High density of FOXP3-positive T cells infiltrating colorectal cancers with microsatellite instability.


:High-level microsatellite instability (MSI-H) in colorectal cancer accounts for about 12% of colorectal cancers and is typically associated with a dense infiltration with cytotoxic CD8-positive lymphocytes. The role of regulatory T cells that may interfere with the host's antitumoural immune response in MSI-H colorectal cancers has not been analysed yet. Using an antibody directed against the regulatory T-cell marker transcription factor forkhead box P3 (FOXP3), regulatory T cells were examined in 70 colorectal cancers with known MSI status (MSI-H, n=37; microsatellite stable, n=33). In MSI-H colorectal cancers, we found a significantly higher intraepithelial infiltration with FOXP3-positive cells (median: 8.5 cells per 0.25 mm(2) vs 3.1 cells per 0.25 mm(2) in microsatellite stable, P<0.001), and a significantly elevated ratio of intraepithelial to stromal infiltration (0.05 vs 0.01 in microsatellite stable, P<0.001). CD8-positive cell counts were related positively to the number of FOXP3-positive cells (Spearman's rho=0.56 and 0.55, respectively). Our results show that the elevated number of CD8-positive lymphocytes found in MSI-H colorectal cancers is paralleled by an enhanced infiltration with CD8-negative FOXP3-positive cells. These data suggest that FOXP3-positive cells may play a role in the regulation of the immune response directed against MSI-H colorectal cancers at the primary tumour site.


Br J Cancer


Michel S,Benner A,Tariverdian M,Wentzensen N,Hoefler P,Pommerencke T,Grabe N,von Knebel Doeberitz M,Kloor M




Has Abstract


2008-12-02 00:00:00














  • BAG-1 as a biomarker in early breast cancer prognosis: a systematic review with meta-analyses.

    abstract:BACKGROUND:The co-chaperone protein Bcl-2-associated athanogene-1 (BAG-1) is overexpressed in breast cancer and has been incorporated in the oncotype DX and PAM50 breast cancer prognostic assays. Bcl-2-associated athanogene-1 exists as multiple protein isoforms that interact with diverse partners, including chaperones ...

    journal_title:British journal of cancer

    pub_type: 杂志文章,meta分析,评审


    authors: Papadakis ES,Reeves T,Robson NH,Maishman T,Packham G,Cutress RI

    更新日期:2017-06-06 00:00:00

  • Elevated P53 expression correlates with a history of heavy smoking in squamous cell carcinoma of the head and neck.

    abstract::Expression of the tumour suppressor gene p53 was examined in squamous cell carcinoma of the head and neck using two p53 antibodies, PAb 421 and PAb 1801. Elevated p53 expression was found in 67% of the 73 patients investigated. P53 expression was not found to correlate with whether the patient had been previously trea...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Field JK,Spandidos DA,Malliri A,Gosney JR,Yiagnisis M,Stell PM

    更新日期:1991-09-01 00:00:00

  • Whole-exome sequencing of long-term, never relapse exceptional responders of trastuzumab-treated HER2+ metastatic breast cancer.

    abstract::Trastuzumab has significantly improved the overall survival of patients with HER2+ metastatic breast cancer (MBC). However, outcomes can vary, with patients progressing within 1 year of treatment or exceptional cases of complete response to trastuzumab for ≥10 years. Identification of the underlying genomic aberration...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Walsh N,Andrieu C,O'Donovan P,Quinn C,Maguire A,Furney SJ,Gullo G,Crown J

    更新日期:2020-10-01 00:00:00

  • First-line bevacizumab and capecitabine-oxaliplatin in elderly patients with mCRC: GEMCAD phase II BECOX study.

    abstract:BACKGROUND:Subgroup analyses of clinical studies suggest that bevacizumab plus XELOX is effective and tolerable in elderly patients with metastatic colorectal cancer (mCRC). The prospective BECOX study examined the efficacy and safety of bevacizumab plus XELOX, followed by bevacizumab plus capecitabine in elderly patie...

