Type distribution, viral load and integration status of high-risk human papillomaviruses in pre-stages of cervical cancer (CIN).

abstract：:Increasingly, reverse transcriptase polymerase chain reaction (RT-PCR) is used to detect clinically significant tumour cells in blood or bone marrow. This may result in a redefinition of disease-free and clinical relapse. However, its clinical utility may be limited by lack of automation or reproducibility. Recent stu...

journal_title：British journal of cancer

authors： Burchill SA,Perebolte L,Johnston C,Top B,Selby P

更新日期：2002-01-07 00:00:00

abstract：:The tumour-suppressor gene TP53 is frequently mutated in breast tumours, and the majority of the mutations are clustered within the core domain, the region involved in DNA binding. We searched for alterations in this central domain of the TP53gene in 222 human breast cancer specimens using polymerase chain reaction-si...

journal_title：British journal of cancer

authors： Berns EM,van Staveren IL,Look MP,Smid M,Klijn JG,Foekens JA

更新日期：1998-04-01 00:00:00

abstract：:Phyto-oestrogens are plant compounds structurally similar to oestradiol, which have been proposed to have protective effects against breast cancer. The main class of phyto-oestrogens in the Western diet is lignans. Literature reports on the effect of lignans in breast cancer risk have been conflicting. We performed th...

journal_title：British journal of cancer

authors： Velentzis LS,Cantwell MM,Cardwell C,Keshtgar MR,Leathem AJ,Woodside JV

更新日期：2009-05-05 00:00:00

abstract：BACKGROUND:Tumour hypoxia is associated with impaired apoptosis, resistance to therapy and poor prognosis. We previously reported that high stromal expression of the endogenous marker of hypoxia, carbonic anhydrase IX (CAIX), is associated with significantly reduced survival in oral squamous cell carcinoma (OSCC). In a...

journal_title：British journal of cancer

authors： Klimowicz AC,Bose P,Petrillo SK,Magliocco AM,Dort JC,Brockton NT

更新日期：2013-10-01 00:00:00

abstract：:We cytogenetically investigated six osteoid osteomas, one osteoblastoma and one aggressive osteoblastoma, and observed clonal structural changes in one osteoid osteoma and in the aggressive osteoblastoma. Clonal chromosome changes had not been reported previously in osteoid osteoma, whereas the only reported chromosom...

journal_title：British journal of cancer

authors： Dal Cin P,Sciot R,Samson I,De Wever I,Van den Berghe H

更新日期：1998-08-01 00:00:00

abstract：:A cytogenetic study was performed in 27 patients suspected of t-MDS or t-ANLL. In 12 patients the diagnosis of t-MDS or t-ANLL was confirmed by morphological, cytochemical and immunophenotypical analysis. The cases were classified as RA (one), RAEB (four), CMML (two), ANLL (five). They had received chemotherapy and/or...

journal_title：British journal of cancer

authors： Sozzi G,Miozzo M,Orazi A,Calderone C,Castellano M,Viviani S,Santoro A,Pierotti MA,Della Porta G

更新日期：1990-03-01 00:00:00

abstract：BACKGROUND:Lithium accumulates in the colon and inhibits the enzyme GSK-3β that possesses anti-carcinogenic effects. We therefore examined the association between lithium use and colorectal cancer risk in a nationwide study. METHODS:We used the Danish Cancer Registry to identify all patients diagnosed with incident co...

journal_title：British journal of cancer

authors： Pottegård A,Ennis ZN,Hallas J,Jensen BL,Madsen K,Friis S

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:To evaluate the possible association between paediatric head computed tomography (CT) examination and increased subsequent risk of malignancy and benign brain tumour. METHODS:In the exposed cohort, 24 418 participants under 18 years of age, who underwent head CT examination between 1998 and 2006, were ident...

journal_title：British journal of cancer

authors： Huang WY,Muo CH,Lin CY,Jen YM,Yang MH,Lin JC,Sung FC,Kao CH

更新日期：2014-04-29 00:00:00

abstract：:Increasingly, treatment choices leading to the same survival outcome can be offered to cancer patients (e.g. mastectomy or conservative surgery in early breast cancer). Two approaches available for post-orchidectomy, stage I patients with non-seminomatous germ cell tumours of the testis (NSGCTT), particularly those at...

journal_title：British journal of cancer

authors： Cullen MH,Billingham LJ,Cook J,Woodroffe CM

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND:Favourable outcomes of breast cancer screening trials in the 1970s and 1980s resulted in the launch of population-based service screening programmes in many Western countries. We investigated whether improvements in mammography and treatment modalities have had an influence on the effectiveness of breast can...

journal_title：British journal of cancer

authors： van Schoor G,Moss SM,Otten JD,Donders R,Paap E,den Heeten GJ,Holland R,Broeders MJ,Verbeek AL

