Abstract：
:High-level microsatellite instability (MSI-H) in colorectal cancer accounts for about 12% of colorectal cancers and is typically associated with a dense infiltration with cytotoxic CD8-positive lymphocytes. The role of regulatory T cells that may interfere with the host's antitumoural immune response in MSI-H colorectal cancers has not been analysed yet. Using an antibody directed against the regulatory T-cell marker transcription factor forkhead box P3 (FOXP3), regulatory T cells were examined in 70 colorectal cancers with known MSI status (MSI-H, n=37; microsatellite stable, n=33). In MSI-H colorectal cancers, we found a significantly higher intraepithelial infiltration with FOXP3-positive cells (median: 8.5 cells per 0.25 mm(2) vs 3.1 cells per 0.25 mm(2) in microsatellite stable, P<0.001), and a significantly elevated ratio of intraepithelial to stromal infiltration (0.05 vs 0.01 in microsatellite stable, P<0.001). CD8-positive cell counts were related positively to the number of FOXP3-positive cells (Spearman's rho=0.56 and 0.55, respectively). Our results show that the elevated number of CD8-positive lymphocytes found in MSI-H colorectal cancers is paralleled by an enhanced infiltration with CD8-negative FOXP3-positive cells. These data suggest that FOXP3-positive cells may play a role in the regulation of the immune response directed against MSI-H colorectal cancers at the primary tumour site.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Michel S,Benner A,Tariverdian M,Wentzensen N,Hoefler P,Pommerencke T,Grabe N,von Knebel Doeberitz M,Kloor Mdoi
10.1038/sj.bjc.6604756subject
Has Abstractpub_date
2008-12-02 00:00:00pages
1867-73issue
11eissn
0007-0920issn
1532-1827pii
6604756journal_volume
99pub_type
杂志文章abstract：BACKGROUND:The co-chaperone protein Bcl-2-associated athanogene-1 (BAG-1) is overexpressed in breast cancer and has been incorporated in the oncotype DX and PAM50 breast cancer prognostic assays. Bcl-2-associated athanogene-1 exists as multiple protein isoforms that interact with diverse partners, including chaperones ...
journal_title：British journal of cancer
pub_type： 杂志文章,meta分析,评审
doi：10.1038/bjc.2017.130
更新日期：2017-06-06 00:00:00
abstract：:Expression of the tumour suppressor gene p53 was examined in squamous cell carcinoma of the head and neck using two p53 antibodies, PAb 421 and PAb 1801. Elevated p53 expression was found in 67% of the 73 patients investigated. P53 expression was not found to correlate with whether the patient had been previously trea...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1991.352
更新日期：1991-09-01 00:00:00
abstract：:Trastuzumab has significantly improved the overall survival of patients with HER2+ metastatic breast cancer (MBC). However, outcomes can vary, with patients progressing within 1 year of treatment or exceptional cases of complete response to trastuzumab for ≥10 years. Identification of the underlying genomic aberration...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-020-0999-z
更新日期：2020-10-01 00:00:00
abstract：BACKGROUND:Subgroup analyses of clinical studies suggest that bevacizumab plus XELOX is effective and tolerable in elderly patients with metastatic colorectal cancer (mCRC). The prospective BECOX study examined the efficacy and safety of bevacizumab plus XELOX, followed by bevacizumab plus capecitabine in elderly patie...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究
doi：10.1038/bjc.2014.346
更新日期：2014-07-15 00:00:00
abstract：:Allele imbalance on chromosome 11 loci in ovarian cancer is a frequent event, suggesting the presence of tumour-suppressor genes for ovarian carcinogenesis on this chromosome. Ten highly polymorphic (CA) repeat microsatellites were used to determine allele imbalance in 60 primary ovarian tumours, including 47 epitheli...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1995.340
更新日期：1995-08-01 00:00:00
abstract：:We have investigated the production, growth and inactivation of gastrin-releasing peptide (GRP)-like peptides in human breast cancer cell lines. Radioimmunoassay detected GRP-like immunoreactivity (GRP-LI) in T47D breast cancer cells but not in the conditioned medium, indicating rapid clearance. No GRP-LI was found in...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6690036
更新日期：1999-01-01 00:00:00
abstract：:A brief account is given of two types of rare soft tissue sarcoma of uncertain histogenesis. The danger of mistaking the epitheloid sarcoma for a benign lesion is emphasized. ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1971.58
更新日期：1971-09-01 00:00:00
abstract：:A monoclonal antibody recognizing the blood group H type 2 antigen has been obtained from a BALB/c mouse immunized with MCF-7 (human mammary carcinoma) cells. The specificity of this antibody (A46-B/B10, IgM, kappa) has been identified by haemagglutination tests, immunohistochemistry, binding inhibition studies, and a...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1988.187
更新日期：1988-08-01 00:00:00
