Nitric oxide of human colorectal adenocarcinoma cell lines promotes tumour cell invasion.

abstract：:The potential antitumoral effect of granulocyte-macrophage colony-stimulating factor (GM-CSF) led us to evaluate GM-CSF alone or with dacarbazine (DTIC) in metastatic melanoma in first line randomized phase II. Treatment was arm A: GM-CSF: 5 microg kg(-1), bid, 14 consecutive days every 21 days and arm B: GM-CSF: 5 mi...

journal_title：British journal of cancer

authors： Ravaud A,Delaunay M,Chevreau C,Coulon V,Debled M,Bret-Dibat C,Courbon F,Gualde N,Nguyen Bui B

更新日期：2001-11-16 00:00:00

abstract：BACKGROUND:Current standards for assessment of tumour response to therapy (a) categorise therapeutic efficacy values, inappropriate for patient-specific and deterministic studies, (b) neglect the natural growth characteristics of tumours, (c) are based on tumour shrinkage, inappropriate for cytostatic therapies, and (d...

journal_title：British journal of cancer

authors： Mehrara E,Forssell-Aronsson E,Bernhardt P

更新日期：2011-08-23 00:00:00

abstract：BACKGROUND:A Population-Based Cancer Registry (PBCR) was set up in Sikkim (a state in the North Eastern India) in 2003. We examined incidence rates by ethnic groups from 2003-2008. METHODS:Age-adjusted incidence rates (AARs) per 100,000 person-years were calculated by direct method using the world standard population,...

journal_title：British journal of cancer

authors： Verma Y,Pradhan PK,Gurung N,Sapkota SD,Giri P,Sundas P,Bhattarai BN,Nadayil D,Ramnath T,Nandakumar A

更新日期：2012-02-28 00:00:00

abstract：BACKGROUND:Global hypomethylation has been suggested to cause genomic instability and lead to an increased risk of cancer. We examined the association between the global methylation level of peripheral blood leukocyte DNA and breast cancer among Japanese women. METHODS:We conducted a hospital-based case-control study ...

journal_title：British journal of cancer

authors： Kuchiba A,Iwasaki M,Ono H,Kasuga Y,Yokoyama S,Onuma H,Nishimura H,Kusama R,Tsugane S,Yoshida T

更新日期：2014-05-27 00:00:00

abstract：BACKGROUND:Accurate assessment of the prevalence of the human papilloma virus (HPV) in oropharyngeal tumours (OpSCC) is important because HPV-positive OpSCC are consistently associated with an improved overall survival. Recently, an algorithm has become available that reliably detects clinically relevant HPV in tumour ...

journal_title：British journal of cancer

authors： Melchers LJ,Mastik MF,Samaniego Cameron B,van Dijk BA,de Bock GH,van der Laan BF,van der Vegt B,Speel EJ,Roodenburg JL,Witjes MJ,Schuuring E

更新日期：2015-04-14 00:00:00

abstract：:The cytocidal properties of metronidazole against hypoxic mammalian cells are described. This chemotherapeutic action has been shown to be dependent on drug concentration and duration of exposure. The x-ray TCD50 for a murine anaplastic carcinoma was reduced from 6081 rad to 4643 rad when animals were given metronidaz...

journal_title：British journal of cancer

authors： Foster JL,Conroy PJ,Searle AJ,Willson RL

更新日期：1976-05-01 00:00:00

abstract：BACKGROUND:Glioma stem-like cell (GSC) properties are responsible for gliomagenesis and recurrence. GSCs are invasive but its mechanism remains to be elucidated. Here, we attempted to identify the molecules that promote invasion in GSCs. METHODS:Neurospheres and CD133⁺ cells were collected from glioblastoma (GBM) spec...

journal_title：British journal of cancer

authors： Nakada M,Nambu E,Furuyama N,Yoshida Y,Takino T,Hayashi Y,Sato H,Sai Y,Tsuji T,Miyamoto KI,Hirao A,Hamada JI

更新日期：2013-06-25 00:00:00

abstract：:A brief review is presented of the evidence linking the development of certain types of neoplasms, and of the malignant lymphomas in particular, to chronic immunosuppression in animals and man and to the naturally occurring human immunologic deficiency states. The discussion then focuses on Hodgkin's disease and consi...

journal_title：British journal of cancer

authors： Kaplan HS

更新日期：1971-12-01 00:00:00

abstract：BACKGROUND:Most oestrogen receptor (ER)-positive early breast cancer diagnosed today is highly curable with multimodality treatment. Systemic adjuvant treatments including endocrine therapy and chemotherapy have made a significant contribution to the increasing cure rates over the past three decades. However not all wo...

journal_title：British journal of cancer

authors： Yeo B,Zabaglo L,Hills M,Dodson A,Smith I,Dowsett M

更新日期：2015-07-28 00:00:00

abstract：BACKGROUND:Evidence suggests that dysregulation of energy-sensing pathways closely associates with renal cell carcinoma (RCC) development. The metabolic regulation is largely controlled by 5'-AMP activated protein kinase (AMPK) which is activated through phosphorylation by LKB1. METHODS:The expression of LKB1 was dete...