    journal_title:British journal of cancer

    pub_type: 杂志文章,多中心研究


    authors: Feliu J,Salud A,Safont MJ,García-Girón C,Aparicio J,Vera R,Serra O,Casado E,Jorge M,Escudero P,Bosch C,Bohn U,Pérez-Carrión R,Carmona A,Martínez-Marín V,Maurel J

    更新日期:2014-07-15 00:00:00

  • Chromosome 11 allele imbalance and clinicopathological correlates in ovarian tumours.

    abstract::Allele imbalance on chromosome 11 loci in ovarian cancer is a frequent event, suggesting the presence of tumour-suppressor genes for ovarian carcinogenesis on this chromosome. Ten highly polymorphic (CA) repeat microsatellites were used to determine allele imbalance in 60 primary ovarian tumours, including 47 epitheli...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Gabra H,Taylor L,Cohen BB,Lessels A,Eccles DM,Leonard RC,Smyth JF,Steel CM

    更新日期:1995-08-01 00:00:00

  • Breast cancer cell-associated endopeptidase EC 24.11 modulates proliferative response to bombesin.

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    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Burns DM,Walker B,Gray J,Nelson J

    更新日期:1999-01-01 00:00:00

  • Two types of soft tissue sarcoma of uncertain histogenesis.

    abstract::A brief account is given of two types of rare soft tissue sarcoma of uncertain histogenesis. The danger of mistaking the epitheloid sarcoma for a benign lesion is emphasized. ...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Mackenzie DH

    更新日期:1971-09-01 00:00:00

  • A new monoclonal antibody (A46-B/B10) highly specific for the blood group H type 2 epitope: generation, epitope analysis, serological and histological evaluation.

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    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Karsten U,Pilgrim G,Hanisch FG,Uhlenbruck G,Kasper M,Stosiek P,Papsdorf G,Pasternak G

    更新日期:1988-08-01 00:00:00

  • The systemic inflammatory response, performance status and survival in patients undergoing alpha-interferon treatment for advanced renal cancer.

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    journal_title:British journal of cancer

    pub_type: 临床试验,杂志文章


    authors: Bromwich E,McMillan DC,Lamb GW,Vasey PA,Aitchison M

    更新日期:2004-10-04 00:00:00

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    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Hickish T,Cunningham D,Colston K,Millar BC,Sandle J,Mackay AG,Soukop M,Sloane J

    更新日期:1993-10-01 00:00:00

  • Hypoxia potentiates Notch signaling in breast cancer leading to decreased E-cadherin expression and increased cell migration and invasion.

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    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Chen J,Imanaka N,Chen J,Griffin JD

    更新日期:2010-01-19 00:00:00

  • Cellular changes in boric acid-treated DU-145 prostate cancer cells.

    abstract::Epidemiological, animal, and cell culture studies have identified boron as a chemopreventative agent in prostate cancer. The present objective was to identify boron-induced changes in the DU-145 human prostate cancer cell line. We show that prolonged exposure to pharmacologically-relevant levels of boric acid, the nat...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Barranco WT,Eckhert CD

    更新日期:2006-03-27 00:00:00

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    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Hamasaki H,Koga K,Aoki M,Hamasaki M,Koshikawa N,Seiki M,Iwasaki H,Nakayama J,Nabeshima K

    更新日期:2011-09-06 00:00:00

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    journal_title:British journal of cancer

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    authors: Tisdale MJ,Brennan RA

    更新日期:1983-02-01 00:00:00

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    journal_title:British journal of cancer

    pub_type: 杂志文章,多中心研究,随机对照试验


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    更新日期:2018-03-06 00:00:00

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    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Jamieson D,Tung AT,Knox RJ,Boddy AV

    更新日期:2006-11-06 00:00:00

  • Detection of somatic changes in human cancer DNA by DNA fingerprint analysis.

    abstract::Minisatellite DNA probes which can detect a large number of autosomal loci dispersed throughout the human genome were used to examine the constitutional and tumour DNA of 35 patients with a variety of cancers of which eight were of gastrointestinal origin. Somatic changes were seen in the tumour DNA in ten of the 35 c...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Thein SL,Jeffreys AJ,Gooi HC,Cotter F,Flint J,O'Connor NT,Weatherall DJ,Wainscoat JS

    更新日期:1987-04-01 00:00:00

  • Hypoxia inducible factors in cancer stem cells.

    abstract::Oxygen is an essential regulator of cellular metabolism, survival, and proliferation. Cellular responses to oxygen levels are monitored, in part, by the transcriptional activity of the hypoxia inducible factors (HIFs). Under hypoxia, HIFs regulate a variety of pro-angiogenic and pro-glycolysis pathways. In solid cance...

