Regulation of vascular endothelial growth factor expression in human colon cancer by interleukin-1beta.

abstract：:TNF-related apoptosis-inducing ligand (TRAIL, also known as Apo-2L) is a promising novel anticancer agent that selectively induces apoptosis in tumour cells and the activity of which can be enhanced by combined treatment with chemo- or radiotherapy. For therapeutic purposes, the use of full-length TRAIL may be favoura...

journal_title：British journal of cancer

authors： Abou El Hassan MA,Mastenbroek DC,Gerritsen WR,Giaccone G,Kruyt FA

更新日期：2004-07-05 00:00:00

abstract：:A urinary gonadotrophin peptide (UGP) was isolated and purified from semi-purified human chorionic gonadotrophin (hCG), prepared from pregnancy urine. The peptide showed hCG-B subunit activity and no hCG-alpha subunit activity as demonstrated by binding studies with the relevant antibodies. It had a molecular weight s...

journal_title：British journal of cancer

authors： Kardana A,Taylor ME,Southall PJ,Boxer GM,Rowan AJ,Bagshawe KD

更新日期：1988-09-01 00:00:00

abstract：:Sodium polyanethol sulphonate (SPS) when incorporated into rat erythrocyte lysate (REL) containing semi-solid agar medium at 1 mg ml-1. markedly enhanced colony formation by a number of anchorage-independent cell lines. REL usually needed to be included for the expression of SPS induced potentiation as in its absence ...

journal_title：British journal of cancer

authors： Sheridan JW,Bishop CJ,Simmons RJ,Ward CJ,Baumann KC

更新日期：1984-11-01 00:00:00

abstract：:To evaluate whether green tea consumption provides protection against stomach cancer death, relative risks were calculated using Cox proportional hazards regression analysis in the Japan Collaborative Study for Evaluation of Cancer Risk, sponsored by the Ministry of Health and Welfare (JACC Study). The study was based...

journal_title：British journal of cancer

authors： Hoshiyama Y,Kawaguchi T,Miura Y,Mizoue T,Tokui N,Yatsuya H,Sakata K,Kondo T,Kikuchi S,Toyoshima H,Hayakawa N,Tamakoshi A,Ohno Y,Yoshimura T,Japan Collaborative Cohort Study Group.

更新日期：2002-07-29 00:00:00

abstract：BACKGROUND:CD70 is a costimulatory molecule of the tumour necrosis factor family expressed in activated immune cells and some solid tumours. In lymphocytes CD70 triggers T cell-mediated cytotoxicity and mitogen-activated protein kinase phosphorylation. METHODS:We evaluated the expression of CD70 in biopsies and melano...

journal_title：British journal of cancer

authors： Pich C,Sarrabayrouse G,Teiti I,Mariamé B,Rochaix P,Lamant L,Favre G,Maisongrosse V,Tilkin-Mariamé AF

更新日期：2016-01-12 00:00:00

abstract：:Three intraperitoneal human ovarian cancer xenografts (OS, HU, and LA) were used to assess the antitumour activity of intraperitoneal therapy with liposome encapsulated MTP-PE. MTP-PE led to significant prolongation of survival in all three xenograft models, but with varying efficacy. In one tumour model (OS), 80% of ...

journal_title：British journal of cancer

authors： Malik ST,Martin D,Hart I,Balkwill F

更新日期：1991-03-01 00:00:00

abstract：BACKGROUND:We evaluated the associations of anthropometric indicators of general obesity (body mass index, BMI), an established risk factor of various cancer, and body fat distribution (waist circumference, WC; hip circumference, HC; and waist-to-hip ratio, WHR), which may better reflect metabolic complications of obes...

journal_title：British journal of cancer

authors： Freisling H,Arnold M,Soerjomataram I,O'Doherty MG,Ordóñez-Mena JM,Bamia C,Kampman E,Leitzmann M,Romieu I,Kee F,Tsilidis K,Tjønneland A,Trichopoulou A,Boffetta P,Benetou V,Bueno-de-Mesquita HBA,Huerta JM,Brenner H,Wils

更新日期：2017-05-23 00:00:00

abstract：:Three hundred and ninety women participated in the quality of life (QL) study of ACCOG1, a high-dose vs conventional adjuvant chemotherapy breast cancer trial, for patients with a high risk of relapse. Patients completed the European Organisation for Research and Treatment of Cancer QLQ-C30, questions on menopausal sy...

journal_title：British journal of cancer

authors： Malinovszky KM,Gould A,Foster E,Cameron D,Humphreys A,Crown J,Leonard RC,Anglo Celtic Co-operative Oncology Group.

