Abstract：
:In clinically organ-confined prostate cancer patients, bloodstream tumour cell dissemination generally occurs, and may be enhanced by surgical prostate manipulation. To evaluate cancer-cell seeding impact upon patient recurrence-free survival, 155 patients were prospectively enrolled then followed. Here, 57 patients presented blood prostate cell shedding preoperatively and intraoperatively (group I). Of the 98 preoperatively negative patients, 53 (54%) remained negative (group II) and 45 (46%) became intraoperatively positive (group III). Median biological and clinical recurrence-free time was far shorter in group I (36.2 months, P<0.0001) than in group II (69.6 months) but did not significantly differ in group II and III (69.6 months vs 65.0). Such 5-year follow-up data show that preoperative circulating prostate cells are an independent prognosis factor of recurrence. Moreover, tumour handling induces cancer-cell seeding but surgical blood dissemination does not accelerate cancer evolution.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Eschwège P,Moutereau S,Droupy S,Douard R,Gala JL,Benoit G,Conti M,Manivet P,Loric Sdoi
10.1038/sj.bjc.6604912subject
Has Abstractpub_date
2009-02-24 00:00:00pages
608-10issue
4eissn
0007-0920issn
1532-1827pii
6604912journal_volume
100pub_type
杂志文章abstract：:Thirty-three patients with squamous cell carcinoma of the head and neck region were studied concerning p53 protein expression and mutations in exons 4-9 of the p53 gene using immunohistochemistry, polymerase chain reaction (PCR)-single strand conformation polymorphism analysis and DNA sequencing. Immunoreactivity was ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1995.159
更新日期：1995-04-01 00:00:00
abstract：:A pilot study of continuous infusional 5-fluorouracil 200 mg m-2 per 24 h by ambulatory pump and Hickman line for the entire treatment cycle with mitomycin C 8 mg m-2 i.v. on day 1 and cisplatin 75 mg m-2 i.v. on day 1, both repeated every 28 days, was carried out in 31 previously untreated patients with advanced non-...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/bjc.1995.255
更新日期：1995-06-01 00:00:00
abstract：:Germline mutations in the LKB1 (STK11) gene (chromosome sub-band 19p13.3) cause characteristic hamartomas and pigmentation to develop in patients with Peutz-Jeghers syndrome. Peutz-Jeghers syndrome carries an overall risk of cancer that may be up to 20 times that of the general population and Peutz-Jeghers patients ar...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6690323
更新日期：1999-04-01 00:00:00
abstract：:HER-2/neu gene amplification and cell surface overexpression are important factors in breast cancer for prognosis and prediction of sensitivity to anti-HER-2/neu monoclonal antibody therapy. In lung cancer, the clinical significance of HER-2/neu expression is currently under evaluation. We investigated 238 non-small l...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600286
更新日期：2002-05-06 00:00:00
abstract：BACKGROUND:A combination of S-1 and cisplatin has been shown to be effective with acceptable safety for the first-line treatment of far-advanced gastric cancer in Japan. This is the first randomised phase II trial to compare S-1+paclitaxel with S-1+cisplatin in this setting. METHODS:Patients with unresectable and/or r...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1038/bjc.2012.222
更新日期：2012-06-26 00:00:00
abstract：:A brief account is given of two types of rare soft tissue sarcoma of uncertain histogenesis. The danger of mistaking the epitheloid sarcoma for a benign lesion is emphasized. ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1971.58
更新日期：1971-09-01 00:00:00
abstract：:We assayed methyl-p-hydroxyphenyllactate esterase (MeHPLAase) activity in 63 cases of primary laryngeal squamous cell carcinoma. MeHPLAase activity did not show any correlation with oestrogen, progesterone and epidermal growth factor (EGF) receptor levels. No significant relationship was found between MeHPLAase activi...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1998.210
更新日期：1998-04-01 00:00:00
abstract：:Summary Antibodies against Candida albicans antigenic determinants have been reported to cross-react with human tumour cells. We have found that two monoclonal antibodies, C6 and PA1OF, developed at our laboratory against C. albicans antigenic determinants, cross-react with human ovarian cancer on Western blots and im...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1998.167
更新日期：1998-03-01 00:00:00
abstract：:This corrects the article DOI: 10.1038/bjc.2017.327. ...
