Drug transporters: recent advances concerning BCRP and tyrosine kinase inhibitors.

abstract：:For stage III non-small cell lung cancer (NSCLC), approximately a third of patients survive up to 5 years, with decreasing 5-year survival rates for stage IIIB and stage IIIC disease. Although curable, stage III NSCLC encompasses a diverse range of disease presentation, with an equally complex range of multi-modal tre...

journal_title：British journal of cancer

authors： Evison M,AstraZeneca UK Limited.

更新日期：2020-12-01 00:00:00

abstract：:The National Registry of Childhood Tumours contains over 51000 records of children born in Great Britain who developed cancer under the age of 15 years. Patterns of childhood cancer among families containing more than one child with cancer have been studied. A total of 225 "sib pair' families have been ascertained fro...

journal_title：British journal of cancer

authors： Draper GJ,Sanders BM,Lennox EL,Brownbill PA

更新日期：1996-07-01 00:00:00

abstract：:We investigated whether dietary intakes of total fat, monounsaturated fat (MUFA), polyunsaturated fat (PUFA) and saturated fat (SFA) were associated with breast cancer risk in a prospective cohort of 49 261 Swedish women (30-49 years at enrolment), which yielded 974 breast cancer cases by December 2005. Further, we ev...

journal_title：British journal of cancer

authors： Löf M,Sandin S,Lagiou P,Hilakivi-Clarke L,Trichopoulos D,Adami HO,Weiderpass E

更新日期：2007-12-03 00:00:00

abstract：:This study evaluates the efficacy of capecitabine using data from a large, well-characterised population of patients with metastatic colorectal cancer (mCRC) treated in two identically designed phase III studies. A total of 1207 patients with previously untreated mCRC were randomised to either oral capecitabine (1250 ...

journal_title：British journal of cancer

authors： Van Cutsem E,Hoff PM,Harper P,Bukowski RM,Cunningham D,Dufour P,Graeven U,Lokich J,Madajewicz S,Maroun JA,Marshall JL,Mitchell EP,Perez-Manga G,Rougier P,Schmiegel W,Schoelmerich J,Sobrero A,Schilsky RL

更新日期：2004-03-22 00:00:00

abstract：BACKGROUND:Pancreaticoduodenectomy remains a major undertaking. A preoperative blood test, which could confidently predict the benefits of surgery would improve the selection of pancreatic cancer patients for surgery. This study aimed to identify protein biomarkers prognostic for long-term survival and to validate them...

journal_title：British journal of cancer

authors： Xue A,Chang JW,Chung L,Samra J,Hugh T,Gill A,Butturini G,Baxter RC,Smith RC

更新日期：2012-11-20 00:00:00

abstract：:Eleven human bladder carcinomata of different degrees of differentiation were implanted in mice immunosuppressed by thymectomy, anti-thymocyte serum and x-rays. Seven carcinomata grew well and one poorly and 3 produced mainly fibrous nodules in the mice. Normal human bladder tissues were grown from 4 other patients. T...

journal_title：British journal of cancer

authors： Kelly JF,Snell ME,Berenbaum MC

更新日期：1975-02-01 00:00:00

abstract：BACKGROUND:The most significant problem of intra-arterial chemotherapy for advanced paranasal sinus carcinomas and residual cancers supplied by internal carotid artery (ICA) and involving the skull base is the lack of salvage therapies. OBJECTIVE:The objective of the study was to evaluate the usefulness of intra-arter...

journal_title：British journal of cancer

authors： Yokoyama J,Ohba S,Fujimaki M,Anzai T,Kojima M,Ikeda K,Suzuki M,Yoshimoto H,Inoue K

更新日期：2014-12-09 00:00:00

abstract：BACKGROUND:Sindbis virus (SIN) infection causes no or only mild symptoms (fever, rash, and arthralgia) in humans. However, SIN has a strong cytopathic effect (CPE) on various cancer cells. This study focuses on the oncolytic activity of SIN AR399 on oral cancer cells compared with reovirus, a well-known oncolytic virus...

