Axitinib plus immune checkpoint inhibitor: evidence- and expert-based consensus recommendation for treatment optimisation and management of related adverse events.

abstract：:Even though the majority of patients with bladder malignancies initially present with low stage disease, the clinical epidemiology of these so-called superficial bladder tumours is not well known. In this paper, disease characteristics at initial presentation and during follow-up are described in 1,745 primary cases d...

journal_title：British journal of cancer

authors： Kiemeney LA,Witjes JA,Verbeek AL,Heijbroek RP,Debruyne FM

更新日期：1993-04-01 00:00:00

abstract：BACKGROUND:This phase 1 study examined the safety, maximum-tolerated dose (MTD) and antitumour activity of E7449, a novel PARP 1/2 and tankyrase 1/2 inhibitor. METHODS:E7449 was orally administered once daily in 28-day cycles to patients with advanced solid tumours (50-800-mg doses). Archival tumour samples from conse...

journal_title：British journal of cancer

authors： Plummer R,Dua D,Cresti N,Drew Y,Stephens P,Foegh M,Knudsen S,Sachdev P,Mistry BM,Dixit V,McGonigle S,Hall N,Matijevic M,McGrath S,Sarker D

更新日期：2020-08-01 00:00:00

abstract：:The efficacy of high-dose chemotherapy (HDC) and circulating progenitor cell (CPC) transplantation in metastatic breast cancer (MBC) relies mainly on giving this treatment after a response to conventional induction chemotherapy has been achieved. For this reason an optimal mobilization regimen should be therapeuticall...

journal_title：British journal of cancer

authors： Pedrazzoli P,Perotti C,Da Prada GA,Bertolini F,Gibelli N,Torretta L,Battaglia M,Pavesi L,Preti P,Salvaneschi L,Robustelli della Cuna G

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Childhood cancer survivors can experience learning problems resulting in lower-than-expected attained education as adults. It is unclear whether learning problems manifest already during adolescence. METHODS:We analysed nationwide Danish registries on school grades for Danish children during 2001-2014. Appl...

journal_title：British journal of cancer

authors： Andersen KK,Duun-Henriksen AK,Frederiksen MH,Winther JF

更新日期：2017-01-01 00:00:00

abstract：:Molecular and immunohistochemical studies of genetic events on chromosome 17p were prospectively compared with conventional clinical and pathological parameters and disease behaviour at a minimum of 72 months follow-up. In a series of 91 patients with primary operable breast cancer, 37 out of 91 (41%) patients had dis...

journal_title：British journal of cancer

authors： Thompson AM,Crichton DN,Elton RA,Clay MF,Chetty U,Steel CM

更新日期：1998-03-01 00:00:00

abstract：:The novel compound 7(-)[4'-(2-nitroimidazol-l-yl)-butyl]-theophylline (NITP) can be used as an immunologically detectable probe for hypoxic cells. Because of the limited water solubility of NITP, it has been administered dissolved in peanut oil with 10% dimethylsulphoxide (DMSO). A new aqueous formulation has been dev...

journal_title：British journal of cancer

authors： Hodgkiss RJ,Stratford MR,Dennis MF,Hill SA

更新日期：1995-12-01 00:00:00

abstract：:The vaso-active drug hydralazine causes a considerable increase in the cytotoxic effect of melphalan towards the KHT tumour in mice. The enhancement in response, measured as the concentration of melphalan required to achieve a given tumour response, is 3.0 and 2.35 when determined using the regrowth delay assay and th...

journal_title：British journal of cancer

authors： Stratford IJ,Adams GE,Godden J,Nolan J,Howells N,Timpson N

更新日期：1988-08-01 00:00:00

abstract：BACKGROUND:This phase 1 study evaluated the maximum tolerated dose (MTD), safety, and efficacy of bosutinib (competitive Src/Abl tyrosine kinase inhibitor) plus capecitabine. METHODS:Patients with locally advanced/metastatic breast, pancreatic, or colorectal cancers; cholangiocarcinoma; or glioblastoma received bosuti...