更新日期：2011-03-15 00:00:00

abstract：:The characteristics of 7 human melanoma cell lines were compared with those of the xenografts from which they were established. The ultrastructure, melanin content, isozyme pattern and chromosome numbers of the cell lines were closely similar to those of the corresponding xenografts. The different cell lines gave rise...

journal_title：British journal of cancer

authors： Tveit KM,Pihl A

更新日期：1981-12-01 00:00:00

abstract：:The MBD4 gene is involved in the repair of mutation at methyl-CpG dinucleotides. In microsatellite unstable tumours MBD4 can itself be mutated at an exonic polynucleotide tract. By analysing DNA from microdissected tumour samples we have found that both frequency and pattern of mutation are more significant than origi...

journal_title：British journal of cancer

authors： Bader S,Walker M,Harrison D

更新日期：2000-12-01 00:00:00

abstract：:Oestrogen receptor (ER) is used routinely to predict endocrine responsiveness in patients with breast cancer. A second ER, ERbeta has been described but its significance remains undefined; most studies have described mRNA levels rather than protein expression. Here, we demonstrate for the first time, immunohistochemic...

journal_title：British journal of cancer

authors： Skliris GP,Carder PJ,Lansdown MR,Speirs V

更新日期：2001-04-20 00:00:00

abstract：:The efficacy of cisplatin [cis-diamminedichloroplatinum (II); DDP] is hampered by acquired or de novo resistance of malignant cells to its cytotoxic effects. We have previously reported that cisplatin resistance parallels glutathione S-transferase (GST) activity in several human small-cell lung cancer cell lines. In t...

journal_title：British journal of cancer

authors： Awasthi S,Sharma R,Singhal SS,Herzog NK,Chaubey M,Awasthi YC

更新日期：1994-08-01 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide. We tested megestrol acetate (MA) against placebo in the treatment of advanced HCC. METHODS:From 2002 through 2007, this randomised double-blind trial enrolled 204 patients with treatment-naive advanced HCC (Eastern Coopera...

journal_title：British journal of cancer

authors： Chow PK,Machin D,Chen Y,Zhang X,Win KM,Hoang HH,Nguyen BD,Jin MY,Lobo R,Findlay M,Lim CH,Tan SB,Gandhi M,Soo KC,Asia-Pacific Hepatocellular Carcinoma Trials Group.

更新日期：2011-09-27 00:00:00

abstract：:1-5% of cancer patients treated with cytotoxic chemotherapy die within a month after the administration of chemotherapy. Risk factors for these early deaths (ED) are not well known. The purpose of this study was to establish a risk model for ED after chemotherapy applicable to all tumour types. The model was delineate...

journal_title：British journal of cancer

authors： Ray-Coquard I,Ghesquière H,Bachelot T,Borg C,Biron P,Sebban C,LeCesne A,Chauvin F,Blay JY,ELYPSE Study Group.

更新日期：2001-09-14 00:00:00

abstract：:The purpose of this study was to investigate the effect of breast density on breast cancer (BC) mortality in a mammography screening programme. The cohort included 48 052 women participating in mammography screening in Copenhagen, Denmark, where biennial screening is offered to women aged 50-69 years. We collected inf...

journal_title：British journal of cancer

authors： Olsen AH,Bihrmann K,Jensen MB,Vejborg I,Lynge E

更新日期：2009-04-07 00:00:00

abstract：:Short-term cultures from one synovial chondroma and three cases of synovial chondromatosis, a lesion for which no previous karyotypic information exists, were cytogenetically analysed. Whereas the chondroma displayed the relatively simple karyotype 46,XY,add(12)(q13),der(17)t(12;17)(q13;q21), more complex changes were...

journal_title：British journal of cancer

authors： Mertens F,Jonsson K,Willén H,Rydholm A,Kreicbergs A,Eriksson L,Olsson-Sandin G,Mitelman F,Mandahl N

更新日期：1996-07-01 00:00:00

abstract：:Mutations of the p53 tumour suppressor gene are infrequent at presentation of both acute myeloblastic leukaemia (AML) and acute lymphoblastic leukaemia (ALL), being found in between 5-10% of AML and 2-3% of ALL. Here we have studied the frequency of detection of p53 mutations at relapse of both AML and B-precursor ALL...

journal_title：British journal of cancer

authors： Zhu YM,Foroni L,McQuaker IG,Papaioannou M,Haynes A,Russell HH

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND:We used bleomycin, etoposide, cisplatin (BEP), the most effective regimen in the treatment of germ cell tumours (GCTs) and increased dose-density by using pegfilgrastim to shorten cycle length. Our aim was to assess safety and tolerability. METHODS:Sixteen male patients with intermediate or poor prognosis m...

journal_title：British journal of cancer

authors： Rimmer Y,Chester J,Joffe J,Stark D,Shamash J,Powles T,White J,Wason J,Parashar D,Armstrong G,Mazhar D,Williams MV