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    authors: Heddleston JM,Li Z,Lathia JD,Bao S,Hjelmeland AB,Rich JN

    更新日期:2010-03-02 00:00:00

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    journal_title:British journal of cancer

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    authors: Baas P,van Geel IP,Oppelaar H,Meyer M,Beynen JH,van Zandwijk N,Stewart FA

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  • Multivariate regression analyses of data from a randomised, double-blind, placebo-controlled study confirm quality of life benefit of epoetin alfa in patients receiving non-platinum chemotherapy.

    abstract::Cancer-related anaemia is associated with a wide spectrum of symptoms that can negatively affect quality of life. Because epoetin alfa has demonstrated efficacy in correcting cancer-related anaemia, the impact of this treatment on quality of life was evaluated in a multinational, randomised, double-blind, placebo-cont...

    journal_title:British journal of cancer

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Fallowfield L,Gagnon D,Zagari M,Cella D,Bresnahan B,Littlewood TJ,McNulty P,Gorzegno G,Freund M,Epoetin Alfa Study Group.

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    journal_title:British journal of cancer

    pub_type: 杂志文章,meta分析,评审


    authors: Zhou CK,Sutcliffe S,Welsh J,Mackinnon K,Kuh D,Hardy R,Cook MB

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    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Wilbur DW,Camacho ES,Hilliard DA,Dill PL,Weisenthal LM

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  • Chromosomal radiosensitivity in head and neck cancer patients: evidence for genetic predisposition?

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    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: De Ruyck K,de Gelder V,Van Eijkeren M,Boterberg T,De Neve W,Vral A,Thierens H

    更新日期:2008-05-20 00:00:00

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    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Wolk M,Martin JE,Nowicki M

    更新日期:2007-08-06 00:00:00

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    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Cook LS,Pestak CR,Leung AC,Steed H,Nation J,Swenerton K,Gallagher R,Magliocco A,Köbel M,Brooks-Wilson A,Le N

    更新日期:2017-01-17 00:00:00

  • Differential expression of translation-associated genes in benign and malignant human breast tumours.

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    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Adams SM,Sharp MG,Walker RA,Brammar WJ,Varley JM

    更新日期:1992-01-01 00:00:00

  • A multinational phase 2 study of nanoliposomal irinotecan sucrosofate (PEP02, MM-398) for patients with gemcitabine-refractory metastatic pancreatic cancer.

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    journal_title:British journal of cancer

    pub_type: 杂志文章,多中心研究


    authors: Ko AH,Tempero MA,Shan YS,Su WC,Lin YL,Dito E,Ong A,Wang YW,Yeh CG,Chen LT

    更新日期:2013-08-20 00:00:00

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    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Stewart AM

    更新日期:1973-06-01 00:00:00

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    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Sharma R,Kacevska M,London R,Clarke SJ,Liddle C,Robertson G

    更新日期:2008-01-15 00:00:00

  • Sensitivity and specificity of CA242 in gastro-intestinal cancer. A comparison with CEA, CA50 and CA 19-9.

    abstract::A serological assay for the quantitative determination of the novel tumour-associated epitope CA242 was developed and used for determination of sensitivity and specificity of CA242 in gastrointestinal cancer. The CA242 assay showed a better tumour specificity than CA50 (and CA 19-9). This was most noticeable in benign...

    journal_title:British journal of cancer

    pub_type: 杂志文章


    authors: Nilsson O,Johansson C,Glimelius B,Persson B,Nørgaard-Pedersen B,Andrén-Sandberg A,Lindholm L

    更新日期:1992-02-01 00:00:00