journal_title：British journal of cancer

authors： Saito K,Uzawa K,Kasamatsu A,Shinozuka K,Sakuma K,Yamatoji M,Shiiba M,Shino Y,Shirasawa H,Tanzawa H

更新日期：2009-08-18 00:00:00

abstract：:We carried out a comparison of three commonly used mucin markers, CA549, CA15.3 and MCA. Serum samples from 184 healthy women and 237 patients with primary breast cancer were evaluated. The markers were measured using commercially available immunometric assays. Like CA15.3 and MCA, CA549 was significantly associated w...

journal_title：British journal of cancer

authors： Gion M,Plebani M,Mione R,Penzo C,Meo S,Burlina A

更新日期：1994-04-01 00:00:00

abstract：:Choriocarcinoma can be imaged by external scintigraphy after intravenous administration of radiolabelled antibody directed against human chorionic gonadotrophin (HCG). The purpose of this study was to investigate whether antibody imaging was sufficiently sensitive and specific to improve the selection of patients for ...

journal_title：British journal of cancer

authors： Begent RH,Bagshawe KD,Green AJ,Searle F

更新日期：1987-06-01 00:00:00

abstract：:We evaluated the myelotoxicity and the anti-tumor potential of tallimustine, three of its analogues and carzelesin, with melphalan as reference substance. Tallimustine was tested by clonogenic assays on both human bone marrow (BM) and cord blood (hCB) cells, the other compounds on hCB only. The degree of inhibition of...

journal_title：British journal of cancer

authors： Ghielmini M,Bosshard G,Capolongo L,Geroni MC,Pesenti E,Torri V,D'Incalci M,Cavalli F,Sessa C

更新日期：1997-01-01 00:00:00

abstract：:Clonal subpopulations of different ploidy values and metastatic capacities, isolated from the RIF-1 mouse sarcoma, have been tested for in vitro X-radiation sensitivity, for in vitro sensitivity to adriamycin and for in vitro and in vivo sensitivity to melphalan and CCNU. Following X-radiation, no consistent differenc...

journal_title：British journal of cancer

authors： Reeve JG,Wright KA,Twentyman PR

更新日期：1983-06-01 00:00:00

abstract：BACKGROUND:Current evidence indicates that a stem cell-like sub-population within malignant glioblastomas, that overexpress members of the adenosine triphosphate-binding cassette (ABC) family transporters, is responsible for multidrug resistance and tumour relapse. Eradication of the brain tumour stem cell (BTSC) compa...

journal_title：British journal of cancer

authors： Martín V,Sanchez-Sanchez AM,Herrera F,Gomez-Manzano C,Fueyo J,Alvarez-Vega MA,Antolín I,Rodriguez C

更新日期：2013-05-28 00:00:00

abstract：:Tumour recurrence and metastases of hepatocellular carcinoma (HCC) after hepatectomy are the major obstacles of long-term survival. The present study investigated the clinicopathological significance of a possible metastasis regulator Six1 in HCC patients who were undergone hepatectomy. Seventy-two pairs of RNA and 10...

journal_title：British journal of cancer

authors： Ng KT,Man K,Sun CK,Lee TK,Poon RT,Lo CM,Fan ST

更新日期：2006-10-23 00:00:00

abstract：:To: (1) estimate the prevalence of clinically significant emotional distress in patients attending a cancer outpatient department and (2) determine the associations between distress and demographic and clinical variables, we conducted a survey of outpatients attending selected clinics of a regional cancer centre in Ed...

journal_title：British journal of cancer

authors： Strong V,Waters R,Hibberd C,Rush R,Cargill A,Storey D,Walker J,Wall L,Fallon M,Sharpe M