journal_title：British journal of cancer

authors： Isakoff SJ,Wang D,Campone M,Calles A,Leip E,Turnbull K,Bardy-Bouxin N,Duvillié L,Calvo E

更新日期：2014-11-25 00:00:00

abstract：:The ribosome-inactivating proteins, bryodin, from Bryonia dioica, and momordin, from Momordica charantia, were coupled by a disulphide bond to a monoclonal anti-Thy 1.1 antibody (OX7). Both immunotoxins were specifically cytotoxic to the Thy 1.1-expressing mouse lymphoma cell line AKR-A in vitro. The OX7-bryodin immun...

journal_title：British journal of cancer

authors： Stirpe F,Wawrzynczak EJ,Brown AN,Knyba RE,Watson GJ,Barbieri L,Thorpe PE

更新日期：1988-11-01 00:00:00

abstract：:Ovulation is believed to contribute to the development of ovarian cancers that derive from the ovarian surface epithelium (OSE). The process of ovulation is synonymous with inflammation and inflammatory cytokines such as interleukin-1alpha (IL-1alpha) have recently been shown to induce both inflammatory and anti-infla...

journal_title：British journal of cancer

authors： Gubbay O,Guo W,Rae MT,Niven D,Langdon SP,Hillier SG

更新日期：2005-05-23 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) was studied in ovarian tumours with immunohistochemical (IH) and ligand-binding assay (LBA). Two different monoclonal antibodies (MoAbs: 2E9, EGFR1) with respect to detecting EGFR with different ligand-binding affinities (low, high and low) were used. When comparing the IH data ...

journal_title：British journal of cancer

authors： Henzen-Logmans SC,Berns EM,Klijn JG,van der Burg ME,Foekens JA

更新日期：1992-12-01 00:00:00

abstract：BACKGROUND:This study had two aims: (a) to test the hypothesis that advanced age is associated with lower levels of tolerability and clinical benefit to experimental Phase I trial agents; (b) to assess the validity of the Royal Marsden Hospital (RMH) prognostic score as a patient selection tool in older patients. METH...

journal_title：British journal of cancer

authors： Khan KH,Yap TA,Ring A,Molife LR,Bodla S,Thomas K,Zivi A,Smith A,Judson I,Banerji U,de Bono JS,Kaye SB

更新日期：2016-02-02 00:00:00

abstract：:Exposure to the fibrous mineral erionite is known to induce mesothelioma in man and laboratory animals. Previous studies demonstrated the presence of a trypsin-like protease associated with tumour cells. This protease could be demonstrated by the use of fluorescent probes which located cells possessing this enzyme. We...

journal_title：British journal of cancer

authors： Steven FS,Hill RJ

更新日期：1988-11-01 00:00:00

abstract：:This study aimed to evaluate the clinical and economic implications of integrating human papilloma virus (HPV) load testing into the follow-up and management protocol of women postconisation for high-grade cervical intraepithelial neoplasia (CIN2-3). We evaluated 130 suitable women: 63 were screened biannually by Pap ...

journal_title：British journal of cancer

authors： Almog B,Gamzu R,Bornstein J,Levin I,Fainaru O,Niv J,Lessing JB,Bar-Am A

更新日期：2003-07-07 00:00:00

abstract：BACKGROUND:The aim of this study was to elucidate the prognostic impact of putative cancer stem cell markers CD133, CD166, CD44s, EpCAM, and aldehyde dehydrogenase-1 (ALDH1) in colorectal cancer. METHODS:A tissue microarray of 1420 primary colorectal cancers and 57 normal mucosa samples was immunostained for CD133, CD...

journal_title：British journal of cancer

authors： Lugli A,Iezzi G,Hostettler I,Muraro MG,Mele V,Tornillo L,Carafa V,Spagnoli G,Terracciano L,Zlobec I

