当前位置： SCI文献检索 > BRITISH JOURNAL OF CANCER期刊下所有文献 > Validation of a novel diagnostic standard in HPV-positive oropharyngeal squamous cell carcinoma.

Validation of a novel diagnostic standard in HPV-positive oropharyngeal squamous cell carcinoma.

Abstract：

BACKGROUND:Human papillomavirus (HPV) testing in oropharyngeal squamous cell carcinoma (OPSCC) is now advocated. Demonstration of transcriptionally active high-risk HPV (HR-HPV) in fresh tumour tissue is considered to be the analytical 'gold standard'. Clinical testing has focused on formalin-fixed paraffin-embedded (FFPE) tissue at the expense of sensitivity and specificity. Recently, a novel RNA in situ hybridisation test (RNAscope) has been developed for the detection of HR-HPV in FFPE tissue; however, validation against the 'gold standard' has not been reported. METHODS:A tissue microarray comprising FFPE cores from 79 OPSCC was tested using HR-HPV RNAscope. Analytical accuracy and prognostic capacity were established by comparison with the reference test; qRT-PCR for HR-HPV on matched fresh-frozen samples. RESULTS:High-risk HPV RNAscope had a sensitivity and specificity of 97 and 93%, respectively, against the reference test. Kaplan-Meier estimates of disease-specific survival (DSS, P=0.001) and overall survival (OS, P<0.001) by RNAscope were similar to the reference test (DSS, P=0.003, OS, P<0.001) and at least, not inferior to p16 immunohistochemistry +/- HR-HPV DNA-based tests. CONCLUSION:HR-HPV RNAscope demonstrates excellent analytical and prognostic performance against the 'gold standard'. These data suggest that the test could be developed to provide the 'clinical standard' for assigning a diagnosis of HPV-related OPSCC.

journal_name

Br J Cancer

journal_title

British journal of cancer

authors

Schache AG,Liloglou T,Risk JM,Jones TM,Ma XJ,Wang H,Bui S,Luo Y,Sloan P,Shaw RJ,Robinson M

doi

10.1038/bjc.2013.63

subject

Has Abstract

pub_date

2013-04-02 00:00:00

pages

1332-9

issue

6

eissn

0007-0920

issn

1532-1827

pii

bjc201363

journal_volume

108

pub_type

杂志文章

相关文献

BRITISH JOURNAL OF CANCER文献大全
  • Angiotensin II type 1 receptor expression in ovarian cancer and its correlation with tumour angiogenesis and patient survival.

    abstract：:Angiotensin II, a main effector peptide in the renin-angiotensin system, acts as a growth-promoting and angiogenic factor via type 1 angiotensin II receptors (AT(1)R). We have recently demonstrated that angiotensin II enhanced tumour cell invasion and vascular endothelial growth factor (VEGF) secretion via AT1R in ova...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6602961

    authors： Ino K,Shibata K,Kajiyama H,Yamamoto E,Nagasaka T,Nawa A,Nomura S,Kikkawa F

    更新日期：2006-02-27 00:00:00

  • Effect of eicosapentaenoic acid and other fatty acids on the growth in vitro of human pancreatic cancer cell lines.

    abstract：:A number of polyunsaturated fatty acids have been shown to inhibit the growth of malignant cells in vitro. To investigate whether fatty acids modify the growth of human pancreatic cancer, lauric, stearic, palmitic, oleic, linoleic, alpha-linolenic, gamma-linolenic, arachidonic, docosahexaenoic and eicosapentaenoic (EP...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1994.161

    authors： Falconer JS,Ross JA,Fearon KC,Hawkins RA,O'Riordain MG,Carter DC

    更新日期：1994-05-01 00:00:00

  • Proto-oncogenic isoform A2 of eukaryotic translation elongation factor eEF1 is a target of miR-663 and miR-744.

    abstract：BACKGROUND:Eukaryotic translation elongation factor 1A2 (eEF1A2) is a known proto-oncogene. We proposed that stimulation of the eEF1A2 expression in cancer tissues is caused by the loss of miRNA-mediated control. METHODS:Impact of miRNAs on eEF1A2 at the mRNA and protein levels was examined by qPCR and western blot, r...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2013.243

    authors： Vislovukh A,Kratassiouk G,Porto E,Gralievska N,Beldiman C,Pinna G,El'skaya A,Harel-Bellan A,Negrutskii B,Groisman I

