Increased frequency of the k-ras G12C mutation in MYH polyposis colorectal adenomas.

abstract：BACKGROUND:Consumption of wholegrain (WG) products may protect against colon and rectal cancer. METHODS:The associations between total and individual WG product consumption and colon and rectal cancer risk were prospectively examined using data on 461 incident cases of colon cancer and 283 incident cases of rectal can...

journal_title：British journal of cancer

authors： Egeberg R,Olsen A,Loft S,Christensen J,Johnsen NF,Overvad K,Tjønneland A

更新日期：2010-08-24 00:00:00

abstract：:Carcinomas of unknown primary (CUP) represent between 3 and 10% of malignancies. Treatment with nonspecific chemotherapy is commonly unhelpful and the median survival is between 3 and 6 months. Gene expression microarray (GEM) analysis has demonstrated that molecular signatures can aid in tumour classification and pro...

journal_title：British journal of cancer

authors： Bridgewater J,van Laar R,Floore A,Van'T Veer L

更新日期：2008-04-22 00:00:00

abstract：:Low-dose hyper-radiosensitivity (HRS) (below 0.5 Gy) has been extensively documented in the past few years. The molecular basis of this phenomenon remains largely unknown and the purpose of this study was to investigate the possible implication of the DNA repair DNA-PK complex. The activity of the DNA-PK complex, i.e....

journal_title：British journal of cancer

authors： Vaganay-Juéry S,Muller C,Marangoni E,Abdulkarim B,Deutsch E,Lambin P,Calsou P,Eschwege F,Salles B,Joiner M,Bourhis J

更新日期：2000-08-01 00:00:00

abstract：BACKGROUND:The diagnosis of neuroendocrine neoplasms (NENs) is often delayed. This first UK population-based epidemiological study of NENs compares outcomes with non-NENs to identify any inequalities. METHODS:Age-standardised incidence rate (ASR), 1-year overall survival, hazard ratios and standardised mortality rates...

journal_title：British journal of cancer

authors： Genus TSE,Bouvier C,Wong KF,Srirajaskanthan R,Rous BA,Talbot DC,Valle JW,Khan M,Pearce N,Elshafie M,Reed NS,Morgan E,Deas A,White C,Huws D,Ramage J

更新日期：2019-11-01 00:00:00

abstract：:We have treated 40 patients was relapsed or resistant lymphoma with the combination of Etoposide, Prednisolone, Ifosfamide and Cisplatin (EPIC). Complete response was obtained in 11 patients (28%) with an overall response of 58%. The presence of bulky disease (P < 0.005), elevated LDH serum levels (P < 0.005), respons...

journal_title：British journal of cancer

authors： Hickish T,Roldan A,Cunningham D,Mansi J,Ashley S,Nicolson V,Gore ME,Catovsky D,Smith IE

更新日期：1993-09-01 00:00:00

abstract：BACKGROUND:Whether red and processed meat consumption is a risk factor for pancreatic cancer remains unclear. We conducted a meta-analysis to summarise the evidence from prospective studies of red and processed meat consumption and pancreatic cancer risk. METHODS:Relevant studies were identified by searching PubMed an...

journal_title：British journal of cancer

authors： Larsson SC,Wolk A

更新日期：2012-01-31 00:00:00

abstract：BACKGROUND:This phase I, dose-finding study determined the safety, maximum tolerated dose (MTD)/recommended phase 2 dose (RP2D), pharmacokinetics, and antitumour activity of PX-866, a phosphatidylinositol 3-kinase inhibitor, combined with docetaxel in patients with incurable solid tumours. METHODS:PX-866 was administe...

journal_title：British journal of cancer

authors： Bowles DW,Ma WW,Senzer N,Brahmer JR,Adjei AA,Davies M,Lazar AJ,Vo A,Peterson S,Walker L,Hausman D,Rudin CM,Jimeno A

更新日期：2013-09-03 00:00:00

abstract：BACKGROUND:Gamma-glutamyltransferase (GGT) - a membrane-bound enzyme crucially involved in the cell's detoxification pathway and apoptotic balance - is involved in tumour development, progression and chemotherapy resistance. Elevated GGT serum levels are associated with increased cancer risk in women and worse prognosi...

journal_title：British journal of cancer

authors： Grimm C,Hofstetter G,Aust S,Mutz-Dehbalaie I,Bruch M,Heinze G,Rahhal-Schupp J,Reinthaller A,Concin N,Polterauer S

更新日期：2013-08-06 00:00:00

abstract：:The NCA (nonspecific cross-reacting antigen) was assayed in sera of patients with chronic myeloid leukaemia (CML). It was elevated to a mean value of 145·6 ng/ml (± 104·4 ng/ml) compared to 37·8 ng/ml (± 14·6 ng/ml) the sera of normal subjects. Patients with active disease generally had higher serum NCA levels than th...

journal_title：British journal of cancer

authors： Frénoy N,Ben-Bunant M,Berruel C,Child JA,Gendron MC,Missett JL,Razafimahaleo E,Burtin P