journal_title：British journal of cancer
pub_type： 杂志文章,已发布勘误
doi：10.1038/bjc.2017.438
更新日期：2018-01-01 00:00:00
abstract：:Immunoglobulins (Ig) and some complement components (C) were quantified in sera from patients with gastric carcinoma before surgery and at regular intervals during a 5-year follow-up. The preoperative concentrations of C1-INH and C4 were higher (P < 0.0005 and P < 0.005) and IgG lower (P < 0.0005) in 50 patients with ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1992.376
更新日期：1992-11-01 00:00:00
abstract：:A crude membrane fraction isolated from mouse tumour cells was treated with various chemicals. The effects on the immunogenicity of the membrane sample were tested in syngeneic mice for tumour protection, using a challenge dose of 10(5) viable tumour cells. Best protection was obtained after immunization of mice with ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1978.236
更新日期：1978-10-01 00:00:00
abstract：:The aim of this phase I study was to determine the maximum tolerated dose of a 3-h infusion of paclitaxel, combined with carboplatin at a fixed AUC of 7 mg ml-1 min every 4 weeks for up to six cycles and to evaluate any possible pharmacokinetic interaction. Twelve chemonaive patients with ovarian cancer were treated w...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/bjc.1997.47
更新日期：1997-01-01 00:00:00
abstract：BACKGROUND:Numerous markers have been evaluated to facilitate the non-invasive diagnostic work-up of mesothelioma. The purpose of this study was to conduct a structured review of the diagnostic performance of non-invasive marker tests for the detection of mesothelioma in patients with suspected mesothelioma. METHODS:S...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/bjc.2011.104
更新日期：2011-04-12 00:00:00
abstract：:DBA/2J mice bearing a clonal isolate of the transplantable murine lymphocytic leukaemia line P388 were used to examine the effects of L-histidinol on the antitumour activity of three alkalyating agents (bis-chloroethylnitrosourea (BCNU), cis-diamminedichloroplatinum (II) (cisDDP) and cyclophosphamide) and the antitumo...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1989.333
更新日期：1989-11-01 00:00:00
abstract：:We investigated trends in first-time hospital admissions and deaths attributable to hepatocellular carcinoma (HCC) in a large population-based cohort of 22 073 individuals diagnosed with hepatitis C viral (HCV) infection through laboratory testing in Scotland in 1991-2006. We identified new cases of HCC through record...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604563
更新日期：2008-09-02 00:00:00
abstract：:A risk model for febrile neutropenia (FN) after conventional cytotoxic chemotherapy, based on early (day 5) lymphopenia and the dose of chemotherapy, has been described. A risk index based on parameters available at day 1 would be easier in daily practice. The objectives of this work were (1) to investigate a risk mod...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究
doi：10.1038/sj.bjc.6600724
更新日期：2003-01-27 00:00:00
abstract：BACKGROUND:Abiraterone and enzalutamide are novel endocrine treatments that abrogate androgen receptor (AR) signalling in castration-resistant prostate cancer (CRPC). Here, we developed a circulating tumour cells (CTCs)-based assay to evaluate AR expression in real-time in CRPC and investigated nuclear AR expression in...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2015.63
更新日期：2015-03-31 00:00:00
abstract：:Gain of 1q is one of the most common alterations in cancer and has been associated with adverse clinical behaviour in ependymoma. The aim of this study was to investigate this region to gain insight into the role of 1q genes in intracranial paediatric ependymoma. To address this issue we generated profiles of eleven e...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604651
更新日期：2008-10-07 00:00:00
abstract：:A human tamoxifen-resistant mammary carcinoma, MaCa 3366/TAM, originating from a sensitive parental xenograft 3366 was successfully established by treatment of tumour-bearing nude mice with 1-50 mg kg(-1) tamoxifen for 3 years during routine passaging. Both tumours did not differ significantly in OR- and PR-positivity...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2000.1156
