i...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2016.201
更新日期:2016-07-26 00:00:00
abstract::In the BUPA study, a prospective study of 22,000 men attending a screening centre in London, the mean serum cholesterol level of the 267 men who developed cancer was 6.66 mmol l-1, not significantly different from the mean level of 6.72 mmol l-1 among the 525 unaffected controls matched for age, smoking history and th...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1989.198
更新日期:1989-06-01 00:00:00
abstract:BACKGROUND:Observational studies suggest greater height is associated with increased ovarian cancer risk, but cannot exclude bias and/or confounding as explanations for this. Mendelian randomisation (MR) can provide evidence which may be less prone to bias. METHODS:We pooled data from 39 Ovarian Cancer Association Con...
journal_title:British journal of cancer
pub_type: 杂志文章,meta分析
doi:10.1038/s41416-018-0011-3
更新日期:2018-04-01 00:00:00
abstract::The effects of local tumour radiation over the dose range 7.5-30 Gy on the growth and cell kinetics of rat hepatoma H-4-II-E have been investigated. A plot of growth delays against log surviving fraction was linear below a fraction of 0.03, but failed to extrapolate to the origin. Following a single dose of 15 Gy to t...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1980.283
更新日期:1980-10-01 00:00:00
abstract:BACKGROUND:We aimed to analyse clinical and gene expression profiles to predict pathologic complete response and disease-free survival using two consecutive, prospective, preoperative chemotherapy trial cohorts. METHODS:Clinicopathological and gene expression data were evaluated in a cohort from two consecutive phase ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2016.184
更新日期:2016-08-09 00:00:00
abstract::With recent development in molecular biology, reverse transcriptase polymerase chain reaction (RT-PCR) has been applied to detect occult lymph node metastasis, but there have been few reports concerning oesophageal cancer. The objective of this study is to investigate the usefulness of the squamous cell carcinoma (SCC...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.1999.0938
更新日期:2000-01-01 00:00:00
abstract::Based on observations that for certain cancers, mortality varies according to sun exposure, vitamin D has been proposed to influence on disease progression. This study aims to investigate whether serum levels of 25(OH)D are associated with prognosis in patients with prostate cancer. In total, 160 patients with a serum...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604865
更新日期:2009-02-10 00:00:00
abstract::The p53 tumour suppressor protein inhibits malignant progression by mediating cell cycle arrest, apoptosis or repair following cellular stress. One of the major regulators of p53 function is the MDM2 protein, and multiple forms of cellular stress activate p53 by inhibiting the MDM2-mediated degradation of p53. Mutatio...
journal_title:British journal of cancer
pub_type: 杂志文章,评审
doi:10.1054/bjoc.2001.2128
更新日期:2001-12-14 00:00:00
abstract::Detailed serological studies have been undertaken in a small group of cancer patients receiving nonspecific immunotherapy with Corynebacterium parvum (C. parvum). These patients included 4 cases of recurrent malignant melanoma, 2 of stomach cancer and 2 of recurrent breast cancer. They all received an initial i.v. inf...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1975.229
更新日期:1975-09-01 00:00:00
abstract:BACKGROUND:Glomerular filtration rate (GFR) is used in the calculation of carboplatin dose. Glomerular filtration rate is measured using a radioisotope method (radionuclide GFR (rGFR)), however, estimation equations are available (estimated GFR (eGFR)). Our aim was to assess the accuracy of three eGFR equations and the...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2012.393
更新日期:2012-10-09 00:00:00
abstract::We evaluated the therapeutic usefulness of adjuvant chemotherapy in patients with completely resected non-small cell lung cancer (NSCLC). We also examined the relation between DNA ploidy pattern and the response to chemotherapy. A total of 267 patients with NSCLC (pathologically documented stage I, II, or IIIA) underw...
journal_title:British journal of cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1038/sj.bjc.6603336
更新日期:2006-10-09 00:00:00
abstract::Even though the majority of patients with bladder malignancies initially present with low stage disease, the clinical epidemiology of these so-called superficial bladder tumours is not well known. In this paper, disease characteristics at initial presentation and during follow-up are described in 1,745 primary cases d...
journal_title:British journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1038/bjc.1993.147
更新日期:1993-04-01 00:00:00
abstract::One hundred and eighteen doctors who treat pulmonary neoplasms in Ontario were asked how they would wish to be treated if they had non-small cell lung cancer. Four different scenarios were given. The physicians were then asked if they would consent to take part as subjects in one or more clinical trials for which they...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1986.224
更新日期:1986-10-01 00:00:00
abstract:BACKGROUND:We investigated whether pazopanib maintenance following first-line chemotherapy would improve survival in patients with extensive disease small-cell lung cancer (ED-SCLC). METHODS:This study is a randomised, placebo-controlled, phase II study that enroled ED-SCLC patients who had not progressed after four c...
journal_title:British journal of cancer
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1038/bjc.2017.465
更新日期:2018-03-06 00:00:00
abstract::The sera of 80 newly diagnosed lung-cancer patients have been examined for immune complexes and autoantibodies. Control subjects consisted of 20 bronchitic patients and 150 normal blood donors. Immune-complex measurements used 4 established and sensitive techniques (Raji cell assay, fluid and solid-phase C1q assays an...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1981.45
更新日期:1981-03-01 00:00:00
abstract::In a population-based cohort study of all women aged over 50 years with breast cancer in the Swedish Cancer Register in 1961-2003, those diagnosed before 31 December 1987 were regarded as unexposed to tamoxifen, whereas those diagnosed after that date were considered potentially exposed. Crosslinkages within the Cance...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6603214
更新日期:2006-07-03 00:00:00