Abstract:
:Molecular and immunohistochemical studies of genetic events on chromosome 17p were prospectively compared with conventional clinical and pathological parameters and disease behaviour at a minimum of 72 months follow-up. In a series of 91 patients with primary operable breast cancer, 37 out of 91 (41%) patients had disease relapse and 23 out of 91 (25%) had died during the follow-up period. Allelic imbalance at the YNZ22 locus (17p13.3), demonstrated in 33 out of 63 (52%) informative patients, was significantly associated with disease recurrence (P < 0.01, 2 d.f. Cox analysis) and showed a trend towards impaired survival (P = 0.08, 2 d.f. Cox analysis) after a mean follow-up of 84 months for survivors. By contrast, p53 mutation (in 10 out of 60, 17% of cancers), p53 allelic imbalance (in 23 out of 56, 41% informative patients), p53 mRNA expression (in 47 out of 87, 54% patients), p53 mRNA overexpression (in 24 out of 87, 28%) or p53 protein expression (detected in 25/76, 32%) were not associated with disease behaviour. There was no significant association between allelic imbalance at YNZ22 and any abnormality of p53 DNA, RNA or protein. Allelic imbalance at 17p13.3 (YNZ22) serves as a marker of poor prognosis in breast cancer. As yet unidentified genes on 17p13.3, distinct from and telomeric to p53, are therefore likely to be of clinical importance in breast cancer.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Thompson AM,Crichton DN,Elton RA,Clay MF,Chetty U,Steel CMdoi
10.1038/bjc.1998.129subject
Has Abstractpub_date
1998-03-01 00:00:00pages
797-800issue
5eissn
0007-0920issn
1532-1827journal_volume
77pub_type
杂志文章abstract::Women referred to a familial breast cancer clinic completed questionnaires before and after counselling and at annual follow-up to assess their risk estimate and psychological characteristics. The aims were to determine whether those who attended the clinic overestimated their risk or were highly anxious and whether c...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6690078
更新日期:1999-02-01 00:00:00
abstract::This study has been designed to verify the specific toxicity of saporin, a type 1 ribosome-inactivating protein (RIP), with the same activity as ricin A chain, targeted by a bispecific monoclonal antibody (bimAb) recognising both the CD25 antigen and the RIP. The CD25 antigen is expressed by lymphoid populations upon ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1993.233
更新日期:1993-06-01 00:00:00
abstract::To clarify the mechanism of acquired CDDP resistance in ovarian cancer, we compared the microsatellite instability (MSI) by the amplification of 10 microsatellite loci and immunohistochemical detection of hMSH2 and hMLH1 expression between the primary resected tumours and the secondary resected residual tumours after ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.2001.2037
更新日期:2001-09-28 00:00:00
abstract:BACKGROUND:Topoisomerase I (Topo I) poisons (e.g., camptothecin (CPT)), used to treat cancer, cause DNA breaks that are most cytotoxic during S phase. PARP-1 promotes DNA repair and PARP inhibitors (PARPi) sensitise cells to Topo I poisons. We aimed to determine whether chemosensitisation is also S phase specific using...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2014.378
更新日期:2014-09-23 00:00:00
abstract:BACKGROUND:OCT3/4 (POU5F1) is an established diagnostic immunohistochemical marker for specific histological variants of human malignant germ cell tumours (GCTs), including the seminomatous types and the stem cell component of non-seminomas, known as embryonal carcinoma. OCT3/4 is crucial for the regulation of pluripot...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2011.270
更新日期:2011-09-06 00:00:00
