Abstract:
:Capecitabine and docetaxel have considerable single-agent activity in gastric cancer with distinct mechanisms of action and no overlap of key toxicities. A synergistic interaction between these two drugs is mediated by taxane-induced upregulation of thymidine phosphorylase. We investigated the activity and the feasibility of capecitabine and docetaxel combination chemotherapy in patients with previously untreated advanced gastric cancer (AGC). From September 2001 to March 2003, 42 patients with AGC received 21-day cycles of oral capecitabine (1250 mg x m(-2) twice daily on days 1-14) and docetaxel (75 mg x m(-2) i.v. on day 1). The patients received a total of 164 cycles of chemotherapy. The median age was 53.5 years (range 33-73 years). The overall response rate in the 38 efficacy-evaluable patients was 60% (95% confidence interval, 45-74%). The median progression-free survival was 5.2 months (range, 1.0-15.5+ months) and the median overall survival was 10.5 months (range, 2.9-23.7+ months). The most common grade 3/4 adverse events were hand-foot syndrome (HFS: G3 50%), neutropenia (15%) and leucopenia (12%). Further studies of this combination are clearly warranted, albeit with lower doses of both agents (1000 mg x m(-2) twice daily and 60 mg x m(-2)) to reduce the rate of HFS and onycholysis.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Park YH,Ryoo BY,Choi SJ,Kim HTdoi
10.1038/sj.bjc.6601724subject
Has Abstractpub_date
2004-04-05 00:00:00pages
1329-33issue
7eissn
0007-0920issn
1532-1827pii
6601724journal_volume
90pub_type
临床试验,杂志文章abstract:BACKGROUND:We conducted a multicentre feasibility study for single agent long-term S-1 chemotherapy following docetaxel plus cisplatin in patients with curatively resected stage II-IIIA non-small cell lung cancer. METHODS:Patients received three cycles of docetaxel (60 mg m(-2)) plus cisplatin (80 mg m(-2)) and then r...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1038/bjc.2013.378
更新日期:2013-08-06 00:00:00
abstract::Antibody drug conjugates (ADCs) employ the exquisite specificity of tumour-specific monoclonal antibodies (mAb) for the targeted delivery of highly potent cytotoxic drugs to the tumour site. The chemistry of the linker, which connects the drug to the mAb, determines how and when the drug is released from the mAb. This...
journal_title:British journal of cancer
pub_type: 杂志文章,评审
doi:10.1038/bjc.2017.367
更新日期:2017-12-05 00:00:00
abstract::A total of 164 consecutive adults with newly confirmed stage IIIB, IVA or IVB Hodgkin's disease (HD) commenced cyclical combination chemotherapy comprising mustine, vinblastine, prednisolone and procarbazine (MVPP) every 6 weeks (145 patients) or minor variants (19) at St Bartholomew's Hospital between 1968 and 1984. ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1992.88
更新日期:1992-03-01 00:00:00
abstract::Portal vein embolisation (PVE) is used to increase the remnant liver volume before major liver resection for colorectal metastases. The resection rate after PVE is 60-70%, mainly limited by disease progression. The effect of PVE on tumour growth rate has not been investigated. The objective of this study was to compar...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604872
更新日期:2009-02-24 00:00:00
abstract:BACKGROUND AND AIMS:The serum/plasma proteome was explored for biomarkers to improve the diagnostic ability of CA19-9 in pancreatic adenocarcinoma (PC). METHODS:A Training Set of serum samples from 20 resectable and 18 stage IV PC patients, 54 disease controls (DCs) and 68 healthy volunteers (HVs) were analysed by sur...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6605764
更新日期:2010-07-27 00:00:00
abstract::HER2 / neu is a potential antigen candidate for immunotherapy because of its correlation to a poor prognosis and high expressions in many kinds of epithelial tumours. Especially in the colorectal carcinomas, the higher expression of HER2 / neu is recognized in metastatic regions as well as in primary sites. Several CT...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.2000.1547
更新日期:2001-01-05 00:00:00
abstract:BACKGROUND:The vascular disrupting agent combretastatin A4 phosphate (CA4P) causes major regression of animal tumours when given as combination therapy. METHODS:Patients with advanced cancer refractory to standard therapy were treated with CA4P as a 10-min infusion, 20 h before carboplatin, paclitaxel, or paclitaxel, ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6605650
更新日期:2010-04-27 00:00:00
abstract:BACKGROUND:Previous studies have demonstrated that senescent cancer-associated fibroblasts (CAFs) derived from genetically unstable oral squamous cell carcinomas (GU-OSCC), unlike non-senescent CAFs from genetically stable carcinomas (GS-OSCC), promoted keratinocyte invasion in vitro in a paracrine manner. The mechanis...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2014.438
更新日期:2014-09-09 00:00:00
abstract::A number of rare human inherited syndromes are associated with apparent defects in DNA repair and a greatly increased frequency of cancer. Cell lines derived from such individuals phenotypically resemble certain bacterial mutant strains that have increased sensitivity to radiation or chemical agents and well character...
