High rate of extra-haematological toxicity compromises dose-dense sequential adjuvant chemotherapy for breast cancer.


BACKGROUND:A dose-dense strategy has been considered to improve results of adjuvant chemotherapy for breast cancer. This randomised phase II trial investigated the feasibility of this approach with sequential anthracyclines and taxanes-based chemotherapy. METHODS:Patients with high-risk node-positive breast cancer were treated with three cycles of fluorouracil 500 mg m(-2), epirubicin 100 mg m(-2), cyclophosphamide 500 mg m(-2) (FEC 100) followed by three cycles of docetaxel 100 mg m(-2) delivered at 2-weekly intervals supported by primary prophylaxis with filgrastim. All patients were randomised to either uninterrupted treatment (arm A) or to have a 2-week additional period of rest between the FEC and docetaxel (arm B). The primary endpoint was the rate of success of chemotherapy delivery. Using a two-stage Fleming design, 120 patients were required with one interim analysis. RESULTS:In March 2005, enrolment was stopped into arm A after the observation of severe skin toxicities. Following the planned interim analysis, the study was closed because of the high rate of grade 3/4 skin toxicities in both arms (arm A: 32.4% and arm B: 18.9%). CONCLUSION:Sequential dose-dense FEC 100 followed by docetaxel 100 mg m(-2) is not feasible. Feasibility still depends largely on several factors including the choice of drugs, dosage and sequence of administration.


Br J Cancer


Brain E,Levy C,Serin D,Roché H,Spielmann M,Delva R,Veyret C,Mauriac L,Rios M,Martin AL,Jimenez M,Asselain B,Gauthier M,Bonnetain F,Fumoleau P




Has Abstract


2011-11-08 00:00:00














  • Phenotypic effects of overexpression of the MMAC1 gene in prostate epithelial cells.

    abstract::The prostate cancer cell lines PC3 and LNCaP have been shown to lack expression of the tumour suppressor gene MMAC1/PTEN, in contrast to the immortalized non-tumorigenic epithelial lines PNT1a and PNT2. We have measured the effects of reintroduction of wild type (wt) and mutant MMAC1 genes on to these genetic backgrou...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Sharrard RM,Maitland NJ

    更新日期:2000-10-01 00:00:00

  • Combination versus sequential single agent chemotherapy in advanced breast cancer: associations with metastatic sites and long-term survival. The Western Cancer Study Group and The Southeastern Cancer Study Group.

    abstract::Two hundred and twenty-two patients with advanced breast cancer were randomised in two separate trials of similar design to either concomitant combination treatment or sequential use of the same drugs given as single agents changed only at disease progression. Both trials used cyclophosphamide, methotrexate, 5-fluorou...

    journal_title:British journal of cancer

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Chlebowski RT,Smalley RV,Weiner JM,Irwin LE,Bartolucci AA,Bateman JR

    更新日期:1989-02-01 00:00:00

  • KSHV infection skews macrophage polarisation towards M2-like/TAM and activates Ire1 α-XBP1 axis up-regulating pro-tumorigenic cytokine release and PD-L1 expression.

    abstract:BACKGROUND:Kaposi's Sarcoma Herpesvirus (KSHV) is a gammaherpesvirus strongly linked to human cancer. The virus is also able to induce immune suppression, effect that contributes to onset/progression of the viral-associated malignancies. As KSHV may infect macrophages and these cells abundantly infiltrate Kaposi's sarc...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Gilardini Montani MS,Falcinelli L,Santarelli R,Granato M,Romeo MA,Cecere N,Gonnella R,D'Orazi G,Faggioni A,Cirone M

    更新日期:2020-07-01 00:00:00

  • Rare BRAF mutations in melanoma patients: implications for molecular testing in clinical practice.

    abstract:BACKGROUND:The detection of V600E BRAF mutation in melanoma is fundamental since here BRAF inhibitors represent an effective treatment. Non-V600E BRAF mutations that may also respond are not detected by certain screening methods. Thus, knowledge about detection of these mutations is needed. METHODS:A total of 276 tumo...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Heinzerling L,Kühnapfel S,Meckbach D,Baiter M,Kaempgen E,Keikavoussi P,Schuler G,Agaimy A,Bauer J,Hartmann A,Kiesewetter F,Schneider-Stock R

