Immunohistochemical localization of chondroitin sulphate and dermatan sulphate proteoglycans in tumour tissues.

abstract：:A series of three dose escalating studies were conducted to investigate the ability of the 17alpha-hydroxylase/C(17,20)-lyase inhibitor abiraterone acetate, to cause maximum suppression of testosterone synthesis when delivered to castrate and noncastrate males with prostate cancer. Study A was a single dose study in c...

journal_title：British journal of cancer

authors： O'Donnell A,Judson I,Dowsett M,Raynaud F,Dearnaley D,Mason M,Harland S,Robbins A,Halbert G,Nutley B,Jarman M

更新日期：2004-06-14 00:00:00

abstract：:Photodynamic therapy (PDT) using Photofrin was used in combination with a hypoxic toxin (mitomycin C, MMC) to treat four patients with recurrent skin metastasis of a mammary carcinoma. In preclinical experiments an additive effect was found for the combination of MMC and PDT for treating subcutaneous RIF1 tumours in m...

journal_title：British journal of cancer

authors： Baas P,van Geel IP,Oppelaar H,Meyer M,Beynen JH,van Zandwijk N,Stewart FA

更新日期：1996-04-01 00:00:00

abstract：BACKGROUND:Understanding the molecular biology of colorectal cancer (CRC) provides opportunities for effective personalised patient management. We evaluated whether chromosomal aberrations, mutations in the PI(3)K signalling pathway and the CpG-island methylator phenotype (CIMP) in primary colorectal tumours can predic...

journal_title：British journal of cancer

authors： Bruin SC,He Y,Mikolajewska-Hanclich I,Liefers GJ,Klijn C,Vincent A,Verwaal VJ,de Groot KA,Morreau H,van Velthuysen ML,Tollenaar RA,van 't Veer LJ

更新日期：2011-07-12 00:00:00

abstract：:On the basis of preclinical data suggesting the possibility of maximising the efficacy of 5-fluorouracil and cisplatin by interferon, a pilot clinical trial was initiated in recurrent and/or metastatic head and neck cancer. Thirty-four patients were treated with cisplatin at 100 mg m-2, followed by 5-fluorouracil at 1...

journal_title：British journal of cancer

authors： Cascinu S,Fedeli A,Luzi Fedeli S,Catalano G

更新日期：1994-02-01 00:00:00

abstract：:The relationship between melanoma incidence and latitude was investigated in North American and Europe, using the data collected by 43 population-based cancer registries. In North America melanoma incidence increased with decreasing latitude, supporting the role of UV light in the induction of melanoma. Within England...

journal_title：British journal of cancer

authors： Crombie IK

更新日期：1979-11-01 00:00:00

abstract：BACKGROUND:Most lung cancer patients are diagnosed at an advanced disease stage and predominantly receive palliative treatment, which increasingly consists of several chemotherapy lines. We report on patients' quality of life (QOL) to gain knowledge on QOL during and across multiple lines of chemotherapy. This includes...

journal_title：British journal of cancer

authors： Wintner LM,Giesinger JM,Zabernigg A,Sztankay M,Meraner V,Pall G,Hilbe W,Holzner B

更新日期：2013-10-29 00:00:00

abstract：BACKGROUND:In neuroblastoma (NB), the most powerful prognostic marker, the MYCN amplification (MNA), occasionally shows intratumoural heterogeneity (ITH), i.e. coexistence of MYCN-amplified and non-MYCN-amplified tumour cell clones, called heterogeneous MNA (hetMNA). Prognostication and therapy allocation are still uns...

journal_title：British journal of cancer

authors： Berbegall AP,Bogen D,Pötschger U,Beiske K,Bown N,Combaret V,Defferrari R,Jeison M,Mazzocco K,Varesio L,Vicha A,Ash S,Castel V,Coze C,Ladenstein R,Owens C,Papadakis V,Ruud E,Amann G,Sementa AR,Navarro S,Ambros PF