更新日期：2011-09-06 00:00:00

abstract：:Even though the majority of patients with bladder malignancies initially present with low stage disease, the clinical epidemiology of these so-called superficial bladder tumours is not well known. In this paper, disease characteristics at initial presentation and during follow-up are described in 1,745 primary cases d...

journal_title：British journal of cancer

authors： Kiemeney LA,Witjes JA,Verbeek AL,Heijbroek RP,Debruyne FM

更新日期：1993-04-01 00:00:00

abstract：:Choriocarcinoma can be imaged by external scintigraphy after intravenous administration of radiolabelled antibody directed against human chorionic gonadotrophin (HCG). The purpose of this study was to investigate whether antibody imaging was sufficiently sensitive and specific to improve the selection of patients for ...

journal_title：British journal of cancer

authors： Begent RH,Bagshawe KD,Green AJ,Searle F

更新日期：1987-06-01 00:00:00

abstract：:In a longitudinal study of the evolution of serum beta 2-microglobulin (beta 2-m) levels in 37 patients with myelomatosis, those patients with a level of < 4 mg/l at first presentation had a median survival of 46 months, whereas those with an initial level of > mg/l had a median survival of 15 months. THe beta 2-m app...

journal_title：British journal of cancer

authors： Norfolk D,Child JA,Cooper EH,Kerruish S,Ward AM

更新日期：1980-10-01 00:00:00

abstract：BACKGROUND:Previous studies on the effects of different prostate cancer treatments on quality of life, were confounded because patients were not comparable. This study examined treatment effects in more comparable groups. METHODS:From 2008-2011, 240 patients with localised prostate cancer were selected to be eligible ...

journal_title：British journal of cancer

authors： van Tol-Geerdink JJ,Leer JW,van Oort IM,van Lin EJ,Weijerman PC,Vergunst H,Witjes JA,Stalmeier PF

更新日期：2013-05-14 00:00:00

abstract：:A substantial excess risk of lymphomas and nonmelanoma skin cancer has been demonstrated following organ transplantation. Large sample size and long follow-up time may, however, allow more accurate risk estimates and detailed understanding of long-term cancer risk. The objective of the study was to assess the risk of ...

journal_title：British journal of cancer

authors： Adami J,Gäbel H,Lindelöf B,Ekström K,Rydh B,Glimelius B,Ekbom A,Adami HO,Granath F

更新日期：2003-10-06 00:00:00

abstract：BACKGROUND:PI3K/Akt (PKB) pathway has been shown in several cell types to be activated by ligands to cell surface integrins, leading to the metastasis of tumour cells. The signalling pathways involved in the metastatic spread of human scirrhous gastric carcinoma cells have not been defined. METHODS:The role of the PI3...

journal_title：British journal of cancer

authors： Matsuoka T,Yashiro M,Nishioka N,Hirakawa K,Olden K,Roberts JD

更新日期：2012-04-24 00:00:00

abstract：:In clinically organ-confined prostate cancer patients, bloodstream tumour cell dissemination generally occurs, and may be enhanced by surgical prostate manipulation. To evaluate cancer-cell seeding impact upon patient recurrence-free survival, 155 patients were prospectively enrolled then followed. Here, 57 patients p...

journal_title：British journal of cancer

authors： Eschwège P,Moutereau S,Droupy S,Douard R,Gala JL,Benoit G,Conti M,Manivet P,Loric S

更新日期：2009-02-24 00:00:00

abstract：:Cells of a patient with Turcot's syndrome and of her parents were evaluated for the presence of molecular alterations in the p53 and the Ki-ras gene. Deletions on chromosome 17p, overexpression and point mutations of the p53 gene as well as mutations of the Ki-ras gene were detected in primary and metastatic tumour bu...

journal_title：British journal of cancer

authors： Rochlitz CF,Heide I,de Kant E,Neubauer A,Schmidt CA,Neuhaus P,Huhn D,Herrmann R

更新日期：1993-09-01 00:00:00

abstract：:The nature of the invasive growth pattern and microvessel density (MVD) have been suggested to be predictors of prognosis in primary colorectal cancer (CRC) and colorectal liver metastases. The purpose of the present study was to determine whether these two histological features were interrelated and to assess their r...

journal_title：British journal of cancer

authors： Rajaganeshan R,Prasad R,Guillou PJ,Chalmers CR,Scott N,Sarkar R,Poston G,Jayne DG

更新日期：2007-04-10 00:00:00

abstract：:We investigated expression of a human p53-inducible gene, P2XM, a member of the P2X-receptor family of ATP-gated ion channels, in 56 human primary soft-tissue tumours including 47 sarcomas and nine benign tumors. Among the 47 sarcomas examined by reverse transcription polymerase chain reaction, 12 had lost expression ...

journal_title：British journal of cancer

authors： Nawa G,Miyoshi Y,Yoshikawa H,Ochi T,Nakamura Y

更新日期：1999-06-01 00:00:00