更新日期：2010-07-27 00:00:00

abstract：:Between 1971 and 1988, 20 patients with previously undiagnosed non-Hodgkin's lymphoma (NHL), of intermediate or high grade histology presented with extradural spinal cord compression. All had decompressive surgery. The first treatment after surgery was chemotherapy in nine and radiotherapy in 11 patients. At presentat...

journal_title：British journal of cancer

authors： Eeles RA,O'Brien P,Horwich A,Brada M

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:Breast cancer, a heterogeneous disease has been broadly classified into oestrogen receptor positive (ER+) or oestrogen receptor negative (ER-) tumour types. Each of these tumours is dependent on specific signalling pathways for their progression. While high levels of survivin, an anti-apoptotic protein, incr...

journal_title：British journal of cancer

authors： Pervin S,Tran L,Urman R,Braga M,Parveen M,Li SA,Chaudhuri G,Singh R

更新日期：2013-03-05 00:00:00

abstract：BACKGROUND:This study aimed to evaluate the safety and efficacy of dose-dense weekly chemotherapy, followed by resection and/or thoracic radiotherapy. METHODS:Patients with histologically documented thymoma with unresectable stage III disease received 9 weeks of chemotherapy: cisplatin 25 mg m(-2) on weeks 1-9; vincri...

journal_title：British journal of cancer

authors： Kunitoh H,Tamura T,Shibata T,Takeda K,Katakami N,Nakagawa K,Yokoyama A,Nishiwaki Y,Noda K,Watanabe K,Saijo N,JCOG Lung Cancer Study Group.

更新日期：2010-06-29 00:00:00

abstract：:Immunohistochemical localization of chondroitin sulphate and dermatan sulphate proteoglycans (PGs) was observed in 70 tumour tissues, using monoclonal antibodies 9A-2 and 3B-3 raised against core molecules obtained from chondroitin sulphate PG by chondroitinase ABC-treatment. They recognize a stub of delta Di-4S and d...

journal_title：British journal of cancer

authors： Fukatsu T,Sobue M,Nagasaka T,Ohiwa N,Fukata S,Nakashima N,Takeuchi J

更新日期：1988-01-01 00:00:00

abstract：:High expression of thymidylate synthase (TS) and inactivation of p53 are allegedly associated with chemoresistance. The authors evaluated TS and p53 expression in gastric cancer treated with neoadjuvant S-1/cisplatin chemotherapy. Paraffin sections of pretreatment biopsy and surgical specimens from 41 gastric cancers ...

journal_title：British journal of cancer

authors： Kamoshida S,Suzuki M,Shimomura R,Sakurai Y,Komori Y,Uyama I,Tsutsumi Y

更新日期：2007-01-29 00:00:00

abstract：:Some 1220 male and 2102 female cases of malignant neoplasms diagnosed histologically at the Department of Pathology of the Gadjah Mada University in Yogyakarta during the period 1970-73 were analysed. The most frequent tumour sites were among men: nasopharyngeal cancer, 21-8% and skin cancer, 17-6%. Among women the ge...

journal_title：British journal of cancer

authors： Soeripto,Jensen OM,Muir CS

更新日期：1977-07-01 00:00:00

abstract：:Teratomas have been induced in Japanese quail (Coturnix coturnix Japonica) by intra-testicular injections of 3% zinc chloride solution during a period of testicular growth artificially stimulated by increased photoperiod. These tumours resemble those previously induced by similar methods in domestic fow1 and have hist...

journal_title：British journal of cancer

authors： Guthrie J

更新日期：1971-06-01 00:00:00

abstract：:This cross-sectional survey aimed to evaluate the prevalence of burnout and estimated psychiatric disorders among haemato-oncology healthcare professionals in Italy. The aspects of work that respondents perceive as stressful and satisfying have also been examined. The assessments were made using the Maslach Burnout In...