abstract：:The prognostic value of C-reactive protein, compared with ECOG performance status (ECOG-ps), in patients receiving alpha-interferon treatment for advanced renal cancer was assessed in 58 patients. In all, 55 patients died on follow-up. On multivariate analysis with ECOG-ps and C-reactive protein entered as covariates,...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/sj.bjc.6602152
更新日期：2004-10-04 00:00:00
abstract：:1,25(OH)2D3 promotes differentiation and has an antiproliferative effect in a variety of cell lines derived from the immunohaematopoetic system. alpha-Calcidol which is metabolised to 1,25(OH)2D3 has been shown to produce tumour regression in follicular low grade non-Hodgkin's lymphoma (NHL) and the dose limiting toxi...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1993.406
更新日期：1993-10-01 00:00:00
abstract：BACKGROUND:Epithelial-to-mesenchymal transition (EMT) is associated with decreased adhesion and acquisition of metastatic potential of breast cancer cells. Epithelial-to-mesenchymal transition is mediated, in part, by two transcription repressors, Snail and Slug, that are known to be targets of the Notch signaling path...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605486
更新日期：2010-01-19 00:00:00
abstract：:Epidemiological, animal, and cell culture studies have identified boron as a chemopreventative agent in prostate cancer. The present objective was to identify boron-induced changes in the DU-145 human prostate cancer cell line. We show that prolonged exposure to pharmacologically-relevant levels of boric acid, the nat...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603009
更新日期：2006-03-27 00:00:00
abstract：BACKGROUND:Laminin-5 (Ln5), a heterotrimer composed of three chains (α3, β3, and γ2), is a major component of the basement membrane in most adult tissues. One of the chains, Ln5-γ2, is a marker of invasive tumours because it is frequently expressed as a monomer in malignant tumours. Recent studies from our laboratories...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2011.283
更新日期：2011-09-06 00:00:00
abstract：:The presence of succinyl-coenzyme A: acetoacetate CoA--transferase (3-oxo acid-CoA transferase), an initiator of ketone body utilization in non-hepatic tissue was examined in a number of animal and human tumours of peripheral tissues. While enzyme levels in heart, kidney, lymphocytes and bladder were high, the tumours...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1983.38
更新日期：1983-02-01 00:00:00
abstract：BACKGROUND:We investigated whether pazopanib maintenance following first-line chemotherapy would improve survival in patients with extensive disease small-cell lung cancer (ED-SCLC). METHODS:This study is a randomised, placebo-controlled, phase II study that enroled ED-SCLC patients who had not progressed after four c...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1038/bjc.2017.465
更新日期：2018-03-06 00:00:00
abstract：:NRH:Quinone Oxidoreductase 2 (NQO2) has been described as having no enzymatic activity with nicotinamide adenine dinucleotide (NADH) or NADPH as electron donating cosubstrates. Mitomycin C (MMC) is both a substrate for and a mechanistic inhibitor of the NQO2 homologue NQO1. NRH:quinone oxidoreductase 2 catalysed the r...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603414
更新日期：2006-11-06 00:00:00
abstract：:Minisatellite DNA probes which can detect a large number of autosomal loci dispersed throughout the human genome were used to examine the constitutional and tumour DNA of 35 patients with a variety of cancers of which eight were of gastrointestinal origin. Somatic changes were seen in the tumour DNA in ten of the 35 c...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1987.71
更新日期：1987-04-01 00:00:00
abstract：:Oxygen is an essential regulator of cellular metabolism, survival, and proliferation. Cellular responses to oxygen levels are monitored, in part, by the transcriptional activity of the hypoxia inducible factors (HIFs). Under hypoxia, HIFs regulate a variety of pro-angiogenic and pro-glycolysis pathways. In solid cance...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/sj.bjc.6605551
更新日期：2010-03-02 00:00:00
abstract：:Photodynamic therapy (PDT) using Photofrin was used in combination with a hypoxic toxin (mitomycin C, MMC) to treat four patients with recurrent skin metastasis of a mammary carcinoma. In preclinical experiments an additive effect was found for the combination of MMC and PDT for treating subcutaneous RIF1 tumours in m...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1996.186
更新日期：1996-04-01 00:00:00
abstract：:Cancer-related anaemia is associated with a wide spectrum of symptoms that can negatively affect quality of life. Because epoetin alfa has demonstrated efficacy in correcting cancer-related anaemia, the impact of this treatment on quality of life was evaluated in a multinational, randomised, double-blind, placebo-cont...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1038/sj.bjc.6600657
更新日期：2002-12-02 00:00:00
abstract：BACKGROUND:It has been hypothesised that intrauterine exposures are important for subsequent prostate cancer risk. Prior epidemiological studies have used birthweight as a proxy of cumulative intrauterine exposures to test this hypothesis, but results have been inconsistent partly because of limited statistical power. ...
