当前位置： SCI文献检索 > BRITISH JOURNAL OF CANCER期刊下所有文献 > Dietary induction of NQO1 increases the antitumour activity of mitomycin C in human colon tumours in vivo.

Dietary induction of NQO1 increases the antitumour activity of mitomycin C in human colon tumours in vivo.

Abstract：

:The bioreductive antitumour agent, mitomycin C (MMC), requires activation by reductive enzymes like NAD(P)H:quinone oxidoreductase 1 (NQO1). We used a novel approach to increase MMC efficacy by selectively inducing NQO1 in tumour cells in vivo. CD-1 nude mice were implanted with HCT116 cells, and fed control diet or diet containing 0.3% of the NQO1 inducer, dimethyl fumarate (DMF). The mice were then treated with saline, 2.0, 3.5 or 2.0 mg kg(-1) MMC and dicoumarol, an NQO1 inhibitor. The DMF diet increased NQO1 activity by 2.5-fold in the tumours, but had no effect in marrow cells. Mice given control diet/2.0 mg kg(-1) MMC had tumours with the same volume as control mice; however, mice given DMF diet/2.0 mg kg(-1) MMC had significantly smaller tumours. Tumour volumes in mice given DMF/2.0 mg kg(-1) MMC were similar to those in mice given control diet/3.5 mg kg(-1) MMC. Tumour inhibition was partially reversed in mice given DMF/2.0 mg kg(-1) MMC and dicoumarol. DMF diet/2.0 mg kg(-1) MMC treatment did not increase myelosuppression and did not produce any organ toxicity. These results provide strong evidence that dietary inducers of NQO1 can increase the antitumour activity of bioreductive agents like MMC without increasing toxicity.

journal_name

Br J Cancer

journal_title

British journal of cancer

authors

Begleiter A,Leith MK,Thliveris JA,Digby T

doi

10.1038/sj.bjc.6602171

subject

Has Abstract

pub_date

2004-10-18 00:00:00

pages

1624-31

issue

8

eissn

0007-0920

issn

1532-1827

pii

6602171

journal_volume

91

pub_type

杂志文章

相关文献

BRITISH JOURNAL OF CANCER文献大全
  • Gene trapping identifies chloride channel 4 as a novel inducer of colon cancer cell migration, invasion and metastases.

    abstract：BACKGROUND:To date, there are few reports on gene products contributing to colon cancer progression. METHODS:We used a gene trap comprised of an enhanced retroviral mutagen (ERM) cassette that includes a tetracycline-responsive promoter upstream of a haemagglutinin (HA) tag and a splice donor site. Integration of the ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6605536

    authors： Ishiguro T,Avila H,Lin SY,Nakamura T,Yamamoto M,Boyd DD

    更新日期：2010-02-16 00:00:00

  • Health-related quality of life impact of cobimetinib in combination with vemurafenib in patients with advanced or metastatic BRAFV600 mutation-positive melanoma.

    abstract：BACKGROUND:In the coBRIM study, cobimetinib plus vemurafenib (C+V) significantly improved survival outcomes vs placebo and vemurafenib (P+V) in patients with advanced/metastatic BRAFV600-mutated melanoma. An analysis of health-related quality of life (HRQOL) from coBRIM is reported. METHODS:Patients completing the Eur...

    journal_title：British journal of cancer

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1038/bjc.2017.488

    authors： Dréno B,Ascierto PA,Atkinson V,Liszkay G,Maio M,Mandalà M,Demidov L,Stroyakovskiy D,Thomas L,de la Cruz-Merino L,Dutriaux C,Garbe C,Bartley K,Karagiannis T,Chang I,Rooney I,Koralek DO,Larkin J,McArthur GA,Ribas A

    更新日期：2018-03-20 00:00:00

  • Bacterial lipopolysaccharide as negative predictor of gemcitabine efficacy in advanced pancreatic cancer - translational results from the AIO-PK0104 Phase 3 study.

    abstract：BACKGROUND:Gram-negative bacteria mediated gemcitabine resistance in pre-clinical models. We determined if intratumoural lipopolysaccharide (LPS) detection by immunohistochemistry is associated with outcome in advanced pancreatic ductal adenocarcinoma (PDAC) treated with gemcitabine and non-gemcitabine containing 1st-l...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/s41416-020-01029-7

    authors： Guenther M,Haas M,Heinemann V,Kruger S,Westphalen CB,von Bergwelt-Baildon M,Mayerle J,Werner J,Kirchner T,Boeck S,Ormanns S

