Abstract:
:The mature epidermal growth factor receptor (EGFR) neither associates with nor requires the molecular chaperone heat-shock protein 90 (Hsp90). Mutations in EGFR exons 18, 19, and 21 confer Hsp90 chaperone dependence. In non-small cell lung cancer (NSCLC), these mutations are associated with enhanced sensitivity to EGFR inhibitors in vitro and with clinical response in vivo. Although less prevalent, insertions in EGFR exon 20 have also been described in NSCLC. These mutations, however, confer resistance to EGFR inhibitors. In NSCLC, exon 20 insertions have also been identified in the EGFR family member ErbB2. Here, we examined the sensitivity of exon 20 insertion mutants to an Hsp90 inhibitor currently in the clinic. Our data demonstrate that both EGFR and ErbB2 exon 20 insertion mutants retain dependence on Hsp90 for stability and downstream-signalling capability, and remain highly sensitive to Hsp90 inhibition. Use of Hsp90 inhibitors should be considered in NSCLC harbouring exon 20 insertions in either EGFR or ErbB2.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Xu W,Soga S,Beebe K,Lee MJ,Kim YS,Trepel J,Neckers Ldoi
10.1038/sj.bjc.6603950subject
Has Abstractpub_date
2007-09-17 00:00:00pages
741-4issue
6eissn
0007-0920issn
1532-1827pii
6603950journal_volume
97pub_type
杂志文章abstract:BACKGROUND:Metabolomics has shown promise in gastric cancer (GC) detection. This research sought to identify whether GC has a unique urinary metabolomic profile compared with benign gastric disease (BN) and healthy (HE) patients. METHODS:Urine from 43 GC, 40 BN, and 40 matched HE patients was analysed using (1)H nucle...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2015.414
更新日期:2016-01-12 00:00:00
abstract:BACKGROUND:Congenital anomalies have been found more often in children with cancer than in those without. Rib abnormalities (RAs) have been associated with childhood cancer; however, studies have differed in the type of RAs and cancers implicated. METHODS:Rib abnormalities were assessed predominantly by X-ray in a hos...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2011.366
更新日期:2011-10-25 00:00:00
abstract:BACKGROUND:Aspirin use has been shown to lower incidence and mortality in cancer patients. The aim of this population-based study was to determine the effect of postdiagnosis low-dose aspirin use on survival of patients with oesophageal cancer. METHODS:Patients with oesophageal cancer (1998-2010) were selected from th...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2016.65
更新日期:2016-04-26 00:00:00
abstract::Epidermal growth factor receptor (EGFR) gene mutations and increased copy numbers are considered as predictors of response to EGFR tyrosine kinase inhibitors (EGFR-TKI) in non-small-cell lung cancer (NSCLC). Lung cancer diagnosis is often based on cytology alone. However, almost all published data on EGFR gene analyse...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604142
更新日期:2008-01-15 00:00:00
abstract::Large-scale genomic analyses of cutaneous melanoma have revealed insights into the aetiology and heterogeneity of this disease, as well as opportunities to further personalise treatment for patients with targeted and immune therapies. Herein, we review the proposed genomic classification of cutaneous melanoma from lar...
journal_title:British journal of cancer
pub_type: 杂志文章,评审
doi:10.1038/bjc.2016.195
更新日期:2016-07-12 00:00:00
abstract::In a meta-analysis of testicular cancer in twins, twins had a 30% increased risk (estimate 1.31, 95% CI 1.1-1.6), providing indirect support for the hypothesis that in utero hormone variations influence risk of testicular cancer. The summary-estimate for dizygotic twins was 1.3 (1.0-1.7) and for monozygotic or same se...
