Abstract：
BACKGROUND:In neuroblastoma (NB), the most powerful prognostic marker, the MYCN amplification (MNA), occasionally shows intratumoural heterogeneity (ITH), i.e. coexistence of MYCN-amplified and non-MYCN-amplified tumour cell clones, called heterogeneous MNA (hetMNA). Prognostication and therapy allocation are still unsolved issues. METHODS:The SIOPEN Biology group analysed 99 hetMNA NBs focussing on the prognostic significance of MYCN ITH. RESULTS:Patients <18 months (18 m) showed a better outcome in all stages as compared to older patients (5-year OS in localised stages: <18 m: 0.95 ± 0.04, >18 m: 0.67 ± 0.14, p = 0.011; metastatic: <18 m: 0.76 ± 0.15, >18 m: 0.28 ± 0.09, p = 0.084). The genomic 'background', but not MNA clone sizes, correlated significantly with relapse frequency and OS. No relapses occurred in cases of only numerical chromosomal aberrations. Infiltrated bone marrows and relapse tumour cells mostly displayed no MNA. However, one stage 4s tumour with segmental chromosomal aberrations showed a homogeneous MNA in the relapse. CONCLUSIONS:This study provides a rationale for the necessary distinction between heterogeneous and homogeneous MNA. HetMNA tumours have to be evaluated individually, taking age, stage and, most importantly, genomic background into account to avoid unnecessary upgrading of risk/overtreatment, especially in infants, as well as in order to identify tumours prone to developing homogeneous MNA.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Berbegall AP,Bogen D,Pötschger U,Beiske K,Bown N,Combaret V,Defferrari R,Jeison M,Mazzocco K,Varesio L,Vicha A,Ash S,Castel V,Coze C,Ladenstein R,Owens C,Papadakis V,Ruud E,Amann G,Sementa AR,Navarro S,Ambros PFdoi
10.1038/s41416-018-0098-6subject
Has Abstractpub_date
2018-05-01 00:00:00pages
1502-1512issue
11eissn
0007-0920issn
1532-1827pii
10.1038/s41416-018-0098-6journal_volume
118pub_type
杂志文章,多中心研究abstract：:Deregulated expression of myc proto-oncogenes is implicated in several human neoplasias. We analysed the expression of c-myc, N-myc, L-myc, max and RB1 mRNAs in a panel of human gliomas and glioma cell lines and compared the findings with normal neural cells. The max and RB1 genes were included in the study because th...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1994.3
更新日期：1994-01-01 00:00:00
abstract：BACKGROUND:The role of processed meat in the aetiology of several cancers was explored in detail. METHODS:In the time period 1996-2004, a multisite case-control study was conducted in Montevideo, Uruguay. The study included 6 060 participants (3 528 cases and 2 532 controls) corresponding to cancers of the oral cavity...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究
doi：10.1038/bjc.2012.433
更新日期：2012-10-23 00:00:00
abstract：:The role of the anti-apoptotic protein Bcl-2 in lung cancer remains controversial. In order to clarify its impact on survival in small and non-small cell lung cancer (NSCLC), we performed a systematic review of the literature. Trials were selected for further analysis if they provided an independent assessment of Bcl-...
journal_title：British journal of cancer
pub_type： 杂志文章,meta分析,评审
doi：10.1038/sj.bjc.6601095
更新日期：2003-07-07 00:00:00
abstract：:Detailed data and statistics per each morphological site of various digestive neoplasms were obtained for the period 1976-87 from the Vaud Cancer Registry datafile, a population-based cancer registration scheme covering about 530,000 inhabitants from the French-speaking part of Switzerland. Tabulations presented inclu...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1991.132
更新日期：1991-04-01 00:00:00
abstract：:The efficacy of radioimmunotherapy of tumours with radiolabelled monoclonal antibodies (MAbs) depends on the amount of antibody taken up by the tumour and on its intratumoral distribution. In the case of MAbs directed against intracellular antigens, increasing the permeability of the cytoplasmic membrane may augment t...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1995.468
更新日期：1995-11-01 00:00:00
abstract：:A sedentary lifestyle, obesity, and a Westernized diet have been implicated in the aetiology of both colorectal cancer and non-insulin dependent diabetes mellitus, leading to the hypothesis that hyperinsulinaemia may promote colorectal cancer. We prospectively examined the association between colorectal cancer risk an...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2000.1582
更新日期：2001-02-02 00:00:00
abstract：:Ninety-nine patients with advanced breast cancer were randomized to receive either cyclophosphamide continuously or a combination of cyclophosphamide, methotrexate, 5-fluorouracil and vinblastine given intermittently. The number and duration of objective responses were greater in patients receiving the combination but...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/bjc.1975.284
更新日期：1975-12-01 00:00:00
abstract：:Currently the only tumour marker to have a well-defined and validated role in the management of ovarian cancer is CA125. Changes in the level of CA125 can be used as a reliable indication of response or progression according to various criteria, but it does not yet have a clear place in diagnosis or prognosis. Its val...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1054/bjoc.2000.1174
