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A simple, reproducible method for monitoring the treatment of tumours using dynamic contrast-enhanced MR imaging.

Abstract：

:Dynamic contrast-enhanced MR imaging (DCE-MRI) may act as a biomarker for successful cancer therapy. Simple, reproducible techniques may widen this application. This paper demonstrates a single slice imaging technique. The image acquisition is performed in less than 500 ms making it relatively insensitive to respiratory motion. Data from phantom studies and a reproducibility study in solid human tumours are presented. The reproducibility study showed a coefficient of variation (CoV) of 19.1% for K(trans) and 15.8% for the initial area under the contrast enhancement curve (IAUC). This was improved to 16 and 13.9% if tumours of diameter less than 3 cm were excluded. The individual repeatability (the range within which individual measurements are expected to fall) was 30.6% for K(trans) and 26.5% for IAUC for tumours greater than 3 cm diameter. This approach to DCE-MRI image acquisition can be performed with standard clinical scanners, and data analysis is straightforward. For treatment trials with 10 patients in a cohort, the CoV implies that the method would be sensitive to a treatment effect of greater than 18%. The individual repeatability is well inside the 40% change shown to be important in clinical studies using this DCE-MRI technique.

journal_name

Br J Cancer

journal_title

British journal of cancer

authors

Morgan B,Utting JF,Higginson A,Thomas AL,Steward WP,Horsfield MA

doi

10.1038/sj.bjc.6603140

subject

Has Abstract

pub_date

2006-05-22 00:00:00

pages

1420-7

issue

10

eissn

0007-0920

issn

1532-1827

pii

6603140

journal_volume

94

pub_type

杂志文章

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