journal_title:British journal of cancer
pub_type: 杂志文章,评审
doi:10.1038/bjc.1987.163
更新日期:1987-08-01 00:00:00
abstract::Pleural effusion fluid obtained from eleven patients with metastatic spread to the pleura was screened for the ability to cause the dispersal--'scattering'--of MDCK colonies in vitro. Four of these samples proved to be positive using this assay. Of these two had titres high enough to warrant further purification on a ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1992.251
更新日期:1992-08-01 00:00:00
abstract:BACKGROUND:Immunoscore have shown a promising prognostic value in many cancers. We aimed to establish and validate an immune classifier to predict survival after curative resection of hepatocellular carcinoma (HCC) patients who have undergone curative resection. METHODS:The immunohistochemistry (IHC) classifier assay ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-0864-0
更新日期:2020-07-01 00:00:00
abstract::Lipoxygenase metabolites of arachidonic acid can act as growth promoting factors for various cancer cell lines. Here we demonstrate that the 5-lipoxygenase inhibitor nordihydroguaiaretic acid potently inhibits anchorage-independent growth of human pancreatic and cervical cancer cells in soft agar and delays growth of ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6600186
更新日期:2002-04-08 00:00:00
abstract::While statins have been highly effective for lowering serum cholesterol and reducing the incidence of coronary events, they have multiple other effects. Certain statins block the interaction of adhesion molecules that are important for cell-cell interactions including those between EBV-transformed B cells. These same ...
journal_title:British journal of cancer
pub_type: 杂志文章,评审
doi:10.1038/sj.bjc.6602561
更新日期:2005-05-09 00:00:00
abstract::The risk for sinonasal cancer associated with tobacco use was examined in a case-control study in males diagnosed between 1978 and 1981 in the Netherlands. Of the 116 cases of sinonasal cancer and 259 controls identified, interviews were completed for 92 (79%) of the cases and 195 (75%) of the controls. Ever-users of ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1987.303
更新日期:1987-12-01 00:00:00
abstract:BACKGROUND:Favourable outcomes of breast cancer screening trials in the 1970s and 1980s resulted in the launch of population-based service screening programmes in many Western countries. We investigated whether improvements in mammography and treatment modalities have had an influence on the effectiveness of breast can...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2011.44
更新日期:2011-03-15 00:00:00
abstract:BACKGROUND:High amplification of epiregulin (EREG) and amphireglin (AREG) in tumour tissues has been previously reported to be associated with better outcome in metastatic colorectal cancer (mCRC) patients who were treated with anti-EGFR antibodies. Here we investigated associations between the expression of other cand...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2016.74
更新日期:2016-04-26 00:00:00
abstract::Canine transmissible venereal sarcoma (CTVS) is a naturally occurring contagious neoplasm which can be transplanted with intact viable cells across major histocompatibility (MHC) barriers within the species and even to other members of the canine family, such as foxes, coyotes, and wolves. After 2 to 4 months of progr...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1987.27
更新日期:1987-02-01 00:00:00
abstract::Response to endocrine therapy in 51 patients with advanced breast cancer was compared with the amount of elastosis in histological sections from their primary tumours. There appeared to be an association between elastosis and response: tumours with no elastosis showed a lower rate of response than those with gross ela...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1979.98
更新日期:1979-05-01 00:00:00
abstract::During the COVID-19 era, Chinese hospitals have developed a system that enables vulnerable cancer patients to continue to receive high-quality medical care, optimising their survival whilst protecting them. This includes use of digital quick codes, fever clinics and optimal scheduling. We wish to share our experiences...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-020-0856-0
更新日期:2020-07-01 00:00:00