journal_title:British journal of cancer
pub_type: 杂志文章,meta分析
doi:10.1038/sj.bjc.6604136
更新日期:2008-01-15 00:00:00
abstract::A case-control study was conducted in Italy and Switzerland between 1992 and 2000 on 527 cases of laryngeal cancer and 1,297 hospital controls. The risk of laryngeal cancer steadily decreased from 3 years after stopping smoking. Some decline in risk was observed only 20 years or more after stopping drinking. ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6600638
更新日期:2002-11-18 00:00:00
abstract::Accuracy in the assessment of performance status by oncologists has not been well evaluated. We investigated possible discrepancies in the assessment of performance status among patients, nurses, and oncologists, and evaluated the prognostic importance of each assessment. Two hundred and six inpatients with inoperable...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.2001.2162
更新日期:2001-11-30 00:00:00
abstract::Radiographically occult bronchogenic squamous cell carcinomas are early lung cancers that localize mainly in the bronchial wall, and are thought to be a good model for investigating genetic alterations through lung cancer progression. In order to elucidate sequential genetic changes in lung cancers, we analysed the in...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1998.549
更新日期:1998-09-01 00:00:00
abstract::For the first time in a clinical study oral Ifosfamide was used: 65 elderly or unfit patients with small cell lung cancer (SCLC) were treated as outpatients with fractionated oral Ifosfamide and Etoposide. Forty patients (62%) had extensive stage (ED) disease. The median age of the patients was 66 years. In the 60 pat...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1989.265
更新日期:1989-08-01 00:00:00
abstract::Using flow cytometry and immunocytochemistry, we investigated the reactivities of two different murine monoclonal antibodies (MAbs), MRK 16 and MRK 20, specific to adriamycin-resistant K562 cells (K562/ADM) with peripheral human mononuclear cells (MNC) (mainly blastic cells and lymphocytes) from 31 patients with leuka...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1989.309
更新日期:1989-10-01 00:00:00
abstract:BACKGROUND:Although mortality rates are elevated in psychiatric patients relative to their healthy counterparts, little is known about the impact of mental health on survival in people with cancer. METHODS AND RESULTS:Among 16 498 Swedish men with cancer, survival was worse in those with a history of psychiatric hospi...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2012.150
更新日期:2012-05-22 00:00:00
abstract::Computed tomographic scanning of the chest in 100 patients with newly diagnosed malignant lymphoma detected mediastinal lymphadenopathy (39%) and parenchymal deposits (15%) with a significantly greater sensitivity and specificity than conventional radiological techniques. This principally affected the staging and trea...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1984.97
更新日期:1984-05-01 00:00:00
abstract::The effect of 10(-6) M tamoxifen on MCF-7 cells adapted to growth in 0.5% foetal calf serum has been studied. The growth inhibitory effect of this tamoxifen concentration was abolished by simultaneous addition of 10(-8) M oestradiol, indicating that tamoxifen may exert its effect via binding to the oestrogen receptor....
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1984.113
更新日期:1984-06-01 00:00:00
abstract::Vascular and angiogenic processes provide an important target for novel cancer therapeutics. Dynamic contrast-enhanced magnetic resonance imaging is being used increasingly to noninvasively monitor the action of these therapeutics in early-stage clinical trials. This publication reports the outcome of a workshop that ...
journal_title:British journal of cancer
pub_type: 指南,杂志文章
doi:10.1038/sj.bjc.6602550
更新日期:2005-05-09 00:00:00
abstract::In haemagglutination tests we have found that the monoclonal antibody B5 discriminates between erythrocytes from patients with malignant cancer (total 386; greater than 80% B5 positive) and individuals with no known tumour (total 247; less than 20% B5 positive). The B5 antigen detected on intact erythrocytes is a tigh...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1984.53
更新日期:1984-03-01 00:00:00
abstract::The identification of peptide vaccine candidates to date has been focused on human leukocyte antigen (HLA)-A2 and -A24 alleles. In this study, we attempted to identify cytotoxic T lymphocyte (CTL)-directed Lck-derived peptides applicable to HLA-A11(+), -A31(+), or -A33(+) cancer patients, because these HLA-A alleles s...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604071
更新日期:2007-12-17 00:00:00
abstract::We identified 2384 patients in the Danish Cancer Register in whom cancer had been diagnosed in 1960-1996 before they reached the age of 20 and compared them with 53 143 sex- and age-matched controls identified from the Register of Population Statistics. Complete education records and demographic and socioeconomic info...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6602085
