Abstract：
BACKGROUND:This randomised controlled trial examined the impact of screening for distress followed by two different triage methods on clinically relevant outcomes over a 12-month period. METHODS:Newly diagnosed patients attending a large tertiary cancer centre were randomised to one of the two conditions: (1) screening with computerised triage or (2) screening with personalised triage, both following standardised clinical triage algorithms. Patients completed the Distress Thermometer, Pain and Fatigue Thermometers, the Psychological Screen for Cancer (PSSCAN) Part C and questions on resource utilisation at baseline, 3, 6 and 12 months. RESULTS:In all, 3133 patients provided baseline data (67% of new patients); with 1709 (54.5%) retained at 12 months (15.4% deceased). Mixed effects models revealed that both groups experienced significant decreases in distress, anxiety, depression, pain and fatigue over time. People receiving personalised triage and people reporting higher symptom burden were more likely to access services, which was subsequently related to greater decreases in distress, anxiety and depression. Women may benefit more from personalised triage, whereas men may benefit more from a computerised triage model. CONCLUSION:Screening for distress is a viable intervention that has the potential to decrease symptom burden up to 12 months post diagnosis. The best model of screening may be to incorporate personalised triage for patients indicating high levels of depression and anxiety while providing computerised triage for others.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Carlson LE,Waller A,Groff SL,Zhong L,Bultz BDdoi
10.1038/bjc.2012.309subject
Has Abstractpub_date
2012-08-07 00:00:00pages
617-25issue
4eissn
0007-0920issn
1532-1827pii
bjc2012309journal_volume
107pub_type
杂志文章,随机对照试验abstract：:The oestrogen receptor (RE) status of the primary tumour has been assessed in 466 of a consecutive series of 550 patients with primary operable breast cancer. All patients were followed up (without treatment) until the development of recurrence or metastases. Distant metastases have so far occurred in 124 patients and...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1981.205
更新日期：1981-09-01 00:00:00
abstract：BACKGROUND:LIM and SH3 protein 1 (LASP-1) is a nucleo-cytoplasmatic signalling protein involved in cell proliferation and migration and is upregulated in breast cancer in vitro studies have shown that LASP-1 might be regulated by prostate-derived ETS factor (PDEF), p53 and/or LASP1 gene amplification. This current stud...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605685
更新日期：2010-05-25 00:00:00
abstract：:Many cancers express Fas ligand (FasL/CD95L) in vivo, and can kill lymphoid cells by Fas-mediated apoptosis in vitro. However, overexpression of recombinant FasL in murine tumour allografts revealed a potential antitumour effect of FasL, via recruitment of neutrophils. Transforming growth factor-beta1 (TGF-beta1) coul...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601240
更新日期：2003-10-06 00:00:00
abstract：BACKGROUND:Tumours are responsive to temozolomide (TMZ) if they are deficient in O(6)-methylguanine-DNA methyltransferase (MGMT), and mismatch repair (MMR) proficient. METHODS:The effect of TMZ on medulloblastoma (MB) cell killing was analysed with clonogenic survival assays. Expression of DNA repair genes and enzymes...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2012.403
更新日期：2012-10-09 00:00:00
abstract：BACKGROUND:Liver metastases present with distinct histopathological growth patterns (HGPs), including the desmoplastic, pushing and replacement HGPs and two rarer HGPs. The HGPs are defined owing to the distinct interface between the cancer cells and the adjacent normal liver parenchyma that is present in each pattern ...
