Abstract：
:Fifteen patients with acute myelogenous leukaemia were studied to determine if their remission blood leucocytes could be stimulated into taking up [3H] thymidine after in vitro culture with their own cryo-preserved irradiated AML leukaemia cells. In 6/15 patients it was possible to show autologous recognition and equal recognition of their stored leukaemia cells, even when they had previously been maintained in in vitro proliferative cultures in liquid suspension and undergoing myeloid maturation for one week. After in vitro proliferative culture, 4 populations of leukaemia cells produced material in the supernatant media between 3 and 7 days capable of inducing [3H] thymidine uptake in autologous (2 pts, 5 supernatants) and allogeneic (2 pts, 2 supernatants) AML remission lymphocytes, but not in normal donor lymphocytes. The relevance of these observations to tumour-associated AML antigen is discussed.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Cocks P,Powles RL,Chapuis B,Alexander Pdoi
10.1038/bjc.1977.39subject
Has Abstractpub_date
1977-03-01 00:00:00pages
273-9issue
3eissn
0007-0920issn
1532-1827journal_volume
35pub_type
杂志文章abstract：:Fibroblast growth factor receptor 3 (FGFR3) is one of four high-affinity tyrosine kinase receptors for the FGF family of ligands, frequently associated with growth arrest and induction of differentiation. The extracellular immunoglobulin (IgG)-like domains II and III are responsible for ligand binding; alternative usa...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601249
更新日期：2003-10-06 00:00:00
abstract：BACKGROUND:Systemic failure remains a challenge in rectal cancer. We investigated the possible systemic anti-tumour immune activity invoked within oxaliplatin-based neoadjuvant therapy. METHODS:In two high-risk patient cohorts, we assessed the circulating levels of the fms-like tyrosine kinase 3 ligand (Flt3L), a fact...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-018-0085-y
更新日期：2018-05-01 00:00:00
abstract：:Wnt-5a is one of the most highly investigated non-canonical Wnts and has been implicated in almost all aspects of non-canonical Wnt signalling. In terms of cancer development, Wnt-5a has, until recently, lived in the shadow of its better-characterised relatives. This was largely because of its apparent inability to tr...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/sj.bjc.6605174
更新日期：2009-07-21 00:00:00
abstract：:Metallothioneins (MT) are ubiquitous, intracellular small proteins with high affinity for heavy metal ions. In the last decades, it was shown that MT overexpression in a variety of cancers is associated with resistance to anticancer drugs and is combined with a poor prognosis. In this prospective study, we examined th...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603028
更新日期：2006-03-27 00:00:00
abstract：:The aim of this study was to determine the dose-limiting toxicity (DLT) and establish the recommended dose for mitomycin C added every 3 weeks to the standard combination dose of capecitabine. Cohorts of at least three patients with pretreated gastrointestinal carcinoma received capecitabine 1000 mg m(-2) orally twice...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1038/sj.bjc.6602025
更新日期：2004-08-31 00:00:00
abstract：:Disseminating disease is a predictive and prognostic indicator of poor outcome in children with neuroblastoma. Its accurate and sensitive assessment can facilitate optimal treatment decisions. The International Neuroblastoma Risk Group (INRG) Task Force has defined standardised methods for the determination of minimal...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究,实务指引
doi：10.1038/sj.bjc.6605029
更新日期：2009-05-19 00:00:00
abstract：:Over the period 1966-1995, based on 11,662 patients, the incidence of squamous cell carcinoma of the skin increased three to four times in Norway mainly as a result of an increased number of localized tumours. In men, cancer of the auricle was the second most common site; in women the incidence was low. ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6690725
更新日期：1999-10-01 00:00:00
abstract：:Monoclonal antibody MUC 2-63 recognises neurogenic tumours and has been used successfully for radioimaging human malignant gliomas. We now show that the MUC 2-63 antigen has the same tissue distribution and molecular weight range as the CD44 antigen and confirm the identity of these two molecules in blocking studies u...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1994.402
更新日期：1994-11-01 00:00:00