更新日期：2007-03-26 00:00:00

abstract：:A pilot study of continuous infusional 5-fluorouracil 200 mg m-2 per 24 h by ambulatory pump and Hickman line for the entire treatment cycle with mitomycin C 8 mg m-2 i.v. on day 1 and cisplatin 75 mg m-2 i.v. on day 1, both repeated every 28 days, was carried out in 31 previously untreated patients with advanced non-...

journal_title：British journal of cancer

authors： Ellis PA,Talbot DC,Nicolson MC,Priest K,Ashley S,Smith IE

更新日期：1995-06-01 00:00:00

abstract：BACKGROUND:Children with cancer are frequently immunocompromised. While children are generally thought to be at less risk of severe SARS-CoV-2 infection than adults, comprehensive population-based evidence for the risk in children with cancer is unavailable. We aimed to produce evidence of the incidence and outcomes fr...

journal_title：British journal of cancer

authors： Millen GC,Arnold R,Cazier JB,Curley H,Feltbower RG,Gamble A,Glaser AW,Grundy RG,Lee LYW,McCabe MG,Phillips RS,Stiller CA,Várnai C,Kearns PR

更新日期：2020-12-10 00:00:00

abstract：:Identification of a biomarker of prognosis and response to therapy that can be assessed preoperatively would significantly improve overall outcomes for patients with pancreatic cancer. In this study, patients whose tumours exhibited high LMO4 expression had a significant survival advantage following operative resectio...

journal_title：British journal of cancer

authors： Murphy NC,Scarlett CJ,Kench JG,Sum EY,Segara D,Colvin EK,Susanto J,Cosman PH,Lee CS,Musgrove EA,Sutherland RL,Lindeman GJ,Henshall SM,Visvader JE,Biankin AV

更新日期：2008-02-12 00:00:00

abstract：:Three hundred and ninety women participated in the quality of life (QL) study of ACCOG1, a high-dose vs conventional adjuvant chemotherapy breast cancer trial, for patients with a high risk of relapse. Patients completed the European Organisation for Research and Treatment of Cancer QLQ-C30, questions on menopausal sy...

journal_title：British journal of cancer

authors： Malinovszky KM,Gould A,Foster E,Cameron D,Humphreys A,Crown J,Leonard RC,Anglo Celtic Co-operative Oncology Group.

更新日期：2006-12-18 00:00:00

abstract：:The relationship between mammalian facilitative glucose transport proteins (GLUT) and multidrug resistance was examined in two vincristine (VCR)-selected murine erythroleukaemia (MEL) PC4 cell lines. GLUT proteins, GLUT1 and GLUT3, were constitutively coexpressed in the parental cell line and also in the VCR-selected ...

journal_title：British journal of cancer

authors： Martell RL,Slapak CA,Levy SB

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Metabolomics has shown promise in gastric cancer (GC) detection. This research sought to identify whether GC has a unique urinary metabolomic profile compared with benign gastric disease (BN) and healthy (HE) patients. METHODS:Urine from 43 GC, 40 BN, and 40 matched HE patients was analysed using (1)H nucle...

journal_title：British journal of cancer

authors： Chan AW,Mercier P,Schiller D,Bailey R,Robbins S,Eurich DT,Sawyer MB,Broadhurst D

更新日期：2016-01-12 00:00:00

abstract：:Cellular DNA was analysed by flow cytometry in fine needles aspirates (FNA) from both benign and malignant breast lesions in order to determine the feasibility of flow cytometric analysis. In 22 of 26 (84%) benign and 69 of 74 (93%) malignant aspirates, sufficient cells were present to produce good quality DNA histogr...

journal_title：British journal of cancer

authors： Levack PA,Mullen P,Anderson TJ,Miller WR,Forrest AP

更新日期：1987-11-01 00:00:00

abstract：:The risk for sinonasal cancer associated with tobacco use was examined in a case-control study in males diagnosed between 1978 and 1981 in the Netherlands. Of the 116 cases of sinonasal cancer and 259 controls identified, interviews were completed for 92 (79%) of the cases and 195 (75%) of the controls. Ever-users of ...