更新日期：2000-05-01 00:00:00
abstract：:Spontaneous and radiation-induced genetic instability of peripheral blood mononuclear cells derived from unselected breast cancer (BC) patients (n=50) was examined using the single-cell gel electrophoresis (Comet) assay and a modified G2 micronucleus (MN) test. Cells from apparently healthy donors (n=16) and from canc...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603005
更新日期：2006-04-24 00:00:00
abstract：BACKGROUND:Geriatric oncology guidelines state that fit older men with prostate cancer should receive curative treatment. In a population-based study, we investigated associations between age and non-receipt of curative treatment in men with localised prostate cancer, and the effect of clinical variables on this in dif...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2013.268
更新日期：2013-07-09 00:00:00
abstract：BACKGROUND:Record-based studies have generally reported association of higher childhood leukaemia incidence with higher socioeconomic status (SES), but recent findings are less consistent. METHODS:We examined records from the National Registry of Childhood Tumours for evidence of this association in England and Wales ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2011.415
更新日期：2011-11-22 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1994.136
更新日期：1994-04-01 00:00:00
abstract：:Multidrug resistance is often associated with the (over)expression of drug efflux transporters of the ATP-binding cassette (ABC) protein family. This minireview discusses the role of one selected ABC-transporter family member, the breast cancer resistance protein (BCRP/ABCG2), in the (pre)clinical efficacy of novel ex...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/sj.bjc.6604213
更新日期：2008-03-11 00:00:00
abstract：:Screen-detected (SD) breast cancers are smaller and biologically more indolent than clinically presenting cancers. An often debated question is: if left undiagnosed during their preclinical phase, would they become more aggressive or would they only increase in size? This study considered a registry-based series (1988...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602289
更新日期：2005-01-17 00:00:00
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pub_type： 杂志文章
doi：10.1054/bjoc.2001.1699
更新日期：2001-07-06 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-019-0622-3
更新日期：2020-02-01 00:00:00
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journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1054/bjoc.2001.1725
更新日期：2001-06-01 00:00:00
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pub_type： 杂志文章
doi：10.1038/sj.bjc.6602023
更新日期：2004-08-16 00:00:00
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pub_type： 杂志文章
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更新日期：2003-11-03 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
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更新日期：1990-07-01 00:00:00
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doi：10.1038/sj.bjc.6600946
更新日期：2003-06-02 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
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更新日期：2012-10-23 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
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更新日期：1995-04-01 00:00:00
abstract：:beta2-Microglobulin (beta2M), a component of MHC class I molecules, is believed to be associated with tumour status in various cancers. In this study, we examined the expression of beta2M at different malignant stages of oral cavity squamous cell carcinoma (OCSCC). To determine the possible correlation between beta2M ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604698
更新日期：2008-11-04 00:00:00
abstract：:The frequency of M-components was studied by agar gel electrophoresis in sera from 807 patients, 467 (57%) females and 340 (43%) males with histologically proven solid malignant neoplasms.M-components were found in the sera of 40 male and 20 female patients. Apart from two known cases of multiple myeloma and one case ...
journal_title：British journal of cancer
pub_type： 杂志文章
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更新日期：1973-04-01 00:00:00
abstract：BACKGROUND:Doxorubicin and cyclophosphamide (AC) therapy is an effective treatment for early-stage breast cancer. Doxorubicin is a substrate for ABCB1 and SLC22A16 transporters. Cyclophosphamide is a prodrug that requires oxidation to 4-hydroxycyclophosphamide, which yields a cytotoxic alkylating agent. The initial oxi...
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pub_type： 杂志文章
doi：10.1038/sj.bjc.6605587
更新日期：2010-03-16 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2017.73
更新日期：2017-04-11 00:00:00
abstract：BACKGROUND:Germline mutations within DNA-repair genes are implicated in susceptibility to multiple forms of cancer. For prostate cancer (PrCa), rare mutations in BRCA2 and BRCA1 give rise to moderately elevated risk, whereas two of B100 common, low-penetrance PrCa susceptibility variants identified so far by genome-wid...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2016.50
更新日期：2016-04-12 00:00:00
