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p53 mutations in non-small-cell lung cancers occurring in individuals without a past history of active smoking.

Abstract：

:Accumulating evidence suggests that the p53 gene is a good target for molecular epidemiological studies. We previously reported an association between the presence of p53 mutations and lifetime cigarette consumption. Although over 675 p53 mutations have been reported in lung cancers in the literature thus far, very little is known about the nature of such changes in lung cancers in the absence of a smoking background. In the present study, we therefore analysed 69 non-small-cell lung cancer specimens from individuals without any history of active smoking and identified p53 mutations in 26% of the cases. Statistical analysis of the present cohort of non-smokers also showed absence of significant relationship between p53 mutations and age, sex, histological type or disease stage. Comparison of mutational spectra between the present results in non-smokers and previously reported mutations in smokers clearly demonstrated G:C to T:A transversions to be significantly less frequent in non-smokers than in smokers (OR 5.35, 95% CI 1.77-16.12). Interestingly, G:C to C:G and G:C to A:T mutations were also observed in tumours of non-smokers at similar frequencies to G:C to T:A mutations, suggesting that these mutations can occur relatively frequently in the absence of active smoking. This study is, to our knowledge, the largest so far analysing a well-defined cohort of non-smokers in a single laboratory.

journal_name

Br J Cancer

journal_title

British journal of cancer

authors

Takagi Y,Osada H,Kuroishi T,Mitsudomi T,Kondo M,Niimi T,Saji S,Gazdar AF,Takahashi T,Minna JD,Takahashi T

doi

10.1038/bjc.1998.258

subject

Has Abstract

pub_date

1998-05-01 00:00:00

pages

1568-72

issue

10

eissn

0007-0920

issn

1532-1827

journal_volume

77

pub_type

杂志文章

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