    更新日期:2013-05-28 00:00:00

  • Increasingly strong reduction in breast cancer mortality due to screening.

    abstract:BACKGROUND:Favourable outcomes of breast cancer screening trials in the 1970s and 1980s resulted in the launch of population-based service screening programmes in many Western countries. We investigated whether improvements in mammography and treatment modalities have had an influence on the effectiveness of breast can...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: van Schoor G,Moss SM,Otten JD,Donders R,Paap E,den Heeten GJ,Holland R,Broeders MJ,Verbeek AL

    更新日期:2011-03-15 00:00:00

  • Cytogenetic study in therapy-related myelodysplastic syndromes (t-MDS) and acute non-lymphocytic leukaemia (t-ANLL).

    abstract::A cytogenetic study was performed in 27 patients suspected of t-MDS or t-ANLL. In 12 patients the diagnosis of t-MDS or t-ANLL was confirmed by morphological, cytochemical and immunophenotypical analysis. The cases were classified as RA (one), RAEB (four), CMML (two), ANLL (five). They had received chemotherapy and/or...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Sozzi G,Miozzo M,Orazi A,Calderone C,Castellano M,Viviani S,Santoro A,Pierotti MA,Della Porta G

    更新日期:1990-03-01 00:00:00

  • Establishing long-term survival and cure in young patients with Ewing's sarcoma.

    abstract::This paper investigates the potential for long-term survivorship for young patients diagnosed with Ewing's sarcoma. Data are examined from two successive UKCCSG Ewing's Tumour studies (ET-1 and ET-2). Patients have been followed for up to 20 years. These studies had suggested that better 5-year survival with ET-2 over...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Weston CL,Douglas C,Craft AW,Lewis IJ,Machin D

    更新日期:2004-07-19 00:00:00

  • Discovery of serum biomarkers for pancreatic adenocarcinoma using proteomic analysis.

    abstract:BACKGROUND AND AIMS:The serum/plasma proteome was explored for biomarkers to improve the diagnostic ability of CA19-9 in pancreatic adenocarcinoma (PC). METHODS:A Training Set of serum samples from 20 resectable and 18 stage IV PC patients, 54 disease controls (DCs) and 68 healthy volunteers (HVs) were analysed by sur...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Xue A,Scarlett CJ,Chung L,Butturini G,Scarpa A,Gandy R,Wilson SR,Baxter RC,Smith RC

    更新日期:2010-07-27 00:00:00

  • BRCA1 mutations and other sequence variants in a population-based sample of Australian women with breast cancer.

    abstract::The frequency, in women with breast cancer, of mutations and other variants in the susceptibility gene, BRCA1, was investigated using a population-based case-control-family study. Cases were women living in Melbourne or Sydney, Australia, with histologically confirmed, first primary, invasive breast cancer, diagnosed ...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Southey MC,Tesoriero AA,Andersen CR,Jennings KM,Brown SM,Dite GS,Jenkins MA,Osborne RH,Maskiell JA,Porter L,Giles GG,McCredie MR,Hopper JL,Venter DJ

    更新日期:1999-01-01 00:00:00

  • Induction of the growth arrest and DNA damage-inducible gene GADD153 by cisplatin in vitro and in vivo.

    abstract::The inability to assess the extent of tumour damage immediately following treatment is a major clinical obstacle to improving the management of cancer patients. Normally, the effectiveness of chemotherapy or radiation therapy cannot be determined for at least several weeks after treatment. We studied the increase in m...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Gately DP,Jones JA,Christen R,Barton RM,Los G,Howell SB

    更新日期:1994-12-01 00:00:00

  • Anti-emetic efficacy and toxicity of nabilone, a synthetic cannabinoid, in lung cancer chemotherapy.