abstract::In vivo growth characteristics of myeloid leukaemia induced by whole-body irradiation of CBA/H male mice were examined in the strain of origin by procedures expected to enhance or depress immunological responses. Syngeneic growth in vivo (survival time and frequency of takes) was not modified by attempted active immun...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1982.68
更新日期:1982-03-01 00:00:00
abstract:BACKGROUND:Recent studies have indicated the prognostic value of tumour subtype and pathological complete response (pCR) after neoadjuvant chemotherapy (NAC). However these results were reported after a short follow-up and using a standard Cox model which could be unsatisfactory for time-dependent factors. In the prese...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2015.174
更新日期:2015-06-30 00:00:00
abstract::On the basis of preclinical data suggesting the possibility of maximising the efficacy of 5-fluorouracil and cisplatin by interferon, a pilot clinical trial was initiated in recurrent and/or metastatic head and neck cancer. Thirty-four patients were treated with cisplatin at 100 mg m-2, followed by 5-fluorouracil at 1...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章
doi:10.1038/bjc.1994.72
更新日期:1994-02-01 00:00:00
abstract::We used the nationwide Swedish Family-Cancer Database with 2060 childhood brain tumours diagnosed in the period 1958-1996 to analyse the risk of this tumour by parental cancers and in siblings of childhood brain tumour probands. Groups of patients were compared by calculating standardized incidence ratios (SIRs) for b...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.2000.1252
更新日期:2000-08-01 00:00:00
abstract::The radiation response of Epstein-Barr virus (EBV)-immortalised lymphoblastoid cell lines derive from Li-Fraumeni syndrome (LFS) and LFS-like individuals was investigated. Cells from all LFS and LFS-like cases showed an accumulation of p53 protein following 137Cs gamma-irradiation, which was associated with cell cycle...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1996.424
更新日期:1996-09-01 00:00:00
abstract::A retrospective seroepidemiologic study was performed to examine the association between human papillomaviruses (HPV) 16 infection and carcinomas of the oropharynx, the oesophagus, penis and vagina. Sera were selected from the serum bank from the Antoni van Leeuwenhoek Hospital (Netherlands Cancer Institute) and the S...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6600870
更新日期:2003-04-07 00:00:00
abstract::To investigate whether parents of children with congenital malformations more often developed cancer after birth of the child, a population-based case-control study in Denmark was undertaken. By linking the Cancer Registry with the Central Population Registry, we identified 8783 cancer patients having their first chil...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6600488
更新日期:2002-08-27 00:00:00
abstract::Thirty-three patients with squamous cell carcinoma of the head and neck region were studied concerning p53 protein expression and mutations in exons 4-9 of the p53 gene using immunohistochemistry, polymerase chain reaction (PCR)-single strand conformation polymorphism analysis and DNA sequencing. Immunoreactivity was ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1995.159
更新日期:1995-04-01 00:00:00
abstract::Treatment of ex-breeder male NMRI mice with lipid mobilising factor isolated from the urine of cachectic cancer patients, caused a significant increase in glucose oxidation to CO2 compared with control mice receiving phosphate buffered saline. Glucose utilisation by various tissues was determined by the 2-deoxyglucose...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6600493
更新日期:2002-08-27 00:00:00
abstract:BACKGROUND:Efficacy and safety are the two considerations when characterising the effects of a new therapy. We sought to apply an innovative method of assessing the benefit-risk balance using data from a completed randomised controlled trial that compared erlotinib vs placebo added to gemcitabine in patients with advan...
journal_title:British journal of cancer
pub_type: 杂志文章,随机对照试验
doi:10.1038/bjc.2015.55
更新日期:2015-03-17 00:00:00
abstract::I.p. administration at several dose levels over periods of up to 12 weeks, or continuous i.v. infusion of high doses of misonidazole (MISO) for 15 h, produced no significant change in peripheral nerve conduction velocity (NCV) and did not prevent the normal increase in NCV as the animals matured from 12 to 24 weeks of...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1980.94
更新日期:1980-04-01 00:00:00