Abstract：
:Basal cell carcinomas (BCCs) are very frequent cutaneous cancers, often located on the face. Cure rates with surgery and radiotherapy are high, but these treatments have never been compared prospectively. A randomized trial was initiated in 1982 to compare surgery and radiotherapy in the treatment of primary BCC of the face measuring less than 4 cm. The primary end point was the failure rate (persistent or recurrent disease) after 4 years of follow-up. The secondary end point was the cosmetic results assessed by the patient, the dermatologist and three persons not involved in the trial. In the course of the trial, 347 patients were treated. Of the 174 patients in the surgery group, 71% had local anaesthesia and 91% frozen section examination. Of the 173 patients in the radiotherapy group, 55% were treated with interstitial brachytherapy, 33% with contactherapy and 12% with conventional radiotherapy. The 4-year actuarial failure rate (95% CI) was 0.7% (0.1-3.9%) in the surgery group compared with 7.5% (4.2-13.1%) in the radiotherapy group (log-rank P = 0.003). The cosmetic results assessed by four of the five judges were significantly better after surgery than after radiotherapy. Eighty-seven per cent of the surgery-treated patients and 69% of the radiation-treated patients considered the cosmetic result as good (P < 0.01). Thus, in the treatment of BCC of the face of less than 4 cm in diameter, surgery should be preferred to radiotherapy.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Avril MF,Auperin A,Margulis A,Gerbaulet A,Duvillard P,Benhamou E,Guillaume JC,Chalon R,Petit JY,Sancho-Garnier H,Prade M,Bouzy J,Chassagne Ddoi
10.1038/bjc.1997.343subject
Has Abstractpub_date
1997-01-01 00:00:00pages
100-6issue
1eissn
0007-0920issn
1532-1827journal_volume
76pub_type
临床试验,杂志文章,随机对照试验abstract：:The aim of this study is to evaluate different options for introducing liquid-based cytology (LBC) and human papillomavirus (HPV) testing into the UK cervical cancer screening programme. These include options that incorporate HPV testing either as a triage for mild and borderline smear abnormalities or as a primary sc...
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journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,随机对照试验
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