abstract：:High-mol.-wt levan injected locally inhibits the growth of Lewis lung carcinoma in C57BL mice. The inhibition is dependent on the number of tumour cells injected and on the dose of levan. The inhibition decreases tumour incidence and size as well as prolonging survival. The polysaccharide is most effective when inject...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1979.225
更新日期：1979-10-01 00:00:00
abstract：:We have recently established a cancer-reactive human monoclonal antibody, GAH, with a positive ratio of over 90% against stomach cancer. GAH was formulated as polyethyleneglycol (PEG)-modified immunoliposomal doxorubicin (DXR) (ILD) and its efficacy was examined against gastrointestinal human cancers. In in vitro stud...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601341
更新日期：2003-10-20 00:00:00
abstract：:The frequency of M-components was studied by agar gel electrophoresis in sera from 807 patients, 467 (57%) females and 340 (43%) males with histologically proven solid malignant neoplasms.M-components were found in the sera of 40 male and 20 female patients. Apart from two known cases of multiple myeloma and one case ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1973.34
更新日期：1973-04-01 00:00:00
abstract：BACKGROUND:The role of chemotherapy for neuroendocrine tumours remains controversial and there is no standard regimen. METHOD:We report the outcome for a consecutive series of chemonaive patients with metastatic or locally advanced neuroendocrine tumours treated with a combination of 5-fluorouracil (500 mg m(-2)), cis...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/sj.bjc.6605618
更新日期：2010-03-30 00:00:00
abstract：:The inhibitor of apoptosis protein, XIAP, is frequently overexpressed in chemoresistant human tumours. An antisense oligonucleotide (AEG 35156/GEM 640) that targets XIAP has recently entered phase I trials in the UK. Method validation data are presented on three pharmacodynamic assays that will be utilised during this...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602363
更新日期：2005-02-14 00:00:00
abstract：BACKGROUND:CYFRA 21-1 serves as biomarker in several epithelial malignancies. However, its role in pancreatic cancer (PC) has not yet been investigated. METHODS:Within a prospective single-centre study serial blood samples were collected from patients with confirmed advanced PC. Pre-treatment values and weekly measure...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/bjc.2013.158
更新日期：2013-04-30 00:00:00
abstract：BACKGROUND:The importance of lymphocyte subtypes in determining outcome in primary operable ductal invasive breast cancer remains unclear. The aim of present study was to examine the relationship between tumour lymphocyte subsets infiltrate and standard clinico-pathological factors and survival in patients with primary...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2013.493
更新日期：2013-09-17 00:00:00
abstract：:Histological sections of the primary tumour and of homolateral axillary lymph nodes from 500 women with operable invasive breast cancer have been examined. The tumours have been graded and the degree of round cell infiltration assessed. These features, together with clinical palpability and pathological involvement of...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1972.19
更新日期：1972-04-01 00:00:00
abstract：:The expression of urokinase-type plasminogen activator (uPA) was investigated in squamous cell carcinoma of the human larynx. For this purpose, tissue extracts from 25 matched samples of normal mucosa and neoplastic larynx were compared for the levels of uPA activity as evaluated by a chromogenic PA assay and sodium d...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1996.512
更新日期：1996-10-01 00:00:00
abstract：:Patients affected by squamous cell carcinoma of the head and neck (HNSCC) show frequent occurrence of multiple cancers and widespread precancerous lesions in the mucosa of the upper respiratory tract, a phenomenon known as field cancerization. In this study, we investigated the role of genetic instability in the devel...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1998.644
更新日期：1998-11-01 00:00:00
abstract：BACKGROUND:The diagnosis of neuroendocrine neoplasms (NENs) is often delayed. This first UK population-based epidemiological study of NENs compares outcomes with non-NENs to identify any inequalities. METHODS:Age-standardised incidence rate (ASR), 1-year overall survival, hazard ratios and standardised mortality rates...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-019-0606-3
更新日期：2019-11-01 00:00:00