journal_title：British journal of cancer
pub_type： 杂志文章,meta分析,评审
doi：10.1038/bjc.2016.38
更新日期：2016-03-29 00:00:00
abstract：:Specimens from 45 patients with previously-untreated non-small cell lung cancer (NSCLC) were tested for in vitro chemosensitivity to ten drugs utilising the DiSC assay, which measures cell kill in the total (largely non-dividing) tumour cell population. Thirty-five assays were successful and 25 patients with advanced ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1992.5
更新日期：1992-01-01 00:00:00
abstract：:The association between chromosomal radiosensitivity and genetic predisposition to head and neck cancer was investigated in this study. In all, 101 head and neck cancer patients and 75 healthy control individuals were included in the study. The G(2) assay was used to measure chromosomal radiosensitivity. The results d...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604345
更新日期：2008-05-20 00:00:00
abstract：:Tumour markers are important in the diagnosis and monitoring of many tumours. This study tested the hypothesis that an oncofoetal protein, foetal haemoglobin (HbF) is a potential tumour marker in embryonic tumours, useful for management. An immunohistochemical investigation of HbF blood cell (Fc) distribution was carr...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603867
更新日期：2007-08-06 00:00:00
abstract：BACKGROUND:Combined oral contraceptive (COC) use reduces epithelial ovarian cancer (EOC) risk. However, little is known about risk with COC use before the first full-term pregnancy (FFTP). METHODS:This Canadian population-based case-control study (2001-2012) included 854 invasive cases/2139 controls aged ⩾40 years who...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2016.400
更新日期：2017-01-17 00:00:00
abstract：:The human gene sequences encoding the translation-associated functions of alpha-subunit of elongation factor 1 (EF-1 alpha) and the ubiquitin carboxyl extension protein (HUBCEP80) have been isolated by differential cDNA screening, and found to have significantly higher levels of expression in fibroadenomas (benign) co...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1992.12
更新日期：1992-01-01 00:00:00
abstract：BACKGROUND:PEP02, also known as MM-398, is a novel nanoliposomal irinotecan that has improved pharmacokinetics and tumour bio-distribution of the free drug. This phase 2 study evaluated PEP02 monotherapy as second-line treatment for pancreatic cancer. METHODS:Patients who had metastatic pancreatic adenocarcinoma, Karn...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究
doi：10.1038/bjc.2013.408
更新日期：2013-08-20 00:00:00
abstract：:Data from the Oxford Survey have shown that childhood cancers are causes of in utero deaths which affect leukaemias more than solid tumours and difficult deliveries more than easy ones. As a result of these biases singletons give the impression of being more leukaemia-sensitive than twins. This is a false impression w...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1973.59
更新日期：1973-06-01 00:00:00
abstract：:There is increasing evidence of a systemic inflammatory response associated with malignancy, which may have an impact on both drug disposition and resistance to cytotoxic therapy. The impact of inflammation on drug disposition was studied in mice bearing a number of common tumour xenografts. C57BL/6 mice were inoculat...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604101
更新日期：2008-01-15 00:00:00
abstract：:A serological assay for the quantitative determination of the novel tumour-associated epitope CA242 was developed and used for determination of sensitivity and specificity of CA242 in gastrointestinal cancer. The CA242 assay showed a better tumour specificity than CA50 (and CA 19-9). This was most noticeable in benign...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1992.44
更新日期：1992-02-01 00:00:00