    更新日期：2013-06-11 00:00:00

  • Intraarterial chemotherapy as the first-line therapy in penile cancer.

    abstract：BACKGROUND:Limited literature on the role of intraarterial chemotherapy as first-line therapy for penile squamous cell carcinoma is available. METHODS:From 2005 to 2013, a total of 12 patients with various stages of penile squamous cell carcinoma received intraarterial chemotherapy. The chemotherapeutic agents used we...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2014.394

    authors： Chiang PH,Chen CH,Shen YC

    更新日期：2014-09-09 00:00:00

  • Anxiety in women "at risk' of developing breast cancer.

    abstract：:Do family history clinics offering counselling, surveillance and preventative programmes alleviate or exacerbate anxiety in women at a high risk of developing breast cancer? In this study risk perceptions and anxiety of 99 'at risk' women participating in the Tamoxifen Prevention Trial were compared with those of 87 '...

    journal_title：British journal of cancer

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1038/bjc.1996.269

    authors： Thirlaway K,Fallowfield L,Nunnerley H,Powles T

    更新日期：1996-06-01 00:00:00

  • Diagnostic accuracy systematic review of rectal bleeding in combination with other symptoms, signs and tests in relation to colorectal cancer.

    abstract：BACKGROUND:Rectal bleeding is a recognised early symptom of colorectal cancer. This study aimed to assess the diagnostic accuracy of symptoms, signs and diagnostic tests in patients with rectal bleeding in relation to risk of colorectal cancer in primary care. METHODS:Diagnostic accuracy systematic review. Medline (19...

    journal_title：British journal of cancer

    pub_type： 杂志文章,meta分析,评审

    doi：10.1038/sj.bjc.6605426

    authors： Olde Bekkink M,McCowan C,Falk GA,Teljeur C,Van de Laar FA,Fahey T

    更新日期：2010-01-05 00:00:00

  • Type 2 diabetes mellitus, blood cholesterol, triglyceride and colorectal cancer risk in Lynch syndrome.

    abstract：BACKGROUND:Type 2 diabetes mellitus and high total cholesterol and triglycerides are known to be associated with increased colorectal cancer risk for the general population. These associations are unknown for people with a germline DNA mismatch repair gene mutation (Lynch syndrome), who are at high risk of colorectal c...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/s41416-019-0580-9

    authors： Dashti SG,Li WY,Buchanan DD,Clendenning M,Rosty C,Winship IM,Macrae FA,Giles GG,Hardikar S,Hua X,Thibodeau SN,Figueiredo JC,Casey G,Haile RW,Gallinger S,Le Marchand L,Newcomb PA,Potter JD,Lindor NM,Hopper JL,Jenki

    更新日期：2019-11-01 00:00:00

  • EpCAM is overexpressed in local and metastatic prostate cancer, suppressed by chemotherapy and modulated by MET-associated miRNA-200c/205.

    abstract：BACKGROUND:Expression of epithelial cell adhesion molecule (EpCAM) is deregulated in epithelial malignancies. Beside its role in cell adhesion, EpCAM acts as signalling molecule with tumour-promoting functions. Thus, EpCAM is part of the molecular network of oncogenic receptors and considered an interesting therapeutic...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2014.366

    authors： Massoner P,Thomm T,Mack B,Untergasser G,Martowicz A,Bobowski K,Klocker H,Gires O,Puhr M

    更新日期：2014-08-26 00:00:00

  • Effects of Cremophor EL on distribution of Taxol to serum lipoproteins.

    abstract：:The clinical formulation of the anti-tumour agent Taxol involves the use of a mixture of ethanol and Cremophor EL. Gel electrophoresis and density-gradient ultracentrifugation were used to detect effects of Taxol infusions on serum lipoproteins. Use of the Cremophor vehicle results in a decrease in the electrophoretic...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1994.317

    authors： Sykes E,Woodburn K,Decker D,Kessel D

    更新日期：1994-09-01 00:00:00

  • Detection and prognostic role of heterogeneous populations of melanoma circulating tumour cells.