更新日期：2006-12-18 00:00:00

abstract：BACKGROUND:Ovarian and endometrial high-grade serous carcinomas (HGSCs) have similar clinical and pathological characteristics; however, exhaustive protein expression profiling of these cancers has yet to be reported. METHODS:We performed protein expression profiling on 14 cases of HGSCs (7 ovarian and 7 endometrial) ...

journal_title：British journal of cancer

authors： Hiramatsu K,Yoshino K,Serada S,Yoshihara K,Hori Y,Fujimoto M,Matsuzaki S,Egawa-Takata T,Kobayashi E,Ueda Y,Morii E,Enomoto T,Naka T,Kimura T

更新日期：2016-03-01 00:00:00

abstract：:Loss of the short arm of chromosome 1 is a hallmark of oligodendroglial tumours (OTs). Deletion mapping studies in OTs have revealed multiple commonly deleted regions on chromosome 1p, suggesting that there are more than one tumour suppressor gene. To map critical deletion regions on 1p, a series of 25 OTs were examin...

journal_title：British journal of cancer

authors： Dong Z,Pang JS,Ng MH,Poon WS,Zhou L,Ng HK

更新日期：2004-09-13 00:00:00

abstract：:Accumulating evidence suggests that the p53 gene is a good target for molecular epidemiological studies. We previously reported an association between the presence of p53 mutations and lifetime cigarette consumption. Although over 675 p53 mutations have been reported in lung cancers in the literature thus far, very li...

journal_title：British journal of cancer

authors： Takagi Y,Osada H,Kuroishi T,Mitsudomi T,Kondo M,Niimi T,Saji S,Gazdar AF,Takahashi T,Minna JD,Takahashi T

更新日期：1998-05-01 00:00:00

abstract：:Window of opportunity trials exploit the 'window' of time after cancer diagnosis, typically prior to initiation of cancer therapy. In recent years this study design has become a more regular feature of drug development, as this 'window' provides an opportunity to carry out a thorough pharmacodynamic assessment of a th...

journal_title：British journal of cancer

authors： Aroldi F,Lord SR

更新日期：2020-01-01 00:00:00

abstract：:Chromosomal translocation t(11;22)(q24:q12) is detected in approximately 90% of tumours of the Ewing family (ET). This translocation results in EWS-Fli1 gene fusion which produces a EWS-Fli1 fusion protein acting as an aberrant transcriptional activator. We previously reported that the inhibition of EWS-Fli1 expressio...

journal_title：British journal of cancer

authors： Matsumoto Y,Tanaka K,Nakatani F,Matsunobu T,Matsuda S,Iwamoto Y

更新日期：2001-03-23 00:00:00

abstract：:The sera of 80 newly diagnosed lung-cancer patients have been examined for immune complexes and autoantibodies. Control subjects consisted of 20 bronchitic patients and 150 normal blood donors. Immune-complex measurements used 4 established and sensitive techniques (Raji cell assay, fluid and solid-phase C1q assays an...

journal_title：British journal of cancer

authors： Guy K,Di Mario U,Irvine WJ,Hunter AM,Hadley A,Horne NW

更新日期：1981-03-01 00:00:00

abstract：:The level of Gross cell-surface antigen (GCSAa) expression at the surface of murine retrovirus-infected fibroblasts was determined by quantitative absorption of the anti-GCSAa activity of a serum produced in syngeneic W/Fu rats immunized against (C58NT)D lymphoma, and tested in a cytotoxicity assay against E male G2 l...

