Elevated P53 expression correlates with a history of heavy smoking in squamous cell carcinoma of the head and neck.

abstract：:Cells of a patient with Turcot's syndrome and of her parents were evaluated for the presence of molecular alterations in the p53 and the Ki-ras gene. Deletions on chromosome 17p, overexpression and point mutations of the p53 gene as well as mutations of the Ki-ras gene were detected in primary and metastatic tumour bu...

journal_title：British journal of cancer

authors： Rochlitz CF,Heide I,de Kant E,Neubauer A,Schmidt CA,Neuhaus P,Huhn D,Herrmann R

更新日期：1993-09-01 00:00:00

abstract：BACKGROUND:Lithium accumulates in the colon and inhibits the enzyme GSK-3β that possesses anti-carcinogenic effects. We therefore examined the association between lithium use and colorectal cancer risk in a nationwide study. METHODS:We used the Danish Cancer Registry to identify all patients diagnosed with incident co...

journal_title：British journal of cancer

authors： Pottegård A,Ennis ZN,Hallas J,Jensen BL,Madsen K,Friis S

更新日期：2016-03-01 00:00:00

abstract：:The therapeutic efficacy of gemcitabine, a new nucleoside analogue, was assessed in a variety of well-established human soft tissue sarcoma and ovarian cancer xenografts grown s.c. in nude mice. Tumour lines selected had different histological subtypes, growth rates and sensitivities to conventional cytostatic agents....

journal_title：British journal of cancer

authors： Boven E,Schipper H,Erkelens CA,Hatty SA,Pinedo HM

更新日期：1993-07-01 00:00:00

abstract：BACKGROUND:The conventional treatment options for advanced gastric patients remain unsatisfactory in terms of response rate, response duration, toxicity, and overall survival benefit. The purpose of this phase II study was to evaluate the activity and safety of cetuximab combined with cisplatin and docetaxel as a first...

journal_title：British journal of cancer

authors： Pinto C,Di Fabio F,Barone C,Siena S,Falcone A,Cascinu S,Rojas Llimpe FL,Stella G,Schinzari G,Artale S,Mutri V,Giaquinta S,Giannetta L,Bardelli A,Martoni AA

更新日期：2009-10-20 00:00:00

abstract：BACKGROUND:Ezrin, which is known as a cytoskeleton linker protein, is closely linked with the metastatic progression of cancer and is frequently abnormally expressed in aggressive cancer types. However, the possible involvement of Ezrin in metastasis and angiogenesis in breast cancer remains unclear. METHODS:Immunohis...

journal_title：British journal of cancer

authors： Li N,Kong J,Lin Z,Yang Y,Jin T,Xu M,Sun J,Chen L

更新日期：2019-04-01 00:00:00

abstract：:Mechanisms of resistance to Tomudex include increased thymidylate synthase activity, as well as reduced intracellular drug uptake and polyglutamation. However, little is known about other mechanisms of resistance, such as a possible protection against Tomudex-induced apoptosis mediated by bcl-2. We transfected the MDA...

journal_title：British journal of cancer

authors： Orlandi L,Bearzatto A,Abolafio G,De Marco C,Daidone MG,Zaffaroni N

更新日期：1999-09-01 00:00:00

abstract：:Bacteriochlorin a (BCA) is a second-generation photosensitizer that is effective in tumour destruction upon illumination with light of a wavelength of 760 nm. Tissue penetration by light at this wavelength is greater compared with wavelengths at which commonly used photosensitizers are illuminated, making it possible ...

journal_title：British journal of cancer

authors： Rovers JP,Schuitmaker JJ,Vahrmeijer AL,van Dierendonck JH,Terpstra OT

更新日期：1998-06-01 00:00:00

abstract：:The influence of anaesthetics on the in vivo response of B16 melanoma to melphalan was studied using an in vitro cell-survival assay. Three anaesthetics were used, Saffan (Althesin) Sagatal (Nembutal) and Hypnorm. When Saffan was administered to tumour-bearing animals before melphalan there was a significant increase ...