更新日期：1982-11-01 00:00:00

abstract：:To test the feasibility and efficacy of epirubicin and ifosfamide added to first-line chemotherapy with cisplatin and paclitaxel in a phase II randomised clinical trial. Patients with histologically proven epithelial ovarian cancer were randomly assigned to receive first-line polychemotherapy with cisplatin/paclitaxel...

journal_title：British journal of cancer

authors： Fruscio R,Colombo N,Lissoni AA,Garbi A,Fossati R,Ieda' N,Torri V,Mangioni C

更新日期：2008-02-26 00:00:00

abstract：:The risk of ovarian epithelial neoplasia following use of hormonal contraceptives (HC) was examined in data from the Norwegian-Swedish Women's Lifestyle and Health cohort including 103551 women aged 30-49 years in 1991-92. Follow-up through 2000 produced 214 incident cases of histologically confirmed epithelial ovaria...

journal_title：British journal of cancer

authors： Kumle M,Weiderpass E,Braaten T,Adami HO,Lund E,Norwegian-Swedish Women's Lifestyle and Health Cohort Study.

更新日期：2004-04-05 00:00:00

abstract：BACKGROUND:The arachidonic acid metabolite 12(S)-HETE is suspected to enhance metastatic spread by inducing cancer cell- and lymph endothelial cell (LEC) motility. However, the molecular mechanisms leading to 12(S)-HETE-triggered cell migration are still elusive. METHODS:To delineate the signalling pathways involved i...

journal_title：British journal of cancer

authors： Nguyen CH,Stadler S,Brenner S,Huttary N,Krieger S,Jäger W,Dolznig H,Krupitza G

更新日期：2016-07-26 00:00:00

abstract：:Associations between work in the electrical and electronic industry and cancer incidence were assessed using data for 371 890 cancers registered in England between 1981 and 1987, of which 7981 were in electrical workers. Proportional registration ratios (PRRs) were calculated, both with and without the commonest cance...

journal_title：British journal of cancer

authors： Fear NT,Roman E,Carpenter LM,Newton R,Bull D

更新日期：1996-04-01 00:00:00

abstract：BACKGROUND:Epidemiological studies evaluating the association of vitamin B6, vitamin B12 and methionine with breast cancer risk have produced inconsistent results. METHODS:Pertinent studies were identified by a search in PubMed and Web of Knowledge. Random-effect model was used. Dose-response relationship was assessed...

journal_title：British journal of cancer

authors： Wu W,Kang S,Zhang D

更新日期：2013-10-01 00:00:00

abstract：:Targeting growth-regulatory pathways is a promising approach in cancer treatment. A prerequisite to the development of such therapies is characterisation of tumour growth regulation in the particular tumour cell type of interest. In order to gain insight into molecular mechanisms underlying proliferative responses in ...

journal_title：British journal of cancer

authors： Hofsli E,Thommesen L,Yadetie F,Langaas M,Kusnierczyk W,Falkmer U,Sandvik AK,Laegreid A

更新日期：2005-04-25 00:00:00

abstract：:A long term follow-up study has been undertaken in 33 patients with acute non-lymphoblastic leukaemia (ANLL) in order to establish whether a correlation exists between the clinical course and the immunologic pattern of lymphoid subpopulations. Peripheral blood lymphoid cells have been investigated longitudinally (each...

journal_title：British journal of cancer

authors： Pizzolo G,Trentin L,Vinante F,Agostini C,Zambello R,Masciarelli M,Feruglio C,Dazzi F,Todeschini G,Chilosi M

更新日期：1988-09-01 00:00:00

abstract：BACKGROUND:Older women have lower breast cancer surgery rates than younger women. UK policy states that differences in cancer treatment by age can only be justified by patient choice or poor health. METHODS:We investigate whether lack of surgery for older patients is explained by patient choice/poor health in a prospe...

journal_title：British journal of cancer

authors： Lavelle K,Sowerbutts AM,Bundred N,Pilling M,Degner L,Stockton C,Todd C

更新日期：2014-02-04 00:00:00

abstract：BACKGROUND:A dose-dense strategy has been considered to improve results of adjuvant chemotherapy for breast cancer. This randomised phase II trial investigated the feasibility of this approach with sequential anthracyclines and taxanes-based chemotherapy. METHODS:Patients with high-risk node-positive breast cancer wer...

journal_title：British journal of cancer

authors： Brain E,Levy C,Serin D,Roché H,Spielmann M,Delva R,Veyret C,Mauriac L,Rios M,Martin AL,Jimenez M,Asselain B,Gauthier M,Bonnetain F,Fumoleau P

更新日期：2011-11-08 00:00:00

abstract：BACKGROUND:A combination of S-1 and cisplatin has been shown to be effective with acceptable safety for the first-line treatment of far-advanced gastric cancer in Japan. This is the first randomised phase II trial to compare S-1+paclitaxel with S-1+cisplatin in this setting. METHODS:Patients with unresectable and/or r...

journal_title：British journal of cancer

authors： Mochiki E,Ogata K,Ohno T,Toyomasu Y,Haga N,Fukai Y,Aihara R,Ando H,Uchida N,Asao T,Kuwano H,North Kanto Gastric Cancer Study Group.