journal_title：British journal of cancer

authors： Gerlier D,Gisselbrecht S,Guillemain B,Doré JF

更新日期：1981-05-01 00:00:00

abstract：:The bioreductive antitumour agent, mitomycin C (MMC), requires activation by reductive enzymes like NAD(P)H:quinone oxidoreductase 1 (NQO1). We used a novel approach to increase MMC efficacy by selectively inducing NQO1 in tumour cells in vivo. CD-1 nude mice were implanted with HCT116 cells, and fed control diet or d...

journal_title：British journal of cancer

authors： Begleiter A,Leith MK,Thliveris JA,Digby T

更新日期：2004-10-18 00:00:00

abstract：BACKGROUND:The urokinase plasminogen activator (uPA) system is one of the best-investigated protease systems, both under physiological and pathological conditions, including various types of cancer. However, effects of co-expression of members of the uPA system in soft-tissue sarcoma (STS) patients at the protein level...

journal_title：British journal of cancer

authors： Taubert H,Würl P,Greither T,Kappler M,Bache M,Lautenschläger C,Füssel S,Meye A,Eckert AW,Holzhausen HJ,Magdolen V,Kotzsch M

更新日期：2010-02-16 00:00:00

abstract：:A phase I study of the bispecific antibody MDX-H210 in combination with granulocyte colony-stimulating factor (G-CSF) was performed in stage IV breast carcinoma patients, overexpressing HER-2/neu. MDX-H210, constructed by crosslinking antigen binding fragments (F(ab') fragments) of monoclonal antibody (mAb) H22 to Fc ...

journal_title：British journal of cancer

authors： Repp R,van Ojik HH,Valerius T,Groenewegen G,Wieland G,Oetzel C,Stockmeyer B,Becker W,Eisenhut M,Steininger H,Deo YM,Blijham GH,Kalden JR,van de Winkel JG,Gramatzki M

更新日期：2003-12-15 00:00:00

abstract：:We examined the levels of expression of the multidrug resistance-associated protein (MRP) gene quantified by Northern blot analysis in comparison with those of the MDR1 gene determined by reverse transcription-polymerase chain reaction (RT-PCR) in 104 non-small-cell lung cancer (NSCLC) specimens [59 adenocarcinoma (Ad...

journal_title：British journal of cancer

authors： Ota E,Abe Y,Oshika Y,Ozeki Y,Iwasaki M,Inoue H,Yamazaki H,Ueyama Y,Takagi K,Ogata T

更新日期：1995-09-01 00:00:00

abstract：:Squamous carcinoma of the oropharynx presents with symptoms common to many benign diseases, and this can cause delay in referral to secondary care. We investigate delay in referral, defining this as the time from symptom-onset to date of general practitioners referral letter to secondary care, and the effect of that d...

journal_title：British journal of cancer

authors： Pitchers M,Martin C

更新日期：2006-04-10 00:00:00

abstract：:A Phase I study of oral daily misonidazole (MISO) with conventional pelvic irradiation, has been conducted in patients with carcinoma of the cervix Stages IB, IIB, IIIB and IVA. MISO was administered in daily dosages to sequential groups of patients at doses of 0.15 g/m2, 0.30 g/m2 or 0.45 g/m2 for 22 days over 5 week...

journal_title：British journal of cancer

authors： Thomas GM,Rauth AM,Black BE,Cummings BJ,Sorenti VL,Bush RS

更新日期：1982-06-01 00:00:00

abstract：BACKGROUND:Head and neck squamous cell carcinoma (HNSCC) is associated with poor survival. To identify prognostic and diagnostic markers and therapeutic targets, we studied ANO1, a recently identified calcium-activated chloride channel (CaCC). METHODS:High-resolution genomic and transcriptomic microarray analysis and ...

journal_title：British journal of cancer

authors： Ayoub C,Wasylyk C,Li Y,Thomas E,Marisa L,Robé A,Roux M,Abecassis J,de Reyniès A,Wasylyk B

更新日期：2010-08-24 00:00:00

abstract：:The role of the anti-apoptotic protein Bcl-2 in lung cancer remains controversial. In order to clarify its impact on survival in small and non-small cell lung cancer (NSCLC), we performed a systematic review of the literature. Trials were selected for further analysis if they provided an independent assessment of Bcl-...