    abstract::Nabilone, a synthetic cannabinoid, and Prochlorperazine were compared in a double-blind crossover study of 34 patients with lung cancer undergoing a 3-day schedule of chemotherapy with Cyclophosphamide, Adriamycin and Etoposide. Symptom scores were significantly better for patients on nabilone for nausea, retching and...

    journal_title:British journal of cancer

    pub_type: 临床试验,杂志文章


    authors: Ahmedzai S,Carlyle DL,Calder IT,Moran F

    更新日期:1983-11-01 00:00:00

  • A case-control study of head and neck cancer in the Republic of Ireland.

    abstract::A retrospective case-control study of 200 patients with head and neck cancer, and 200 controls matched for age and sex, confirmed the importance of tobacco and alcohol consumption in the aetiology of malignant tumours of the upper gastrointestinal and upper respiratory tracts. A male-female ratio of 3:1 was found, and...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Herity B,Moriarty M,Bourke GJ,Daly L

    更新日期:1981-02-01 00:00:00

  • A humanised anti-IGF-1R monoclonal antibody (AVE1642) enhances Bortezomib-induced apoptosis in myeloma cells lacking CD45.

    abstract::The humanised form of an antagonistic anti-IGF-1R mAb (AVE1642) selectively inhibits the growth of CD45(neg) myeloma cells. AVE1642 strongly increased bortezomib-induced apoptosis, correlated with an increase of Noxa expression. These results support the therapeutic use of anti-IGF-1R/bortezomib in CD45(neg) Myeloma p...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Descamps G,Gomez-Bougie P,Venot C,Moreau P,Bataille R,Amiot M

    更新日期:2009-01-27 00:00:00

  • Soya foods and breast cancer risk: a prospective study in Hiroshima and Nagasaki, Japan.

    abstract::The association between soya foods and breast cancer risk was investigated in a prospective study of 34759 women in Hiroshima and Nagasaki, Japan. Women completed dietary questionnaires in 1969-1970 and/or in 1979-1981 and were followed for incident breast cancer until 1993. The analysis involved 427 cases of primary ...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Key TJ,Sharp GB,Appleby PN,Beral V,Goodman MT,Soda M,Mabuchi K

    更新日期:1999-12-01 00:00:00

  • Bosutinib plus capecitabine for selected advanced solid tumours: results of a phase 1 dose-escalation study.

    abstract:BACKGROUND:This phase 1 study evaluated the maximum tolerated dose (MTD), safety, and efficacy of bosutinib (competitive Src/Abl tyrosine kinase inhibitor) plus capecitabine. METHODS:Patients with locally advanced/metastatic breast, pancreatic, or colorectal cancers; cholangiocarcinoma; or glioblastoma received bosuti...

    journal_title:British journal of cancer

    pub_type: 杂志文章,多中心研究


    authors: Isakoff SJ,Wang D,Campone M,Calles A,Leip E,Turnbull K,Bardy-Bouxin N,Duvillié L,Calvo E

    更新日期:2014-11-25 00:00:00

  • Inhibition of the deubiquitinase USP10 induces degradation of SYK.

    abstract:BACKGROUND:There is growing evidence that spleen tyrosine kinase (SYK) is critical for acute myeloid leukaemia (AML) transformation and maintenance of the leukemic clone in AML patients. It has also been found to be over-expressed in AML patients, with activating mutations in foetal liver tyrosine kinase 3 (FLT3), part...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Yang J,Meng C,Weisberg E,Case A,Lamberto I,Magin RS,Adamia S,Wang J,Gray N,Liu S,Stone R,Sattler M,Buhrlage S,Griffin JD

    更新日期:2020-04-01 00:00:00

  • p53 mutations as a marker of malignancy in bladder washing samples from patients with bladder cancer.

    abstract::The diagnosis and follow-up of patients with bladder cancer rely on invasive procedures (cystoscopy with biopsy). Polymerase chain reaction (PCR)-based technologies may allow the sensitive detection of cancer-related genetic mutations in exfoliated tumour material, potentially allowing the development of less invasive...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Phillips HA,Howard GC,Miller WR