更新日期：2018-05-01 00:00:00

abstract：:We have recently established a cancer-reactive human monoclonal antibody, GAH, with a positive ratio of over 90% against stomach cancer. GAH was formulated as polyethyleneglycol (PEG)-modified immunoliposomal doxorubicin (DXR) (ILD) and its efficacy was examined against gastrointestinal human cancers. In in vitro stud...

journal_title：British journal of cancer

authors： Hosokawa S,Tagawa T,Niki H,Hirakawa Y,Nohga K,Nagaike K

更新日期：2003-10-20 00:00:00

abstract：BACKGROUND:The purpose of this study was to identify prostate cancer (PC) oncogenic microRNAs (miRs) based on miR microarray and to investigate whether these oncogenic miRs may be useful as PC biomarkers. METHODS:Initially, we carried out miR microarray and real-time PCR using RWPE-1, PC-3, DU-145 and LNCaP cells. To ...

journal_title：British journal of cancer

authors： Ueno K,Hirata H,Shahryari V,Deng G,Tanaka Y,Tabatabai ZL,Hinoda Y,Dahiya R

更新日期：2013-04-30 00:00:00

abstract：:In a previous report we suggested that the estimation of prothymosin alpha (PTA) levels in primary breast tumours might be used to identify breast cancer patients at high risk for distant metastasis (Dominguez F et al (1993) Eur J Cancer 29A: 893-897). Here the role of tumour PTA levels as predictor was investigated w...

journal_title：British journal of cancer

authors： Magdalena C,Dominguez F,Loidi L,Puente JL

更新日期：2000-02-01 00:00:00

abstract：:This study was designed to evaluate the activity, safety and tolerance of docetaxel (D) in a selected population with metastatic squamous cell carcinoma of the head and neck (SCCHN). Twenty-four patients with no prior palliative therapy were enrolled and received D 100 mg m(-2) by 1 h of infusion, every 3 weeks. All b...

journal_title：British journal of cancer

authors： Couteau C,Chouaki N,Leyvraz S,Oulid-Aissa D,Lebecq A,Domenge C,Groult V,Bordessoule S,Janot F,De Forni M,Armand JP

更新日期：1999-10-01 00:00:00

abstract：:Hyperthermia (42° C.) exerted an inhibitory effect on the O(2) uptake of rabbit VX2 carcinoma cells in vitro, and led to a decrease in viability and growth potential of the cells, as measured by their ability to produce tumours in rabbits. Anaerobic glycolysis of the tumour cells was unaltered by hyperthermia. Respira...

journal_title：British journal of cancer

authors： Muckle DS,Dickson JA

更新日期：1971-12-01 00:00:00

abstract：BACKGROUND:CYFRA 21-1 serves as biomarker in several epithelial malignancies. However, its role in pancreatic cancer (PC) has not yet been investigated. METHODS:Within a prospective single-centre study serial blood samples were collected from patients with confirmed advanced PC. Pre-treatment values and weekly measure...

journal_title：British journal of cancer

authors： Boeck S,Wittwer C,Heinemann V,Haas M,Kern C,Stieber P,Nagel D,Holdenrieder S

更新日期：2013-04-30 00:00:00

abstract：:The identification of peptide vaccine candidates to date has been focused on human leukocyte antigen (HLA)-A2 and -A24 alleles. In this study, we attempted to identify cytotoxic T lymphocyte (CTL)-directed Lck-derived peptides applicable to HLA-A11(+), -A31(+), or -A33(+) cancer patients, because these HLA-A alleles s...

journal_title：British journal of cancer

authors： Naito M,Komohara Y,Ishihara Y,Noguchi M,Yamashita Y,Shirakusa T,Yamada A,Itoh K,Harada M

更新日期：2007-12-17 00:00:00

abstract：:Flavone acetic acid (FAA) was administered at a dose of 4.8 g m-2 over 1 h to patients with advanced malignant disease in combination with Interleukin II. A new high performance liquid chromatography method is described to determine both the parent compound and eight drug-related products, and the conditions required ...