    更新日期：2020-10-01 00:00:00

  • Nitric oxide of human colorectal adenocarcinoma cell lines promotes tumour cell invasion.

    abstract：:The present study investigates the role of nitric oxide and the involvement of nitric oxide synthase II isoform on the invasion of human colorectal adenocarcinoma cell lines HRT-18 and HT-29. HRT-18 cells, which constitutively express nitric oxide synthase II mRNA were three-fold more invasive in a Matrigel invasion a...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6600224

    authors： Siegert A,Rosenberg C,Schmitt WD,Denkert C,Hauptmann S

    更新日期：2002-04-22 00:00:00

  • Prognostic role of ERBB2, MET and VEGFA expression in metastatic colorectal cancer patients treated with anti-EGFR antibodies.

    abstract：BACKGROUND:High amplification of epiregulin (EREG) and amphireglin (AREG) in tumour tissues has been previously reported to be associated with better outcome in metastatic colorectal cancer (mCRC) patients who were treated with anti-EGFR antibodies. Here we investigated associations between the expression of other cand...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2016.74

    authors： Takahashi N,Iwasa S,Taniguchi H,Sasaki Y,Shoji H,Honma Y,Takashima A,Okita N,Kato K,Hamaguchi T,Shimada Y,Yamada Y

    更新日期：2016-04-26 00:00:00

  • Isolation and partial characterization of macromolecular urinary aggregates containing carcinoembryonic antigen-like activity.

    abstract：:Carcinoembryonic antigen-like substances in the urine of patients with bladder carcinoma and of healthy male subjects occur in a wide range of average molecular sizes. Some of these substances are glycoproteins giving reactions of antigenic identity with carcinoembryonic antigen (CEA) derived from colorectal carcinoma...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1974.93

    authors： Nery R,James R,Barsoum AL,Bullman H

    更新日期：1974-06-01 00:00:00

  • Single versus multiple human-equivalent doses of C. parvum in mice: neutralization of the anti-metastatic effect.

    abstract：:The murine dose of i.v. C. parvum (466 microgram) was compared with a single, low, human-equivalent dose of 70 microgram and with repeated weekly low doses. All treatments increased the antibody titre against C. parvum (CP). However, repeated doses stimulated a much higher titre than single doses. In all treated anima...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1980.64

    authors： Mitcheson HD,Sadler TE,Castro JE

    更新日期：1980-03-01 00:00:00

  • Diagnostic radiography and adult acute myeloid leukaemia: an interview and medical chart review study.

    abstract：BACKGROUND:Aetiology of acute myeloid leukaemia (AML) is not well understood, perhaps because of its distinct subtypes. High-dose ionising radiation is a known risk factor, but less is known about risk from low-dose exposure such as from diagnostic radiography. METHODS:Subjects were 412 matched case-control pairs. Ten...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2011.114

    authors： Pogoda JM,Nichols PW,Ross RK,Stram DO,Thomas DC,Preston-Martin S

    更新日期：2011-04-26 00:00:00

  • Tumour cell detection in the bone marrow of breast cancer patients at primary therapy: results of a 3-year median follow-up.

    abstract：:We examined bone marrow aspirates from 100 metastasis-free primary breast cancer patients. In 38/100 patients (38%), tumour cells were detected in the marrow using an immunocytochemical technique with a cocktail of two monoclonal antibodies: anti-EMA and anti-cytokeratin. Median follow-up was 34 months: 15/38 (39%) tu...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1994.103

    authors： Harbeck N,Untch M,Pache L,Eiermann W

    更新日期：1994-03-01 00:00:00

  • Cellular and humoral mechanisms of osteoclast formation in Ewing's sarcoma.

    abstract：:Cellular mechanisms that account for tumour osteolysis associated with Ewing's sarcoma are uncertain. Osteoclasts are marrow-derived multinucleated cells (MNCs) that effect tumour osteolysis. Osteoclasts are known to form from macrophages by both receptor activator for nuclear factor-kappaB (RANK) ligand (RANKL)-depen...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6603774

    authors： Lau YS,Adamopoulos IE,Sabokbar A,Giele H,Gibbons CL,Athanasou NA

    更新日期：2007-06-04 00:00:00

  • Novel diagnostic value of circulating miR-18a in plasma of patients with pancreatic cancer.