abstract::Evidence in the literature suggests that hyperthermia (HT) or inhibitors of calmodulin can increase the sensitivity of rodent cells to bleomycin (BLM) by interfering with DNA repair functions. In an attempt to explore methods of improving the efficacy of thermochemotherapy we have investigated the individual and combi...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1986.14
更新日期:1986-01-01 00:00:00
abstract::Human pancreatic exocrine adenocarcinoma cells established in tissue culture expressed both HLA and beta 2-microglobulin (beta 2M). Plasma-membrane components of this pancreatic cancer cell line were purified from plasma membrane fractions enriched by sucrose density-gradient centrifugation, using immunoaffinity chrom...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1979.250
更新日期:1979-11-01 00:00:00
abstract::High-level microsatellite instability (MSI-H) in colorectal cancer accounts for about 12% of colorectal cancers and is typically associated with a dense infiltration with cytotoxic CD8-positive lymphocytes. The role of regulatory T cells that may interfere with the host's antitumoural immune response in MSI-H colorect...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604756
更新日期:2008-12-02 00:00:00
abstract::Spontaneous and radiation-induced genetic instability of peripheral blood mononuclear cells derived from unselected breast cancer (BC) patients (n=50) was examined using the single-cell gel electrophoresis (Comet) assay and a modified G2 micronucleus (MN) test. Cells from apparently healthy donors (n=16) and from canc...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6603005
更新日期:2006-04-24 00:00:00
abstract::The relationship between oestrogen receptor (RE) content of primary breast cancer and subsequent prognosis was examined with regard to nodal status. It was found that, within a particular nodal group, patients with tumours containing fully functional RE experienced a longer disease-free interval than those with RE- di...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1981.9
更新日期:1981-01-01 00:00:00
abstract::Studies in animal models of mouse mammary carcinoma have shown that ovine submaxillary mucin, which carries multiple sialyl-Tn (STn) epitopes, is effective in stimulating an immune response and inhibiting tumour growth. In similar studies using carbohydrate antigens, pretreatment with low-dose cyclophosphamide has bee...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1038/bjc.1996.532
更新日期:1996-10-01 00:00:00
abstract::The metabolism of serotonin was studied in cancer patients of their first day of their first course of chemotherapeutic drugs either with strongly or moderately emetogenic regimens. It was observed that strongly emetogenic treatments induce greater increases in serotonin release than moderately emetogenic regimens. Hi...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1992.242
更新日期:1992-07-01 00:00:00
abstract:BACKGROUND:Clear cell renal cancer frequently harbours von Hippel-Lindau (VHL) gene mutations, leading to stabilisation of the hypoxia-inducible factors (HIFs) and expression of their target genes. We investigated HIF-1 and HIF-2 in the regulation of microRNA-210 (miR-210), and its clinical relevance in renal tumours. ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2013.56
更新日期:2013-03-19 00:00:00
abstract:BACKGROUND:Recent studies suggest that older patients in the United Kingdom are not benefiting as much from improvements in cancer treatments as their younger counterparts. We investigate whether this might be partly due to differential referral rates using ovarian cancer as an example. METHODS:From the General Practi...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6605593
更新日期:2010-03-16 00:00:00
abstract:BACKGROUND:It has been hypothesised that intrauterine exposures are important for subsequent prostate cancer risk. Prior epidemiological studies have used birthweight as a proxy of cumulative intrauterine exposures to test this hypothesis, but results have been inconsistent partly because of limited statistical power. ...
