Abstract：
:The evolution and structure of adenomatous polyps and adenocarcinomata of the colon in NMRI mice induced by dimethylhydrazine are described. Severe toxic reactions in the liver and other organs are produced by dimethylhydrazine (DMH), but tumours are induced only in the colon and around the anus. The 100% incidence and growth characteristics of the tumours make it potentially a good model system, but investigators should take into account the widespread nonspecific cellular injury induced by this carcinogen.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Haase P,Cowen DM,Knowles JC,Cooper EHdoi
10.1038/bjc.1973.183subject
Has Abstractpub_date
1973-12-01 00:00:00pages
530-43issue
6eissn
0007-0920issn
1532-1827journal_volume
28pub_type
杂志文章abstract：:Colorectal tumours from MYH polyposis patients display an excess of somatic G : C --> T : A transversions in the adenomatous polyposis coli gene. Here, we identify k-ras mutations in nine out of 54 (16.7%) MYH polyposis tumours. Their presence was associated with increased dysplasia and tubulovillous morphology (P=0.0...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601747
更新日期：2004-04-19 00:00:00
abstract：:Fine-needle aspiration cytology, which is well established to be accurate for the diagnosis of thyroid cancer, may be inconclusive for the follicular thyroid neoplasms. As galectin-3 was suggested to be a marker of malignant thyrocytes, we investigated whether this protein might be helpful in the diagnosis of aspirate...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/sj.bjc.6602822
更新日期：2005-11-14 00:00:00
abstract：:An increasing body of evidence indicates that glutathione S-transferases play a role in the intrinsic and acquired resistance of tumours to anticancer drugs. In view of the wide use of tumour cell lines to understand the factors which confer either sensitivity or resistance to chemotherapeutic agents we have determine...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1989.280
更新日期：1989-09-01 00:00:00
abstract：:Cellular DNA was analysed by flow cytometry in fine needles aspirates (FNA) from both benign and malignant breast lesions in order to determine the feasibility of flow cytometric analysis. In 22 of 26 (84%) benign and 69 of 74 (93%) malignant aspirates, sufficient cells were present to produce good quality DNA histogr...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1987.259
更新日期：1987-11-01 00:00:00
abstract：:Prolactin (PRL) has been reported to inhibit apoptosis in various cell types and to serve as a cofactor in the upregulation of CD25 on T cells during activation. We investigated a possible relation between prolactin receptor (PRL-R) or IL-2 receptor alpha (IL-2Ralpha, CD25) expression on circulating T lymphocytes and ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600860
更新日期：2003-04-22 00:00:00
abstract：:Specimens of formalin-fixed, paraffin-embedded non-small-cell lung carcinomas (NSCLCs; n = 187) were analysed immunohistochemically for expression of cyclin A. The analysis was intended to determine whether cyclin A has additional prognostic value for predicting patients' survival and drug response. Of the 187 NSCLCs,...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1997.302
更新日期：1997-01-01 00:00:00
abstract：:Insoluble conanavalin A and wheat germ agglutinin (WGA) were found to bind to carbohydrates on radio-labelled carcinoembryonic antigen (CEA). Binding by WGA was inhibited both by N-acetyl D-glucosamine and fragments of antibody to CEA, but was increased by intact antibody to CEA. This suggests that WGA binds to expose...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1975.63
更新日期：1975-03-01 00:00:00
abstract：:Endosialin is a transmembrane glycoprotein selectively expressed in blood vessels and stromal fibroblasts of various human tumours. It has been functionally implicated in angiogenesis, but the factors that control its expression have remained unclear. As insufficient delivery of oxygen is a driving force of angiogenes...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604685
更新日期：2008-10-21 00:00:00
abstract：:The purpose of the study is to test the hypothesis that expression of cell cycle regulatory proteins p16(INK4a) and pRb is significantly associated with prognosis in ovarian carcinomas. We performed immunohistochemical analysis of p16(INK4a) and pRb expression and correlated with survival in a series of 300 patients w...