    abstract：BACKGROUND:Several recent studies have demonstrated that microRNAs (miRNAs) are stably detectable in the plasma/serum. We hypothesised that miR-18a in the plasma is a potential biomarker in patients with pancreatic cancer. METHODS:miR-18a is located in the miR-17-92 cluster and reported to be highly expressed in pancr...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2011.453

    authors： Morimura R,Komatsu S,Ichikawa D,Takeshita H,Tsujiura M,Nagata H,Konishi H,Shiozaki A,Ikoma H,Okamoto K,Ochiai T,Taniguchi H,Otsuji E

    更新日期：2011-11-22 00:00:00

  • Mammographic density and its interaction with other breast cancer risk factors in an Asian population.

    abstract：BACKGROUND:Joint effects of mammographic density and other risk factors on breast cancer risk remain unclear. METHODS:From The Singapore Breast Screening Project, we selected 491 cases and 982 controls. Mammographic density was measured quantitatively. Data analysis was by conditional logistic regression. RESULTS:Den...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6606085

    authors： Wong CS,Lim GH,Gao F,Jakes RW,Offman J,Chia KS,Duffy SW

    更新日期：2011-03-01 00:00:00

  • Diagnosis of prostate cancer by detection of minichromosome maintenance 5 protein in urine sediments.

    abstract：BACKGROUND:The accuracy of prostate-specific antigen (PSA) testing in prostate cancer detection is constrained by low sensitivity and specificity. Dysregulated expression of minichromosome maintenance (Mcm) 2-7 proteins is an early event in epithelial multistep carcinogenesis and thus MCM proteins represent powerful ca...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6605785

    authors： Dudderidge TJ,Kelly JD,Wollenschlaeger A,Okoturo O,Prevost T,Robson W,Leung HY,Williams GH,Stoeber K

    更新日期：2010-08-24 00:00:00

  • Further evidence of response by leukaemia patients in remission to antigen(s) related to acute myelogenous leukaemia.

    abstract：:Fifteen patients with acute myelogenous leukaemia were studied to determine if their remission blood leucocytes could be stimulated into taking up [3H] thymidine after in vitro culture with their own cryo-preserved irradiated AML leukaemia cells. In 6/15 patients it was possible to show autologous recognition and equa...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1977.39

    authors： Cocks P,Powles RL,Chapuis B,Alexander P

    更新日期：1977-03-01 00:00:00

  • Personalising docetaxel and G-CSF schedules in cancer patients by a clinically validated computational model.

    abstract：BACKGROUND:This study was aimed to develop a new method for personalising chemotherapeutic and granulocyte colony-stimulating factor (G-CSF) combined schedules, and use it for suggesting efficacious chemotherapy with reduced neutropenia. METHODS:Clinical data from 38 docetaxel (Doc)-treated metastatic breast cancer pa...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2012.316

    authors： Vainas O,Ariad S,Amir O,Mermershtain W,Vainstein V,Kleiman M,Inbar O,Ben-Av R,Mukherjee A,Chan S,Agur Z

    更新日期：2012-08-21 00:00:00

  • The effect of 1,25-dihydroxyvitamin D3 on lymphoma cell lines and expression of vitamin D receptor in lymphoma.

    abstract：:1,25(OH)2D3 promotes differentiation and has an antiproliferative effect in a variety of cell lines derived from the immunohaematopoetic system. alpha-Calcidol which is metabolised to 1,25(OH)2D3 has been shown to produce tumour regression in follicular low grade non-Hodgkin's lymphoma (NHL) and the dose limiting toxi...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1993.406

    authors： Hickish T,Cunningham D,Colston K,Millar BC,Sandle J,Mackay AG,Soukop M,Sloane J

    更新日期：1993-10-01 00:00:00

  • Tamoxifen--the treatment of choice. Why look for alternatives?

    abstract：:Tamoxifen is currently established as the endocrine treatment of choice in breast cancer. In advanced breast cancer, response rates of up to 60% in women with oestrogen receptor (ER)-positive tumours have been reported. In early breast cancer, tamoxifen can produce significant benefits, both statistically and clinical...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1998.753

    authors： Baum M

    更新日期：1998-09-01 00:00:00

  • Phosphorylation of the androgen receptor is associated with reduced survival in hormone-refractory prostate cancer patients.