journal_title：British journal of cancer

authors： Stratford MR,Rustin GJ,Dennis MF,Watfa RR,Howells N,O'Reilly SM

更新日期：1993-06-01 00:00:00

abstract：:Alveolar macrophage (AM) phagocytic activity and glucose metabolism were evaluated during lung tumour growth in adult rats challenged i.v. with 10(5) viable Walker 256 tumour cells. Phagocytosis was estimated by the in vitro uptake of (14)C-labelled Pseudomonas aeruginosa and glucose oxidation was evaluated by (14)CO(...

journal_title：British journal of cancer

authors： Gudewicz PW,Saba TM

更新日期：1977-12-01 00:00:00

abstract：BACKGROUND:The potential for cancer-testis (CT) antigens as targets for immunotherapy in cancer patients has been heavily investigated, and currently cancer vaccine trials based on the CT antigens, MAGE-A3 and NY-ESO-1, are being carried out. METHODS:We used specific q-RT-PCR assays to analyse the expression of the CT...

journal_title：British journal of cancer

authors： Dyrskjøt L,Zieger K,Kissow Lildal T,Reinert T,Gruselle O,Coche T,Borre M,Ørntoft TF

更新日期：2012-06-26 00:00:00

abstract：:A Phase I study of oral daily misonidazole (MISO) with conventional pelvic irradiation, has been conducted in patients with carcinoma of the cervix Stages IB, IIB, IIIB and IVA. MISO was administered in daily dosages to sequential groups of patients at doses of 0.15 g/m2, 0.30 g/m2 or 0.45 g/m2 for 22 days over 5 week...

journal_title：British journal of cancer

authors： Thomas GM,Rauth AM,Black BE,Cummings BJ,Sorenti VL,Bush RS

更新日期：1982-06-01 00:00:00

abstract：BACKGROUND:Topoisomerase I (Topo I) poisons (e.g., camptothecin (CPT)), used to treat cancer, cause DNA breaks that are most cytotoxic during S phase. PARP-1 promotes DNA repair and PARP inhibitors (PARPi) sensitise cells to Topo I poisons. We aimed to determine whether chemosensitisation is also S phase specific using...

journal_title：British journal of cancer

authors： Znojek P,Willmore E,Curtin NJ

更新日期：2014-09-23 00:00:00

abstract：:The overall tumour incidence and breast cancer incidence related to hormone replacement therapy (HRT) were followed in a population-based cohort of 29 508 women, aged 25-65 when interviewed in 1990-92. By the end of the follow up in December 1999, there were 226 611 person-years of observation. A total of 1145 maligna...

journal_title：British journal of cancer

authors： Olsson H,Bladström A,Ingvar C,Möller TR

更新日期：2001-09-01 00:00:00

abstract：:The S-phase fraction (SPF) in flow cytometric DNA histograms in soft tissue sarcoma (STS) can be calculated in various ways. The traditional planimetric method of Baisch has been shown to be prognostic, but is hampered by a failure rate of around 40%. We therefore tested other models to see if this rate could be decre...

journal_title：British journal of cancer

authors： Gustafson P,Baldetorp B,Fernö M,Akerman M

更新日期：1999-03-01 00:00:00

abstract：:In vivo models of acquired resistance to the platinum-based agents cisplatin (CDDP), carboplatin (CBDCA), iproplatin (CHIP) and tetraplatin have been established using a panel of six parent human ovarian carcinoma lines, two (HX/110 and PXN/87) being derived from previously untreated patients. Resistance has been gene...

journal_title：British journal of cancer

authors： Jones M,Siracky J,Kelland LR,Harrap KR

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:HOX transcript antisense RNA (HOTAIR), which is expressed from the homebox C gene (HOXC) locus, is capable of reprogramming chromatin organisation and promoting cancer cell metastasis and can simultaneously bind the polycomb repressive complex 2, which enhances H3K27 trimethylation, and the LSD1-CoREST-REST ...

