Abstract：
:We have analysed Li-Fraumeni syndrome families, previously shown to be negative for mutations in TP53, for mutations to the tumour suppressor genes PTEN and CDKN2. These genes function in cell cycle progression or are mutated in a variety of tumours. We have detected no mutations in the family members tested.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Burt EC,McGown G,Thorncroft M,James LA,Birch JM,Varley JMdoi
10.1038/sj.bjc.6690313subject
Has Abstractpub_date
1999-04-01 00:00:00pages
9-10issue
1-2eissn
0007-0920issn
1532-1827journal_volume
80pub_type
杂志文章abstract：:Portal vein embolisation (PVE) is used to increase the remnant liver volume before major liver resection for colorectal metastases. The resection rate after PVE is 60-70%, mainly limited by disease progression. The effect of PVE on tumour growth rate has not been investigated. The objective of this study was to compar...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604872
更新日期：2009-02-24 00:00:00
abstract：BACKGROUND:Several microRNA (miRNA) molecules have emerged as important post-transcriptional regulators of tumour suppressor and oncogene expression. Ras association domain family member 1 (RASSF1) is a critical tumour suppressor that controls multiple aspects of cell proliferation such as cell cycle, cell division and...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2017.110
更新日期：2017-05-23 00:00:00
abstract：BACKGROUND:Childhood cancer survival estimates from developing nations are rare. METHODS:Using the US SEER and the Manila and Rizal Cancer Registry databases in the Philippines, 5-year survival for childhood leukaemia and lymphoma in 2001-2005 among Asian Americans were compared with both Filipinos and Caucasians in t...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605703
更新日期：2010-06-29 00:00:00
abstract：:The purpose of this study was to evaluate the occurrence of lymphatic drainage to non-axillary sentinel nodes and to determine the implications of this phenomenon. A total of 549 breast cancer patients underwent lymphoscintigraphy after intratumoural injection of (99m)Tc-nanocolloid. The sentinel node was intraoperati...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/sj.bjc.6600359
更新日期：2002-09-23 00:00:00
abstract：:The UK National Case-Control Study Group has examined the relationship between smoking (both own smoking and passive), alcohol consumption and caffeine consumption and the risk of breast cancer. A total of 755 women with breast cancer diagnosed before the age of 36, each with an age-matched general population control,...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1994.258
更新日期：1994-07-01 00:00:00
abstract：:On the basis of preclinical data suggesting the possibility of maximising the efficacy of 5-fluorouracil and cisplatin by interferon, a pilot clinical trial was initiated in recurrent and/or metastatic head and neck cancer. Thirty-four patients were treated with cisplatin at 100 mg m-2, followed by 5-fluorouracil at 1...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/bjc.1994.72
更新日期：1994-02-01 00:00:00
abstract：:The aetiologic fractions due to smoking and chewing tobacco have been quantified for the first time, for cancers of the oral cavity, oropharynx, hypopharynx, larynx and oesophagus. The overall aetiologic fractions due to smoking and/or chewing tobacco have been found to be 70% for cancer of the oral cavity, 84% for th...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1977.31
更新日期：1977-02-01 00:00:00
abstract：:I have studied the effects on growth of two tumours in mice and on host toxicity, of combining Misonidazole (MISO) or Metronidazole (METRO) with Methotrexate (MTX)-5-fluorouracil (FU) or Adriamycin (ADR). The nitroimidazoles alone had no effect on the growth of either tumour, but MISO (1 mg/g) led to a small increase ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1980.334
更新日期：1980-12-01 00:00:00
abstract：:A clinical trial conducted according to a schedule of interim analyses written into the protocol, and stopped according to a predetermined rule, is known to statisticians as a sequential clinical trial. This methodology is becoming more widely used in trials concerning life-threatening diseases because of its ability ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1993.500
更新日期：1993-12-01 00:00:00
abstract：:Although epithelial cell adhesion/activating molecule (EpCAM/CD326) is one of the first tumour-associated antigens identified, it has never received the same level of attention as other target proteins for therapy of cancer. It is also striking that ever since its discovery in the late 1970s the actual contribution of...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/sj.bjc.6603494
更新日期：2007-02-12 00:00:00
abstract：BACKGROUND:The eicosanoid signalling pathway promotes the progression of malignancies through the production of proliferative prostaglandins (PGs). Cytosolic phospholipase A(2)α (cPLA(2)α) activity provides the substrate for cyclooxygenase-dependent PG release, and we have previously found that cPLA(2)α expression corr...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6606025
更新日期：2011-01-18 00:00:00
abstract：:Anti-Her-2/neu antibody is known to induce apoptosis in HER-2/neu overexpressing breast cancer cells. However, exact regulatory mechanisms mediating and controlling this phenomenon are still unknown. In the present study, we have investigated the effect of anti-Her-2/neu antibody on apoptosis of HER-2/neu overexpressi...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2001.2197
更新日期：2001-11-30 00:00:00
abstract：:Little is known about the factors that enable the mobilisation of human mesenchymal stem cells (MSC) from the bone marrow into the blood stream and their recruitment to and retention in the tumour. We found specific migration of MSC towards growth factors present in pancreatic tumours, such as PDGF, EGF, VEGF and spec...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604508
更新日期：2008-08-19 00:00:00
abstract：:The important role of the p53 gene in tumour progression and cellular response to DNA damage has prompted investigation of the clinical significance of alterations to this gene. We examined both p53 overexpression and mutation of the gene in endometrial carcinoma in order to evaluate the prognostic significance of the...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1996.401
更新日期：1996-08-01 00:00:00