    更新日期:2000-01-01 00:00:00

  • CXCL9 induces chemotaxis, chemorepulsion and endothelial barrier disruption through CXCR3-mediated activation of melanoma cells.

    abstract:BACKGROUND:Metastasis is associated with poor prognosis for melanoma. The formation of metastases is a multi-step process, in which cancer cells can subsequently acquire the potential to intravasate into the blood or lymph vessels, disseminate through the circulation, extravasate through the endothelium and invade the ...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Amatschek S,Lucas R,Eger A,Pflueger M,Hundsberger H,Knoll C,Grosse-Kracht S,Schuett W,Koszik F,Maurer D,Wiesner C

    更新日期:2011-02-01 00:00:00

  • Mutagenicity of comfrey (Symphytum Officinale) in rat liver.

    abstract::Comfrey is a rat liver toxin and carcinogen that has been used as a vegetable and herbal remedy by humans. In order to evaluate the mechanisms underlying its carcinogenicity, we examined the mutagenicity of comfrey in the transgenic Big Blue rat model. Our results indicate that comfrey is mutagenic in rat liver and th...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Mei N,Guo L,Fu PP,Heflich RH,Chen T

    更新日期:2005-03-14 00:00:00

  • Characterization of radiation resistant hypoxic cell subpopulations in KHT sarcomas. (II). Cell sorting.

    abstract::Hypoxic cells in KHT sarcomas were characterized using fluorescence activated cell sorting based on the diffusion properties of the fluorochrome Hoechst 33342. Tumour-bearing female C3H/HeJ mice were injected i.v. with 10 micrograms g-1 Hoechst 33342 and the cells derived from the tumours sorted on the basis of their ...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Siemann DW,Keng PC

    更新日期:1988-09-01 00:00:00

  • Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array.

    abstract:BACKGROUND:Germline mutations within DNA-repair genes are implicated in susceptibility to multiple forms of cancer. For prostate cancer (PrCa), rare mutations in BRCA2 and BRCA1 give rise to moderately elevated risk, whereas two of B100 common, low-penetrance PrCa susceptibility variants identified so far by genome-wid...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Saunders EJ,Dadaev T,Leongamornlert DA,Al Olama AA,Benlloch S,Giles GG,Wiklund F,Gronberg H,Haiman CA,Schleutker J,Nordestgaard BG,Travis RC,Neal D,Pasayan N,Khaw KT,Stanford JL,Blot WJ,Thibodeau SN,Maier C,Kibel AS

    更新日期:2016-04-12 00:00:00

  • Importance of P450 reductase activity in determining sensitivity of breast tumour cells to the bioreductive drug, tirapazamine (SR 4233).

    abstract::P450 reductase (NADPH:cytochrome P450 reductase, EC is known to be important in the reductive activation of the benzotriazene-di-N-oxide tirapazamine (SR 4233). Using a panel of six human breast adenocarcinoma cell lines we have examined the relationship between P450 reductase activity and sensitivity to tira...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Patterson AV,Barham HM,Chinje EC,Adams GE,Harris AL,Stratford IJ

    更新日期:1995-11-01 00:00:00

  • Ki 67 is a major, but not the sole determinant of Oncotype Dx recurrence score.

    abstract:BACKGROUND:Immunohistological assessment of Ki 67 expression is less expensive than Oncotype Dx, which is currently used to identify patients with lymph node-negative breast cancer, who will benefit from adjuvant chemotherapy. METHODS:The relationship of immunohistologically measured Ki 67 to Oncotype DX recurrence sc...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Sahebjam S,Aloyz R,Pilavdzic D,Brisson ML,Ferrario C,Bouganim N,Cohen V,Miller WH Jr,Panasci LC

    更新日期:2011-10-25 00:00:00

  • A phase I dose-finding and pharmacokinetic study of subcutaneous semisynthetic homoharringtonine (ssHHT) in patients with advanced acute myeloid leukaemia.