journal_title：British journal of cancer

authors： Duivenvoorden WC,Beatty LK,Lhotak S,Hill B,Mak I,Paulin G,Gallino D,Popovic S,Austin RC,Pinthus JH

更新日期：2013-02-05 00:00:00

abstract：:The mature epidermal growth factor receptor (EGFR) neither associates with nor requires the molecular chaperone heat-shock protein 90 (Hsp90). Mutations in EGFR exons 18, 19, and 21 confer Hsp90 chaperone dependence. In non-small cell lung cancer (NSCLC), these mutations are associated with enhanced sensitivity to EGF...

journal_title：British journal of cancer

authors： Xu W,Soga S,Beebe K,Lee MJ,Kim YS,Trepel J,Neckers L

更新日期：2007-09-17 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most malignant human tumours because of its high incidence of metastasis. The mechanisms underlying the metastasis of HCC, however, remain poorly understood. In this study, we performed cDNA microarray analysis to profile gene expression patterns in two subtypes of HCC, sol...

journal_title：British journal of cancer

authors： Wang W,Yang LY,Huang GW,Lu WQ,Yang ZL,Yang JQ,Liu HL

更新日期：2004-06-14 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is recognized to play a predominant role in breast cancer prognosis. The action of VEGF is mediated by two high-affinity receptors with ligand-stimulated tyrosine kinase activity: VEGFR-1/flt-1 and VEGFR-2/flk-1, which are expressed mainly in vascular endothelial cells. To the...

journal_title：British journal of cancer

authors： Xie B,Tam NN,Tsao SW,Wong YC

更新日期：1999-12-01 00:00:00

abstract：:Protracted venous infusion 5-fluorouracil (5FU) combined with mitomycin C (MMC) has demonstrated significant activity against metastatic colorectal cancer. Owing to potential synergy based upon upregulation of thymidine phosphorylase by MMC, the combination of capecitabine and MMC may improve outcomes in irinotecan-re...

journal_title：British journal of cancer

authors： Chong G,Dickson JL,Cunningham D,Norman AR,Rao S,Hill ME,Price TJ,Oates J,Tebbutt N

更新日期：2005-09-05 00:00:00

abstract：:Carzelesin is a cyclopropylpyrroloindole analogue which acts as a DNA-sequence-specific alkylating agent. In this phase I study, Carzelesin was given as a 4-weekly 10 min i.v. infusion to 51 patients with advanced solid tumours. Patients received a median of two courses (range 1-5) at one of nine dose levels: 24, 48, ...

journal_title：British journal of cancer

authors： Awada A,Punt CJ,Piccart MJ,Van Tellingen O,Van Manen L,Kerger J,Groot Y,Wanders J,Verweij J,Wagener DJ

更新日期：1999-03-01 00:00:00

abstract：:Between 1971 and 1988, 20 patients with previously undiagnosed non-Hodgkin's lymphoma (NHL), of intermediate or high grade histology presented with extradural spinal cord compression. All had decompressive surgery. The first treatment after surgery was chemotherapy in nine and radiotherapy in 11 patients. At presentat...

journal_title：British journal of cancer

authors： Eeles RA,O'Brien P,Horwich A,Brada M

更新日期：1991-01-01 00:00:00

abstract：:We have analysed Li-Fraumeni syndrome families, previously shown to be negative for mutations in TP53, for mutations to the tumour suppressor genes PTEN and CDKN2. These genes function in cell cycle progression or are mutated in a variety of tumours. We have detected no mutations in the family members tested. ...

journal_title：British journal of cancer

authors： Burt EC,McGown G,Thorncroft M,James LA,Birch JM,Varley JM

更新日期：1999-04-01 00:00:00

abstract：:The effect of an antiserum containing antibodies against cell surface components of PyBHK cells on the action of certain anticancer agents has been studied using a colony formation inhibition assay. The effects of x-rays, chlorambucil, CCNU and possibly ICRF 159 are augmented by the antiserum whereas methotrexate and ...

journal_title：British journal of cancer

authors： Rubens RD,Vaughan-Smith S,Dulbecco R

更新日期：1975-09-01 00:00:00

abstract：:The association between chromosomal radiosensitivity and genetic predisposition to head and neck cancer was investigated in this study. In all, 101 head and neck cancer patients and 75 healthy control individuals were included in the study. The G(2) assay was used to measure chromosomal radiosensitivity. The results d...

journal_title：British journal of cancer

authors： De Ruyck K,de Gelder V,Van Eijkeren M,Boterberg T,De Neve W,Vral A,Thierens H

更新日期：2008-05-20 00:00:00

abstract：:Fine needle aspiration (FNA) biopsy is the least invasive method of sampling breast cancer in vivo and provides material for breast cancer diagnosis. FNA has also been used to examine cellular markers to predict and monitor the effects of therapy. The aim of this study was to assess the accuracy of using FNA material ...