journal_title：British journal of cancer

authors： Peacock JH,Stephens TC

更新日期：1978-12-01 00:00:00

abstract：BACKGROUND:Body mass index (BMI) has been associated with the risk of oesophageal cancer. But the influence of BMI on postoperative complication and prognosis has always been controversial. METHODS:In total, 2031 consecutive patients who underwent oesophagectomy between 1998 and 2008 were classified according to Asian...

journal_title：British journal of cancer

authors： Zhang SS,Yang H,Luo KJ,Huang QY,Chen JY,Yang F,Cai XL,Xie X,Liu QW,Bella AE,Hu RG,Wen J,Hu Y,Fu JH

更新日期：2013-11-26 00:00:00

abstract：BACKGROUND:WFDC1/Prostate stromal 20 (ps20) is a small secreted protein highly expressed within the prostate stroma. WFDC1/ps20 expression is frequently downregulated or lost in prostate cancer (PCa) and ps20 has demonstrated growth-suppressive functions in numerous tumour model systems, although the mechanisms of this...

journal_title：British journal of cancer

authors： Hickman OJ,Smith RA,Dasgupta P,Rao SN,Nayak S,Sreenivasan S,Vyakarnam A,Galustian C

更新日期：2016-05-24 00:00:00

abstract：BACKGROUND:Lapatinib, a dual EGFR and HER2 inhibitor has shown disappointing results in clinical trials of metastatic oesophago-gastric adenocarcinomas (OGAs), and in vitro studies suggest that MET, IGFR, and HER3 confer resistance. This trial applied Lapatinib in the curative neoadjuvant setting and investigated the f...

journal_title：British journal of cancer

authors： De Silva N,Schulz L,Paterson A,Qain W,Secrier M,Godfrey E,Cheow H,O'Donovan M,Lao-Sirieix P,Jobanputra M,Hochhauser D,Fitzgerald R,Ford H

更新日期：2015-11-03 00:00:00

abstract：:A correction to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：British journal of cancer

authors： Weisberg E,Manley P,Mestan J,Cowan-Jacob S,Ray A,Griffin JD

更新日期：2019-07-01 00:00:00

abstract：:A pilot study of continuous infusional 5-fluorouracil 200 mg m-2 per 24 h by ambulatory pump and Hickman line for the entire treatment cycle with mitomycin C 8 mg m-2 i.v. on day 1 and cisplatin 75 mg m-2 i.v. on day 1, both repeated every 28 days, was carried out in 31 previously untreated patients with advanced non-...

journal_title：British journal of cancer

authors： Ellis PA,Talbot DC,Nicolson MC,Priest K,Ashley S,Smith IE

更新日期：1995-06-01 00:00:00

abstract：:Over the past several years, our group has provided considerable evidence that the expression of sigma-2 (sigma2) receptors may serve as a biomarker of tumour cell proliferation. In these in vitro studies, sigma2 receptors were expressed 8-10 times more in proliferative (P) tumour cells than in quiescent (Q) tumour ce...

journal_title：British journal of cancer

authors： Wheeler KT,Wang LM,Wallen CA,Childers SR,Cline JM,Keng PC,Mach RH

更新日期：2000-03-01 00:00:00

abstract：:Two meta-analyses were conducted to quantify the benefit of combining alpha-IFN to 5FU in advanced colorectal cancer in terms of tumour response and survival. Analyses were based on a total of 3254 individual patient data provided by principal investigators of each trial. The meta-analysis of 5FU +/- LV vs. 5FU +/- LV...

journal_title：British journal of cancer

authors： Thirion P,Piedbois P,Buyse M,O'Dwyer PJ,Cunningham D,Man A,Greco FA,Colucci G,Köhne CH,Di Constanzo F,Piga A,Palmeri S,Dufour P,Cassano A,Pajkos G,Pensel RA,Aykan NF,Marsh J,Seymour MT,Meta-Analysis Group in Cancer.