    abstract::To determine the maximum-tolerated dose (MTD), dose-limiting toxicities and pharmacokinetic of semisynthetic homoharringtonine (ssHHT), given as a twice daily subcutaneous (s.c.) injections for 9 days, in patients with advanced acute leukaemia, 18 patients with advanced acute myeloid leukaemia were included in this se...

    journal_title:British journal of cancer

    pub_type: 杂志文章,随机对照试验


    authors: Lévy V,Zohar S,Bardin C,Vekhoff A,Chaoui D,Rio B,Legrand O,Sentenac S,Rousselot P,Raffoux E,Chast F,Chevret S,Marie JP

    更新日期:2006-08-07 00:00:00

  • Expression of tissue inhibitor of metalloproteinases TIMP-2 in human colorectal cancer--a predictor of tumour stage.

    abstract::The aim of this study was to investigate whether immunohistochemical staining patterns of tissue inhibitor of metalloproteinases TIMP-2 and matrix metalloproteinases MMP-2 and MMP-9 can be predictors of tumour stage and survival time in colorectal cancer. Frozen tumour sections from 212 patients operated on between Ja...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Ring P,Johansson K,Höyhtyä M,Rubin K,Lindmark G

    更新日期:1997-01-01 00:00:00

  • Continued inadequacies in data sources for the evaluation of cancer services.

    abstract::There is a need to evaluate cancer services and provide a baseline on current treatment success and organization. This study shows that this process may be severely hindered by case note destruction or inaccessibility and incomplete information. This is an ongoing problem that needs to be addressed now. ...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Smith SJ,Muir KR,Wolstenholme JL,Thornhill KG,Zamorski A,Tolley K,Logan RF,Chilvers CE

    更新日期:1997-01-01 00:00:00

  • Endometrial cancer risk factors among Lynch syndrome women: a retrospective cohort study.

    abstract:BACKGROUND:Lynch syndrome (LS) is associated with a significant lifetime risk of endometrial cancer (EC). There are limited data on factors modifying the EC risk in LS patients. METHODS:The study cohort included 136 LS mutation-positive women. Exposure data were collected by postal questionnaires. Cox regression model...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Staff S,Aaltonen M,Huhtala H,Pylvänäinen K,Mecklin JP,Mäenpää J

    更新日期:2016-07-26 00:00:00

  • Tumour and cellular localization by use of monoclonal and polyclonal antibodies to placental alkaline phosphatase.

    abstract::Monoclonal and polyclonal antibodies against placental alkaline phosphatase (PLAP) were evaluated for tumour immunolocalization of human PLAP-producing Hep 2 tumours in nude mice. The antibodies were labelled with 125I and injected i.p. in mice with developing Hep 2 tumours. The distribution of 125I-anti PLAP in vario...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Jeppsson A,Wahren B,Millán JL,Stigbrand T

    更新日期:1984-02-01 00:00:00

  • Activity of high-dose epirubicin combined with gemcitabine in advanced non-small-cell lung cancer: a multicenter phase I and II study.

    abstract::The aim of the study was to evaluate efficacy and tolerance of epirubicin and gemcitabine as first-line chemotherapy in patients with advanced non-small-cell lung cancer. A phase I study was performed with the combination of escalating doses of epirubicin intravenously on day 1 and a fixed dose of gemcitabine on days ...

    journal_title:British journal of cancer

    pub_type: 临床试验,杂志文章,多中心研究


    authors: van Putten JW,Eppinga P,Erjavec Z,de Leede G,Nabers J,Smeets JB,Th Sleijfer D,Groen HJ

    更新日期:2000-02-01 00:00:00

  • Vascular function and the probability of skin necrosis after photodynamic therapy: an experimental study.

    abstract::The clearance of an intradermally-injected solution of 133Xenon in 0.9% saline has been used to study the impairment and recovery of blood flow in mouse tail for 5 days following photodynamic therapy (PDT) with 2mg TPPS i.v. per mouse and a range of doses of white light. Impairment of blood flow was observed within 10...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Benstead K,Moore JV

    更新日期:1988-05-01 00:00:00