更新日期:2004-08-31 00:00:00
abstract::Loss of cell cycle control through the structural or functional aberration of checkpoint genes and their products is a potentially important process in carcinogenesis. In this study, a panel of well-characterised established human bladder cancer cell lines was screened by the polymerase chain reaction for homozygous l...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1995.488
更新日期:1995-11-01 00:00:00
abstract::The incidence of nodal metastasis in early gastric carcinoma (EGC) is 10-20%. However, the optimal nodal dissection for early gastric carcinoma has not been established. A retrospective study was conducted in 392 consecutive patients who underwent potentially curative distal gastrectomy for EGC between 1962 and 1990. ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1995.540
更新日期:1995-12-01 00:00:00
abstract::Monoclonal antibody MUC 2-63 recognises neurogenic tumours and has been used successfully for radioimaging human malignant gliomas. We now show that the MUC 2-63 antigen has the same tissue distribution and molecular weight range as the CD44 antigen and confirm the identity of these two molecules in blocking studies u...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1994.402
更新日期:1994-11-01 00:00:00
abstract::Aminoglutethimide has been used in combination with hydrocortisone in patients with advanced prostatic cancer with the rationale that it causes a 'medical adrenalectomy'. Both objective and subjective responses have been recorded. We have examined the effect of AG and HC alone and in combination on plasma androgen lev...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1988.40
更新日期:1988-02-01 00:00:00
abstract:BACKGROUND:RECORD-3 assessed non-inferiority of progression-free survival (PFS) with everolimus vs sunitinib in previously untreated patients with metastatic renal cell carcinoma. Baseline plasma sample collection and randomised design enabled correlation of circulating biomarkers with efficacy. METHODS:Samples were a...
journal_title:British journal of cancer
pub_type: 杂志文章,随机对照试验
doi:10.1038/bjc.2016.21
更新日期:2016-03-15 00:00:00
abstract::The reactivation of U.V.-irradiated adenovirus 2 in HeLa cells is enhanced 8-9 fold if the cells are given a brief hyperthermic shock before infection. Maximum reactivation is achieved by heating for 10 min at 45.5 degrees C and with a delay of 36 h between heating and infection. The induction process requires protein...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1984.32
更新日期:1984-02-01 00:00:00
abstract::This study was planned to evaluate the feasibility of mouth self-examination (MSE). Some 450 college students distributed to 9000 households a brochure describing the risk factors of oral cancer, the appearance of premalignant and malignant lesions of the oral cavity and the methods of MSE with pictures. All subjects ...
journal_title:British journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1038/bjc.1995.81
更新日期:1995-02-01 00:00:00
abstract::The NCA (nonspecific cross-reacting antigen) was assayed in sera of patients with chronic myeloid leukaemia (CML). It was elevated to a mean value of 145·6 ng/ml (± 104·4 ng/ml) compared to 37·8 ng/ml (± 14·6 ng/ml) the sera of normal subjects. Patients with active disease generally had higher serum NCA levels than th...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1982.269
更新日期:1982-11-01 00:00:00
abstract::In a case-control study using a large UK primary care database, we found that non-steroidal anti-inflammatory drugs had no protective effect against biliary carcinomas (cholangiocarcinoma and gall bladder cancer). Increased risks were observed for cigarette smoking, diabetes, gallstone disease and obesity. ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604765
更新日期:2009-01-13 00:00:00
abstract::Survival data on female invasive breast cancer with 9-year follow-up from five French cancer registries were analysed by logistic regression for prognostic factors of cancer stage. The Kaplan-Meier method and log-rank test were used to estimate and compare the overall survival probability at 5 and 7 years, and at the ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604163
更新日期:2008-01-15 00:00:00
abstract::From 1,211 breast cancers, 15 oestrogen receptor (ER) negative-progesterone receptor (PgR) positive breast cancers by conventional dextran coated charcoal steroid binding assays in cytosol were reassessed using Elisa techniques with monoclonal antireceptors antibodies in the cytosolic and nuclear fractions, and immuno...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1992.187
更新日期:1992-06-01 00:00:00
abstract::Accumulating evidence suggests that the p53 gene is a good target for molecular epidemiological studies. We previously reported an association between the presence of p53 mutations and lifetime cigarette consumption. Although over 675 p53 mutations have been reported in lung cancers in the literature thus far, very li...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1998.258
更新日期:1998-05-01 00:00:00