journal_title：British journal of cancer

authors： Li X,Wu Z,Mei Q,Li X,Guo M,Fu X,Han W

更新日期：2013-10-15 00:00:00

abstract：:The purpose of this study was to evaluate the occurrence of lymphatic drainage to non-axillary sentinel nodes and to determine the implications of this phenomenon. A total of 549 breast cancer patients underwent lymphoscintigraphy after intratumoural injection of (99m)Tc-nanocolloid. The sentinel node was intraoperati...

journal_title：British journal of cancer

authors： Tanis PJ,Nieweg OE,Valdés Olmos RA,Peterse JL,Rutgers EJ,Hoefnagel CA,Kroon BB

更新日期：2002-09-23 00:00:00

abstract：BACKGROUND:Here, we explore the therapeutic potential of dasatinib, a small-molecule inhibitor that targets multiple cytosolic and membrane-bound tyrosine kinases, including members of the Src kinase family, EphA2, and focal adhesion kinase for the treatment of ovarian cancer. METHODS:We examined the effects of dasati...

journal_title：British journal of cancer

authors： Konecny GE,Glas R,Dering J,Manivong K,Qi J,Finn RS,Yang GR,Hong KL,Ginther C,Winterhoff B,Gao G,Brugge J,Slamon DJ

更新日期：2009-11-17 00:00:00

abstract：BACKGROUND:The natural history of prostate cancer is highly variable and difficult to predict accurately. Better markers are needed to guide management and avoid unnecessary treatment. In this study, we validate the prognostic value of a cell cycle progression score (CCP score) independently and in a prespecified linea...

journal_title：British journal of cancer

authors： Cuzick J,Stone S,Fisher G,Yang ZH,North BV,Berney DM,Beltran L,Greenberg D,Møller H,Reid JE,Gutin A,Lanchbury JS,Brawer M,Scardino P

更新日期：2015-07-28 00:00:00

abstract：:The present study set out to evaluate perceptions of risk, psychological morbidity and health behaviours in women with a family history of breast cancer who have attended genetic counselling and determine how these differ from general population risk women. Data were collected from 62 genetic counselees (cases) attend...

journal_title：British journal of cancer

authors： Lloyd S,Watson M,Waites B,Meyer L,Eeles R,Ebbs S,Tylee A

更新日期：1996-08-01 00:00:00

abstract：BACKGROUND:When tumour tissue is unavailable, cell-free DNA (cfDNA)can serve as a surrogate for genetic analyses. Because mutated alleles in cfDNA are usually below 1%, next-generation sequencing (NGS)must be narrowed to target only clinically relevant genes. In this proof-of-concept study, we developed a panel to use ...

journal_title：British journal of cancer

authors： Malapelle U,Mayo de-Las-Casas C,Rocco D,Garzon M,Pisapia P,Jordana-Ariza N,Russo M,Sgariglia R,De Luca C,Pepe F,Martinez-Bueno A,Morales-Espinosa D,González-Cao M,Karachaliou N,Viteri Ramirez S,Bellevicine C,Molina-Vila M

更新日期：2017-03-14 00:00:00

abstract：:The retinoblastoma gene product (RB) contributes to normal cell growth control. One of its functions is manifest as a block to exit from G1, which is carried out by an RB subspecies which is un- or underphosphorylated. After RB phosphorylation, a process which occurs towards the end of G1 in cycling cells, the block i...

journal_title：British journal of cancer

authors： Livingston DM,Kaelin W,Chittenden T,Qin X

更新日期：1993-08-01 00:00:00

abstract：BACKGROUND:We evaluated the associations of anthropometric indicators of general obesity (body mass index, BMI), an established risk factor of various cancer, and body fat distribution (waist circumference, WC; hip circumference, HC; and waist-to-hip ratio, WHR), which may better reflect metabolic complications of obes...

journal_title：British journal of cancer

authors： Freisling H,Arnold M,Soerjomataram I,O'Doherty MG,Ordóñez-Mena JM,Bamia C,Kampman E,Leitzmann M,Romieu I,Kee F,Tsilidis K,Tjønneland A,Trichopoulou A,Boffetta P,Benetou V,Bueno-de-Mesquita HBA,Huerta JM,Brenner H,Wils

更新日期：2017-05-23 00:00:00