    abstract：BACKGROUND:Circulating tumour cells (CTCs) can be assessed through a minimally invasive blood sample with potential utility as a predictive, prognostic and pharmacodynamic biomarker. The large heterogeneity of melanoma CTCs has hindered their detection and clinical application. METHODS:Here we compared two microfluidi...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/s41416-020-0750-9

    authors： Aya-Bonilla CA,Morici M,Hong X,McEvoy AC,Sullivan RJ,Freeman J,Calapre L,Khattak MA,Meniawy T,Millward M,Ziman M,Gray ES

    更新日期：2020-03-01 00:00:00

  • Immunotherapy of acute myeloid leukaemia. Medical Research Council.

    abstract：:Seventy-one patients suffering from acute myeloid leukaemia (AML) who were already in complete remission and had already received one further course of cytotoxic drugs as consolidation therapy were randomised to receive maintenance chemotherapy alone or the same maintenance chemotherapy plus immunotherapy with BCG and...

    journal_title：British journal of cancer

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1038/bjc.1978.1

    authors：

    更新日期：1978-01-01 00:00:00

  • Effects of opioids on immunologic parameters that are relevant to anti-tumour immune potential in patients with cancer: a systematic literature review.

    abstract：BACKGROUND:The immune system has a central role in controlling cancer, and factors that influence protective antitumour immunity could therefore have a significant impact on the course of malignant disease. Opioids are essential for the management of cancer pain, and preclinical studies indicate that opioids have the p...

    journal_title：British journal of cancer

    pub_type： 杂志文章,评审

    doi：10.1038/bjc.2014.384

    authors： Boland JW,McWilliams K,Ahmedzai SH,Pockley AG

    更新日期：2014-08-26 00:00:00

  • One-step nucleic acid amplification assay is an accurate technique for sentinel lymph node biopsy of breast cancer patients: a meta-analysis.

    abstract：BACKGROUND:To estimate the accuracy of one-step nucleic acid amplification (OSNA) assay as an intra-operative sentinel lymph node biopsy (SLNB) for sentinel lymph node (SLN) metastasis in breast cancer. METHODS:PubMed, Cochrane Library and Web of Science databases were searched by two independent reviewers to retrieve...

    journal_title：British journal of cancer

    pub_type： 杂志文章,meta分析

    doi：10.1038/bjc.2017.262

    authors： Shi F,Zhang Q,Liang Z,Zhang M,Liu X

    更新日期：2017-10-10 00:00:00

  • Intrathecal treatment of neoplastic meningitis due to breast cancer with a slow-release formulation of cytarabine.

    abstract：:DepoCyte is a slow-release formulation of cytarabine designed for intrathecal administration. The goal of this multi-centre cohort study was to determine the safety and efficacy of DepoCyte for the intrathecal treatment of neoplastic meningitis due to breast cancer. DepoCyte 50 mg was injected once every 2 weeks for o...

    journal_title：British journal of cancer

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1054/bjoc.2000.1574

    authors： Jaeckle KA,Phuphanich S,Bent MJ,Aiken R,Batchelor T,Campbell T,Fulton D,Gilbert M,Heros D,Rogers L,O'Day SJ,Akerley W,Allen J,Baidas S,Gertler SZ,Greenberg HS,LaFollette S,Lesser G,Mason W,Recht L,Wong E,Chamber

    更新日期：2001-01-01 00:00:00

  • BRCA1 mutations and other sequence variants in a population-based sample of Australian women with breast cancer.

    abstract：:The frequency, in women with breast cancer, of mutations and other variants in the susceptibility gene, BRCA1, was investigated using a population-based case-control-family study. Cases were women living in Melbourne or Sydney, Australia, with histologically confirmed, first primary, invasive breast cancer, diagnosed ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6690008

    authors： Southey MC,Tesoriero AA,Andersen CR,Jennings KM,Brown SM,Dite GS,Jenkins MA,Osborne RH,Maskiell JA,Porter L,Giles GG,McCredie MR,Hopper JL,Venter DJ

    更新日期：1999-01-01 00:00:00

  • Birth characteristics and risk of Wilms' tumour: a nationwide prospective study in Norway.

    abstract：:Relationships between incidence of Wilms' tumour and information recorded at birth were investigated in a prospective study of the 1,489,297 children born in Norway between 1967 and 1992. A total of 119 individuals were diagnosed with Wilms' tumour in the age interval 0-14 years. A high length at birth was significant...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1996.505

    authors： Heuch JM,Heuch I,Kvåle G

    更新日期：1996-10-01 00:00:00

  • Malignant melanoma is genetically distinct from clear cell sarcoma of tendons and aponeurosis (malignant melanoma of soft parts).