    abstract：:Cell line studies demonstrate that the PI3K/Akt pathway is upregulated in hormone-refractory prostate cancer (HRPC) and can result in phosphorylation of the androgen receptor (AR). The current study therefore aims to establish if this has relevance to the development of clinical HRPC. Immunohistochemistry was employed...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6604152

    authors： McCall P,Gemmell LK,Mukherjee R,Bartlett JM,Edwards J

    更新日期：2008-03-25 00:00:00

  • Efficacy of immunoliposomes on cancer models in a cell-surface-antigen-density-dependent manner.

    abstract：:We have recently established a cancer-reactive human monoclonal antibody, GAH, with a positive ratio of over 90% against stomach cancer. GAH was formulated as polyethyleneglycol (PEG)-modified immunoliposomal doxorubicin (DXR) (ILD) and its efficacy was examined against gastrointestinal human cancers. In in vitro stud...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6601341

    authors： Hosokawa S,Tagawa T,Niki H,Hirakawa Y,Nohga K,Nagaike K

    更新日期：2003-10-20 00:00:00

  • Molecular analysis of local relapse in high-risk breast cancer patients: can radiotherapy fractionation and time factors make a difference?

    abstract：:Large primary breast tumours and extensive lymph node involvement are linked to a high rate of local recurrence after surgery. In 10-20% of such high-risk breast cancer patients, local relapse will occur despite postoperative radiotherapy. In the present study, we investigated whether molecular features, such as angio...

    journal_title：British journal of cancer

    pub_type： 临床试验,杂志文章

    doi：10.1038/sj.bjc.6600755

    authors： Koukourakis MI,Giatromanolaki A,Galazios G,Sivridis E

    更新日期：2003-03-10 00:00:00

  • A common polymorphism in the retinoic acid pathway modifies adrenocortical carcinoma age-dependent incidence.

    abstract：BACKGROUND:Genome-wide association studies (GWASs) have enriched the fields of genomics and drug development. Adrenocortical carcinoma (ACC) is a rare cancer with a bimodal age distribution and inadequate treatment options. Paediatric ACC is frequently associated with TP53 mutations, with particularly high incidence in...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/s41416-020-0764-3

    authors： Surakhy M,Wallace M,Bond E,Grochola LF,Perez H,Di Giovannantonio M,Zhang P,Malkin D,Carter H,Parise IZS,Zambetti G,Komechen H,Paraizo MM,Pagadala MS,Pinto EM,Lalli E,Figueiredo BC,Bond GL

    更新日期：2020-04-01 00:00:00

  • Systemic immune-inflammation index in germ-cell tumours.

    abstract：BACKGROUND:We evaluated systemic immune-inflammation index (SII) and its association with patient outcome in germ-cell tumours (GCTs). METHODS:Two independent cohorts of patients were analysed; the discovery set (n=171) from a single institution and the validation set (n=181) previously included in a study evaluating ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2017.460

    authors： Chovanec M,Cierna Z,Miskovska V,Machalekova K,Kalavska K,Rejlekova K,Svetlovska D,Macak D,Spanik S,Kajo K,Babal P,De Giorgi U,Mego M,Mardiak J

    更新日期：2018-03-20 00:00:00

  • Variability in functional p53 reactivation by PRIMA-1(Met)/APR-246 in Ewing sarcoma.

    abstract：BACKGROUND:Though p53 mutations are rare in ES, there is a strong indication that p53 mutant tumours form a particularly bad prognostic group. As such, novel treatment strategies are warranted that would specifically target and eradicate tumour cells containing mutant p53 in this subset of ES patients. METHODS:PRIMA-1...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2013.635

    authors： Aryee DN,Niedan S,Ban J,Schwentner R,Muehlbacher K,Kauer M,Kofler R,Kovar H

    更新日期：2013-11-12 00:00:00

  • Clinical and microarray analysis of breast cancers of all subtypes from two prospective preoperative chemotherapy studies.

