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International consensus guidelines for scoring the histopathological growth patterns of liver metastasis.

Abstract：

BACKGROUND:Liver metastases present with distinct histopathological growth patterns (HGPs), including the desmoplastic, pushing and replacement HGPs and two rarer HGPs. The HGPs are defined owing to the distinct interface between the cancer cells and the adjacent normal liver parenchyma that is present in each pattern and can be scored from standard haematoxylin-and-eosin-stained (H&E) tissue sections. The current study provides consensus guidelines for scoring these HGPs. METHODS:Guidelines for defining the HGPs were established by a large international team. To assess the validity of these guidelines, 12 independent observers scored a set of 159 liver metastases and interobserver variability was measured. In an independent cohort of 374 patients with colorectal liver metastases (CRCLM), the impact of HGPs on overall survival after hepatectomy was determined. RESULTS:Good-to-excellent correlations (intraclass correlation coefficient >0.5) with the gold standard were obtained for the assessment of the replacement HGP and desmoplastic HGP. Overall survival was significantly superior in the desmoplastic HGP subgroup compared with the replacement or pushing HGP subgroup (P=0.006). CONCLUSIONS:The current guidelines allow for reproducible determination of liver metastasis HGPs. As HGPs impact overall survival after surgery for CRCLM, they may serve as a novel biomarker for individualised therapies.

journal_name

Br J Cancer

journal_title

British journal of cancer

authors

van Dam PJ,van der Stok EP,Teuwen LA,Van den Eynden GG,Illemann M,Frentzas S,Majeed AW,Eefsen RL,Coebergh van den Braak RRJ,Lazaris A,Fernandez MC,Galjart B,Laerum OD,Rayes R,Grünhagen DJ,Van de Paer M,Sucaet Y,Mudhar H

doi

10.1038/bjc.2017.334

subject

Has Abstract

pub_date

2017-11-07 00:00:00

pages

1427-1441

issue

10

eissn

0007-0920

issn

1532-1827

pii

bjc2017334

journal_volume

117

pub_type

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