Integrin α3 is overexpressed in glioma stem-like cells and promotes invasion.

abstract：:Gain of 1q is one of the most common alterations in cancer and has been associated with adverse clinical behaviour in ependymoma. The aim of this study was to investigate this region to gain insight into the role of 1q genes in intracranial paediatric ependymoma. To address this issue we generated profiles of eleven e...

journal_title：British journal of cancer

authors： Rand V,Prebble E,Ridley L,Howard M,Wei W,Brundler MA,Fee BE,Riggins GJ,Coyle B,Grundy RG,Children's Cancer and Leukaemia Group Biological Studies Committee.

更新日期：2008-10-07 00:00:00

abstract：BACKGROUND:Global hypomethylation has been suggested to cause genomic instability and lead to an increased risk of cancer. We examined the association between the global methylation level of peripheral blood leukocyte DNA and breast cancer among Japanese women. METHODS:We conducted a hospital-based case-control study ...

journal_title：British journal of cancer

authors： Kuchiba A,Iwasaki M,Ono H,Kasuga Y,Yokoyama S,Onuma H,Nishimura H,Kusama R,Tsugane S,Yoshida T

更新日期：2014-05-27 00:00:00

abstract：BACKGROUND:Dulanermin (rhApo2L/TRAIL) induces apoptosis by binding to death receptors DR4 and DR5, leading to caspase activation and subsequent cell death. A Phase1a trial evaluated the safety and tolerability of dulanermin in patients with advanced tumours. One aim was to develop and validate pharmacodynamic biomarker...

journal_title：British journal of cancer

authors： Pan Y,Xu R,Peach M,Huang CP,Branstetter D,Novotny W,Herbst RS,Eckhardt SG,Holland PM

更新日期：2011-12-06 00:00:00

abstract：:For stage III non-small cell lung cancer (NSCLC), approximately a third of patients survive up to 5 years, with decreasing 5-year survival rates for stage IIIB and stage IIIC disease. Although curable, stage III NSCLC encompasses a diverse range of disease presentation, with an equally complex range of multi-modal tre...

journal_title：British journal of cancer

authors： Evison M,AstraZeneca UK Limited.

更新日期：2020-12-01 00:00:00

abstract：:The aetiologic fractions due to smoking and chewing tobacco have been quantified for the first time, for cancers of the oral cavity, oropharynx, hypopharynx, larynx and oesophagus. The overall aetiologic fractions due to smoking and/or chewing tobacco have been found to be 70% for cancer of the oral cavity, 84% for th...

journal_title：British journal of cancer

authors： Jayant K,Balakrishnan V,Sanghvi LD,Jussawalla DJ

更新日期：1977-02-01 00:00:00

abstract：:The important role of the p53 gene in tumour progression and cellular response to DNA damage has prompted investigation of the clinical significance of alterations to this gene. We examined both p53 overexpression and mutation of the gene in endometrial carcinoma in order to evaluate the prognostic significance of the...

journal_title：British journal of cancer

authors： Soong R,Knowles S,Williams KE,Hammond IG,Wysocki SJ,Iacopetta BJ

更新日期：1996-08-01 00:00:00

abstract：BACKGROUND:The need to unfold the underlying mechanisms of lung cancer aggressiveness, the deadliest cancer in the world, is of prime importance. Because Fas-associated death domain protein (FADD) is the key adaptor molecule transmitting the apoptotic signal delivered by death receptors, we studied the presence and cor...

journal_title：British journal of cancer

authors： Cimino Y,Costes A,Damotte D,Validire P,Mistou S,Cagnard N,Alifano M,Régnard JF,Chiocchia G,Sautès-Fridman C,Tourneur L

更新日期：2012-06-05 00:00:00

abstract：:The cancer vaccine 105AD7 is an anti-idiotypic monoclonal antibody that mimics the tumour-associated antigen 791T/gp72 (CD55, Decay Accelerating Factor) on colorectal cancer cells. Phase I studies in patients with advanced disease confirmed that 105AD7 is non-toxic, and that T cell responses could be generated. A pros...