journal_title：British journal of cancer
pub_type： 杂志文章,实务指引
doi：10.1038/bjc.2017.334
更新日期：2017-11-07 00:00:00
abstract：BACKGROUND:Interferon (IFN)-based therapies could eradicate hepatitis C (HCV) and reduce the risk of hepatocellular carcinoma (HCC). However, HCC could still happen after sustained virological response (SVR). We aimed to develop a simple scoring system to predict the risk of HCC development among HCV patients after ant...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2013.564
更新日期：2013-10-29 00:00:00
abstract：:An analysis of the occurrence of breast cancer in this long-term prospective cohort study shows a significant relative risk (RR) in women who have ever used oral contraceptives (OC) of 3.33 in women age 30 to 34 years at diagnosis and an RR of 5.88 (P = 0.0011) in women who were parity 1 at the time of diagnosis. In w...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1988.285
更新日期：1988-11-01 00:00:00
abstract：:The cytocidal properties of metronidazole against hypoxic mammalian cells are described. This chemotherapeutic action has been shown to be dependent on drug concentration and duration of exposure. The x-ray TCD50 for a murine anaplastic carcinoma was reduced from 6081 rad to 4643 rad when animals were given metronidaz...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1976.78
更新日期：1976-05-01 00:00:00
abstract：:Hypoxia, a hallmark of most solid tumours, is a negative prognostic factor due to its association with an aggressive tumour phenotype and therapeutic resistance. Given its prominent role in oncology, accurate detection of hypoxia is important, as it impacts on prognosis and could influence treatment planning. A variet...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/bjc.2014.610
更新日期：2015-01-20 00:00:00
abstract：BACKGROUND:Record-based studies have generally reported association of higher childhood leukaemia incidence with higher socioeconomic status (SES), but recent findings are less consistent. METHODS:We examined records from the National Registry of Childhood Tumours for evidence of this association in England and Wales ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2011.415
更新日期：2011-11-22 00:00:00
abstract：:It is suggested that the proximate carcinogenic forms of dialkylnitrosamines are their oxidation products, which retain the alkylnitrosamino moiety, but have acquired a carbonyl function as a result of omega or beta oxidation of an alkyl group. Such metabolites resemble the locally acting carcinogenic "nitrosamides" a...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1973.169
更新日期：1973-11-01 00:00:00
abstract：:We have recently reported the activation of a new oncogene in human papillary thyroid carcinomas. This oncogene, named PTC, is a novel rearranged version of the ret proto-oncogene. In fact PTC is the product of the fusion of the tyrosine kinase domain of the ret proto-oncogene with the 5'-terminal region of another ge...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1992.416
更新日期：1992-12-01 00:00:00
abstract：:The aim of this study was to investigate the expression of the protein tyrosine phosphatases (PTP) PRL-1, PRL-2, and PRL-3 in human breast cancer and to evaluate its clinical and prognostic significance. PRL-PTP mRNA expression was examined in malignant (n = 7) and nonmalignant (n = 7) cryoconserved breast tissue samp...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603261
更新日期：2006-08-07 00:00:00
abstract：:Vascular and angiogenic processes provide an important target for novel cancer therapeutics. Dynamic contrast-enhanced magnetic resonance imaging is being used increasingly to noninvasively monitor the action of these therapeutics in early-stage clinical trials. This publication reports the outcome of a workshop that ...
journal_title：British journal of cancer
pub_type： 指南,杂志文章
doi：10.1038/sj.bjc.6602550
更新日期：2005-05-09 00:00:00
abstract：BACKGROUND:Bevacizumab has broad anti-tumour activity, but substantial risk of hypertension. No reliable markers are available for predicting bevacizumab-induced hypertension. METHODS:A genome-wide association study (GWAS) was performed in the phase III bevacizumab-based adjuvant breast cancer trial, ECOG-5103, to eva...
journal_title：British journal of cancer
pub_type： 杂志文章,随机对照试验
doi：10.1038/bjc.2014.430
更新日期：2014-09-09 00:00:00
abstract：:Caveolin-1 and -2 (CAV1, CAV2) are closely linked genes localised to the fragile region of 7q31 (FRA7G), and loss of heterozygosity involving this region has been reported in breast cancer. Several studies have suggested that CAV1 is a negative regulator of HER2/neu signal transduction in vitro. However, the clinical ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602029
更新日期：2004-08-31 00:00:00
abstract：:Chemical structures of the sugar chains of various human alpha-fetoprotein (AFP) species with different affinity for Concanavalin A (Con A) and Lens culinaris agglutinin (LCA) were examined by pyridylamination of their oligosaccharides and stepwise exoglycosidase digestion. Using reversed-phase and size-fractionation ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1993.91
更新日期：1993-03-01 00:00:00