journal_title：British journal of cancer
pub_type： 杂志文章,随机对照试验
doi：10.1038/sj.bjc.6603531
更新日期：2007-01-29 00:00:00
abstract：:DBA/2J mice bearing a clonal isolate of the transplantable murine lymphocytic leukaemia line P388 were used to examine the effects of L-histidinol on the antitumour activity of three alkalyating agents (bis-chloroethylnitrosourea (BCNU), cis-diamminedichloroplatinum (II) (cisDDP) and cyclophosphamide) and the antitumo...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1989.333
更新日期：1989-11-01 00:00:00
abstract：:From 1,211 breast cancers, 15 oestrogen receptor (ER) negative-progesterone receptor (PgR) positive breast cancers by conventional dextran coated charcoal steroid binding assays in cytosol were reassessed using Elisa techniques with monoclonal antireceptors antibodies in the cytosolic and nuclear fractions, and immuno...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1992.187
更新日期：1992-06-01 00:00:00
abstract：:In an Italian case-control study of oral cancer, number of missing teeth and other aspects of dental care were similar, but the general condition of the mouth, as indicated by gum bleeding, tartar deposits and mucosal irritation, was worse among oral cancer cases than controls. No differences were detected in sexual p...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2000.1398
更新日期：2000-11-01 00:00:00
abstract：:The levels of polyamines (putrescine, spermidine and spermine) in erythrocytes and plasma were studied using Cloudman S-91 melanoma grown in the lungs of DBA/2 mice. Polyamine levels and the numbers of tumour-cell colonies in the lungs were determined at weekly intervals. Putrescine levels in both erythrocytes and pla...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1980.137
更新日期：1980-05-01 00:00:00
abstract：:The effects of interferon-alpha (IFN) plus tamoxifen (TMX) in the treatment of advanced breast cancer were assessed. Changes of in vivo biologic determinants including hormone receptors, P24 protein, Ki-67 and growth factor expression were evaluated. Seven patients with advanced, heavily pretreated, breast cancer with...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1993.339
更新日期：1993-08-01 00:00:00
abstract：:Question prompt lists (QPLs) have been shown to be an inexpensive and effective communication tool for patients in oncology consultations. We aimed to develop and pilot a QPL for palliative care (PC) patients. In order to identify suitable questions for inclusion in the QPL, we conducted focus groups and individual in...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601380
更新日期：2003-12-01 00:00:00
abstract：:Despite encouraging results from recent studies, there is still no consensus to undertake mass screening using the Haemoccult test in the general population. The success of mass screening for colorectal cancer depends among other things on Haemoccult test properties. In on-going screening programmes, the Haemoccult te...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1995.459
更新日期：1995-10-01 00:00:00
abstract：:It is known that interferon-gamma (IFN-gamma) is produced by activated T and NK lymphoid cells, mononuclear cells, and macrophage and dendritic cells. Our previous studies have shown that IFN-gamma-like immunoreactivity also appears in human adrenal cortical tumour and phaeochromocytoma. To investigate whether human t...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603870
更新日期：2007-08-06 00:00:00
abstract：:The aim of this study was to ascertain whether assessing the growth fraction of cervical carcinoma of 28 patients, using antibody Ki-67, would be of value in clinical practice. The results showed no relationship between growth fraction and age, clinical stage, lymph node involvement or short term (3-5 years) survival....