journal_title：British journal of cancer

authors： Hayes RB,Kardaun JW,de Bruyn A

更新日期：1987-12-01 00:00:00

abstract：:Metastatic variant sublines of the murine large-cell lymphoma cell line RAW117 were tested for their growth and migration properties in vitro in medium conditioned by soluble factors released from syngeneic mouse liver-, lung-, and brain-derived microvessel endothelial cells. Medium conditioned with hepatic sinusoidal...

journal_title：British journal of cancer

authors： Hamada J,Cavanaugh PG,Lotan O,Nicolson GL

更新日期：1992-08-01 00:00:00

abstract：:With the recent approval of the combinations of axitinib with the immune checkpoint inhibitor (ICI) pembrolizumab or avelumab for first-line treatment of advanced renal cell carcinoma, guidance on how to distinguish between immune-related adverse events (AEs) caused by ICI versus axitinib-related AEs is necessary to o...

journal_title：British journal of cancer

authors： Grünwald V,Voss MH,Rini BI,Powles T,Albiges L,Giles RH,Jonasch E

更新日期：2020-09-01 00:00:00

abstract：:Forty-two patients with clinical stage IIIA or IIIB breast cancer were treated with neoadjuvant chemotherapy followed by mastectomy and radiotherapy. The median follow-up was 32 months (range 10-72 months) and the median time to progression was 17 months (range 10-30 months). A multivariate analysis showed that a long...

journal_title：British journal of cancer

authors： Honkoop AH,van Diest PJ,de Jong JS,Linn SC,Giaccone G,Hoekman K,Wagstaff J,Pinedo HM

更新日期：1998-02-01 00:00:00

abstract：:Serum samples taken between 6 and 20 weeks of gestation were obtained from 28 mothers who gave birth to cryptorchid sons (cases) and from 108 control mothers. In comparison with controls the cases had 10% higher geometric mean oestradiol (95% CI -13% to +39%: P=0.42) and 10% lower geometric mean testosterone (95% CI -...

journal_title：British journal of cancer

authors： Key TJ,Bull D,Ansell P,Brett AR,Clark GM,Moore JW,Chilvers CE,Pike MC

更新日期：1996-03-01 00:00:00

abstract：:In this study we have screened a series of 29 primary leiomyosarcomas for abnormalities of both the p53 gene and the MDM2 gene, which encodes a p53-associated protein. SSCP (single-strand conformation polymorphism) analysis and direct sequencing of polymerase chain reaction (PCR)-amplified DNA were used to establish t...

journal_title：British journal of cancer

authors： Patterson H,Gill S,Fisher C,Law MG,Jayatilake H,Fletcher CD,Thomas M,Grimer R,Gusterson BA,Cooper CS

更新日期：1994-06-01 00:00:00

abstract：:Allele imbalance on chromosome 11 loci in ovarian cancer is a frequent event, suggesting the presence of tumour-suppressor genes for ovarian carcinogenesis on this chromosome. Ten highly polymorphic (CA) repeat microsatellites were used to determine allele imbalance in 60 primary ovarian tumours, including 47 epitheli...

journal_title：British journal of cancer

authors： Gabra H,Taylor L,Cohen BB,Lessels A,Eccles DM,Leonard RC,Smyth JF,Steel CM

更新日期：1995-08-01 00:00:00

abstract：:Bcl-2 expression in colorectal carcinomas was studied in a series of 224 patients and the relation to p53 expression, stage and survival assessed. Bcl-2 expression was down-regulated compared with normal mucosa in 67% (151) of the cases. In 144 cases staining was positive for p53 (MAB DO7), and 41 of these 144 p53-pos...

journal_title：British journal of cancer

authors： Kaklamanis L,Savage A,Whitehouse R,Doussis-Anagnostopoulou I,Biddolph S,Tsiotos P,Mortensen N,Gatter KC,Harris AL

更新日期：1998-06-01 00:00:00