    abstract：:Clear cell sarcoma of tendons and aponeuroses (malignant melanoma of soft parts) and conventional malignant melanoma may demonstrate significant morphologic overlap at the light microscopic and ultrastructural level. Consequently, the clinically relevant distinction between primary clear cell sarcoma and metastatic me...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1054/bjoc.2000.1628

    authors： Langezaal SM,Graadt van Roggen JF,Cleton-Jansen AM,Baelde JJ,Hogendoorn PC

    更新日期：2001-02-01 00:00:00

  • The suppression of fibroblast growth factor 2/fibroblast growth factor 4-dependent tumour angiogenesis and growth by the anti-growth factor activity of dextran derivative (CMDB7).

    abstract：:Our previous studies showed that carboxymethyl benzylamide dextran (CMDB7) blocks basic fibroblast growth factor (FGF-2)-dependent cell proliferation of a human breast epithelial line (HBL100), suggesting its potential role as a potent antiangiogenic substance. The derived cell line (HH9), which was transformed with t...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1998.451

    authors： Bagheri-Yarmand R,Kourbali Y,Mabilat C,Morère JF,Martin A,Lu H,Soria C,Jozefonvicz J,Crépin M

    更新日期：1998-07-01 00:00:00

  • Breast density and outcome of mammography screening: a cohort study.

    abstract：:The purpose of this study was to investigate the effect of breast density on breast cancer (BC) mortality in a mammography screening programme. The cohort included 48 052 women participating in mammography screening in Copenhagen, Denmark, where biennial screening is offered to women aged 50-69 years. We collected inf...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6604989

    authors： Olsen AH,Bihrmann K,Jensen MB,Vejborg I,Lynge E

    更新日期：2009-04-07 00:00:00

  • Second primary cancers of the breast: incidence and risk factors.

    abstract：:Between 1946 and 1976 over 9,000 women with breast cancer were seen within one year of diagnosis at the A. Maxwell Evans Clinic (AMEC) in Vancouver, British Columbia. By 1978, 275 had a subsequent diagnosis of a second primary in the contralateral breast: 100 were diagnosed within 1 year, and 175 after 1 year of the f...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1984.12

    authors： Hislop TG,Elwood JM,Coldman AJ,Spinelli JJ,Worth AJ,Ellison LG

    更新日期：1984-01-01 00:00:00

  • MDM2 gene amplification and expression in non-small-cell lung cancer: immunohistochemical expression of its protein is a favourable prognostic marker in patients without p53 protein accumulation.

    abstract：:MDM2 is an oncoprotein that inhibits p53 tumour-suppressor protein. Amplification of the MDM2 gene and overexpression of its protein have been observed in some human malignancies, and these abnormalities have a role in tumorigenesis through inactivation of p53 function. To determine the clinicopathological and prognos...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1997.221

    authors： Higashiyama M,Doi O,Kodama K,Yokouchi H,Kasugai T,Ishiguro S,Takami K,Nakayama T,Nishisho I

    更新日期：1997-01-01 00:00:00

  • Elevated serum insulin-like growth factor (IGF)-II and IGF binding protein-2 in patients with colorectal cancer.

    abstract：:This study explored the relationships of serum insulin-like growth factors, IGF-I and IGF-II, and their binding proteins (IGFBP)-2 and IGFBP-3, with key clinicopathological parameters in 92 patients with colorectal cancer (cases). Comparisons were made with 57 individuals who had a normal colonoscopy (controls). Seria...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1054/bjoc.2000.1462

    authors： Renehan AG,Jones J,Potten CS,Shalet SM,O'Dwyer ST

    更新日期：2000-11-01 00:00:00

  • Evaluation of dimethylhydrazine induced tumours in mice as a model system for colorectal cancer.

    abstract：:The evolution and structure of adenomatous polyps and adenocarcinomata of the colon in NMRI mice induced by dimethylhydrazine are described. Severe toxic reactions in the liver and other organs are produced by dimethylhydrazine (DMH), but tumours are induced only in the colon and around the anus. The 100% incidence an...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1973.183

    authors： Haase P,Cowen DM,Knowles JC,Cooper EH

    更新日期：1973-12-01 00:00:00

  • Promoting patient participation and shortening cancer consultations: a randomised trial.