abstract：BACKGROUND:Limited literature on the role of intraarterial chemotherapy as first-line therapy for penile squamous cell carcinoma is available. METHODS:From 2005 to 2013, a total of 12 patients with various stages of penile squamous cell carcinoma received intraarterial chemotherapy. The chemotherapeutic agents used we...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2014.394
更新日期：2014-09-09 00:00:00
abstract：:A substantial excess risk of lymphomas and nonmelanoma skin cancer has been demonstrated following organ transplantation. Large sample size and long follow-up time may, however, allow more accurate risk estimates and detailed understanding of long-term cancer risk. The objective of the study was to assess the risk of ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601219
更新日期：2003-10-06 00:00:00
abstract：:In this study, the immunohistochemical expression of a new inducible elastase inhibitor, SKALP (skin-derived anti-leucoproteinase)/elafin, in the tissue of squamous cell carcinoma and uninvolved oesophageal mucosa was studied using a polyclonal rabbit anti-serum against SKALP/elafin. The results were compared with the...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1997.511
更新日期：1997-01-01 00:00:00
abstract：:Cultured H35 hepatoma cells release a cytotoxic factor in response to irradiation with X-rays. When the conditioned medium from irradiated cells is given to nonirradiated cells, growth is inhibited and followed by cell death, possibly apoptosis, Analysis of the conditioned medium reveals a dramatic change in the ornit...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600700
更新日期：2003-02-10 00:00:00
abstract：:Capecitabine is an oral prodrug of 5-fluorouracil (FU). Since FU concentrations achieved in malignant lesions are an important determinant of efficacy, we investigated the intratumoral transcapillary transfer of capecitabine and its metabolites in vivo. A total of 10 patients with skin metastases from breast cancer re...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600809
更新日期：2003-03-10 00:00:00
abstract：:The degree of lymphocyte infiltration is a prognostic factor in liver cancer, but to date the mechanisms by which lymphocytes infiltrate into and are retained in hepatic tumours are poorly understood. We hypothesised that the extracellular matrix glycoprotein vitronectin, a major component of the stroma of hepatic tum...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603467
更新日期：2006-12-04 00:00:00
abstract：:We evaluated the risk of bladder cancer in a cohort of 79,280 Swedish men hospitalised for benign prostatic hyperplasia (BPH), identified in the Swedish Inpatient Register between 1964 and 1983 and followed until 1989 via multiple record linkages with nationwide data on cancer registry, death and emigration. Standardi...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603730
更新日期：2007-05-07 00:00:00
abstract：:Carcinoembryonic antigen-like substances in the urine of patients with bladder carcinoma and of healthy male subjects occur in a wide range of average molecular sizes. Some of these substances are glycoproteins giving reactions of antigenic identity with carcinoembryonic antigen (CEA) derived from colorectal carcinoma...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1974.93
更新日期：1974-06-01 00:00:00
abstract：:Epidermal growth factor receptor (EGFR) was studied in ovarian tumours with immunohistochemical (IH) and ligand-binding assay (LBA). Two different monoclonal antibodies (MoAbs: 2E9, EGFR1) with respect to detecting EGFR with different ligand-binding affinities (low, high and low) were used. When comparing the IH data ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1992.403
更新日期：1992-12-01 00:00:00
abstract：:Cancer-associated fibroblasts (CAFs) were originally presumed to represent a homogeneous population uniformly driving tumorigenesis, united by their morphology and peritumoural location. Our understanding of CAFs has since been shaped by sophisticated in vitro and in vivo experiments, pathological association and, mor...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/s41416-019-0509-3
更新日期：2019-08-01 00:00:00
abstract：:We have established a highly sensitive and quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) method to detect axillary lymph node metastases of breast cancer. Amplifying cytokeratin 19 (CK19) mRNA transcripts using real-time TaqMan PCR made it possible to quantify axillary metastatic burden. Metast...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601248
更新日期：2003-11-03 00:00:00
abstract：:Axillary lymph nodes draining mammary carcinoma showed an alteration of both micro-architectue and lymphocyte subpopulations. Lymph nodes with a normal or increased T and/or B lymphocyte compartment (assessed by histology) had a low incidence of nodal tumour spread, whilst hypocellularity of the T- or B-lymphocyte-dep...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1980.8
更新日期：1980-01-01 00:00:00
abstract：:Small cell bronchial carcinoma (SCC) xenografts with differing sensitivity to cyclophosphamide (CY) were investigated using a variety of techniques. Two xenografts (HX78 and HX88) were relatively sensitive to CY, one xenograft (HX72) was inherently resistant to CY and a fourth xenograft (HX78Cy) was a CY induced resis...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1985.98
更新日期：1985-05-01 00:00:00
abstract：:The influence of vascular endothelial growth factor (VEGF) expression and microvessel density (MVD) on prognosis and the relationship between VEGF expression and MVD in ovarian carcinoma are not well defined. We studied VEGF expression in parallel with MVD by immunohistochemistry in 94 ovarian tumours (64 malignant, 1...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2000.1228
更新日期：2000-07-01 00:00:00
abstract：:Measurement of DNA polymerase in leukaemic guinea-pig plasms reveals the presence of low levels of sedimentable and non-sedimentable enzymic activities. Since the sedimentable DNA polymerase is ribonuclease sensitive, uses poly(C).oligo(dG) as template, and bands in a sucrose density gradient at 1-17 g/ml it is though...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1976.67
更新日期：1976-04-01 00:00:00
abstract：BACKGROUND:The PI3K/Akt signalling pathway, induced by epidermal growth factor receptor (EGFR) and Her-2, is involved in the constitutive activation of NF-kappaB in prostate cancer cell lines. In this study, we extended the in vitro observation using an ex vivo model of prostate cancer tissues and assessed the prognost...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605571
更新日期：2010-03-30 00:00:00