journal_title：British journal of cancer

authors： Maxwell-Armstrong CA,Durrant LG,Buckley TJ,Scholefield JH,Robins RA,Fielding K,Monson JR,Guillou P,Calvert H,Carmichael J,Hardcastle JD

更新日期：2001-06-01 00:00:00

abstract：:Although epithelial cell adhesion/activating molecule (EpCAM/CD326) is one of the first tumour-associated antigens identified, it has never received the same level of attention as other target proteins for therapy of cancer. It is also striking that ever since its discovery in the late 1970s the actual contribution of...

journal_title：British journal of cancer

authors： Baeuerle PA,Gires O

更新日期：2007-02-12 00:00:00

abstract：:Wistar rats were sensitized to rat embryonic tissue by immunization with irradiated (5000 rad) rat embryo cells (2 X 10(6) s.c. + 1 X 10(6) i.p.) derived from embryos aged 14-15 days, or by implantation of irradiated (5000 rad) tissue grafts from these embryos. Three to five immunizations were given at weekly interval...

journal_title：British journal of cancer

authors： Shah LP,Rees RC,Baldwin RW

更新日期：1976-06-01 00:00:00

abstract：BACKGROUND:Vegetable and/or fruit intakes in association with hepatocellular carcinoma (HCC) risk have been investigated in case-control studies conducted in specific European countries and cohort studies conducted in Asia, with inconclusive results. No multi-centre European cohort has investigated the indicated associ...

journal_title：British journal of cancer

authors： Bamia C,Lagiou P,Jenab M,Aleksandrova K,Fedirko V,Trichopoulos D,Overvad K,Tjønneland A,Olsen A,Clavel-Chapelon F,Boutron-Ruault MC,Kvaskoff M,Katzke VA,Kühn T,Boeing H,Nöthlings U,Palli D,Sieri S,Panico S,Tumino R

更新日期：2015-03-31 00:00:00

abstract：:In rats a maximal tolerated dose of carboplatin (60 mg kg-1, i.v.) caused severe anaemia, leucopenia and thrombocytopenia. These indices of haematological toxicity were also observed with a maximal tolerated dose of cis-platin (6.5 mg kg-1, i.v.), but reductions in blood cell counts were less than those observed with ...

journal_title：British journal of cancer

authors： Siddik ZH,Boxall FE,Harrap KR

更新日期：1987-04-01 00:00:00

abstract：BACKGROUND:We assessed the association between symptoms reported at breast cancer screening visits and interval cancers (ICs) in a prospective manner. METHODS:This population-based matched cohort study uses data of the Finnish National Breast Cancer Screening Programme that invites women aged 50-69 years old during 19...

journal_title：British journal of cancer

authors： Singh D,Miettinen J,Duffy S,Malila N,Pitkäniemi J,Anttila A

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:This phase I, dose-finding study determined the safety, maximum tolerated dose (MTD)/recommended phase 2 dose (RP2D), pharmacokinetics, and antitumour activity of PX-866, a phosphatidylinositol 3-kinase inhibitor, combined with docetaxel in patients with incurable solid tumours. METHODS:PX-866 was administe...

journal_title：British journal of cancer

authors： Bowles DW,Ma WW,Senzer N,Brahmer JR,Adjei AA,Davies M,Lazar AJ,Vo A,Peterson S,Walker L,Hausman D,Rudin CM,Jimeno A

更新日期：2013-09-03 00:00:00

abstract：:The neuropsychological performance of 85 women with early stage breast cancer scheduled for chemotherapy, 43 women scheduled for endocrine therapy and/or radiotherapy and 49 healthy control subjects was assessed at baseline (T1), postchemotherapy (or 6 months) (T2) and at 18 months (T3). Repeated measures analysis fou...