    abstract：BACKGROUND:We aimed to analyse clinical and gene expression profiles to predict pathologic complete response and disease-free survival using two consecutive, prospective, preoperative chemotherapy trial cohorts. METHODS:Clinicopathological and gene expression data were evaluated in a cohort from two consecutive phase ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2016.184

    authors： Okuma HS,Koizumi F,Hirakawa A,Nakatochi M,Komori O,Hashimoto J,Kodaira M,Yunokawa M,Yamamoto H,Yonemori K,Shimizu C,Fujiwara Y,Tamura K

    更新日期：2016-08-09 00:00:00

  • Responses of an experimental solid tumour to irradiation: A comparison of modes of fractionation.

    abstract：:Several radiotherapeutic schedules compatible with continued structural-functional integrity of the gastrointestinal (GI) mucosa were compared utilizing the P815X2 murine mastocytoma grown as a solid subcutaneous tumour. Both the tumour and underlying normal tissues were irradiated during the treatments. The tumour ex...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1975.29

    authors： Schenken LL,Poulakos L,Hagemann RF

    更新日期：1975-02-01 00:00:00

  • Bcl-2 protein expression: association with p53 and prognosis in colorectal cancer.

    abstract：:Bcl-2 expression in colorectal carcinomas was studied in a series of 224 patients and the relation to p53 expression, stage and survival assessed. Bcl-2 expression was down-regulated compared with normal mucosa in 67% (151) of the cases. In 144 cases staining was positive for p53 (MAB DO7), and 41 of these 144 p53-pos...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1998.310

    authors： Kaklamanis L,Savage A,Whitehouse R,Doussis-Anagnostopoulou I,Biddolph S,Tsiotos P,Mortensen N,Gatter KC,Harris AL

    更新日期：1998-06-01 00:00:00

  • Changes in E-cadherin associated with cytoplasmic molecules in well and poorly differentiated endometrial cancer.

    abstract：:E-cadherin function is thought to be impaired in epithelial cancer. To investigate the alterations in E-cadherin associated with cytoplasmic molecules including alpha-catenin, beta-catenin, gamma-catenin, p120CAS, and IQGAP1 in various endometrial cancers with different degree of differentiation, we examined the local...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1054/bjoc.2000.1386

    authors： Miyamoto S,Baba H,Kuroda S,Kaibuchi K,Fukuda T,Maehara Y,Saito T

    更新日期：2000-11-01 00:00:00

  • Pathological features of 11,337 patients with primary ductal carcinoma in situ (DCIS) and subsequent events: results from the UK Sloane Project.

    abstract：BACKGROUND:The Sloane audit compares screen-detected ductal carcinoma in situ (DCIS) pathology with subsequent management and outcomes. METHODS:This was a national, prospective cohort study of DCIS diagnosed during 2003-2012. RESULTS:Among 11,337 patients, 7204 (64%) had high-grade DCIS. Over time, the proportion of ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/s41416-020-01152-5

    authors： Shaaban AM,Hilton B,Clements K,Provenzano E,Cheung S,Wallis MG,Sawyer E,Thomas JS,Hanby AM,Pinder SE,Thompson AM,Sloane Project Steering Committee.

    更新日期：2020-11-17 00:00:00

  • Bcl-2 protein: a prognostic factor inversely correlated to p53 in non-small-cell lung cancer.

    abstract：:Non-small-cell lung cancer (NSCLC) prognosis is strictly related to well-established clinicopathological parameters which have unfortunately become insufficient in the prognostic evaluation of this type of cancer. As p53 and bcl-2 gene deregulations are frequently involved in several types of epithelial malignancies, ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1995.193

    authors： Fontanini G,Vignati S,Bigini D,Mussi A,Lucchi M,Angeletti CA,Basolo F,Bevilacqua G

    更新日期：1995-05-01 00:00:00

  • Is birthweight associated with total and aggressive/lethal prostate cancer risks? A systematic review and meta-analysis.

    abstract：BACKGROUND:It has been hypothesised that intrauterine exposures are important for subsequent prostate cancer risk. Prior epidemiological studies have used birthweight as a proxy of cumulative intrauterine exposures to test this hypothesis, but results have been inconsistent partly because of limited statistical power. ...

    journal_title：British journal of cancer

    pub_type： 杂志文章,meta分析,评审

    doi：10.1038/bjc.2016.38

    authors： Zhou CK,Sutcliffe S,Welsh J,Mackinnon K,Kuh D,Hardy R,Cook MB

    更新日期：2016-03-29 00:00:00