更新日期：2001-03-02 00:00:00

abstract：BACKGROUND:FOXA1 expression is a good prognostic marker for endocrine therapy in hormone-positive breast cancer. We retrospectively examined breast cancer patients with luminal human epidermal growth factor receptor 2 (HER2)-negative tumours, as defined by immunohistochemistry, who received neo-adjuvant chemotherapy (N...

journal_title：British journal of cancer

authors： Horimoto Y,Arakawa A,Harada-Shoji N,Sonoue H,Yoshida Y,Himuro T,Igari F,Tokuda E,Mamat O,Tanabe M,Hino O,Saito M

更新日期：2015-01-20 00:00:00

abstract：BACKGROUND:Previous studies have demonstrated that senescent cancer-associated fibroblasts (CAFs) derived from genetically unstable oral squamous cell carcinomas (GU-OSCC), unlike non-senescent CAFs from genetically stable carcinomas (GS-OSCC), promoted keratinocyte invasion in vitro in a paracrine manner. The mechanis...

journal_title：British journal of cancer

authors： Hassona Y,Cirillo N,Heesom K,Parkinson EK,Prime SS

更新日期：2014-09-09 00:00:00

abstract：:In this review, we discuss the recent identification in vivo of a population of CD11c+ cells exhibiting simultaneous expression of both endothelial and dendritic cell markers, termed vascular leukocytes (VLCs). VLCs are highly represented in human ovarian carcinomas and, depending on the milieu, can assemble into func...

journal_title：British journal of cancer

authors： Coukos G,Benencia F,Buckanovich RJ,Conejo-Garcia JR

更新日期：2005-04-11 00:00:00

abstract：:The purpose of the study is to test the hypothesis that expression of cell cycle regulatory proteins p16(INK4a) and pRb is significantly associated with prognosis in ovarian carcinomas. We performed immunohistochemical analysis of p16(INK4a) and pRb expression and correlated with survival in a series of 300 patients w...

journal_title：British journal of cancer

authors： Kommoss S,du Bois A,Ridder R,Trunk MJ,Schmidt D,Pfisterer J,Kommoss F,AGO-OVAR.

更新日期：2007-01-29 00:00:00

abstract：:High response rates have been reported in the treatment of advanced gastric cancer with epirubicin, cisplatin and continuous infusion 5-fluorouracil (ECF), including instances of unresectable disease being rendered operable by chemotherapy. We report our experience with ECF as neoadjuvant treatment in gastric and lowe...

journal_title：British journal of cancer

authors： Melcher AA,Mort D,Maughan TS

更新日期：1996-11-01 00:00:00

abstract：:Eighteen patients with inoperable hepatocellular carcinoma (HCC) were treated with intrahepatic arterial yttrium-90 microspheres. All these patients showed a lung shunting below 15% and a tumour-to-normal ratio higher than 2 as determined by diagnostic technetium-99m macroaggregated albumin (Tc-MAA) gamma scintigraphy...

journal_title：British journal of cancer

authors： Lau WY,Leung WT,Ho S,Leung NW,Chan M,Lin J,Metreweli C,Johnson P,Li AK

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND:The urokinase plasminogen activator (uPA) system is one of the best-investigated protease systems, both under physiological and pathological conditions, including various types of cancer. However, effects of co-expression of members of the uPA system in soft-tissue sarcoma (STS) patients at the protein level...

journal_title：British journal of cancer

authors： Taubert H,Würl P,Greither T,Kappler M,Bache M,Lautenschläger C,Füssel S,Meye A,Eckert AW,Holzhausen HJ,Magdolen V,Kotzsch M

更新日期：2010-02-16 00:00:00

abstract：:Individuals with a deficiency in the enzyme dihydropyrimidine dehydrogenase (DPD) may experience severe life-threatening toxicity when treated with 5-fluorouracil (5-FU). As routine measurement of enzyme activity is not practical in many clinical centres, we have investigated the use of DNA mutation analysis to identi...

