Abstract:
:Temozolomide is an oral alkylating agent that readily crosses the blood-brain barrier and has activity in patients with advanced melanoma. Carboplatin is a convenient outpatient treatment that also has activity in patients with melanoma. The purpose of this study was to assess the safety of a combination of temozolomide and carboplatin, and provide preliminary evidence of efficacy. In all, 30 patients were treated in two stages. In stage 1, patients received temozolomide 750 mg x m(-2), with escalating doses of carboplatin AUC 3-6. In stage 2, patients received temozolomide 1000 mg x m(-2), with increasing doses of carboplatin until dose-limiting toxicity (DLT) was experienced. In stage 1, 12 patients received 33 cycles of treatment. No grade 3/4 haematological toxicity was experienced up to carboplatin AUC 6. In stage 2, 18 patients received 55 cycles of treatment. The DLT was haematological with grade 4 myelosuppression seen with carboplatin AUC 5. In all, 11 patients were treated with carboplatin AUC 4 to gain further information on toxicity. Myelosuppression remained significant and common with grade 4 thrombocytopenia experienced in 50% of cycles. Two of 28 patients (7%) assessable for efficacy achieved a partial response. None of the 11 patients with brain metastases responded to treatment. The addition of carboplatin to temozolomide 1000 mg x m(-2) significantly adds to toxicity with frequent grade 3/4 myelosuppression. Preliminary information on efficacy demonstrates that it is unlikely that the combination can be given in doses sufficient to improve on the efficacy of temozolomide alone.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Strauss SJ,Marples M,Napier MP,Meyer T,Boxall J,Rustin GJdoi
10.1038/sj.bjc.6601414subject
Has Abstractpub_date
2003-11-17 00:00:00pages
1901-5issue
10eissn
0007-0920issn
1532-1827pii
6601414journal_volume
89pub_type
临床试验,杂志文章abstract::Several radiotherapeutic schedules compatible with continued structural-functional integrity of the gastrointestinal (GI) mucosa were compared utilizing the P815X2 murine mastocytoma grown as a solid subcutaneous tumour. Both the tumour and underlying normal tissues were irradiated during the treatments. The tumour ex...
journal_title:British journal of cancer
pub_type: 杂志文章
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journal_title:British journal of cancer
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pub_type: 杂志文章,多中心研究
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journal_title:British journal of cancer
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1038/sj.bjc.6600419
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journal_title:British journal of cancer
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pub_type: 杂志文章
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doi:10.1038/sj.bjc.6690333
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