journal_title:British journal of cancer
pub_type: 杂志文章,meta分析,评审
doi:10.1038/bjc.2016.38
更新日期:2016-03-29 00:00:00
abstract:BACKGROUND:Record-based studies have generally reported association of higher childhood leukaemia incidence with higher socioeconomic status (SES), but recent findings are less consistent. METHODS:We examined records from the National Registry of Childhood Tumours for evidence of this association in England and Wales ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2011.415
更新日期:2011-11-22 00:00:00
abstract:BACKGROUND:Immune checkpoint blockade (ICB) therapy improved the prognosis of cancer patients, but general administration of ICBs occasionally induces side effects that include immune-related adverse events and tumour hyper-progression. Here, we established a protein-based system, by which endogenous expression of IC m...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-019-0708-y
更新日期:2020-03-01 00:00:00
abstract::A series of 176 archival cervical intraepithelial neoplasia (CIN) was analysed for the presence, viral load and integration status of 'high-risk' types of human papillomavirus (HR-HPV). The samples were assayed using newly developed methods based on real-time PCR. Two methods for the extraction of DNA from the paraffi...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6602648
更新日期:2005-06-20 00:00:00
abstract::Tamoxifen is currently established as the endocrine treatment of choice in breast cancer. In advanced breast cancer, response rates of up to 60% in women with oestrogen receptor (ER)-positive tumours have been reported. In early breast cancer, tamoxifen can produce significant benefits, both statistically and clinical...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1998.753
更新日期:1998-09-01 00:00:00
abstract::Apoptosis plays an important role in tumorigenesis. Tumour growth is determined by the rate of cell proliferation and cell death. We counted the number of apoptotic cells in haematoxylin and eosin (H&E)-stained tumour sections in series of 172 grade I and II invasive breast cancers with long-term follow-up. The number...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.1999.0928
更新日期:2000-01-01 00:00:00
abstract::Both biodegradable emboli and pharmacological agents can enhance regional therapy for hepatic targeting. Using a rat model with similar haemodynamic characteristics to human colorectal liver tumour and a radio-labelled marker of similar molecular weight to Adriamycin, we have combined the two approaches to see if the ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1992.7
更新日期:1992-01-01 00:00:00
abstract::During the period from 1950 to 1952, three patients were studied by electrophoresis according to Tiselius on account of anticomplementary activity at WR; the presence of an M-component was demonstrated. On several later occasions it was observed that this component at first seemed to remain unchanged, later it was sli...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1971.53
更新日期:1971-09-01 00:00:00
abstract:BACKGROUND:Heterogeneity and low incidence comprise the biggest challenge in sarcoma diagnosis and treatment. Chemotherapy, although efficient for some sarcoma subtypes, generally results in poor clinical responses and is mostly recommended for advanced disease. Specific genomic aberrations have been identified in some...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-018-0359-4
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:Melanoma is highly resistant to current modalities of therapy, with the extent of pigmentation playing an important role in therapeutic resistance. Nuclear factor-κB (NF-κB) is constitutively activated in melanoma and can serve as a molecular target for cancer therapy and steroid/secosteroid action. METHODS...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2011.458
更新日期:2011-12-06 00:00:00
abstract::Chromosomal translocation t(11;22)(q24:q12) is detected in approximately 90% of tumours of the Ewing family (ET). This translocation results in EWS-Fli1 gene fusion which produces a EWS-Fli1 fusion protein acting as an aberrant transcriptional activator. We previously reported that the inhibition of EWS-Fli1 expressio...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.2000.1652
更新日期:2001-03-23 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:British journal of cancer
pub_type: 已发布勘误
doi:10.1038/s41416-020-0830-x
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND:There is clinical evidence to suggest that tumour necrosis factor-α (TNF-α) may be a therapeutic target in renal cell carcinoma (RCC). Multi-targeted kinase inhibitors, such as sorafenib and sunitinib, have become standard of care in advanced RCC. The anti-TNF-α monoclonal antibody infliximab and sorafenib h...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6605889
更新日期:2010-10-12 00:00:00
abstract::The effect on cell-cycle progression in various phases of the cell cycle caused by an acute exposure to hypoxia in absence and presence of misonidazole (MISO) was investigated. Exponentially growing and synchronized cells of the human line NHIK 3025 were exposed to different degrees of hypoxia for a short period (1.5 ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1983.271
更新日期:1983-12-01 00:00:00
abstract:BACKGROUND:Multiple myeloma is a plasma cell disorder that is characterised by clonal proliferation of malignant plasma cells in the bone marrow, monoclonal paraprotein in the blood or urine and associated organ dysfunction. It accounts for approximately 1% of cancers and 13% of haematological cancers. Myeloma arises f...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2012.525
更新日期:2012-12-04 00:00:00
abstract:BACKGROUND:This study aimed to evaluate the prognostic value of pre-treatment NLR in patients with oropharyngeal cancer. METHODS:Patients who completed definitive radiotherapy (RT) for oropharyngeal cancer and had blood counts taken pre-RT from 2002 to 2013 were included. NLR was calculated as total neutrophil/lymphoc...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-01106-x
更新日期:2020-10-14 00:00:00