journal_title：British journal of cancer

authors： Ridge SA,Sludden J,Wei X,Sapone A,Brown O,Hardy S,Canney P,Fernandez-Salguero P,Gonzalez FJ,Cassidy J,McLeod HL

更新日期：1998-01-01 00:00:00

abstract：:Serum laminin P1 was studied in patients with small cell lung cancer (SCLC), non-small cell lung cancer (NSCLC), respiratory infections, pulmonary fibrosis, and in normal subjects. The level of serum laminin P1 was elevated (greater than 1.27 U ml-1) in 58.9% of SCLC and in 11.5% of NSCLC patients. Median value in SCL...

journal_title：British journal of cancer

authors： Nakano T,Iwahashi N,Maeda J,Hada T,Higashino K

更新日期：1992-04-01 00:00:00

abstract：:The pathophysiology of Raynaud's phenomenon after Cisplatin-Bleomycin-Vinblastine combination chemotherapy, its relationship to polyneuropathy, and response to transcutaneous nerve stimulation (TNS), was studied in eight patients previously treated for testicular cancer. Peripheral circulation in the index finger was ...

journal_title：British journal of cancer

authors： Heier MS,Nilsen T,Graver V,Aass N,Fosså SD

更新日期：1991-04-01 00:00:00

abstract：BACKGROUND:Thymidine phosphorylase (TP) is often overexpressed in tumours and has a role in tumour aggressiveness and angiogenesis. Here, we determined whether TP increased tumour invasion and whether TP-expressing cancer cells stimulated angiogenesis. METHODS:Angiogenesis was studied by exposing endothelial cells (HU...

journal_title：British journal of cancer

authors： Bijnsdorp IV,Capriotti F,Kruyt FA,Losekoot N,Fukushima M,Griffioen AW,Thijssen VL,Peters GJ

更新日期：2011-03-29 00:00:00

abstract：:Two techniques for growing colonies of human tumour cells in soft agar have been applied to cell suspensions derived from fresh tumour tissue from 48 patients. Colonies were obtained in 31 cases, with plating efficiencies between 0.01 and 15%. In 11 cases the plating efficiencies were 1% or above. There was evidence t...

journal_title：British journal of cancer

authors： Courtenay VD,Selby PJ,Smith IE,Mills J,Peckham MJ

更新日期：1978-07-01 00:00:00

abstract：:Periodate-treated, non-anticoagulant heparin-carrying polystyrene consists of about ten periodate-oxidized, alkaline-degraded low molecular weight-heparin chains linked to a polystyrene core and has a markedly lower anti-coagulant activity than heparin. In this study, we evaluated the effect of non-anticoagulant hepar...

journal_title：British journal of cancer

authors： Ono K,Ishihara M,Ishikawa K,Ozeki Y,Deguchi H,Sato M,Hashimoto H,Saito Y,Yura H,Kurita A,Maehara T

更新日期：2002-06-05 00:00:00

abstract：:Accumulation of mutations in tumour suppressor genes and oncogenes has been proposed to underlie the initiation and progression of sporadic colorectal cancer (CRC). Evidence is accumulating to suggest that the caudal homeobox gene CDX2 is implicated in the pathogenesis of CRC. The CDX2 transcription factor is expresse...

journal_title：British journal of cancer

authors： Sivagnanasundaram S,Islam I,Talbot I,Drummond F,Walters JR,Edwards YH

更新日期：2001-01-01 00:00:00

abstract：:Initial glycosylation of mucin-type O-linked protein is catalysed by one of the UDP-GalNAc: polypeptide N-acetyl-galactosaminyl transferase-3 (GalNAc-T3). O-glycosylation is important in the binding of cell adhesion molecules, cell differentiation, invasion, and metastasis in tumours. This study was designed to detect...

journal_title：British journal of cancer

authors： Gu C,Oyama T,Osaki T,Li J,Takenoyama M,Izumi H,Sugio K,Kohno K,Yasumoto K

更新日期：2004-01-26 00:00:00