journal_title：British journal of cancer

authors： Jenkins V,Shilling V,Deutsch G,Bloomfield D,Morris R,Allan S,Bishop H,Hodson N,Mitra S,Sadler G,Shah E,Stein R,Whitehead S,Winstanley J

更新日期：2006-03-27 00:00:00

abstract：:Hypoxia is a key factor contributing to the progression of human neoplasias and to the development of resistance to chemotherapy. BNIP3 is a proapoptotic member of the Bcl-2 protein family involved in hypoxia-induced cell death. We evaluated the expression and methylation status of BNIP3 gene to better understand the ...

journal_title：British journal of cancer

authors： Murai M,Toyota M,Satoh A,Suzuki H,Akino K,Mita H,Sasaki Y,Ishida T,Shen L,Garcia-Manero G,Issa JP,Hinoda Y,Tokino T,Imai K

更新日期：2005-03-28 00:00:00

abstract：:Apoptosis plays an important role in tumorigenesis. Tumour growth is determined by the rate of cell proliferation and cell death. We counted the number of apoptotic cells in haematoxylin and eosin (H&E)-stained tumour sections in series of 172 grade I and II invasive breast cancers with long-term follow-up. The number...

journal_title：British journal of cancer

authors： de Jong JS,van Diest PJ,Baak JP

更新日期：2000-01-01 00:00:00

abstract：:Even though the majority of patients with bladder malignancies initially present with low stage disease, the clinical epidemiology of these so-called superficial bladder tumours is not well known. In this paper, disease characteristics at initial presentation and during follow-up are described in 1,745 primary cases d...

journal_title：British journal of cancer

authors： Kiemeney LA,Witjes JA,Verbeek AL,Heijbroek RP,Debruyne FM

更新日期：1993-04-01 00:00:00

abstract：BACKGROUND:Heterogeneity and low incidence comprise the biggest challenge in sarcoma diagnosis and treatment. Chemotherapy, although efficient for some sarcoma subtypes, generally results in poor clinical responses and is mostly recommended for advanced disease. Specific genomic aberrations have been identified in some...

journal_title：British journal of cancer

authors： Brodin BA,Wennerberg K,Lidbrink E,Brosjö O,Potdar S,Wilson JN,Ma L,Moens LN,Hesla A,Porovic E,Bernhardsson E,Papakonstantinou A,Bauer H,Tsagkozis P,von Sivers K,Wejde J,Östling P,Kallioniemi O,Stragliotto CL

更新日期：2019-02-01 00:00:00

abstract：:Bacteriochlorin a (BCA) is a second-generation photosensitizer that is effective in tumour destruction upon illumination with light of a wavelength of 760 nm. Tissue penetration by light at this wavelength is greater compared with wavelengths at which commonly used photosensitizers are illuminated, making it possible ...

journal_title：British journal of cancer

authors： Rovers JP,Schuitmaker JJ,Vahrmeijer AL,van Dierendonck JH,Terpstra OT

更新日期：1998-06-01 00:00:00

abstract：BACKGROUND:Head and neck squamous cell carcinoma (HNSCC) is associated with poor survival. To identify prognostic and diagnostic markers and therapeutic targets, we studied ANO1, a recently identified calcium-activated chloride channel (CaCC). METHODS:High-resolution genomic and transcriptomic microarray analysis and ...

journal_title：British journal of cancer

authors： Ayoub C,Wasylyk C,Li Y,Thomas E,Marisa L,Robé A,Roux M,Abecassis J,de Reyniès A,Wasylyk B

更新日期：2010-08-24 00:00:00

abstract：:Metallothioneins (MT) are ubiquitous, intracellular small proteins with high affinity for heavy metal ions. In the last decades, it was shown that MT overexpression in a variety of cancers is associated with resistance to anticancer drugs and is combined with a poor prognosis. In this prospective study, we examined th...