    abstract：:Patient participation in medical consultations has been demonstrated to benefit their subsequent psychological well being. Question asking is one way in which patients can be active. We investigated 2 means of promoting cancer patient question asking. One was the provision of a question prompt sheet to patients prior ...

    journal_title：British journal of cancer

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1054/bjoc.2001.2073

    authors： Brown RF,Butow PN,Dunn SM,Tattersall MH

    更新日期：2001-11-02 00:00:00

  • Role of prolactin receptor and CD25 in protection of circulating T lymphocytes from apoptosis in patients with breast cancer.

    abstract：:Prolactin (PRL) has been reported to inhibit apoptosis in various cell types and to serve as a cofactor in the upregulation of CD25 on T cells during activation. We investigated a possible relation between prolactin receptor (PRL-R) or IL-2 receptor alpha (IL-2Ralpha, CD25) expression on circulating T lymphocytes and ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6600860

    authors： Bauernhofer T,Kuss I,Friebe-Hoffmann U,Baum AS,Dworacki G,Vonderhaar BK,Whiteside TL

    更新日期：2003-04-22 00:00:00

  • miR-23a promotes IKKα expression but suppresses ST7L expression to contribute to the malignancy of epithelial ovarian cancer cells.

    abstract：BACKGROUND:Dysregulation of microRNAs (miRNAs) has been found in human epithelial ovarian cancer (EOC). However, the role and mechanism of action of miR-23a in EOC remain unclear. METHODS:The roles of miR-23a, IKKα, and ST7L in EOC were determined by MTT, colony formation, wounding healing, transwell, flow cytometry, ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2016.244

    authors： Yang Z,Wang XL,Bai R,Liu WY,Li X,Liu M,Tang H

    更新日期：2016-09-06 00:00:00

  • Analysis of differential gene expression in human melanocytic tumour lesions by custom made oligonucleotide arrays.

    abstract：:Melanoma is one of the most aggressive types of cancer and resection of the tumour prior to dissemination of tumour cells is still the most effective treatment. Therefore, early diagnosis of melanocytic lesions is important and identification of novel (molecular) markers would be helpful to improve diagnosis. Moreover...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6602612

    authors： de Wit NJ,Rijntjes J,Diepstra JH,van Kuppevelt TH,Weidle UH,Ruiter DJ,van Muijen GN

    更新日期：2005-06-20 00:00:00

  • Angiogenesis is associated with the onset of hyperplasia in human ductal breast disease.

    abstract：BACKGROUND:The precise timing of the angiogenic switch and the role of angiogenesis in the development of breast malignancy is currently unknown. METHODS:Therefore, the expression of CD31 (pan endothelial cells (ECs)), endoglin (actively proliferating ECs), hypoxia-inducible factor-1 (HIF-1alpha), vascular endothelial...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6605196

    authors： Bluff JE,Menakuru SR,Cross SS,Higham SE,Balasubramanian SP,Brown NJ,Reed MW,Staton CA

    更新日期：2009-08-18 00:00:00

  • Association of tumour necrosis factor alpha and its receptors with thymidine phosphorylase expression in invasive breast carcinoma.

    abstract：:Angiogenesis is an essential requirement for tumour growth and metastasis and is regulated by a complex network of factors produced by both stromal cells and neoplastic cells within solid tumours. The cytokine tumour necrosis factor alpha (TNF-alpha) and the enzyme thymidine phosphorylase (TP) are two factors known to...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1998.373

    authors： Leek RD,Landers R,Fox SB,Ng F,Harris AL,Lewis CE

    更新日期：1998-06-01 00:00:00

  • Effect of modulation of the transferrin receptor on gallium-67 uptake and cytotoxicity in lymphoma cell lines.

    abstract：:Gallium-67 is a radionuclide that accumulates in haematological malignancies and is used for diagnostic purposes. Uptake of 67Ga into the cell occurs via the transferrin receptor, which is differentially expressed during the various cell cycle phases. With the aim of selectively increasing 67Ga uptake, we studied whet...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1996.411

    authors： van Leeuwen-Stok AE,Schuurhuis GJ,Dräger AM,Visser-Platier AW,Teule GJ,Huijgens PC

    更新日期：1996-08-01 00:00:00