更新日期：2000-06-01 00:00:00
abstract：BACKGROUND:The aim was to evaluate whether this gastric cancer-screening programme was effective in reducing oesophageal cancer mortality. METHODS:A population-based retrospective cohort study was conducted using the Korean National Cancer Screening Programme (NCSP) database. The study cohort comprised 16,969 oesophag...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-020-0883-x
更新日期：2020-08-01 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章,随机对照试验
doi：10.1038/bjc.2012.309
更新日期：2012-08-07 00:00:00
abstract：BACKGROUND:This study explored the association between smoking and colorectal malignant carcinoma (CRC) in the Chinese population at the national level for the first time. METHODS:In the China Nationwide Retrospective Mortality Survey conducted during 1989-1991, 12,942 CRC cases among 1,136,336 all-cause deaths aged ≥...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2014.9
更新日期：2014-03-04 00:00:00
abstract：:Malignant melanoma (MM) is thought to arise by sequential accumulation of genetic alterations in normal melanocytes. Previous cytogenetic and molecular studies indicated the 9p21 as the chromosomal region involved in MM pathogenesis. In addition to the CDKN genes (p16/CDKN2A, p15/CDKN2B and p19(ARF), frequently inacti...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2000.1513
更新日期：2000-12-01 00:00:00
abstract：BACKGROUND:Bortezomib is a proteasome inhibitor with minimal clinical activity as a monotherapy in solid tumours, but its combination with other targeted therapies is being actively investigated as a way to increase its anticarcinogenic properties. Here, we evaluate the therapeutic potential of co-treatment with bortez...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2011.546
更新日期：2012-01-17 00:00:00
abstract：:Mutation and overexpression are the main activating mechanisms for the ras family of genes in human cancer and the variable tandem repeat (VTR) located at the 3' end of H-ras has been associated with this risk. In the present study, we have analysed the relative levels of expression of H-ras mRNA in 26 samples of squa...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1995.287
更新日期：1995-07-01 00:00:00
abstract：:The risk of ovarian epithelial neoplasia following use of hormonal contraceptives (HC) was examined in data from the Norwegian-Swedish Women's Lifestyle and Health cohort including 103551 women aged 30-49 years in 1991-92. Follow-up through 2000 produced 214 incident cases of histologically confirmed epithelial ovaria...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601715
更新日期：2004-04-05 00:00:00
abstract：:The relationship between mammalian facilitative glucose transport proteins (GLUT) and multidrug resistance was examined in two vincristine (VCR)-selected murine erythroleukaemia (MEL) PC4 cell lines. GLUT proteins, GLUT1 and GLUT3, were constitutively coexpressed in the parental cell line and also in the VCR-selected ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1997.27
更新日期：1997-01-01 00:00:00
abstract：:The micronucleus (MN) test has been carefully characterized in four human tumour cell lines of widely differing radiosensitivity. Two radioresistant bladder carcinoma cell lines (MGH-U1 and RT112), one sensitive medulloblastoma cell line (D283MED) and a sensitive neuroblastoma cell line (HX142) were used. The number o...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1993.17
更新日期：1993-01-01 00:00:00
abstract：:Human peripheral-blood mononuclear cells, separated by Isopaque-Ficoll flotation and E-rosette formation, were tested by the fluorescein fluorescence polarization method of Cercek & Cercek (the SCM test). The response to stimulation with PHA or cancer tissue leads to a decreased polarization value TP). The responding ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1979.228
更新日期：1979-10-01 00:00:00
abstract：:The abilities of chemokines in orchestrating cellular migration are utilised by different (patho-)biological networks including malignancies. However, except for CXCR4/CXCL12, little is known about the relation between tumour-related chemokine expression and the development and progression of solid tumours like breast...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604621
更新日期：2008-09-16 00:00:00