journal_title：British journal of cancer

authors： Martin B,Paesmans M,Berghmans T,Branle F,Ghisdal L,Mascaux C,Meert AP,Steels E,Vallot F,Verdebout JM,Lafitte JJ,Sculier JP

更新日期：2003-07-07 00:00:00

abstract：:Basal cell carcinomas (BCCs) are very frequent cutaneous cancers, often located on the face. Cure rates with surgery and radiotherapy are high, but these treatments have never been compared prospectively. A randomized trial was initiated in 1982 to compare surgery and radiotherapy in the treatment of primary BCC of th...

journal_title：British journal of cancer

authors： Avril MF,Auperin A,Margulis A,Gerbaulet A,Duvillard P,Benhamou E,Guillaume JC,Chalon R,Petit JY,Sancho-Garnier H,Prade M,Bouzy J,Chassagne D

更新日期：1997-01-01 00:00:00

abstract：:Hypoxia, a hallmark of most solid tumours, is a negative prognostic factor due to its association with an aggressive tumour phenotype and therapeutic resistance. Given its prominent role in oncology, accurate detection of hypoxia is important, as it impacts on prognosis and could influence treatment planning. A variet...

journal_title：British journal of cancer

authors： Fleming IN,Manavaki R,Blower PJ,West C,Williams KJ,Harris AL,Domarkas J,Lord S,Baldry C,Gilbert FJ

更新日期：2015-01-20 00:00:00

abstract：:Dipyridamole has been shown to enhance the in vitro activity of antimetabolite anticancer drugs through the inhibition of nucleoside transport. However, the clinical potential of dipyridamole has not been realized because of the avid binding of the drug to the plasma protein alpha1-acid glycoprotein (AGP). Dipyridamol...

journal_title：British journal of cancer

authors： Curtin NJ,Bowman KJ,Turner RN,Huang B,Loughlin PJ,Calvert AH,Golding BT,Griffin RJ,Newell DR

更新日期：1999-08-01 00:00:00

abstract：BACKGROUND:Golgi phosphoprotein 3 (GOLPH3) has been reported to be involved in the development of several human cancers. The present study was conducted to investigate the expression of GOLPH3 and its prognostic significance in renal cell carcinoma (RCC). Meanwhile, the function of GOLPH3 in human RCC was further inves...

journal_title：British journal of cancer

authors： Xue Y,Wu G,Liao Y,Xiao G,Ma X,Zou X,Zhang G,Xiao R,Wang X,Liu Q,Long D,Yang J,Xu H,Liu F,Liu M,Xie K,Huang R

更新日期：2014-04-29 00:00:00

abstract：:Minisatellite DNA probes which can detect a large number of autosomal loci dispersed throughout the human genome were used to examine the constitutional and tumour DNA of 35 patients with a variety of cancers of which eight were of gastrointestinal origin. Somatic changes were seen in the tumour DNA in ten of the 35 c...

journal_title：British journal of cancer

authors： Thein SL,Jeffreys AJ,Gooi HC,Cotter F,Flint J,O'Connor NT,Weatherall DJ,Wainscoat JS

更新日期：1987-04-01 00:00:00

abstract：:The objective of this study was to document the occurrence and to correlate the prevalence of different human papillomavirus (HPV) types with the cytological results on simultaneously performed thin-layer preparations in a large population of Flemish women. During 1 year, 69 290 thin-layer preparations were interprete...

journal_title：British journal of cancer

authors： Depuydt CE,Vereecken AJ,Salembier GM,Vanbrabant AS,Boels LA,van Herck E,Arbyn M,Segers K,Bogers JJ

更新日期：2003-02-24 00:00:00

abstract：:Intrapleurally injected cells of an ascitic rat tumour produced intrapleural effusions and solid pleural deposits. BCG, or its methanol extraction residue (MER) injected into the pleural space, suppressed tumour development and prolonged survival. Treatment was effective if given a few days before or after tumour inje...

journal_title：British journal of cancer

authors： Pimm MV,Hopper DG,Baldwin RW

更新日期：1976-10-01 00:00:00