更新日期：2012-06-26 00:00:00

abstract：:We investigated whether lower birth weight was associated with lower risk of melanoma later in life. This population-based case-control study included all incident cases of histologically verified invasive melanoma diagnosed until 31 December 2003 in the Norwegian population born between 1967 and 1986 (n=709). The con...

journal_title：British journal of cancer

authors： Franco-Lie I,Iversen T,Robsahm TE,Abdelnoor M

更新日期：2008-01-15 00:00:00

abstract：:The toxicity produced by two courses of methotrexate separated by different intervals has been studied in matched groups of rats. The maximum degree of neutropenia reached when courses were separated by 8 days or more was no greater than that seen after a single course of methotrexate. However, when courses of neutrop...

journal_title：British journal of cancer

authors： Harding B,Culvenor J,MacLennan IC

更新日期：1977-01-01 00:00:00

abstract：:Urokinase plasminogen activator (uPA) is a serine protease involved in cancer invasion and metastasis. uPA acts in vivo by binding to a membrane receptor known as uPAR. In this study, uPA and uPAR levels were semiquantitated by immunocytochemistry in 36 primary breast carcinomas. Using monoclonal antibody HD-UK 1, uPA...

journal_title：British journal of cancer

authors： Kennedy S,Duffy MJ,Duggan C,Barnes C,Rafferty R,Kramer MD

更新日期：1998-05-01 00:00:00

abstract：:The death certificate only (DCO) index, which quantifies the proportion of patients for whom the death certificate provides the only notification to the registry, is a widely used measure of incompleteness of population-based cancer registration. This paper provides an algebraic assessment and a quantitative illustrat...

journal_title：British journal of cancer

authors： Brenner H

更新日期：1995-08-01 00:00:00

abstract：:The integrin alpha(v)beta6 is not detectable on normal keratinocytes in vivo but expression is increased significantly in oral squamous cell carcinoma where this heterodimer has been shown to play a role in cell migration, invasion and protease expression. Although regarded initially as a fibronectin receptor, alpha(v...

journal_title：British journal of cancer

authors： Thomas GJ,Hart IR,Speight PM,Marshall JF

更新日期：2002-10-07 00:00:00

abstract：:Tumour-associated prostaglandin-like material, assessed by bioassay, has been examined in 37 patients with primary and metastatic squamous carcinomas of the head and neck, previously treated by radiotherapy and chemotherapy followed by radical surgery. High amounts of prostaglandin-like material were extracted from tu...

journal_title：British journal of cancer

authors： Bennett A,Carter RL,Stamford IF,Tanner NS

更新日期：1980-02-01 00:00:00

abstract：:The work presented here has concerned the study of early, as well as late, enzymic changes occurring during diethylnitrosamine-induced hepatocarcinogenesis and liver regeneration after partial hepatectomy in comparison with normal liver differentiation. Rank correlation analysis of the enzyme data suggested a step-wis...

journal_title：British journal of cancer

authors： Curtin NJ,Snell K

更新日期：1983-10-01 00:00:00

abstract：:The risk for sinonasal cancer associated with tobacco use was examined in a case-control study in males diagnosed between 1978 and 1981 in the Netherlands. Of the 116 cases of sinonasal cancer and 259 controls identified, interviews were completed for 92 (79%) of the cases and 195 (75%) of the controls. Ever-users of ...

journal_title：British journal of cancer

authors： Hayes RB,Kardaun JW,de Bruyn A

更新日期：1987-12-01 00:00:00

abstract：:Fifty-one patients with advanced non-small cell lung carcinoma were treated with a combination of mitomycin C, vinblastine and cis-platin (MVP). Most cycles were given on an out-patient basis. Major side effects were leukopenia and peripheral neurotoxicity; one patient died of sepsis while leukopenic. In 44 evaluable ...

journal_title：British journal of cancer

authors： Giaccone G,Bagatella M,Donadio M,Bonardi GM,Testore F,Ferrati P,Ciuffreda L,Calciati A

更新日期：1987-10-01 00:00:00

abstract：:Cellular senescence is an established tumour-suppressive mechanism that prevents the proliferation of premalignant cells. However, several lines of evidence show that senescent cells, which often persist in vivo, can also promote tumour progression in addition to other age-related pathologies via the senescence-associ...

journal_title：British journal of cancer

authors： Lecot P,Alimirah F,Desprez PY,Campisi J,Wiley C

更新日期：2016-05-24 00:00:00

abstract：:A chelating derivative of alpha-melanocyte stimulating hormone (MSH) has been synthesised, in which two molecules of the hormone are cross-linked by diethylenetriamine pentaacetic acid (DTPA). This compound, bisMSH-DTPA, was equipotent with MSH in an in vitro tyrosinase assay with Cloudman S91 melanoma cells. When DBA...

journal_title：British journal of cancer

authors： Bard DR,Knight CG,Page-Thomas DP

更新日期：1990-12-01 00:00:00