journal_title：British journal of cancer

authors： Bressi C,Manenti S,Porcellana M,Cevales D,Farina L,Felicioni I,Meloni G,Milone G,Miccolis IR,Pavanetto M,Pescador L,Poddigue M,Scotti L,Zambon A,Corrao G,Lambertenghi-Deliliers G,Invernizzi G

更新日期：2008-03-25 00:00:00

abstract：BACKGROUND:We used bleomycin, etoposide, cisplatin (BEP), the most effective regimen in the treatment of germ cell tumours (GCTs) and increased dose-density by using pegfilgrastim to shorten cycle length. Our aim was to assess safety and tolerability. METHODS:Sixteen male patients with intermediate or poor prognosis m...

journal_title：British journal of cancer

authors： Rimmer Y,Chester J,Joffe J,Stark D,Shamash J,Powles T,White J,Wason J,Parashar D,Armstrong G,Mazhar D,Williams MV

更新日期：2011-09-06 00:00:00

abstract：:Hyper-activation of mitogen-activated protein kinase (MAPK) has recently been reported in several human cancers and activation of MAPK in those cancers may be associated with carcinogenesis through aberrant cell proliferation. To understand the roles of the MAPK pathway in colorectal tumorigenesis, we examined the sta...

journal_title：British journal of cancer

authors： Park KS,Kim NG,Kim JJ,Kim H,Ahn YH,Choi KY

更新日期：1999-12-01 00:00:00

abstract：:We have employed molecular probes produced from DNA fragments of human papillomavirus, cloned into prokaryotic vectors, to detect virus nucleic acid sequences in extracts of human oral tissues. The study was conducted with duplicate coded snap-frozen tissue biopsies from which frozen sections had been taken to accurat...

journal_title：British journal of cancer

authors： Maitland NJ,Cox MF,Lynas C,Prime SS,Meanwell CA,Scully C

更新日期：1987-09-01 00:00:00

abstract：:The triple drug combination consisting of irinotecan, oxaliplatin and 5-fluorouracil (FOLFOXIRI) has demonstrated higher activity and efficacy compared to the doublet FOLFIRI. 5-Fluorouracil could be substituted in FOLFOXIRI regimen by capecitabine, an oral fluoropyrimidine with similar efficacy. Recently, a dose-find...

journal_title：British journal of cancer

authors： Vasile E,Masi G,Fornaro L,Cupini S,Loupakis F,Bursi S,Petrini I,Di Donato S,Brunetti IM,Ricci S,Antonuzzo A,Chiara S,Amoroso D,Andreuccetti M,Falcone A

更新日期：2009-06-02 00:00:00

abstract：BACKGROUND:The interaction between human prostate cancer (PCa) cells and bone marrow (BM) endothelium follows a rolling-and-adhesion cascade mediated by E-selectin ligand (ESL): E-selectin. This adhesion is enabled by elevated expression of α-1,3-fucosyltransferases (FTs), enzymes responsible for ESL-mediated bone meta...

journal_title：British journal of cancer

authors： Li J,Guillebon AD,Hsu JW,Barthel SR,Dimitroff CJ,Lee YF,King MR

更新日期：2013-12-10 00:00:00

abstract：:The prostate cancer cell lines PC3 and LNCaP have been shown to lack expression of the tumour suppressor gene MMAC1/PTEN, in contrast to the immortalized non-tumorigenic epithelial lines PNT1a and PNT2. We have measured the effects of reintroduction of wild type (wt) and mutant MMAC1 genes on to these genetic backgrou...

journal_title：British journal of cancer

authors： Sharrard RM,Maitland NJ

更新日期：2000-10-01 00:00:00

abstract：:High experienced continuity of care in patients with cancer is associated with lower needs for care, better quality of life and better psychological outcomes. We developed and evaluated an intervention to improve experienced continuity. The intervention, consisted of (1) a 17-item patient-completed continuity assessme...

journal_title：British journal of cancer

authors： King M,Jones L,McCarthy O,Rogers M,Richardson A,Williams R,Tookman A,Nazareth I

更新日期：2009-01-27 00:00:00