abstract：:A number of rare human inherited syndromes are associated with apparent defects in DNA repair and a greatly increased frequency of cancer. Cell lines derived from such individuals phenotypically resemble certain bacterial mutant strains that have increased sensitivity to radiation or chemical agents and well character...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/bjc.1987.163
更新日期：1987-08-01 00:00:00
abstract：:Our objective was to determine whether oral etoposide and cisplatin combination (EoP) is superior to paclitaxel in the treatment of advanced breast cancer (ABC) patients pretreated with anthracyclines. From December 1997 to August 2003, 201 patients were randomised, 100 to EoP and 101 to paclitaxel arms. Four patients...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1038/sj.bjc.6602388
更新日期：2005-02-28 00:00:00
abstract：:We evaluated the therapeutic usefulness of adjuvant chemotherapy in patients with completely resected non-small cell lung cancer (NSCLC). We also examined the relation between DNA ploidy pattern and the response to chemotherapy. A total of 267 patients with NSCLC (pathologically documented stage I, II, or IIIA) underw...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1038/sj.bjc.6603336
更新日期：2006-10-09 00:00:00
abstract：:The study was originally set up to measure accurate cell kinetic parameters in two murine squamous cell carcinomas (scc) for comparison with radiobiological data on proliferation during radiotherapy. The tumours, AT84 and AT478, were both moderately well differentiated aneuploid scc. In the course of the study, severa...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1993.487
更新日期：1993-12-01 00:00:00
abstract：BACKGROUND:Metastatic clear cell renal cell carcinoma (ccRCC) patients have <9% 5-year survival rate, do not respond well to targeted therapy and eventually develop resistance. A better understanding of molecular pathways of RCC metastasis is the basis for the discovery of novel prognostic markers and targeted therapie...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2013.828
更新日期：2014-03-04 00:00:00
abstract：:Hyper-activation of mitogen-activated protein kinase (MAPK) has recently been reported in several human cancers and activation of MAPK in those cancers may be associated with carcinogenesis through aberrant cell proliferation. To understand the roles of the MAPK pathway in colorectal tumorigenesis, we examined the sta...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6690817
更新日期：1999-12-01 00:00:00
abstract：:The degree of lymphocyte infiltration is a prognostic factor in liver cancer, but to date the mechanisms by which lymphocytes infiltrate into and are retained in hepatic tumours are poorly understood. We hypothesised that the extracellular matrix glycoprotein vitronectin, a major component of the stroma of hepatic tum...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603467
更新日期：2006-12-04 00:00:00
abstract：:Hyperthermia (42° C.) exerted an inhibitory effect on the O(2) uptake of rabbit VX2 carcinoma cells in vitro, and led to a decrease in viability and growth potential of the cells, as measured by their ability to produce tumours in rabbits. Anaerobic glycolysis of the tumour cells was unaltered by hyperthermia. Respira...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1971.91
更新日期：1971-12-01 00:00:00
abstract：:The addition of lapatinib (Tykerb/Tyverb) to capecitabine (Xeloda) delays disease progression more effectively than capecitabine monotherapy in women with previously treated HER2+ metastatic breast cancer (MBC). The quality-adjusted time without symptoms of disease or toxicity of treatment (Q-TWiST) method was used to...
journal_title：British journal of cancer
pub_type： 杂志文章,随机对照试验
doi：10.1038/sj.bjc.6604501
更新日期：2008-09-02 00:00:00
abstract：:The role of the anti-apoptotic protein Bcl-2 in lung cancer remains controversial. In order to clarify its impact on survival in small and non-small cell lung cancer (NSCLC), we performed a systematic review of the literature. Trials were selected for further analysis if they provided an independent assessment of Bcl-...
journal_title：British journal of cancer
pub_type： 杂志文章,meta分析,评审
doi：10.1038/sj.bjc.6601095
更新日期：2003-07-07 00:00:00
abstract：:At baseline, weight-losing pancreatic cancer patients (n=7) had lower leptin (P<0.05) but higher cortisol, interleukin-6, resting energy expenditure and fat oxidation than healthy subjects (n=6, P<0.05). Over a 4 h feeding period, the areas under the curve for glucose, cortisol and interleukin-6 were greater (P<0.05),...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601712
更新日期：2004-03-22 00:00:00
abstract：:Increases of individual beta tubulin isotypes in antimicrotubule drug resistant cell lines have been reported by several laboratories. We have previously described elevations in beta(III)and beta(IVa)isotypes in estramustine and paclitaxel resistant human prostate carcinoma cells. To investigate further the function o...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2001.1956
更新日期：2001-09-01 00:00:00
abstract：BACKGROUND:CYFRA 21-1 serves as biomarker in several epithelial malignancies. However, its role in pancreatic cancer (PC) has not yet been investigated. METHODS:Within a prospective single-centre study serial blood samples were collected from patients with confirmed advanced PC. Pre-treatment values and weekly measure...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/bjc.2013.158
更新日期：2013-04-30 00:00:00