abstract：:When assessing the value of a particular treatment, it is important to consider the impact it may have on the quality of life of those being treated. This is particularly so for cancer patients, whose life expectancy may be short. Patients with advanced colorectal cancer who participated in two international comparati...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1038/bjc.1998.420
更新日期：1998-01-01 00:00:00
abstract：BACKGROUND:Regulator of cullins-1 (ROC1) is a key subunit in the cullin-RING ligase (CRL) protein complex. Our previous study indicated that ROC1 was essential for bladder cancer cell survival and that ROC1 knockdown inhibited CRL activity, triggering G2 phase arrest and senescence. However, the role of ROC1 in the mal...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2015.444
更新日期：2016-02-02 00:00:00
abstract：:Mutation of c-K-ras oncogene is an important step in progression of colon cancer. We used a hammerhead ribozyme (KrasRz) against mutated K-ras gene transcripts (codon 12, GTT) to inactivate mutant K-ras function in the colon cancer cell line SW480, harbouring a mutant K-ras gene. The beta-actin promoter-driven KrasRz ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2000.1363
更新日期：2000-09-01 00:00:00
abstract：:Human pancreatic exocrine adenocarcinoma cells established in tissue culture expressed both HLA and beta 2-microglobulin (beta 2M). Plasma-membrane components of this pancreatic cancer cell line were purified from plasma membrane fractions enriched by sucrose density-gradient centrifugation, using immunoaffinity chrom...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1979.250
更新日期：1979-11-01 00:00:00
abstract：:Temozolomide is an oral alkylating agent that readily crosses the blood-brain barrier and has activity in patients with advanced melanoma. Carboplatin is a convenient outpatient treatment that also has activity in patients with melanoma. The purpose of this study was to assess the safety of a combination of temozolomi...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/sj.bjc.6601414
更新日期：2003-11-17 00:00:00
abstract：:The abilities of chemokines in orchestrating cellular migration are utilised by different (patho-)biological networks including malignancies. However, except for CXCR4/CXCL12, little is known about the relation between tumour-related chemokine expression and the development and progression of solid tumours like breast...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604621
更新日期：2008-09-16 00:00:00
abstract：:Photodynamic therapy (PDT) for cancer in the oesophagus and bronchi with red (630 nm) light may occasionally lead to wall perforation and fistula. Therefore, we investigated the clinical use of a less penetrating wavelength (514 nm) for the curative treatment of nine superficial carcinomas in the oesophagus and bronch...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1998.330
更新日期：1998-06-01 00:00:00
abstract：:A number of polyunsaturated fatty acids have been shown to inhibit the growth of malignant cells in vitro. To investigate whether fatty acids modify the growth of human pancreatic cancer, lauric, stearic, palmitic, oleic, linoleic, alpha-linolenic, gamma-linolenic, arachidonic, docosahexaenoic and eicosapentaenoic (EP...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1994.161
更新日期：1994-05-01 00:00:00
abstract：:Some 1220 male and 2102 female cases of malignant neoplasms diagnosed histologically at the Department of Pathology of the Gadjah Mada University in Yogyakarta during the period 1970-73 were analysed. The most frequent tumour sites were among men: nasopharyngeal cancer, 21-8% and skin cancer, 17-6%. Among women the ge...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1977.164
更新日期：1977-07-01 00:00:00
abstract：:The effect of the synthetic progesterone, megestrol acetate, on weight loss induced by both tumour necrosis factor alpha (TNF) as a model for the cachexia accompanying the acquired immunodeficiency syndrome and by a cachexia-inducing tumour (MAC16) has been studied in NMRI mice. Megestrol acetate was effective in prev...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1990.310
更新日期：1990-09-01 00:00:00
abstract：BACKGROUND:Wnt-signalling has an important role in renal cancer and it is modulated by genistein in other cancers. Recently, microRNAs (miRNAs) have emerged as new regulators of gene expression. Thus, we focused on miRNAs to examine the regulatory mechanism of genistein on the Wnt-signalling pathway in renal cell carci...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2013.173
更新日期：2013-05-28 00:00:00