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1992.167
更新日期：1992-05-01 00:00:00
abstract：:This study was designed to evaluate the activity, safety and tolerance of docetaxel (D) in a selected population with metastatic squamous cell carcinoma of the head and neck (SCCHN). Twenty-four patients with no prior palliative therapy were enrolled and received D 100 mg m(-2) by 1 h of infusion, every 3 weeks. All b...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,评审
doi：10.1038/sj.bjc.6690715
更新日期：1999-10-01 00:00:00
abstract：:Acute myeloid leukaemia (AML) is a molecularly and clinically heterogeneous disease, and its incidence is increasing as the populations in Western countries age. Despite major advances in understanding the genetic landscape of AML and its impact on the biology of the disease, standard therapy has not changed significa...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/bjc.2017.281
更新日期：2017-10-10 00:00:00
abstract：:Secretary component (SC) is expressed basolaterally as a transmembrane protein (pIg receptor) on secretory epithelial cells. As pIg receptor it plays a central role in humoral immunity by mediating the external translocation of dimeric IgA and pentameric IgM. A few case reports have suggested that reduced or absent SC...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1996.284
更新日期：1996-06-01 00:00:00
abstract：BACKGROUND:Most oestrogen receptor (ER)-positive early breast cancer diagnosed today is highly curable with multimodality treatment. Systemic adjuvant treatments including endocrine therapy and chemotherapy have made a significant contribution to the increasing cure rates over the past three decades. However not all wo...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2015.222
更新日期：2015-07-28 00:00:00
abstract：:Metabolic reprogramming towards aerobic glycolysis is a common feature of transformed cells and can be driven by a network of transcription factors. It is well established that c-Myc and hypoxia-inducible factor-1α (HIF-1α) contribute to metabolic reprogramming by driving the expression of glycolytic target genes. Mor...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/bjc.2015.360
更新日期：2015-12-01 00:00:00
abstract：:We investigated breast cancer incidence in migrants in the Netherlands in 1988-1998. The standardised incidence ratio for breast cancer in Northwest-Netherlands was statistically significantly reduced for women born in Surinam (0.56), Turkey (0.29) and Morocco (0.22). The proportion of women with advanced stages (III ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601821
更新日期：2004-06-01 00:00:00
abstract：:Accumulating evidence suggests that the p53 gene is a good target for molecular epidemiological studies. We previously reported an association between the presence of p53 mutations and lifetime cigarette consumption. Although over 675 p53 mutations have been reported in lung cancers in the literature thus far, very li...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1998.258
更新日期：1998-05-01 00:00:00
abstract：:We have evaluated the relation between cancer of the lower urinary tract ("bladder cancer") and the use of artificial sweeteners, by means of case-control studies in Manchester, U.K., and Nagoya, Japan, areas where extensive use occurred 30-40 years ago. In each area, a broadly based series of cases (555 in Manchester...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1982.59
更新日期：1982-03-01 00:00:00
abstract：:Expression of both P-glycoprotein (P-gp) and mutant p53 have recently been reported to be associated with poor prognosis of breast cancer. The expression of P-gp is associated in vitro and in vivo with cross-resistance to several anti-cancer drugs. p53 plays a regulatory role in apoptosis, and mutant p53 has been sugg...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1996.316
更新日期：1996-07-01 00:00:00
abstract：:HuR, a ubiquitously expressed member of the Hu protein family that binds and stabilizes an AU-rich element (ARE)-containing mRNAs, is known to shuttle between the nucleus and the cytoplasm via several export pathways. When normal cells were treated with heat shock, HuR was exported to the cytoplasm in a chromosome mai...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605084
更新日期：2009-06-16 00:00:00
abstract：:Cancer-related anaemia is associated with a wide spectrum of symptoms that can negatively affect quality of life. Because epoetin alfa has demonstrated efficacy in correcting cancer-related anaemia, the impact of this treatment on quality of life was evaluated in a multinational, randomised, double-blind, placebo-cont...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1038/sj.bjc.6600657
更新日期：2002-12-02 00:00:00
abstract：BACKGROUND:Around 60% of women ≥ 80 years old, in the UK do not have surgery for their breast cancer (vs<10% of younger age groups). The extent to which this difference can be accounted for by co-morbidity has not been established. METHODS:A Cancer Registry/Hospital Episode Statistics-linked data set identified women ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2012.192
更新日期：2012-09-25 00:00:00