journal_title：British journal of cancer

authors： Weinlich G,Eisendle K,Hassler E,Baltaci M,Fritsch PO,Zelger B

更新日期：2006-03-27 00:00:00

abstract：BACKGROUND:The arachidonic acid metabolite 12(S)-HETE is suspected to enhance metastatic spread by inducing cancer cell- and lymph endothelial cell (LEC) motility. However, the molecular mechanisms leading to 12(S)-HETE-triggered cell migration are still elusive. METHODS:To delineate the signalling pathways involved i...

journal_title：British journal of cancer

authors： Nguyen CH,Stadler S,Brenner S,Huttary N,Krieger S,Jäger W,Dolznig H,Krupitza G

更新日期：2016-07-26 00:00:00

abstract：:Ninety-two consecutive adult patients admitted with acute life-threatening complications of haematological malignancy were studied to determine long term outcome. The quality of life was evaluated in seven long term survivors who are currently alive more than 1 year after hospital discharge using three validated metho...

journal_title：British journal of cancer

authors： Yau E,Rohatiner AZ,Lister TA,Hinds CJ

更新日期：1991-11-01 00:00:00

abstract：:It has been reported that the rho genes, which consist of a ras-related small GTPase protein family, regulate cytoskeletal structures and have the potential to transform cultured cells. To investigate the biological relevance of the rho genes in pancreatic carcinogenesis, we examined expressions of the rhoA, B and C g...

journal_title：British journal of cancer

authors： Suwa H,Ohshio G,Imamura T,Watanabe G,Arii S,Imamura M,Narumiya S,Hiai H,Fukumoto M

更新日期：1998-01-01 00:00:00

abstract：:An enzyme activity with the characteristics of reverse transcriptase was detected in marrow from patients with leukaemia in relapse and in firm haematological remission. The endogenous enzyme activities increased following culture, and in remission patients the enzyme activities reached levels equal to or exceeding th...

journal_title：British journal of cancer

authors： Mak TW,Aye MT,Messner H,Sheinin R,Till JE,McCulloch EA

更新日期：1974-06-01 00:00:00

abstract：BACKGROUND:Estimating the future incidence of cancer is important to establish sufficient service provision, however, work in this area is limited for cancer in children, adolescents, and young adults (aged 0-24). METHODS:Age-period-cohort models were applied to cancer incidence rates for the period 1971-2013 in Engla...

journal_title：British journal of cancer

authors： Pesola F,Ferlay J,Sasieni P

更新日期：2017-12-05 00:00:00

abstract：:In a prospective study we determined the frequency and causes of delay in the diagnosis of breast cancer after suspicious screening mammography. We included all women aged 50-75 years who underwent biennial screening mammography in the southern breast cancer screening region of the Netherlands between 1 January 1996 a...

journal_title：British journal of cancer

authors： Duijm LE,Groenewoud JH,Jansen FH,Fracheboud J,van Beek M,de Koning HJ

更新日期：2004-11-15 00:00:00

abstract：:The hybrid cell line BH2 was derived by fusion between an AKR thymoma BW5147 (HGPRT-) and C57BL thymoma EL-4R (TK-). The hybrid cells showed a near-tetraploid modal number of chromosomes, in contrast to the near-diploid stem-lines of both parental cell populations; most of the BH2 hybrid cells acquired marker chromoso...

journal_title：British journal of cancer

authors： Bubeník J,Perlmann P,Jónsdóttir I,Kypĕnová H,Bubeníková D,Símová J

更新日期：1981-11-01 00:00:00

abstract：:Basal cell carcinomas (BCCs) are very frequent cutaneous cancers, often located on the face. Cure rates with surgery and radiotherapy are high, but these treatments have never been compared prospectively. A randomized trial was initiated in 1982 to compare surgery and radiotherapy in the treatment of primary BCC of th...

journal_title：British journal of cancer

authors： Avril MF,Auperin A,Margulis A,Gerbaulet A,Duvillard P,Benhamou E,Guillaume JC,Chalon R,Petit JY,Sancho-Garnier H,Prade M,Bouzy J,Chassagne D

更新日期：1997-01-01 00:00:00