journal_title：British journal of cancer

authors： Ball HM,Hupp TR,Ziyaie D,Purdie CA,Kernohan NM,Thompson AM

更新日期：2001-10-19 00:00:00

abstract：BACKGROUND:Cellular Dissociation Grade (CDG) composed of tumour budding and cell nest size has been shown to independently predict prognosis in pre-therapeutic biopsies and primary resections of oesophageal squamous cell carcinoma (ESCC). Here, we aimed to evaluate the prognostic impact of CDG in ESCC after neoadjuvant...

journal_title：British journal of cancer

authors： Jesinghaus M,Boxberg M,Wilhelm D,Münch S,Dapper H,Quante M,Schlag C,Lange S,Budczies J,Konukiewitz B,Mollenhauer M,Schlitter AM,Becker KF,Feith M,Friess H,Steiger K,Combs SE,Weichert W

更新日期：2019-12-01 00:00:00

abstract：:In resection tissue samples of colorectal carcinomas, the concentration of urokinase-type plasminogen activator (u-Pa) was found to be significantly higher than in the normal parent mucosal tissue, while there was less tissue-type plasminogen activator (t-PA). u-PA and t-PA were also determined in endoscopic biopsies ...

journal_title：British journal of cancer

authors： de Bruin PA,Verspaget HW,Griffioen G,Verheijen JH,Dooijewaard G,Lamers CB

更新日期：1989-09-01 00:00:00

abstract：:Multidrug resistance is often associated with the (over)expression of drug efflux transporters of the ATP-binding cassette (ABC) protein family. This minireview discusses the role of one selected ABC-transporter family member, the breast cancer resistance protein (BCRP/ABCG2), in the (pre)clinical efficacy of novel ex...

journal_title：British journal of cancer

authors： Lemos C,Jansen G,Peters GJ

更新日期：2008-03-11 00:00:00

abstract：:A series of three dose escalating studies were conducted to investigate the ability of the 17alpha-hydroxylase/C(17,20)-lyase inhibitor abiraterone acetate, to cause maximum suppression of testosterone synthesis when delivered to castrate and noncastrate males with prostate cancer. Study A was a single dose study in c...

journal_title：British journal of cancer

authors： O'Donnell A,Judson I,Dowsett M,Raynaud F,Dearnaley D,Mason M,Harland S,Robbins A,Halbert G,Nutley B,Jarman M

更新日期：2004-06-14 00:00:00

abstract：:Hypoxic cells in KHT sarcomas were characterized using fluorescence activated cell sorting based on the diffusion properties of the fluorochrome Hoechst 33342. Tumour-bearing female C3H/HeJ mice were injected i.v. with 10 micrograms g-1 Hoechst 33342 and the cells derived from the tumours sorted on the basis of their ...

journal_title：British journal of cancer

authors： Siemann DW,Keng PC

更新日期：1988-09-01 00:00:00

abstract：:A partially purified fraction of the water soluble photosensitive dye sulphonated aluminium phthalocyanine (AlSPc) was encapsulated in liposomes which were then linked to a targeting monoclonal antibody 791T/36 using a heterobifunctional linking agent. The photocytotoxic effects of the liposomes were determined on two...

journal_title：British journal of cancer

authors： Morgan J,Gray AG,Huehns ER

更新日期：1989-03-01 00:00:00

abstract：:Cell viability following short (1 h) contact with paclitaxel or docetaxel was assayed using synchronised HeLa cells. Docetaxel proved almost totally lethal against S-phase cells. Its toxicity was only partial against cells in mitosis, and declined to a minimum with progression to G1. For paclitaxel, cytotoxicity incre...

journal_title：British journal of cancer

authors： Hennequin C,Giocanti N,Favaudon V

更新日期：1995-06-01 00:00:00

abstract：BACKGROUND:Appreciating variation in the length of pre- or post-presentation diagnostic intervals can help prioritise early diagnosis interventions with either a community or a primary care focus. METHODS:We analysed data from the first English National Audit of Cancer Diagnosis in Primary Care on 10 953 patients with...

journal_title：British journal of cancer

authors： Lyratzopoulos G,Saunders CL,Abel GA,McPhail S,Neal RD,Wardle J,Rubin GP

更新日期：2015-03-31 00:00:00

abstract：:Data from the Oxford Survey have shown that childhood cancers are causes of in utero deaths which affect leukaemias more than solid tumours and difficult deliveries more than easy ones. As a result of these biases singletons give the impression of being more leukaemia-sensitive than twins. This is a false impression w...

journal_title：British journal of cancer

authors： Stewart AM

更新日期：1973-06-01 00:00:00

abstract：:Arginase activity was found to be increased in precancerous nodules and mammary tumour when compared with the mammary gland. Proline inhibited the mammary tumour arginase and up to 30 mmo1 concentration the inhibition follows first order kinetics. Hill analysis of the inhibition of arginase by proline showed that prol...

journal_title：British journal of cancer

authors： Rao KV,Pai SR,Bapat CV

更新日期：1974-08-01 00:00:00